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1. Segmentation of White Matter Hyperintensities and Ischaemic Stroke Lesions in Structural MRI

Author

Phitidis, Jesse, O’Neil, Alison Q., Wiseman, Stewart, Dickie, David Alexander, Sakka, Eleni, Kampaite, Agniete, Whiteley, William, Bernabeu, Miguel O., Alex, Beatrice, Wardlaw, Joanna M., Hernández, Maria Valdés, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Waiter, Gordon, editor, Lambrou, Tryphon, editor, Leontidis, Georgios, editor, Oren, Nir, editor, Morris, Teresa, editor, and Gordon, Sharon, editor

Published
2024
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3. Influence of threshold selection and image sequence in in-vivo segmentation of enlarged perivascular spaces

Author

Valdés Hernández, Maria del C., Duarte Coello, Roberto, Xu, William, Bernal, José, Cheng, Yajun, Ballerini, Lucia, Wiseman, Stewart J., Chappell, Francesca M., Clancy, Una, Jaime García, Daniela, Arteaga Reyes, Carmen, Zhang, Jun-Fang, Liu, Xiaodi, Hewins, Will, Stringer, Michael, Doubal, Fergus, Thrippleton, Michael J., Jochems, Angela, Brown, Rosalind, and Wardlaw, Joanna M.

Published
2024
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4. MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis

Author

York, Elizabeth N, Martin, Sarah-Jane, Meijboom, Rozanna, Thrippleton, Michael J, Bastin, Mark E, Carter, Edwin, Overell, James, Connick, Peter, Chandran, Siddharthan, Waldman, Adam D, Hunt, David PJ, Akula, Amit, Artal, Javier Carod, Baranzini, Sergio, Barret, Fiona, Bastin, Mark, Batchelor, Christine, Beswick, Emily, Brown, Fraser, Chang, Jessie, Chen, Yingdi, Colville, Shuna, Cranley, Denise, Dakin, Rachel, Dhillon, Baljean, Elliot, Elizabeth, Finlayson, James, Foley, Peter, Glasmacher, Stella, Grossart, Angus, Haagenrud, Haane, Hafezi, Katarzyna, Harrison, Emily, Harroud, Adil, Hathorn, Sara, Hopkins, Tracey, Hunt, David, Hutchinson, Aidan, Jayprakash, Kiran, Justin, Matt, Kampaite, Agniete, Kearns, Patrick, Kennedy, Gwen, Kleynhans, Michaela, Kwong, Julian Ng Kee, Larraz, Juan, Love, Kathryn, Lyle, Dawn, MacDonald, James, MacDougall, Niall, Macfarlane, Lesley, Maclennan, Beverly, Maclean, Alan, MacLeod, Margaret Ann, Macleod, Nicola, Mahad, Don, Martin, Sarah Jane, McMahon, Lynn, Megson, Ian, Mollison, Daisy, Monaghan, Mary, Murphy, Lee, Murray, Katy, Newton, Judith, O’Riordan, Jonathan, Perry, David, Quigley, Suzanne, Scotson, Adam, Stenson, Amy, Thrippleton, Michael, Hernandez, Maria Valdez, Waldman, Adam, Weaver, Christine, Webb, Stewart, Weller, Belinda, Williams, Anna, Wiseman, Stewart, Wong, Charis, Wong, Michael, and York, Elizabeth

Subjects
Neurodegenerative, Multiple Sclerosis, Autoimmune Disease, Neurosciences, Biomedical Imaging, Brain Disorders, Neurological, multiple sclerosis, MRI, neurofilament, myelin, g-ratio, Future-MS Consortium
Abstract

