642 results on '"Wistuba I"'
Search Results
2. P2.01-06 NAUTIKA1 Study: Preliminary Efficacy and Safety Data with Neoadjuvant Alectinib in Patients with Stage IB-III ALK+ NSCLC
- Author
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Lee, J.M., primary, Toloza, E.M., additional, Pass, H.I., additional, Johnson, B.E., additional, Heymach, J.V., additional, Sholl, L., additional, Saqi, A., additional, Travis, W.D., additional, Wistuba, I., additional, Lin, J., additional, Kris, M.G., additional, Spira, A.I., additional, Shu, C.A., additional, Saltos, A.N., additional, Ding, B., additional, Schulze, K., additional, Zhu, Q., additional, Ngiam, C., additional, Bara, I., additional, and Chaft, J.E., additional
- Published
- 2023
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3. Peripheral T-Cell Priming and Micrometastatic Disease Control with Metastasis-Directed Therapy: Multidimensional Immunogenomic Profiling of Oligometastatic Prostate Cancer in the EXTEND Trial
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Sherry, A.D., primary, Haymaker, C., additional, Bathala, T., additional, Lu, X., additional, Medina-Rosales, M., additional, Marmonti, E., additional, Pradeep, H., additional, Liu, S., additional, Fellman, B., additional, Mok, H., additional, Choi, S., additional, Chun, S.G., additional, Aparicio, A., additional, Kovitz, C., additional, Zurita-Saavedra, A., additional, Gomez, D.R., additional, Reuben, A., additional, Wistuba, I., additional, Corn, P.G., additional, and Tang, C., additional
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- 2023
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4. Atezolizumab plus bevacizumab in advanced Merkel cell carcinoma: A prospective study
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de Sousa, L. Guimaraes, Liu, S., Bhosale, P., Altan, M., Darbonne, W., Schulze, K., Dervin, S., Yun, C., Mahvash, A., Verma, A., Futreal, A., Gite, S., Cuentas, E. Parra, Cho, W.C., Wistuba, I., Yao, J.C., Woodman, S.E., Halperin, D.M., and Ferrarotto, R.
- Published
- 2024
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5. High prevalence of mutantKRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients
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Allenson, K., Castillo, J., San Lucas, F.A., Scelo, G., Kim, D.U., Bernard, V., Davis, G., Kumar, T., Katz, M., Overman, M.J., Foretova, L., Fabianova, E., Holcatova, I., Janout, V., Meric-Bernstam, F., Gascoyne, P., Wistuba, I., Varadhachary, G., Brennan, P., Hanash, S., Li, D., Maitra, A., and Alvarez, H.
- Published
- 2017
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6. PP01.39 Infrastructure for Interobserver Variability Assessment of Pathologic Response (PR), in Surgical Resection Specimens Following Neoadjuvant Immune Check Point Inhibitor (ICI) Therapies in Early Stage NSCLC
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Bota-Rabassedas, N., primary, Wijeratne, S., additional, Connolly, C., additional, Wynes, M., additional, Sanchez-Espiridion, B., additional, Fujimoto, J., additional, Posadas, J., additional, Walker, A., additional, Zhu, H., additional, Dacic, S., additional, Travis, W., additional, Lee, J., additional, Kerr, K., additional, Glass, C., additional, Saqui, A., additional, Sholl, L., additional, Cooper, W., additional, Roden, A., additional, Poleri, C., additional, Chung, J.-H., additional, Lopez-Martin, J., additional, Borczuk, A., additional, Weissferdt, A., additional, and Wistuba, I., additional
- Published
- 2023
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7. PP01.53 Pathologic Response Assessment Tool – Architecting a Cloud-Based Tool to Streamline Logistics for Shipping, Tracking, Scoring, and Reporting
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Posadas Ruiz, J., primary, Walker, A., additional, Zhu, H., additional, Bota-Rabassedas, N., additional, Wijeratne, S., additional, Connolly, C., additional, Wynes, M., additional, Sanchez-Espiridion, B., additional, Dacic, S., additional, Wistuba, I., additional, and Lee, J., additional
- Published
- 2023
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8. Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes
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San Lucas, F.A., Allenson, K., Bernard, V., Castillo, J., Kim, D.U., Ellis, K., Ehli, E.A., Davies, G.E., Petersen, J.L., Li, D., Wolff, R., Katz, M., Varadhachary, G., Wistuba, I., Maitra, A., and Alvarez, H.
- Published
- 2016
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9. Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer (EXTEND): A Multicenter, Randomized Phase II Trial
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Tang, C., primary, Sherry, A.D., additional, Haymaker, C., additional, Bathala, T., additional, Liu, S., additional, Fellman, B., additional, Aparicio, A., additional, Zurita-Saavedra, A., additional, Chun, S.., additional, Reddy, J., additional, Efstathiou, E., additional, Wang, J., additional, Pilie, P., additional, Reuben, A., additional, Kovitz, C., additional, Kumar, R., additional, Chapin, B., additional, Gomez, D.R., additional, Wistuba, I., additional, and Corn, P.G., additional
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- 2022
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10. ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis
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Peng, D H, Ungewiss, C, Tong, P, Byers, L A, Wang, J, Canales, J R, Villalobos, P A, Uraoka, N, Mino, B, Behrens, C, Wistuba, I I, Han, R I, Wanna, C A, Fahrenholtz, M, Grande-Allen, K J, Creighton, C J, and Gibbons, D L
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- 2017
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11. Multiplatform-based molecular subtypes of non-small-cell lung cancer
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Chen, F, Zhang, Y, Parra, E, Rodriguez, J, Behrens, C, Akbani, R, Lu, Y, Kurie, J M, Gibbons, D L, Mills, G B, Wistuba, I I, and Creighton, C J
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- 2017
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12. P3.08E.01 Perioperative Chemoimmunotherapy Rescue Cold HLA-Deficient Tumors Inducing Strong Immune Responses and Long-Term Survival.
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Molina-Alejandre, M., Perea, F., Calvo, V., Nadal, E., Huidobro, G., Martínez, C., Martínez-Martí, A., Sierra, B., Insa, A., Massutí, B., Aguilar, A., Barneto, I., Rodríguez - Abreu, D., De Castro Carpeño, J., García Campelo, M.R., Cobo, M., Wistuba, I., Parra, E.R., Martín-López, J., and Megías, D.
