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2 results on '"Withangulatin I"'

1. ChemInform Abstract: Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata

Author

Shwu-Woan Lee, Zong-Tsi Chen, Min-Hsiung Pan, and Chiu-Ming Chen

Subjects
Circular dichroism, biology, Physalis angulata, General Medicine, biology.organism_classification, Molecular biology, In vitro, chemistry.chemical_compound, Withanolide, chemistry, Cell culture, Withangulatin I, Cytotoxic T cell, Withangulatin A
Abstract

A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15alpha-acetoxy-5beta,6beta-epoxy-14alpha-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC(50) values of 16.6 and 1.8 and 53.6 and 65.4 muM, respectively.

Published
2008
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2. Withangulatin I, a new cytotoxic withanolide from Physalis angulata

Author

Zong-Tsi Chen, Shwu-Woan Lee, Min-Hsiung Pan, and Chiu-Ming Chen

Subjects
Circular dichroism, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Physalis, Spectrophotometry, Infrared, Stereochemistry, Physalis angulata, chemistry.chemical_compound, Withangulatin I, Cell Line, Tumor, Drug Discovery, Cytotoxic T cell, Humans, Withangulatin A, Withanolides, Antibiotics, Antineoplastic, biology, Chemistry, Plant Extracts, General Chemistry, General Medicine, biology.organism_classification, Molecular biology, Antineoplastic Agents, Phytogenic, In vitro, Withanolide, Cell culture, Doxorubicin, Camptothecin, Spectrophotometry, Ultraviolet, Drug Screening Assays, Antitumor, Oxidation-Reduction
Abstract

A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15alpha-acetoxy-5beta,6beta-epoxy-14alpha-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC(50) values of 16.6 and 1.8 and 53.6 and 65.4 muM, respectively.

Published
2008

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