Myelin loss is associated with axonal damage in established multiple sclerosis. This relationship is challenging to study in vivo in early disease. Here, we ask whether myelin loss is associated with axonal damage at diagnosis by combining non-invasive neuroimaging and blood biomarkers. We performed quantitative microstructural MRI and single-molecule ELISA plasma neurofilament measurement in 73 patients with newly diagnosed, immunotherapy naïve relapsing-remitting multiple sclerosis. Myelin integrity was evaluated using aggregate g-ratios, derived from magnetization transfer saturation and neurite orientation dispersion and density imaging diffusion data. We found significantly higher g-ratios within cerebral white matter lesions (suggesting myelin loss) compared with normal-appearing white matter (0.61 versus 0.57, difference 0.036, 95% CI: 0.029-0.043, P < 0.001). Lesion volume (Spearman's rho rs= 0.38, P < 0.001) and g-ratio (rs= 0.24, P < 0.05) correlated independently with plasma neurofilament. In patients with substantial lesion load (n = 38), those with higher g-ratio (defined as greater than median) were more likely to have abnormally elevated plasma neurofilament than those with normal g-ratio (defined as less than median) [11/23 (48%) versus 2/15 (13%), P < 0.05]. These data suggest that, even at multiple sclerosis diagnosis, reduced myelin integrity is associated with axonal damage. MRI-derived g-ratio may provide useful additional information regarding lesion severity and help to identify individuals with a high degree of axonal damage at disease onset.

Published
2021

5. Paranasal sinuses opacification on magnetic resonance imaging in relation to brain health in sporadic small vessel disease – Systematic review and pilot analysis

Author

Sáenz de Villaverde Cortabarría, Alba, Zhang, Jun-Fang, Valdés Hernández, Maria del C., Clancy, Una, Sakka, Eleni, Ferguson, Karen J., Wiseman, Stewart, Hewins, Will, Jaime García, Daniela, Stringer, Michael, Thrippleton, Michael, Chappell, Francesca, Doubal, Fergus, Wu, Yun-Cheng, and Wardlaw, Joanna M.

Published
2023
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6. Sleep quality, perivascular spaces and brain health markers in ageing - A longitudinal study in the Lothian Birth Cohort 1936

Author

Aribisala, Benjamin S., Valdés Hernández, Maria del C., Okely, Judith A., Cox, Simon R., Ballerini, Lucia, Dickie, David Alexander, Wiseman, Stewart J., Riha, Renata L., Muñoz Maniega, Susana, Radakovic, Ratko, Taylor, Adele, Pattie, Alison, Corley, Janie, Redmond, Paul, Bastin, Mark E., Deary, Ian, and Wardlaw, Joanna M.

Published
2023
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7. Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study

Author

Sleight, Emilie, Stringer, Michael S., Clancy, Una, Arteaga, Carmen, Jaime Garcia, Daniela, Hewins, Will, Jochems, Angela C.C., Hamilton, Olivia K.L., Manning, Cameron, Morgan, Alasdair G., Locherty, Rachel, Cheng, Yajun, Liu, Xiaodi, Zhang, Junfang, Hamilton, Iona, Jardine, Charlotte, Brown, Rosalind, Sakka, Eleni, Kampaite, Agniete, Wiseman, Stewart, Valdés-Hernández, Maria C., Chappell, Francesca M., Doubal, Fergus N., Marshall, Ian, Thrippleton, Michael J., and Wardlaw, Joanna M.

Published
2023
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9. Prevalence and Clinical Implications of Hemosiderin Deposits in Recent Small Subcortical Infarcts.

Author

Xu, Yu-Yuan, Chappell, Francesca M., Valdés Hernández, Maria Del C., Arteaga-Reyes, Carmen, Clancy, Una, Garcia, Daniela Jaime, Wiseman, Stewart, Stringer, Michael S., Thrippleton, Michael, Cheng, Yajun, Zhang, Junfang, Liu, Xiaodi, Jochems, Angela C.C., Doubal, Fergus, Wardlaw, Joanna M., Marshall, Ian, Maniega, Susana Muñoz, Sakka, Eleni, Brown, Rosalind, and Hamilton, Olivia K.L.

