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11 results on '"Witjes, Vera M."'

4. The most efficient and effective BRCA1/2 testing strategy in epithelial ovarian cancer: Tumor-First or Germline-First?

Author

Genetica Klinische Genetica, Cancer, Witjes, Vera M, Ligtenberg, Marjolijn J L, Vos, Janet R, Braspenning, Jozé C C, Ausems, Margreet G E M, Mourits, Marian J E, de Hullu, Joanne A, Adang, Eddy M M, Hoogerbrugge, Nicoline, Genetica Klinische Genetica, Cancer, Witjes, Vera M, Ligtenberg, Marjolijn J L, Vos, Janet R, Braspenning, Jozé C C, Ausems, Margreet G E M, Mourits, Marian J E, de Hullu, Joanne A, Adang, Eddy M M, and Hoogerbrugge, Nicoline

Published
2023

5. Healthcare professionals’ perspectives on implementation of universal tumor DNA testing in ovarian cancer patients: multidisciplinary focus groups

Author

Staf strategisch beleid, Genetica Klinische Genetica, Cancer, Witjes, Vera M., Braspenning, Jozé C.C., Hoogerbrugge, Nicoline, Smolders, Yvonne H.C.M., Hermkens, Dorien M.A., Mourits, Marian J.E., Ligtenberg, Marjolijn J.L., Ausems, Margreet G.E.M., de Hullu, Joanne A., Staf strategisch beleid, Genetica Klinische Genetica, Cancer, Witjes, Vera M., Braspenning, Jozé C.C., Hoogerbrugge, Nicoline, Smolders, Yvonne H.C.M., Hermkens, Dorien M.A., Mourits, Marian J.E., Ligtenberg, Marjolijn J.L., Ausems, Margreet G.E.M., and de Hullu, Joanne A.

Published
2023

6. Healthcare professionals’ perspectives on implementation of universal tumor DNA testing in ovarian cancer patients: multidisciplinary focus groups

Author

Witjes, Vera M., primary, Braspenning, Jozé C. C., additional, Hoogerbrugge, Nicoline, additional, Smolders, Yvonne H. C. M., additional, Hermkens, Dorien M. A., additional, Mourits, Marian J. E., additional, Ligtenberg, Marjolijn J. L., additional, Ausems, Margreet G. E. M., additional, and de Hullu, Joanne A., additional

Published
2022
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7. Probability of detecting germline BRCA1/2 pathogenic variants in histological subtypes of ovarian carcinoma. A meta-analysis

Author

Genetica, Genetica Klinische Genetica, Cancer, Witjes, Vera M., van Bommel, Majke H.D., Ligtenberg, Marjolijn J.L., Vos, Janet R., Mourits, Marian J.E., Ausems, Margreet G.E.M., de Hullu, Joanne A., Bosse, Tjalling, Hoogerbrugge, Nicoline, Genetica, Genetica Klinische Genetica, Cancer, Witjes, Vera M., van Bommel, Majke H.D., Ligtenberg, Marjolijn J.L., Vos, Janet R., Mourits, Marian J.E., Ausems, Margreet G.E.M., de Hullu, Joanne A., Bosse, Tjalling, and Hoogerbrugge, Nicoline

Published
2022

11. [Genetic testing in epithelial ovarian cancer: implementation of the 'Tumor-First' workflow].

Author

Witjes VM and Hoogerbrugge N

Subjects
Female, Humans, BRCA1 Protein genetics, BRCA2 Protein genetics, Genetic Predisposition to Disease, Germ-Line Mutation, Workflow, Carcinoma, Ovarian Epithelial genetics, Genetic Testing methods, Ovarian Neoplasms diagnosis, Ovarian Neoplasms genetics
Abstract

The new 'Tumor-First' workflow for genetic testing in epithelial ovarian cancer detects women with a genetic predisposition effectively and efficiently. 'Tumor-First' indicates that the tumor DNA of all patients diagnosed with epithelial ovarian cancer is examined for the presence of pathogenic variants in, amongst others, BRCA1 and BRCA2 genes. Women with an aberrant tumor DNA test result are eligible for genetic testing using a sample of blood to detect heredity. Simultaneously, the tumor DNA test provides information on the effectiveness of additional treatment with PARP inhibitors. Thereby, the Tumor-First workflow saves time and healthcare costs. This workflow is currently implemented on a national level. The focus of implementation is transferring knowledge to healthcare professionals on requesting, interpreting and reporting the tumor DNA test and providing adequate support. This nationwide implementation of Tumor-First can improve the recognition of heredity in epithelial ovarian cancer.

Published
2023

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