- Published
- 2024
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13. P2.11A.08 Molecular and Immunological Features Associated with Long-Term Benefit in Metastatic NSCLC Patients Undergoing Immune Checkpoint Blockade
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Rocha, P., Bach, R., Masfarre, L., Hernandez, S., Navarro-Gorro, N., Rossell, A., Villanueva, X., Giner, M., Sanchez, I., Galindo, M., del Rey-Vergara, R., Iñañez, A., Sanchéz-Espiridion, B., Lu, W., Acedo-Terrades, A., Berenguer-Molins, P., Sánchez-Font, A., Chalela, R., Curull, V., Taus, Á., Hardy-Werbin, M., Sausen, M., Georgiadis, A., White, J., Jackson, J.B., Moliner, L., Clavé, S., Bellosillo, B., Rovira, A., Wistuba, I., Solis Soto, L.M., Perera-Bel, J., and Arriola, E.
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- 2024
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14. MA15.09 LCMC3: Long-Term Disease-Free and Overall Survival and their Association with ctDNA after Neoadjuvant Atezolizumab for NSCLC
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Owen, D.H., Chaft, J.E., Haura, E.B., Toloza, E., Waqar, S.N., Patterson, G.A., Finley, D., Blasberg, J., Raz, D., Salgia, R., Lee, J.M., Bunn, P., Wistuba, I., Kwiatowski, D.J., Hirsch, F.R., Gopalakrishnan, A., Batra, A., Brandão, E., Grindheim, J.M., Nicholas, A., Johnson, A., Schulze, K., Shum, E., Nagasaka, M., Gainor, J., McNamee, C.J., Johnson, B.E., Kris, M.G., Rusch, V.W., and Carbone, D.P.
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- 2024
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15. Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients
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Castillo, J, Bernard, V, San Lucas, F A, Allenson, K, Capello, M, Kim, D U, Gascoyne, P, Mulu, F C, Stephens, B M, Huang, J, Wang, H, Momin, A A, Jacamo, R O, Katz, M, Wolff, R, Javle, M, Varadhachary, G, Wistuba, I I, Hanash, S, Maitra, A, and Alvarez, H
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- 2018
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16. Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents
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Tsai, W-B, Long, Y, Park, J-R, Chang, J T, Liu, H, Rodriguez-Canales, J, Savaraj, N, Feun, L G, Davies, M A, Wistuba, I I, and Kuo, M T
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- 2016
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17. ESMO expert consensus statements on the management of EGFR mutant non-small-cell lung cancer
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Passaro, A., Leighl, N., Blackhall, F., Popat, S., Kerr, K., Ahn, M. J., Arcila, M. E., Arrieta, O., Planchard, D., de Marinis, F., Dingemans, A. M., Dziadziuszko, R., Faivre-Finn, C., Feldman, J., Felip, E., Curigliano, G., Herbst, R., Janne, P. A., John, T., Mitsudomi, T., Mok, T., Normanno, N., Paz-Ares, L., Ramalingam, S., Sequist, L., Vansteenkiste, J., Wistuba, I. I., Wolf, J., Wu, Y. L., Yang, S. R., Yang, J. C. H., Yatabe, Y., Pentheroudakis, G., Peters, S., Passaro, A., Leighl, N., Blackhall, F., Popat, S., Kerr, K., Ahn, M. J., Arcila, M. E., Arrieta, O., Planchard, D., de Marinis, F., Dingemans, A. M., Dziadziuszko, R., Faivre-Finn, C., Feldman, J., Felip, E., Curigliano, G., Herbst, R., Janne, P. A., John, T., Mitsudomi, T., Mok, T., Normanno, N., Paz-Ares, L., Ramalingam, S., Sequist, L., Vansteenkiste, J., Wistuba, I. I., Wolf, J., Wu, Y. L., Yang, S. R., Yang, J. C. H., Yatabe, Y., Pentheroudakis, G., and Peters, S.
- Abstract
The European Society for Medical Oncology (ESMO) held a virtual consensus-building process on epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer in 2021. The consensus included a multidisciplinary panel of 34 leading experts in the management of lung cancer. The aim of the consensus was to develop recommendations on topics that are not covered in detail in the current ESMO Clinical Practice Guideline and where the available evidence is either limited or conflicting. The main topics identified for discussion were: (i) tissue and biomarkers analyses; (ii) early and locally advanced disease; (iii) metastatic disease and (iv) clinical trial design, patient's perspective and miscellaneous. The expert panel was divided into four working groups to address questions relating to one of the four topics outlined above. Relevant scientific literature was reviewed in advance. Recommendations were developed by the working groups and then presented to the entire panel for further discussion and amendment before voting. This manuscript presents the recommendations developed, including findings from the expert panel discussions, consensus recommendations and a summary of evidence supporting each recommendation.
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- 2022
18. Metastasis of cancer: when and how?
- Author
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Lee, W.-C., Kopetz, S., Wistuba, I. I., and Zhang, J.
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- 2017
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19. Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up
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Kadara, H., Choi, M., Zhang, J., Parra, E. R., Rodriguez-Canales, J., Gaffney, S. G., Zhao, Z., Behrens, C., Fujimoto, J., Chow, C., Yoo, Y., Kalhor, N., Moran, C., Rimm, D., Swisher, S., Gibbons, D. L., Heymach, J., Kaftan, E., Townsend, J. P., Lynch, T. J., Schlessinger, J., Lee, J., Lifton, R. P., Wistuba, I. I., and Herbst, R. S.