Published
2024
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10. Contribution of white matter hyperintensities to ventricular enlargement in older adults

Author

Jochems, Angela C.C., Muñoz Maniega, Susana, del C Valdés Hernández, Maria, Barclay, Gayle, Anblagan, Devasuda, Ballerini, Lucia, Meijboom, Rozanna, Wiseman, Stewart, Taylor, Adele M., Corley, Janie, Chappell, Francesca M., Backhouse, Ellen V., Stringer, Michael S., Dickie, David Alexander, Bastin, Mark E., Deary, Ian J., Cox, Simon R., and Wardlaw, Joanna M.

Published
2022
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12. Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease

Author

Wiseman, Stewart J, Zhang, Jun-Fang, Gray, Calum, Hamid, Charlene, Valdés Hernández, Maria del C, Ballerini, Lucia, Thrippleton, Michael J, Manning, Cameron, Stringer, Michael, Sleight, Emilie, Muñoz Maniega, Susana, Morgan, Alasdair, Cheng, Yajun, Arteaga, Carmen, Jaime Garcia, Dany, Clancy, Una, Doubal, Fergus N, Dhillon, Baljean, MacGillivray, Tom, Wu, Yun-Cheng, and Wardlaw, Joanna M

Published
2023
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13. Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease

Author

Zhang, Jun-Fang, Lim, Hwee Fang, Chappell, Francesca M., Clancy, Una, Wiseman, Stewart, Valdés-Hernández, Maria C., Garcia, Daniela Jaime, Bastin, Mark E., Doubal, Fergus N., Hewins, Will, Cox, Simon R., Maniega, Susana Muñoz, Thrippleton, Michael, Stringer, Michael, Jardine, Charlotte, McIntyre, Donna, Barclay, Gayle, Hamilton, Iona, Kesseler, Lucy, Murphy, Madeleine, Perri, Carol Di, Wu, Yun-Cheng, and Wardlaw, Joanna M.

Published
2021
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14. Characterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive–Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study

Author

Dehsarvi, Amir, primary, Al‐Wasity, Salim, additional, Stefanov, Kristian, additional, Wiseman, Stewart J., additional, Ralston, Stuart H., additional, Wardlaw, Joanna M., additional, Emsley, Richard, additional, Bachmair, Eva‐Maria, additional, Cavanagh, Jonathan, additional, Waiter, Gordon D., additional, and Basu, Neil, additional

Published
2024
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15. The role of systemic inflammation in cerebral small vessel disease

Author

Wiseman, Stewart John, Wardlaw, Joanna, and Ralston, Stuart

Subjects
616.8, lacunar stroke, small vessel disease, SVD, inflammation, rheumatic diseases
Abstract

