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2 results on '"Wnt (wingless-related MMTV integration site)"'

1. Intersection of AHR and Wnt Signaling in Development, Health, and Disease.

Author

Schneider, Andrew J., Branam, Amanda M., and Peterson, Richard E.

Subjects
*ARYL hydrocarbon receptors, *CELLULAR signal transduction, *FETAL development, *FETUS, *FETAL diseases, *HEALTH
Abstract

The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site) signaling pathways have been conserved throughout evolution. Appropriately regulated signaling through each pathway is necessary for normal development and health, while dysregulation can lead to developmental defects and disease. Though both pathways have been vigorously studied, there is relatively little research exploring the possibility of crosstalk between these pathways. In this review, we provide a brief background on (1) the roles of both AHR and Wnt signaling in development and disease, and (2) the molecular mechanisms that characterize activation of each pathway. We also discuss the need for careful and complete experimental evaluation of each pathway and describe existing research that explores the intersection of AHR and Wnt signaling. Lastly, to illustrate in detail the intersection of AHR and Wnt signaling, we summarize our recent findings which show that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced disruption of Wnt signaling impairs fetal prostate development. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Intersection of AHR and Wnt Signaling in Development, Health, and Disease

Author

Amanda M. Branam, Andrew J. Schneider, and Richard E. Peterson

Subjects
Male, Polychlorinated Dibenzodioxins, Beta-catenin, Embryonic Development, Review, Disease, Catalysis, Inorganic Chemistry, lcsh:Chemistry, Wnt (wingless-related MMTV integration site), Animals, Humans, Physical and Theoretical Chemistry, Receptor, Molecular Biology, development, lcsh:QH301-705.5, beta Catenin, Spectroscopy, Genetics, disease, TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), prostate, biology, Organic Chemistry, Wnt signaling pathway, toxicity, General Medicine, Aryl hydrocarbon receptor, Computer Science Applications, Cell biology, Wnt Proteins, Crosstalk (biology), Receptors, Aryl Hydrocarbon, lcsh:Biology (General), lcsh:QD1-999, AHR (aryl hydrocarbon receptor), biology.protein, Signal transduction, Ahr aryl hydrocarbon receptor, β-catenin (CTNNB1), Signal Transduction
Abstract

The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site) signaling pathways have been conserved throughout evolution. Appropriately regulated signaling through each pathway is necessary for normal development and health, while dysregulation can lead to developmental defects and disease. Though both pathways have been vigorously studied, there is relatively little research exploring the possibility of crosstalk between these pathways. In this review, we provide a brief background on (1) the roles of both AHR and Wnt signaling in development and disease, and (2) the molecular mechanisms that characterize activation of each pathway. We also discuss the need for careful and complete experimental evaluation of each pathway and describe existing research that explores the intersection of AHR and Wnt signaling. Lastly, to illustrate in detail the intersection of AHR and Wnt signaling, we summarize our recent findings which show that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced disruption of Wnt signaling impairs fetal prostate development.

Published
2014

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