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- 2017
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20. Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer
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Federico, L., primary, McGrail, D.J., additional, Bentebibel, S.-E., additional, Haymaker, C., additional, Ravelli, A., additional, Forget, M.-A., additional, Karpinets, T., additional, Jiang, P., additional, Reuben, A., additional, Negrao, M.V., additional, Li, J., additional, Khairullah, R., additional, Zhang, J., additional, Weissferdt, A., additional, Vaporciyan, A.A., additional, Antonoff, M.B., additional, Walsh, G., additional, Lin, S.-Y., additional, Futreal, A., additional, Wistuba, I., additional, Roth, J., additional, Byers, L.A., additional, Gaudreau, P.-O., additional, Uraoka, N., additional, Cruz, A.F., additional, Dejima, H., additional, Lazcano, R.N., additional, Solis, L.M., additional, Parra, E.R., additional, Lee, J.J., additional, Swisher, S., additional, Cascone, T., additional, Heymach, J.V., additional, Sepesi, B., additional, Gibbons, D.L., additional, and Bernatchez, C., additional
- Published
- 2022
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21. miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer
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Du, L, Zhao, Z, Ma, X, Hsiao, T-H, Chen, Y, Young, E, Suraokar, M, Wistuba, I, Minna, J D, and Pertsemlidis, A
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- 2014
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22. LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells
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Wei, Q, Chen, Z-H, Wang, L, Zhang, T, Duan, L, Behrens, C, Wistuba, I I, Minna, J D, Gao, B, Luo, J -H, and Liu, Z P
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- 2016
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23. OA06.04 Constructing a Global Molecular Database for Thoracic Malignancies: The IASLC Molecular Subcommittee Lung Cancer Dataset
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Osarogiagbon, R., primary, Nishimura, K., additional, Porta, R. Rami, additional, Montuenga, L., additional, Giroux, D., additional, Suda, K., additional, Araujo, L., additional, Detterbeck, F., additional, Gautschi, O., additional, Kerr, K., additional, Kneuertz, P., additional, Mack, P., additional, Matilla, J., additional, Nicholson, A., additional, Pass, H., additional, Presley, C., additional, Terra, R., additional, Wistuba, I., additional, Yang, D., additional, Yatabe, Y., additional, Travis, W., additional, Tsao, M., additional, Asamura, H., additional, Rusch, V., additional, Hirsch, F., additional, and Carbone, D., additional
- Published
- 2021
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24. MA09.01 LCMC3: Immune Cell Subtypes Predict Nodal Status and Pathologic Response After Neoadjuvant Atezolizumab in Resectable NSCLC
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Oezkan, F., primary, Seweryn, M., additional, Pietrzak, M., additional, Byun, W.Y., additional, Owen, D., additional, Schulze, K., additional, Nicholas, A., additional, Hilz, S., additional, Grindheim, J., additional, Johnson, A., additional, Kwiatkowski, D., additional, Wistuba, I., additional, Johnson, B., additional, Kris, M., additional, Rusch, V., additional, Lee, J., additional, Lozanski, G., additional, and Carbone, D., additional
- Published
- 2021
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25. OA20.01 Long Term Survival in Operable Stage Iiia Nsclc Patients Treated With Neoadjuvant Nivolumab Plus Chemotherapy - Nadim Study
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Provencio, M., primary, Nadal, E., additional, Insa, A., additional, Campelo, M.R. García, additional, Pereiro, D., additional, Domine, M., additional, Majem, M., additional, Abreu, D. Rodriguez, additional, Martinez-Marti, A., additional, De Castro, J., additional, Cobo, M., additional, Vivanco, G. López, additional, Del Barco, E., additional, Bernabé, R., additional, Viñolas, N., additional, Barneto, I., additional, Viteri, S., additional, Pereira, E., additional, Royuela, A., additional, Casarrubios, M., additional, Salas, C., additional, Parra, E.R., additional, Wistuba, I., additional, Calvo, V., additional, Laza - Briviesca, R., additional, Romero, A., additional, Massuti, B., additional, and Cruz, A., additional
- Published
- 2021
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26. PS01.05 Surgical and Clinical Outcomes With Neoadjuvant Atezolizumab in Resectable Stage IB–IIIB NSCLC: LCMC3 Trial Primary Analysis
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Lee, J., Chaft, J., Nicholas, A., Patterson, A., Waqar, S., Toloza, E., Haura, E., Raz, D., Reckamp, K., Merritt, R., Owen, D., Finley, D., Mcnamee, C., Blasberg, J., Garon, E., Mitchell, J., Doebele, R., Baciewicz, F., Nagasaka, M., Pass, H., Schulze, K., Phan, S., Johnson, A., Bunn, P., Johnson, B., Kris, M., Kwiatkowski, D., Wistuba, I., Carbone, D., and Rusch, V.
- Published
- 2021
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27. Pre-treatment tissue TCR repertoire evenness is associated with complete pathological response in patients with NSCLC receiving neoadjuvant chemoimmunotherapy
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Casarrubios M, Cruz-Bermudez A, Nadal E, Insa A, Garcia-Campelo R, Lazaro M, Domine M, Majem M, Rodriguez-Abreu D, Martinez-Marti A, de Castro-Carpeno J, Cobo M, Lopez-Vivanco G, Del Barco E, Bernabe Caro R, Vinolas N, Barneto Aranda I, Viteri S, Massuti B, Barquin M, Laza-Briviesca R, Sierra-Rodero B, Parra E, Sanchez-Espiridion B, Rocha P, Kadara H, Wistuba I, Romero A, Calvo V, and Provencio M
- Abstract
PURPOSE: Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathological response to immunotherapy in locally-advanced non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: In this study, next-generation TCR sequencing was performed in peripheral blood and tissue samples of 40 NSCLC patients, before and after neoadjuvant chemoimmunotherapy (NADIM clinical trial, NCT03081689), considering their complete pathologic response (CPR) or non-CPR. Beyond TCR metrics, tissue clones were ranked by their frequency and spatiotemporal evolution of top 1% clones was determined. RESULTS: We have found a positive association between an uneven TCR repertoire in tissue samples at diagnosis and CPR at surgery. Moreover, TCR most frequent-ranked clones (top 1%) present in diagnostic biopsies occupied greater frequency in the total clonal space of CPR patients, achieving an AUC ROC to identify CPR patients of 0.967 (95% CI, 0.897 to 1.000; p=0.001), and improving the results of PD-L1 TPS (AUC 0.767; p=0.026) or TMB (AUC 0.550; p=0.687). Furthermore, tumors with high pre-treatment top 1% clonal space showed similar immune cell populations but a higher immune reactive gene expression profile. Finally, the selective expansion of pre-treatment tissue top 1% clones in peripheral blood of CPR patients suggests also a peripheral immunosurveillance, which could explain the high survival rate of these patients. CONCLUSIONS: We have identified two parameters derived from TCR repertoire analysis that could outperform PD-L1 TPS and TMB as predictive biomarkers of CPR after neoadjuvant chemoimmunotherapy, and unraveled possible mechanisms of CPR involving enhanced tumor immunogenicity and peripheral immunosurveillance.
- Published
- 2021
28. Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1α in non-small cell lung cancer cells
- Author
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Xu, L, Nilsson, M B, Saintigny, P, Cascone, T, Herynk, M H, Du, Z, Nikolinakos, P G, Yang, Y, Prudkin, L, Liu, D, Lee, J J, Johnson, F M, Wong, K-K, Girard, L, Gazdar, A F, Minna, J D, Kurie, J M, Wistuba, I I, and Heymach, J V
- Published
- 2010
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29. Oncogenic signaling pathways in the Cancer Genome Atlas
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Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., Chakravarty, D., Daian, F., Gao, Q., Bailey, M. H., Liang, W. -W., Foltz, S. M., Shmulevich, I., Ding, L., Heins, Z., Ochoa, A., Gross, B., Gao, J., Zhang, H., Kundra, R., Kandoth, C., Bahceci, I., Dervishi, L., Doğrusöz, Uğur, Zhou, W., Shen, H., Laird, P. W., Way, G. P., Greene, C. S., Liang, H., Xiao, Y., Wang, C., Iavarone, A., Berger, A. H., Bivona, T. G., Lazar, A. J., Hammer, G. D., Giordano, T., Kwong, L. N., McArthur, G., Huang, C., Tward, A. D., Frederick, M. J., McCormick, F., Meyerson, M., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Meier, S., Noble, M. S., Saksena, G., Voet, D., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Thorsson, V., Zhang, W., Akbani, R., Broom, B. M., Hegde, A. M., Ju, Z., Kanchi, R. S., Korkut, A., Li, J., Ling, S., Liu W., Lu, Y., Mills, G. B., Ng, K. -S., Rao, A., Ryan, M., Wang, J., Weinstein, J. N., Zhang, J., Abeshouse, A., de, Bruijn, I., Gross, B. E., Heins, Z. J., La, K., Ladanyi, M., Nissan, M. G., Phillips, S. M., Reznik, E., Sander, C., Schultz, N., Sheridan, R., Sumer, S. O., Sun, Y., Taylor, B. S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J. M., Wong, C. K., Yau, C., Hayes, D. N., Parker, J. S., Wilkerson, M. D., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S. J. M., Kasaian, K., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Robertson, A. G., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A. C., Beroukhim, R., Cherniack, A. D., Cibulskis, C., Gabriel, S. B., Gao, G. F., Ha, G., Schumacher, S. E., Shih, J., Kucherlapati, M. H., Kucherlapati, R. S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M. S., Lai, P. H., Maglinte, D. T., Van, Den, Berg, D. J., Weisenberger, D. J., Auman, J. T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K. A., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, A. H., Perou, C. M., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Bellair, M., Chang, K., Covington, K., Creighton, C. J., Dinh, H., Doddapaneni, H., Donehower, L. A., Drummond, J., Gibbs, R. A., Glenn, R., Hale, W., Han, Y., Hu, J., Korchina, V., Lee, S., Lewis, L., Li, W., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D. A., Xi, L., Zhao, F., Hess, J., Appelbaum, E. L., Bailey, M., Cordes, M. G., Fronick, C. C., Fulton, L. A., Fulton, R. S., Mardis, E. R., McLellan, M. D., Miller, C. A., Schmidt, H. K., Wilson, R. K., Crain, D., Curley, E., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Sherman, M., Thompson, E., Yena, P., Bowen, J., Gastier-Foster, J. M., Gerken, M., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Wise, L., Zmuda, E., Corcoran, N., Costello, T., Hovens, C., Carvalho, A. L., de, Carvalho, A. C., Fregnani, J. H., Longatto-Filho, A., Reis, R. M., Scapulatempo-Neto, C., Silveira, H. C. S., Vidal, D. O., Burnette, A., Eschbacher, J., Hermes, B., Noss, A., Singh, R., Anderson, M. L., Castro, P. D., Ittmann, M., Huntsman, D., Kohl, B., Le, X., Thorp, R., Andry, C., Duffy, E. R., Lyadov, V., Paklina, O., Setdikova, G., Shabunin, A., Tavobilov, M., McPherson, C., Warnick, R., Berkowitz, R., Cramer, D., Feltmate, C., Horowitz, N., Kibel, A., Muto, M., Raut, C. P., Malykh, A., Barnholtz-Sloan, J. S., Barrett, W., Devine, K., Fulop, J., Ostrom, Q. T., Shimmel, K., Wolinsky, Y., Sloan, A. E., De, Rose, A., Giuliante, F., Goodman, M., Karlan, B. Y., Hagedorn, C. H., Eckman, J., Harr, J., Myers, J., Tucker, K., Zach, L. A., Deyarmin, B., Hu, H., Kvecher, L., Larson, C., Mural, R. J., Somiari, S., Vicha, A., Zelinka, T., Bennett, J., Iacocca, M., Rabeno, B., Swanson, P., Latour, M., Lacombe, L., Têtu, B., Bergeron, A., McGraw, M., Staugaitis, S. 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Doddapaneni H., Donehower L.A., Drummond J., Gibbs R.A., Glenn R., Hale W., Han Y., Hu J., Korchina V., Lee S., Lewis L., Li W., Liu X., Morgan M., Morton D., Muzny D., Santibanez J., Sheth M., Shinbrot E., Wang L., Wang M., Wheeler D.A., Xi L., Zhao F., Hess J., Appelbaum E.L., Bailey M., Cordes M.G., Fronick C.C., Fulton L.A., Fulton R.S., Mardis E.R., McLellan M.D., Miller C.A., Schmidt H.K., Wilson R.K., Crain D., Curley E., Gardner J., Lau K., Mallery D., Morris S., Paulauskis J., Penny R., Shelton C., Shelton T., Sherman M., Thompson E., Yena P., Bowen J., Gastier-Foster J.M., Gerken M., Leraas K.M., Lichtenberg T.M., Ramirez N.C., Wise L., Zmuda E., Corcoran N., Costello T., Hovens C., Carvalho A.L., de Carvalho A.C., Fregnani J.H., Longatto-Filho A., Reis R.M., Scapulatempo-Neto C., Silveira H.C.S., Vidal D.O., Burnette A., Eschbacher J., Hermes B., Noss A., Singh R., Anderson M.L., Castro P.D., Ittmann M., Huntsman D., Kohl B., Le X., Thorp R., Andry C., Duffy E.R., Lyadov V., Paklina O., Setdikova G., Shabunin A., Tavobilov M., McPherson C., Warnick R., Berkowitz R., Cramer D., Feltmate C., Horowitz N., Kibel A., Muto M., Raut C.P., Malykh A., Barnholtz-Sloan J.S., Barrett W., Devine K., Fulop J., Ostrom Q.T., Shimmel K., Wolinsky Y., Sloan A.E., De Rose A., Giuliante F., Goodman M., Karlan B.Y., Hagedorn C.H., Eckman J., Harr J., Myers J., Tucker K., Zach L.A., Deyarmin B., Hu H., Kvecher L., Larson C., Mural R.J., Somiari S., Vicha A., Zelinka T., Bennett J., Iacocca M., Rabeno B., Swanson P., Latour M., Lacombe L., Tetu B., Bergeron A., McGraw M., Staugaitis S.M., Chabot J., Hibshoosh H., Sepulveda A., Su T., Wang T., Potapova O., Voronina O., Desjardins L., Mariani O., Roman-Roman S., Sastre X., Stern M.-H., Cheng F., Signoretti S., Berchuck A., Bigner D., Lipp E., Marks J., McCall S., McLendon R., Secord A., Sharp A., Behera M., Brat D.J., Chen A., Delman K., Force S., Khuri F., Magliocca K., Maithel S., Olson J.J., Owonikoko T., Pickens A., Ramalingam 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Goparaju C., Melamed J., Pass H., Botnariuc N., Caraman I., Cernat M., Chemencedji I., Clipca A., Doruc S., Gorincioi G., Mura S., Pirtac M., Stancul I., Tcaciuc D., Albert M., Alexopoulou I., Arnaout A., Bartlett J., Engel J., Gilbert S., Parfitt J., Sekhon H., Thomas G., Rassl D.M., Rintoul R.C., Bifulco C., Tamakawa R., Urba W., Hayward N., Timmers H., Antenucci A., Facciolo F., Grazi G., Marino M., Merola R., de Krijger R., Gimenez-Roqueplo A.-P., Piche A., Chevalier S., McKercher G., Birsoy K., Barnett G., Brewer C., Farver C., Naska T., Pennell N.A., Raymond D., Schilero C., Smolenski K., Williams F., Morrison C., Borgia J.A., Liptay M.J., Pool M., Seder C.W., Junker K., Omberg L., Dinkin M., Manikhas G., Alvaro D., Bragazzi M.C., Cardinale V., Carpino G., Gaudio E., Chesla D., Cottingham S., Dubina M., Moiseenko F., Dhanasekaran R., Becker K.-F., Janssen K.-P., Slotta-Huspenina J., Abdel-Rahman M.H., Aziz D., Bell S., Cebulla C.M., Davis A., Duell R., Elder J.B., Hilty J., Kumar 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Walker J., Zuna R., Feldman M., Valdivieso F., Dhir R., Luketich J., Pinero E.M.M., Quintero-Aguilo M., Carlotti C.G., Dos Santos J.S., Kemp R., Sankarankuty A., Tirapelli D., Catto J., Agnew K., Swisher E., Creaney J., Robinson B., Shelley C.S., Godwin E.M., Kendall S., Shipman C., Bradford C., Carey T., Haddad A., Moyer J., Peterson L., Prince M., Rozek L., Wolf G., Bowman R., Fong K.M., Yang I., Korst R., Rathmell W.K., Fantacone-Campbell J.L., Hooke J.A., Kovatich A.J., Shriver C.D., DiPersio J., Drake B., Govindan R., Heath S., Ley T., Van Tine B., Westervelt P., Rubin M.A., Lee J.I., Aredes N.D., Mariamidze A., Van Allen E.M., and Ciriello G.
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0301 basic medicine ,cancer genome atlas ,cancer genomics ,combination therapy ,pan-cancer ,PanCanAtlas ,precision oncology ,signaling pathways ,TCGA ,therapeutics ,whole exome sequencing ,Signaling pathways ,Somatic cell ,Wnt Protein ,Cancer Genome Atlas Research Network ,Biochemistry ,Medical and Health Sciences ,Phosphatidylinositol 3-Kinases ,Transforming Growth Factor beta ,Neoplasms ,Databases, Genetic ,LS2_1 ,Cancer genomics ,LS4_6 ,610 Medicine & health ,11 Medical and Health Sciences ,Cancer ,biology ,Wnt signaling pathway ,cancer genomic ,Precision oncology ,Biological Sciences ,Cell cycle ,DNA methylation ,Signal transduction ,CICLO CELULAR ,Life Sciences & Biomedicine ,Genes, Neoplasm ,Humans ,Neoplasms/genetics ,Neoplasms/pathology ,Phosphatidylinositol 3-Kinases/genetics ,Phosphatidylinositol 3-Kinases/metabolism ,Signal Transduction/genetics ,Transforming Growth Factor beta/genetics ,Transforming Growth Factor beta/metabolism ,Tumor Suppressor Protein p53/genetics ,Tumor Suppressor Protein p53/metabolism ,Wnt Proteins/genetics ,Wnt Proteins/metabolism ,Biotechnology ,Human ,Signal Transduction ,signaling pathway ,EXPRESSION ,Biochemistry & Molecular Biology ,GENES ,Pan-cancer ,Therapeutics ,General Biochemistry, Genetics and Molecular Biology ,NO ,Databases ,03 medical and health sciences ,Genetic ,Genetics ,Combination therapy ,Protein kinase B ,Gene ,SIGNATURES ,Cancer genome atlas ,Science & Technology ,LANDSCAPE ,MUTATIONS ,Biochemistry, Genetics and Molecular Biology(all) ,Human Genome ,Whole exome sequencing ,Cell Biology ,Transforming growth factor beta ,cancer genome atla ,06 Biological Sciences ,COMPREHENSIVE MOLECULAR CHARACTERIZATION ,Wnt Proteins ,therapeutic ,Good Health and Well Being ,030104 developmental biology ,Genes ,PanCanAtla ,biology.protein ,Cancer research ,Neoplasm ,Phosphatidylinositol 3-Kinase ,Tumor Suppressor Protein p53 ,Digestive Diseases ,Genetics and Molecular Biology(all) ,Developmental Biology - Abstract
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy. An integrated analysis of genetic alterations in 10 signaling pathways in >9,000 tumors profiled by TCGA highlights significant representation of individual and co-occurring actionable alterations in these pathways, suggesting opportunities for targeted and combination therapies. Michael Seiler, Peter G. Smith, Ping Zhu, Silvia Buonamici, and Lihua Yu are employees of H3 Biomedicine, Inc. Parts of this work are the subject of a patent application: WO2017040526 titled “Splice variants associated with neomorphic sf3b1 mutants.” Shouyoung Peng, Anant A. Agrawal, James Palacino, and Teng Teng are employees of H3 Biomedicine, Inc. Andrew D. Cherniack, Ashton C. Berger, and Galen F. Gao receive research support from Bayer Pharmaceuticals. Gordon B. Mills serves on the External Scientific Review Board of Astrazeneca. Anil Sood is on the Scientific Advisory Board for Kiyatec and is a shareholder in BioPath. Jonathan S. Serody receives funding from Merck, Inc. Kyle R. Covington is an employee of Castle Biosciences, Inc. Preethi H. Gunaratne is founder, CSO, and shareholder of NextmiRNA Therapeutics. Christina Yau is a part-time employee/consultant at NantOmics. Franz X. Schaub is an employee and shareholder of SEngine Precision Medicine, Inc. Carla Grandori is an employee, founder, and shareholder of SEngine Precision Medicine, Inc. Robert N. Eisenman is a member of the Scientific Advisory Boards and shareholder of Shenogen Pharma and Kronos Bio. Daniel J. Weisenberger is a consultant for Zymo Research Corporation. Joshua M. Stuart is the founder of Five3 Genomics and shareholder of NantOmics. Marc T. Goodman receives research support from Merck, Inc. Andrew J. Gentles is a consultant for Cibermed. Charles M. Perou is an equity stock holder, consultant, and Board of Directors member of BioClassifier and GeneCentric Diagnostics and is also listed as an inventor on patent applications on the Breast PAM50 and Lung Cancer Subtyping assays. Matthew Meyerson receives research support from Bayer Pharmaceuticals; is an equity holder in, consultant for, and Scientific Advisory Board chair for OrigiMed; and is an inventor of a patent for EGFR mutation diagnosis in lung cancer, licensed to LabCorp. Eduard Porta-Pardo is an inventor of a patent for domainXplorer. Han Liang is a shareholder and scientific advisor of Precision Scientific and Eagle Nebula. Da Yang is an inventor on a pending patent application describing the use of antisense oligonucleotides against specific lncRNA sequence as diagnostic and therapeutic tools. Yonghong Xiao was an employee and shareholder of TESARO, Inc. Bin Feng is an employee and shareholder of TESARO, Inc. Carter Van Waes received research funding for the study of IAP inhibitor ASTX660 through a Cooperative Agreement between NIDCD, NIH, and Astex Pharmaceuticals. Raunaq Malhotra is an employee and shareholder of Seven Bridges, Inc. Peter W. Laird serves on the Scientific Advisory Board for AnchorDx. Joel Tepper is a consultant at EMD Serono. Kenneth Wang serves on the Advisory Board for Boston Scientific, Microtech, and Olympus. Andrea Califano is a founder, shareholder, and advisory board member of DarwinHealth, Inc. and a shareholder and advisory board member of Tempus, Inc. Toni K. Choueiri serves as needed on advisory boards for Bristol-Myers Squibb, Merck, and Roche. Lawrence Kwong receives research support from Array BioPharma. Sharon E. Plon is a member of the Scientific Advisory Board for Baylor Genetics Laboratory. Beth Y. Karlan serves on the Advisory Board of Invitae.
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- 2018
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30. Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications
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Suraokar, M. B., Nunez, M. I., Diao, L., Chow, C. W., Kim, D., Behrens, C., Lin, H., Lee, S., Raso, G., Moran, C., Rice, D., Mehran, R., Lee, J. J., Pass, H. I., Wang, J., Momin, A. A., James, B. P., Corvalan, A., Coombes, K., Tsao, A., and Wistuba, I. I.
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- 2014
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31. OA06.06 Clinical/Biomarker Data for Neoadjuvant Atezolizumab in Resectable Stage IB-IIIB NSCLC: Primary Analysis in the LCMC3 Study
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Carbone, D., primary, Lee, J., additional, Kris, M., additional, Wistuba, I., additional, Kwiatkowski, D., additional, Owen, D., additional, Bunn, P., additional, Johnson, B., additional, Oezkan, F., additional, Tang, Y., additional, Parra, E.R., additional, Lozanski, G., additional, Rivard, C., additional, Schulze, K., additional, Nicholas, A., additional, Johnson, A., additional, Grindheim, J., additional, Shames, D., additional, Phan, S., additional, Toloza, E., additional, Haura, E., additional, Mcnamee, C., additional, Gainor, J., additional, Patterson, A., additional, Waqar, S., additional, Raz, D., additional, Reckamp, K., additional, Finley, D., additional, Rusch, V., additional, Chaft, J., additional, and Abel, J., additional
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- 2021
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32. P71.02 Estrogen Promotes Resistance to Bevacizumab Treatment in Non-Small Cell Lung Cancer (NSCLC) Xenograft Models
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Patel, S., primary, Herynk, M., additional, Cascone, T., additional, Saigal, B., additional, Nilsson, M., additional, Tran, H., additional, Ramachandran, S., additional, Minna, J., additional, Wistuba, I., additional, and Heymach, J., additional
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- 2021
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33. P03.04 Phase II Study of TKIs as Neo(adjuvant) Therapy in Stage II–III Resectable NSCLC with ALK, ROS1, NTRK or BRAFV600 Alterations
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Lee, J., primary, Wistuba, I., additional, Ngiam, C., additional, Yu, W., additional, Schulze, K., additional, Rocha, M., additional, Bara, I., additional, Carbone, D., additional, Johnson, B., additional, Kwiatkowski, D., additional, Center, M.S.K., additional, and Chaft, J., additional
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- 2021
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34. c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells
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Khatlani, T S, Wislez, M, Sun, M, Srinivas, H, Iwanaga, K, Ma, L, Hanna, A E, Liu, D, Girard, L, Kim, Y H, Pollack, J R, Minna, J D, Wistuba, I I, and Kurie, J M
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- 2007
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35. The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival
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William, W. N., Kim, J.-S., Liu, D. D., Solis, L., Behrens, C., Lee, J. J., Lippman, S. M., Kim, E. S., Hong, W. K., Wistuba, I. I., and Lee, H.-Y.
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- 2012
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36. Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))
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Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T. -H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., Ziv, E., Culhane, A. C., Paull, E. O., Sivakumar, I. K. A., Gentles, A. J., Malhotra, R., Farshidfar, F., Colaprico, A., Parker, J. S., Mose, L. E., N. S., Vo, Liu, J., Liu, Y., Rader, J., Dhankani, V., Reynolds, S. M., Bowlby, R., Califano, A., Cherniack, A. D., Anastassiou, D., Bedognetti, D., Mokrab, Y., Newman, A. M., Rao, A., Chen, K., Krasnitz, A., Hu, H., Malta, T. M., Noushmehr, H., Pedamallu, C. S., Bullman, S., Ojesina, A. I., Lamb, A., Zhou, W., Shen, H., Choueiri, T. K., Weinstein, J. N., Guinney, J., Saltz, J., Holt, R. A., Rabkin, C. S., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. J., Chudamani, S., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., Defreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Meier, S., Noble, M. S., Saksena, G., Voet, D., Zhang, H., Bernard, B., Chambwe, N., Knijnenburg, T., Kramer, R., Leinonen, K., Miller, M., Reynolds, S., Shmulevich, I., Zhang, W., Akbani, R., Broom, B. M., Hegde, A. M., Ju, Z., Kanchi, R. S., Korkut, A., Li, J., Liang, H., Ling, S., Liu, W., Lu, Y., Mills, G. B., K. -S., Ng, Ryan, M., Wang, J., Zhang, J., Abeshouse, A., Armenia, J., Chakravarty, D., Chatila, W. K., de Bruijn, I., Gao, J., Gross, B. E., Heins, Z. J., Kundra, R., La, K., Ladanyi, M., Luna, A., Nissan, M. G., Ochoa, A., Phillips, S. M., Reznik, E., Sanchez-Vega, F., Sander, C., Schultz, N., Sheridan, R., Sumer, S. O., Sun, Y., Taylor, B. S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J. M., Wong, C. K., Yau, C., Hayes, D. N., Wilkerson, M. D., Ally, A., Balasundaram, M., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S. J. M., Kasaian, K., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Robertson, A. G., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A. C., Beroukhim, R., Cibulskis, C., Gabriel, S. B., Ha, G., Meyerson, M., Schumacher, S. E., Shih, J., Kucherlapati, M. H., Kucherlapati, R. S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M. S., Lai, P. H., Maglinte, D. T., Van Den Berg, D. J., Weisenberger, D. J., Auman, J. T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K. A., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Perou, A. H., Perou, C. M., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Laird, P. W., Bellair, M., Chang, K., Covington, K., Creighton, C. J., Dinh, H., Doddapaneni, H., Donehower, L. 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- Subjects
immune ,cancer ,methods - Published
- 2019
37. Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium
- Author
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Miquel, J F, Moreno, M, Amigo, L, Molina, H, Mardones, P, Wistuba, I I, and Rigotti, A
- Published
- 2003
38. O.04 Results from the IASLC Global Survey on Molecular Testing in Lung Cancer
- Author
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Garcia, M.V., primary, Smeltzer, M., additional, Wynes, M., additional, Lantuejoul, S., additional, Soo, R.A., additional, Dalurzo, L., additional, Felip, E., additional, Howell, K., additional, Kerr, K., additional, Kim, E., additional, Mathias, C., additional, Postmus, P., additional, Powell, C., additional, Ramalingam, S., additional, Richeimer, K., additional, Taylor, M., additional, Tsuboi, M., additional, Wistuba, I., additional, Wood, K., additional, Scagliotti, G., additional, and Hirsch, F., additional
- Published
- 2019
- Full Text
- View/download PDF
39. OA01.09 Comparing Regional Results from the IASLC Global Survey on Molecular Testing in Lung Cancer
- Author
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Smeltzer, M., primary, Wynes, M., additional, Lantuejoul, S., additional, Soo, R.A., additional, Dalurzo, L., additional, Felip, E., additional, Hollenbeck, G., additional, Howell, K., additional, Kerr, K., additional, Kim, E., additional, Mathias, C., additional, Postmus, P., additional, Powell, C., additional, Ramalingam, S., additional, Richeimer, K., additional, Taylor, M., additional, Tsuboi, M., additional, Varella-Garcia, M., additional, Wistuba, I., additional, Wood, K., additional, Scagliotti, G., additional, and Hirsch, F., additional
- Published
- 2019
- Full Text
- View/download PDF
40. I.12-1 New Next Generation Sequencing Platforms (NGS) Versus Tailored Panels
- Author
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Wistuba, I., primary
- Published
- 2019
- Full Text
- View/download PDF
41. P2.04-88 Surgical Outcomes of a Multicenter Phase II Trial of Neoadjuvant Atezolizumab in Resectable Stages IB-IIIB NSCLC: Update on LCMC3 Clinical Trial
- Author
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Lee, J., primary, Chaft, J., additional, Nicholas, A., additional, Patterson, G., additional, Waqar, S., additional, Toloza, E., additional, Haura, E., additional, Raz, D., additional, Reckamp, K., additional, Merritt, R., additional, Owen, D., additional, Finley, D., additional, Mcnamee, C., additional, Blasberg, J., additional, Garon, E., additional, Mitchell, J., additional, Doebele, R., additional, Baciewicz, F., additional, Nagasaka, M., additional, Pass, H., additional, Johnson, A., additional, Phan, S., additional, Schulze, K., additional, Bunn, P., additional, Johnson, B., additional, Kris, M., additional, Kwiatkowski, D., additional, Wistuba, I., additional, Carbone, D., additional, and Rusch, V., additional
- Published
- 2019
- Full Text
- View/download PDF
42. OA13.07 Neoadjuvant Atezolizumab in Resectable NSCLC Patients: Immunophenotyping Results from the Interim Analysis of the Multicenter Trial LCMC3
- Author
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Oezkan, F., primary, He, K., additional, Owen, D., additional, Pietrzak, M., additional, Cho, J.H., additional, Kitzler, R., additional, Pearson, R., additional, Rusch, V., additional, Chaft, J., additional, Suh, R., additional, Blasberg, J., additional, Reckamp, K., additional, Raz, D., additional, Kneuertz, P., additional, Fiorillo, L., additional, Garon, E., additional, Nicholas, A., additional, Johnson, A., additional, Schulze, K., additional, Grindheim, J., additional, Banchereau, R., additional, Phan, S., additional, Bunn, P., additional, Kwiatkowski, D., additional, Johnson, B., additional, Kris, M., additional, Wistuba, I., additional, Lee, J., additional, Lozanski, G., additional, and Carbone, D., additional
- Published
- 2019
- Full Text
- View/download PDF
43. P1.04-11 Depicting the Intra-Tumoral Viral and Microbial Landscape of Localized NSCLC Using Standard Next Generation Sequencing Data
- Author
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Gaudreau, P., primary, Ajami, N., additional, Sepesi, B., additional, Karpinets, T., additional, Reuben, A., additional, Wong, M., additional, Parra, E., additional, Federico, L., additional, Gopalakrishnan, V., additional, Mitchell, K., additional, Negrao, M., additional, Spencer, C., additional, Vaporciyan, A., additional, Weissferdt, A., additional, Haymaker, C., additional, Tran, H., additional, Bernatchez, C., additional, Landry, L., additional, Roarty, E., additional, Cascone, T., additional, Heymach, J., additional, Zhang, J., additional, Wistuba, I., additional, Wargo, J., additional, and Gibbons, D., additional
- Published
- 2019
- Full Text
- View/download PDF
44. P1.14-17 Genomic Evolution During TKI Treatment in Non-Small Cell Lung Cancer Patients With or Without Acquired T790M Mutation
- Author
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Jin, Y., primary, Bao, H., additional, Le, X., additional, Fan, X., additional, Tang, M., additional, Fan, Y., additional, Zhang, Y., additional, Shi, X., additional, Zhao, J., additional, Lou, G., additional, Shao, L., additional, He, Q., additional, Lin, C., additional, Zhang, J., additional, Futreal, P.A., additional, Wistuba, I., additional, Heymach, J., additional, Wu, X., additional, Shao, Y.W., additional, Yan, J., additional, Chen, Y., additional, Chen, M., additional, Yu, X., additional, and Xu, Y., additional
- Published
- 2019
- Full Text
- View/download PDF
45. P2.04-19 Neoadjuvant Chemotherapy Is Associated with Immunogenic Cell Death and Increased T Cell Infiltration in Early-Stage NSCLC
- Author
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Gaudreau, P., primary, Negrao, M., additional, Mitchell, K., additional, Corsini, E., additional, Karpinets, T., additional, Wang, Q., additional, Diao, L., additional, Wang, J., additional, Federico, L., additional, Parra, E., additional, Li, J., additional, Behrens, C., additional, Correa, A., additional, Gomez, D., additional, Vaporciyan, A., additional, Weissferdt, A., additional, Tran, H., additional, Roarty, E., additional, Wistuba, I., additional, Reuben, A., additional, Haymaker, C., additional, Bernatchez, C., additional, Cascone, T., additional, Heymach, J., additional, Sepesi, B., additional, Zhang, J., additional, and Gibbons, D., additional
- Published
- 2019
- Full Text
- View/download PDF
46. P2.09-24 IASLC Global Survey for Pathologists on PD-L1 Testing for Non-Small Cell Lung Cancer
- Author
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Mino-Kenudson, M., primary, Redman, M., additional, Hedger, J., additional, Daigneault, J., additional, Botling, J., additional, Brambilla, E., additional, Chen, G., additional, Chou, T., additional, Cooper, W., additional, Hirsch, F.R., additional, Jain, D., additional, Kerr, K., additional, Longshore, J., additional, Lopez-Rios, F., additional, Motoi, N., additional, Pelosi, G., additional, Tsao, M., additional, Yatabe, Y., additional, Beasley, M.B., additional, Borczuk, A., additional, Bubendorf, L., additional, Chung, J., additional, Dacic, S., additional, Hwang, D., additional, Minami, Y., additional, Moreira, A., additional, Nicholson, A., additional, Papotti, M., additional, Poleri, C., additional, Rekhtman, N., additional, Roden, A.C., additional, Russell, P., additional, Sholl, L., additional, Thunnissen, E., additional, Travis, W., additional, Yoshida, A., additional, Wynes, M., additional, Wistuba, I., additional, and Lantuejoul, S., additional
- Published
- 2019
- Full Text
- View/download PDF
47. MA17.10 Lactate Transporter Blockade as a Strategy to Overcome VEGF Inhibitor-Resistance in LKB1-Deficient NSCLC
- Author
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Guijarro, I., primary, Poteete, A., additional, Cho, S., additional, Zhou, T., additional, Fan, Y., additional, Roarty, E., additional, Nilsson, M., additional, Parra, E., additional, Mino, B., additional, Wistuba, I., additional, Wang, J., additional, Skoulidis, F., additional, and Heymach, J., additional
- Published
- 2019
- Full Text
- View/download PDF
48. P1.04-79 CD73 Expression in Lung Adenocarcinomas and Immunological and Molecular Associations
- Author
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Rocha, P., primary, Salazar, R., additional, Solorzano, J., additional, Zhang, J., additional, Mino, B., additional, Parra, E., additional, Ledesma, D., additional, Kadara, H., additional, Vaporciyan, A., additional, Rice, D., additional, Kalhor, N., additional, Moran, C., additional, Gibbons, D., additional, Weissferdt, A., additional, Sepesi, B., additional, Wistuba, I., additional, Behrens, C., additional, and Solis, L., additional
- Published
- 2019
- Full Text
- View/download PDF
49. OA15.04 Genomic and TCR Intratumor Heterogeneity of Small-Cell Lung Cancer by Multiregion Sequencing: An Association with Survival
- Author
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Chen, R., primary, Jin, Y., additional, Li, J., additional, Zhang, J., additional, Fujimoto, J., additional, Lee, W., additional, Hu, X., additional, Chen, Y., additional, Behrens, C., additional, Chow, C., additional, Parra, E., additional, Little, L., additional, Gumbs, C., additional, Song, X., additional, Roarty, E., additional, Gibbons, D., additional, Heymach, J., additional, Lee, J.J., additional, William, W., additional, Glisson, B., additional, Wistuba, I., additional, Futreal, P.A., additional, Byers, L., additional, Reuben, A., additional, and Chen, M., additional
- Published
- 2019
- Full Text
- View/download PDF
50. MS17.04 Multiplex Immunohistochemistry
- Author
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Wistuba, I., primary, Parra, E., additional, and Cruz, A. Francisco, additional
- Published
- 2019
- Full Text
- View/download PDF
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