Cerebral small vessel disease (SVD) is a distinct microvascular disorder that can lead to lacunar stroke, an important stroke subtype that accounts for a quarter of all ischaemic strokes. SVD is associated with imaging biomarkers such as white matter hyperintensities (WMH). The cause of SVD is largely unknown, although inflammation and blood-brain barrier failure via endothelial dysfunction have been implicated. Elevated plasma biomarkers of inflammation are associated with coronary heart disease and large vessel stroke but the role of inflammation in SVD is less well understood. Our hypothesis is that inflammation plays a role in SVD and we sought to examine this by reviewing the literature for evidence of this, and by conducting a brain imaging study of patients with a known inflammatory disease and reviewing the images for evidence of inflammation and SVD, and comparing findings with controls groups. Section A: This thesis begins with a systematic review and meta-analysis of 13 plasma biomarkers of four physiological processes (coagulation, fibrinolysis, endothelial dysfunction and inflammation) in lacunar stroke versus non-lacunar stroke (to control for having any stroke) and non-stroke (to compare to the general population). We sought to know if there were differences in these biomarkers between lacunar stroke and other stroke subtypes and non-stroke controls as a way of generating hypotheses for the disease mechanisms that might lead to lacunar stroke. Findings revealed differences in several biomarkers between lacunar stroke and healthy controls but only fibrinogen, D-dimer, von Willebrand factor and interleukin-6 were different (all significantly lower in lacunar stroke) between lacunar stroke and other stroke subtypes. There was heterogeneity between studies, including variations in the definition of lacunar stroke and most studies measured the biomarkers in the acute phase post stroke, which is potentially confounding. To further examine plasma biomarkers of inflammation and endothelial dysfunction in SVD, we used data from a prior study of mild stroke conducted at the Brain Research Imaging Centre, University of Edinburgh, UK. Lacunar stroke patients were compared to cortical stroke patients. The lacunar group had lower levels of tissue plasminogen activator independent of age, sex and vascular risk factors but we found no difference in the other plasma biomarkers. Section B: Non-resolving systemic inflammation is a feature of inflammatory autoimmune rheumatic diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). These patients are at increased risk of stroke but much knowledge relates to stroke in general; less is known about associations with stroke subtypes including SVD, or when in life stroke risk is greatest. Consequently, we sought to better understand the influence of inflammatory rheumatic diseases on stroke and SVD. The review and meta-analysis of cerebrovascular disease in rheumatic diseases showed an excess risk of stroke in RA, SLE, ankylosing spondylitis, gout and psoriasis over the general population. Meta-analyses of stroke subtypes (ischaemic and haemorrhagic) in RA and SLE showed an excess risk of stroke over the general population. Stroke risk across rheumatic diseases was highest in those aged < 50 years and reduced with ageing. We then requested data from NHS Lothian covering 15 years so that we could assess stroke, including stroke subtypes, among patients diagnosed with various arthropathies. We linked 6,613 rheumatology patients’ records with stroke admission records, grouped the various rheumatic diseases into the two main types of arthritis, inflammatory and non-inflammatory, and also compared the strokes in these rheumatology patients to general population data. There was no difference in stroke prevalence between inflammatory and degenerative (non-inflammatory) arthropathies, although the strokes occurred up to two decades earlier than in the general population. Section C: Lastly, we conducted MRI neuroimaging in patients with SLE and reviewed and meta-analysed diffusion tensor imaging (DTI) (an imaging technique used to assess sub-visible white matter microstructure damage) in SLE to place our findings into context. The research question here was to ascertain if patients with a known inflammatory disease had brain imaging evidence of SVD, and to compare findings to controls. We compared imaging markers of SVD and DTI between SLE patients and age-matched healthy controls and sought associations between the imaging biomarkers and plasma biomarkers of inflammation and endothelial dysfunction, measures of fatigue and cognition, and scores of rheumatic disease activity. Fifty-one patients were recruited. There was higher mean diffusivity in all white matter tracts versus controls indicating a diffuse increase in brain water mobility in SLE. Meta-analysis confirmed higher mean diffusivity in SLE patients versus controls. Fatigue in SLE was significantly higher than a normal reference range and was associated with depression, anxiety, higher body mass index, lower mean diffusivity and some blood markers of inflammation and endothelial dysfunction. The most fatigued were youngest which explained the association with lower mean diffusivity. Damage to the brain’s white matter microstructure may be accelerated in SLE as the age-related declines in the general population are normally seen much later in life. The aging pattern is consistent with inflammation-related microvascular-mediated brain damage where the inflammation is systemic in origin. Summary: This thesis has demonstrated an increase in SVD burden in the inflammatory rheumatic disease SLE and increased stroke risk at younger ages in other inflammatory rheumatic diseases. Thus, systemic inflammation as seen in inflammatory rheumatic diseases could have effects on the brain directly, including influencing stroke risk which is clinically noteworthy and would benefit from further testing in appropriately designed studies such as an inception cohort that follows inflammatory rheumatic patients from diagnosis, with regular brain imaging to track brain changes and correlates with inflammatory profiles and impact on cognition.

Published
2016

19. Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress

Author

Jochems, Angela C. C., primary, Muñoz Maniega, Susana, additional, Clancy, Una, additional, Arteaga, Carmen, additional, Jaime Garcia, Daniela, additional, Chappell, Francesca M., additional, Hewins, Will, additional, Locherty, Rachel, additional, Backhouse, Ellen V., additional, Barclay, Gayle, additional, Jardine, Charlotte, additional, McIntyre, Donna, additional, Gerrish, Iona, additional, Kampaite, Agniete, additional, Sakka, Eleni, additional, Valdés Hernández, Maria, additional, Wiseman, Stewart, additional, Bastin, Mark E., additional, Stringer, Michael S., additional, Thrippleton, Michael J., additional, Doubal, Fergus N., additional, and Wardlaw, Joanna M., additional

Published
2024
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20. Impact of long-term white matter hyperintensity changes on mobility and dexterity

Author

Jochems, Angela C C, primary, Muñoz Maniega, Susana, additional, Chappell, Francesca M, additional, Clancy, Una, additional, Arteaga, Carmen, additional, Jaime Garcia, Daniela, additional, Hamilton, Olivia K L, additional, Hewins, Will, additional, Locherty, Rachel, additional, Backhouse, Ellen V, additional, Barclay, Gayle, additional, Jardine, Charlotte, additional, McIntyre, Donna, additional, Gerrish, Iona, additional, Cheng, Yajun, additional, Liu, Xiaodi, additional, Zhang, Junfang, additional, Kampaite, Agniete, additional, Sakka, Eleni, additional, Valdés Hernández, Maria, additional, Wiseman, Stewart, additional, Stringer, Michael S, additional, Thrippleton, Michael J, additional, Doubal, Fergus N, additional, and Wardlaw, Joanna M, additional

Published
2024
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21. Impact of White Matter Hyperintensity Changes on Cognition One Year After Mild Ischemic Stroke

Author

Jochems, Angela CC, primary, Maniega, Susana Muñoz, additional, Clancy, Una, additional, Arteaga, Carmen, additional, Garcia, Daniela Jaime, additional, Hewins, Will, additional, Locherty, Rachel, additional, Wiseman, Stewart, additional, Hernandez, Maria del C. Valdes, additional, Chappell, Francesca M, additional, Stringer, Michael S, additional, Thrippleton, Michael J, additional, Doubal, Fergus N, additional, and Wardlaw, Joanna M, additional

Published
2023
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22. Influence of threshold selection and image sequence in in-vivo segmentation of enlarged perivascular spaces

Author

Valdés Hernández, Maria del C, primary, Coello, Roberto Duarte, additional, Xu, William, additional, Bernal, José, additional, Cheng, Yajun, additional, Ballerini, Lucia, additional, Wiseman, Stewart J., additional, Chappell, Francesca M., additional, Clancy, Una, additional, García, Daniela Jaime, additional, Reyes, Carmen Arteaga, additional, Zhang, Jun-Fang, additional, Liu, Xiaodi, additional, Hewins, Will, additional, Stringer, Michael, additional, Doubal, Fergus, additional, Thrippleton, Michael J., additional, Jochems, Angela, additional, Brown, Rosalind, additional, and Wardlaw, Joanna M., additional

Published
2023
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25. Paranasal sinus occupancy assessed from magnetic resonance images—associations with clinical indicators in patients with systemic lupus erythematosus.

Author

Hernández, Maria del C Valdés, Ferguson, Karen J, Loon, Pearlyn, Kirkwood, Grant, Zhang, Jun-Fang, Amft, Nicole, Ralston, Stuart H, Wu, Yun-Cheng, Wardlaw, Joanna M, and Wiseman, Stewart J

Subjects
KEY performance indicators (Management), AGE distribution, PARANASAL sinuses, MAGNETIC resonance imaging, AUTOIMMUNE diseases, SEX distribution, CLINICAL medicine, DESCRIPTIVE statistics, RESEARCH funding, SYSTEMIC lupus erythematosus, RHEUMATISM
Abstract

Objectives Nasal, paranasal sinus and mucosal disorders are common symptoms in autoimmune rheumatic diseases. Soft tissue changes and fluid accumulation in the osteomeatal complexes and paranasal sinuses manifest as opaqueness on radiological images which can be assessed using visual scoring and computational methods on CT scans, but their results do not always correlate. Using MRI, we investigate the applicability of different image analysis methods in SLE. Methods We assessed paranasal sinus opaqueness on MRI from 51 SLE patients, using three visual scoring systems and expert-delineated computational volumes, and examined their association with markers of disease activity, inflammation, endothelial dysfunction and common small vessel disease (SVD) indicators, adjusting for age and sex-at-birth. Results The average paranasal sinus volume occupation was 4.55 (6.47%) [median (interquartile range) = 0.67 (0.25–2.65) ml], mainly in the maxillary and ethmoid sinuses. It was highly correlated with Lund–Mackay (LM) scores modified at 50% opaqueness cut-off (Spearman's ρ: 0.71 maxillary and 0.618 ethmoids, P  < 0.001 in all), and with more granular variations of the LM system. The modified LM scores were associated with SVD scores (0: B = 5.078, s. e. = 1.69, P  = 0.0026; 2: B = –0.066, s. e. = 0.023, P  = 0.0045) and disease activity (anti-dsDNA: B = 4.59, s. e. = 2.22, P  = 0.045; SLEDAI 3–7: 2.86 < B < 4.30; 1.38 <  s. e. < 1.63; 0.0083 ≤  P   ≤  0.0375). Computationally derived percent opaqueness yielded similar results. Conclusion In patients with SLE, MRI computational assessment of sinuses opaqueness and LM scores modified at a 50% cut-off may be useful tools in understanding the relationships among paranasal sinus occupancy, disease activity and SVD markers. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Paranasal sinus occupancy assessed from magnetic resonance images—associations with clinical indicators in patients with systemic lupus erythematosus

Author

Valdés Hernández, Maria del C, primary, Ferguson, Karen J, additional, Loon, Pearlyn, additional, Kirkwood, Grant, additional, Zhang, Jun-Fang, additional, Amft, Nicole, additional, Ralston, Stuart H, additional, Wu, Yun-Cheng, additional, Wardlaw, Joanna M, additional, and Wiseman, Stewart J, additional

Published
2023
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27. sj-pdf-1-jcb-10.1177_0271678X221135658 - Supplemental material for Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease

Author

Wiseman, Stewart J, Zhang, Jun-Fang, Gray, Calum, Hamid, Charlene, Valdés Hernández, Maria del C, Ballerini, Lucia, Thrippleton, Michael J, Manning, Cameron, Stringer, Michael, Sleight, Emilie, Muñoz Maniega, Susana, Morgan, Alasdair, Cheng, Yajun, Arteaga, Carmen, Jaime Garcia, Dany, Clancy, Una, Doubal, Fergus N, Dhillon, Baljean, MacGillivray, Tom, Wu, Yun-Cheng, and Wardlaw, Joanna M

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221135658 for Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease by Stewart J Wiseman, Jun-Fang Zhang, Calum Gray, Charlene Hamid, Maria del C Valdés Hernández, Lucia Ballerini, Michael J Thrippleton, Cameron Manning, Michael Stringer, Emilie Sleight, Susana Muñoz Maniega, Alasdair Morgan, Yajun Cheng, Carmen Arteaga, Dany Jaime Garcia, Una Clancy, Fergus N Doubal, Baljean Dhillon, Tom MacGillivray, Yun-Cheng Wu and Joanna M Wardlaw in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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29. Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease

Author

Wiseman, Stewart J, primary, Zhang, Jun-Fang, additional, Gray, Calum, additional, Hamid, Charlene, additional, Valdés Hernández, Maria del C, additional, Ballerini, Lucia, additional, Thrippleton, Michael J, additional, Manning, Cameron, additional, Stringer, Michael, additional, Sleight, Emilie, additional, Muñoz Maniega, Susana, additional, Morgan, Alasdair, additional, Cheng, Yajun, additional, Arteaga, Carmen, additional, Jaime Garcia, Dany, additional, Clancy, Una, additional, Doubal, Fergus N, additional, Dhillon, Baljean, additional, MacGillivray, Tom, additional, Wu, Yun-Cheng, additional, and Wardlaw, Joanna M, additional

Published
2022
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30. Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition

Author

Jochems, Angela C. C., primary, Muñoz Maniega, Susana, additional, Clancy, Una, additional, Jaime Garcia, Daniela, additional, Arteaga, Carmen, additional, Hewins, Will, additional, Penman, Rachel, additional, Hamilton, Olivia K. L., additional, Czechoń, Agnieszka, additional, Backhouse, Ellen V., additional, Thrippleton, Michael J., additional, Stringer, Michael S., additional, Bastin, Mark. E., additional, Valdés Hernández, Maria del C., additional, Wiseman, Stewart, additional, Chappell, Francesca M., additional, Doubal, Fergus N., additional, and Wardlaw, Joanna M., additional

Published
2022
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31. Deep attention super-resolution of brain magnetic resonance images acquired under clinical protocols

Author

Li, Bryan M., primary, Castorina, Leonardo V., additional, Valdés Hernández, Maria del C., additional, Clancy, Una, additional, Wiseman, Stewart J., additional, Sakka, Eleni, additional, Storkey, Amos J., additional, Jaime Garcia, Daniela, additional, Cheng, Yajun, additional, Doubal, Fergus, additional, Thrippleton, Michael T., additional, Stringer, Michael, additional, and Wardlaw, Joanna M., additional

Published
2022
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32. Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland

Author

Meijboom, Rozanna, primary, Wiseman, Stewart J., additional, York, Elizabeth N., additional, Bastin, Mark E., additional, Valdés Hernández, Maria del C., additional, Thrippleton, Michael J., additional, Mollison, Daisy, additional, White, Nicole, additional, Kampaite, Agniete, additional, Ng Kee Kwong, Koy, additional, Rodriguez Gonzalez, David, additional, Job, Dominic, additional, Weaver, Christine, additional, Kearns, Patrick K. A., additional, Connick, Peter, additional, Chandran, Siddharthan, additional, and Waldman, Adam D., additional

Published
2022
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35. Super-Resolution of Magnetic Resonance Images Acquired Under Clinical Protocols using Deep Attention-based Method

Author

Li, Bryan M., primary, Castorina, Leonardo V., additional, Vald&eacutes Hern&aacutendez, Maria Del Carmen, additional, Clancy, Una, additional, Wiseman, Stewart J., additional, Sakka, Eleni, additional, Storkey, Amos J., additional, Jaime Garcia, Daniela, additional, Cheng, Yajun, additional, Doubal, Fergus, additional, Thrippleton, Michael T., additional, Stringer, Michael, additional, and Wardlaw, Joanna M., additional

Published
2022
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39. Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage

Author

Manning, Cameron, primary, Stringer, Michael, additional, Dickie, Ben, additional, Clancy, Una, additional, Valdés Hernandez, Maria C., additional, Wiseman, Stewart J., additional, Garcia, Daniela Jaime, additional, Sakka, Eleni, additional, Backes, Walter H., additional, Ingrisch, Michael, additional, Chappell, Francesca, additional, Doubal, Fergus, additional, Buckley, Craig, additional, Parkes, Laura M., additional, Parker, Geoff J. M., additional, Marshall, Ian, additional, Wardlaw, Joanna M., additional, and Thrippleton, Michael J., additional

Published
2021
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40. Contribution of white matter hyperintensities to ventricular enlargement in older adults

Author

Jochems, Angela CC, primary, Maniega, Susana Muñoz, additional, del C Valdés Hernández, Maria, additional, Barclay, Gayle, additional, Anblagan, Devasuda, additional, Ballerini, Lucia, additional, Meijboom, Rozanna, additional, Wiseman, Stewart, additional, Taylor, Adele M, additional, Corley, Janie, additional, Chappell, Francesca M, additional, Backhouse, Ellen V, additional, Stringer, Michael S, additional, Dickie, David Alexander, additional, Bastin, Mark E, additional, Deary, Ian J, additional, Cox, Simon R, additional, and Wardlaw, Joanna M, additional

Published
2021
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41. Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland

Author

Meijboom, Rozanna, primary, Wiseman, Stewart J, additional, York, Elizabeth N, additional, Bastin, Mark E, additional, Valdés Hernández, Maria del C, additional, Thrippleton, Michael J, additional, Mollison, Daisy, additional, White, Nicole, additional, Kampaite, Agniete, additional, Kee Kwong, Koy Chong Ng, additional, Gonzalez, David Rodriguez, additional, Job, Dominic, additional, Weaver, Christine, additional, Kearns, Patrick K A, additional, Connick, Pete, additional, Chandran, Siddharthan, additional, and Waldman, Adam D, additional

Published
2021
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45. Dietary patterns, cognitive function, and structural neuroimaging measures of brain aging

Author

Corley, Janie, primary, Cox, Simon R., additional, Taylor, Adele M., additional, Hernandez, Maria Valdés, additional, Maniega, Susana Muñoz, additional, Ballerini, Lucia, additional, Wiseman, Stewart, additional, Meijboom, Rozanna, additional, Backhouse, Ellen V., additional, Bastin, Mark E., additional, Wardlaw, Joanna M., additional, and Deary, Ian J., additional

Published
2020
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47. Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Author

Clancy, Una, primary, Garcia, Daniela Jaime, additional, Stringer, Michael S, additional, Thrippleton, Michael J, additional, Valdés-Hernández, Maria C, additional, Wiseman, Stewart, additional, Hamilton, Olivia KL, additional, Chappell, Francesca M, additional, Brown, Rosalind, additional, Blair, Gordon W, additional, Hewins, Will, additional, Sleight, Emilie, additional, Ballerini, Lucia, additional, Bastin, Mark E, additional, Maniega, Susana Munoz, additional, MacGillivray, Tom, additional, Hetherington, Kirstie, additional, Hamid, Charlene, additional, Arteaga, Carmen, additional, Morgan, Alasdair G, additional, Manning, Cameron, additional, Backhouse, Ellen, additional, Hamilton, Iona, additional, Job, Dominic, additional, Marshall, Ian, additional, Doubal, Fergus N, additional, and Wardlaw, Joanna M, additional

Published
2020
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48. sj-pdf-1-lup-10.1177_0961203320979045 - Supplemental material for Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus

Author

Hernández, Maria Del C Valdés, Smith, Keith, Bastin, Mark E, E. Nicole Amft, Ralston, Stuart H, Wardlaw, Joanna M, and Wiseman, Stewart J

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-lup-10.1177_0961203320979045 for Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus by Maria del C Valdés Hernández, Keith Smith, Mark E Bastin, E. Nicole Amft, Stuart H Ralston, Joanna M Wardlaw and Stewart J Wiseman in Lupus

Published
2020
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49. sj-pdf-2-eso-10.1177_2396987320929617 - Supplemental material for Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Author

Clancy, Una, Garcia, Daniela Jaime, Stringer, Michael S, Thrippleton, Michael J, Valdés-Hernández, Maria C, Wiseman, Stewart, Hamilton, Olivia KL, Chappell, Francesca M, Brown, Rosalind, Blair, Gordon W, Hewins, Will, Sleight, Emilie, Ballerini, Lucia, Bastin, Mark E, Maniega, Susana Munoz, MacGillivray, Tom, Hetherington, Kirstie, Hamid, