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9. Preface

Author

Wladimiroff, Juriy W., primary and Eik-Nes, Sturla H., additional

Published
2009
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10. Prenatal prediction of pulmonary hypoplasia: clinical, biometric, and doppler velocity correlates

Author

Laudy, Jacqueline A.M., Tibboel, Dick, Robben, Simon G.F., de Krijger, Ronald R., de Ridder, Maria A.J., and Wladimiroff, Juriy W.

Subjects
Lung diseases -- Diagnosis, Prenatal diagnosis -- Innovations, Oligohydramnios -- Complications
Abstract

Objectives. To determine the value of pulmonary artery Doppler velocimetry relative to fetal biometric indices and clinical correlates in the prenatal prediction of lethal lung hypoplasia (LH) in prolonged (>1 week) oligohydramnios. Methods. Forty-two singleton pregnancies with oligohydramnios associated with premature rupture of membranes ([PROM]; n = 31) or bilateral renal pathology (n = 11) were examined using color-coded Doppler ultrasound in a cross-sectional study design. Mean gestational age was 28.0 [+ or -] 4.3 weeks (range: 20-36 weeks). Thoracic, cardiac, and abdominal circumference and the largest vertical amniotic fluid pocket were measured. Pulsed Doppler measurements of the arterial pulmonary branches were made at the level of the cardiac 4-chamber view. Diagnosis of LH was based on clinical, radiologic, and pathologic criteria. Clinicians were blinded to the prenatal measurements. Results. The prevalence of lethal LH was 43%. In the PROM subset, combination of onset of PROM at [less than or equal to] 20 weeks, duration of oligohydramnios at [greater than or equal to] 8 weeks, and degree of oligohydramnios at [less than or equal to] 1 cm presented the highest clinical prediction rate for lethal LH. For both the total group and the PROM subset, the highest prediction rate for lethal LH was presented by thoracic circumference/ abdominal circumference ratio, peak systolic velocity in the proximal branch, and time-averaged and end-diastolic velocity in the middle branch of the pulmonary artery. In the PROM subset, the combination of all 3 clinical, biometric, and Doppler parameters revealed the most favorable combination to predict lethal LH (positive predictive value: 100%; accuracy: 93%; and sensitivity: 71%). Conclusion. Doppler velocimetry may detect changes in pulmonary artery waveforms in the presence of LH but fails to be the ultimate test for the prenatal prediction of lethal LH. The best prediction can be achieved by combining clinical, biometric, and Doppler parameters. Pediatrics 2002;109:250-258; human fetus, pulmonary hypoplasia, pulmonary circulation, premature rupture of membranes, oligohydramnios, Doppler velocimetry., ABBREVIATIONS. PROM, premature rupture of membranes; LH, lung hypoplasia; PPV, positive predictive value; SD, standard deviation; PSV, peak systolic velocity; PDV, peak diastolic velocity; EDV, end-diastolic velocity; TAV time-averaged velocity; [...]

Published
2002

11. CONTRIBUTORS

Author

Abuhamad, Alfred Z., primary, Avni, Fred E., additional, Ball, Robert H., additional, Bega, George, additional, Benacerraf, Beryl R., additional, Benson, Carol B., additional, Berghella, Vincenzo, additional, Blazer, Shraga, additional, Borgida, Adam F., additional, Bronshtein, Moshe, additional, Callen, Peter W., additional, Cassart, Marie, additional, Chavez, Martin R., additional, Cohen-Overbeek, Titia E., additional, Dashefsky, Sidney M., additional, Deprest, Jan, additional, Egan, James F.X., additional, Espinoza, Jimmy, additional, Eurin, Danielle, additional, Feldstein, Vickie A., additional, Filly, Roy A., additional, Frates, Mary C., additional, Galan, Henry L., additional, Goldstein, Steven R., additional, Gonçalves, Luís F., additional, Gotsch, Francesca, additional, Granese, Roberta, additional, Hall, Michelle, additional, Harris, Robert D., additional, Herbst, Sandra Silva, additional, Holt, Susan C., additional, Jaeggi, Edgar, additional, Jeanty, Philippe, additional, Kusanovic, Juan Pedro, additional, Laing, Faye C., additional, Laudy, Jacqueline A.M., additional, Leite, Juliana M., additional, Levi, Clifford S., additional, Levine, Deborah, additional, Lyons, Edward A., additional, Machin, Geoffrey A., additional, Malone, Fergal D., additional, Massez, Anne, additional, Maugey-Laulom, Brigitte, additional, Mendelson, Ellen B., additional, Moise, Kenneth J., additional, Norton, Mary E., additional, Oyelese, Yinka, additional, Pandipati, Santosh, additional, Perolo, Antonella, additional, Pierson, Roger A., additional, Pilu, Gianluigi, additional, Põder, Liina, additional, Qayyum, Aliya, additional, Romero, Roberto, additional, Sebire, Neil J., additional, Segata, Maria, additional, Valentin, Lil, additional, Vintzileos, Anthony M., additional, Westphalen, Antonio C., additional, Wladimiroff, Juriy W., additional, Yeo, Lami, additional, Yoo, Shi-Joon, additional, and Zimmer, Etan Z., additional

Published
2008
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24. Normal fetal Doppler inferior vena cava, transtricuspid, and umbilical artery flow velocity waveforms between 11 and 16 weeks' gestation

Author

Wladimiroff, Juriy W., Huisman, Tjeerd W.A., Stewart, Patricia A., and Stijnen, Th.

Subjects
Doppler ultrasonography, Fetal heart rate -- Measurement, Umbilical arteries -- Physiological aspects, Health
Abstract

OBJECTIVES: Our objectives were to determine flow velocity waveform patterns in the fetal inferior vena cava and to relate these waveforms to transtricuspid and umbilical artery waveforms and fetal heart rate in early gestation. STUDY DESIGN: Doppler waveforms were recorded in 40 normal fetuses at 11 to 16 weeks of gestation. Only transvaginal scanning was carried out at 11 to 12 weeks and only transabdominal scanning was used at 15 to 16 weeks. RESULTS: The ratio of time velocity integrals of flow from the inferior vena cava during systole and early diastole, the percentage of reverse flow in this vessel, the pulsatility index from the umbilical artery, and the fetal heart rate were negatively correlated with gestational age. Peak E-wave and A-wave velocities and E/A ratios from the transtricuspid waveforms were positively correlated with gestational age. CONCLUSION: Early normal pregnancies are associated with remarkable changes in fetal flow velocity waveforms at both the cardiac and the extracardiac level. (Am J Obstet Gynecol 1992;166:921-4.)

Published
1992

25. Intracerebral, aortic, and umbilical artery flow velocity waveforms in the late-first-trimester fetus

Author

Wladimiroff, Juriy W., Huisman, Tjeerd W.A., and Stewart, Patricia A.

Subjects
Fetal heart rate monitoring -- Methods, Doppler ultrasonography, Fetus -- Ultrasonic imaging, Cerebral circulation -- Measurement, Health
Abstract

OBJECTIVES: Our objectives were to determine the success rate in flow velocity waveforms in the first-trimester fetal circulation and to establish possible preferential flow to the fetal cerebrum at this early stage of gestation. STUDY DESIGN: Flow velocity waveform recordings were made in the umbilical artery, fetal descending aorta, and fetal intracerebral arteries in 30 normal pregnancies between 11 and 13 weeks of gestation. RESULTS: Technically acceptable waveforms were obtained from the descending aorta in 15 fetuses, from the intracerebral circulation in 17 fetuses, and from the umbilical artery in all 30 fetuses. Absent end-diastolic velocities in the descending aorta and umbilical artery were associated with forward flow throughout the cardiac cycle in intracerebral arteries. CONCLUSION: A relatively low cerebral vascular resistance in the late-trimester normal fetus is suggested. (Am J Obstet Gynecol 1992; 166-46-9.)

Published
1992

28. Ultrasound in Obstetrics and Gynaecology: European Practice in Gynaecology and Obstetrics Series

Author

Wladimiroff, Juriy W., Eik-Nes, Sturla H, Wladimiroff, Juriy W., and Eik-Nes, Sturla H

Subjects
Ultrasonics in obstetrics, Generative organs, Female--Ultrasonic imaging
Abstract

European Practice in Gynaecology and Obstetrics is a series of books conceived and endorsed by the European Board and College of Obstetrics and Gynaecology (EBCOG). The topics chosen for each volume are those of significant clinical interest where treatment is changing in response to research findings and developments in practice. The volume editor and contributing authors are European specialists invited to contribute because of their expertise in their field. The books concentrate on various types of management used in European practice as well as published results. The authors present treatments for which a consensus exists and - when there is no consensus - they discuss the key elements of the controversy. Each book provides a review of the basic science, recent concepts in pathophysiology, clinical aspects, treatment and unresolved problems or controversies, as well as the major recent references. A final section provides multiple-choice questions for each chapter.Series concentrates on important and changing areas of clinical practiceEach volume editor is a leading European expert in the fieldContributors are drawn from a wide range of European countries All volumes include a review of basic science and pathophysiology, as well as clinical aspects, treatment, unresolved problemsCurrent references are included for each chapterMultiple choice questions are provided at the end of each chapterThis volume comes with a CD containing all the colour images in the book plus 106 extra images

Published
2009

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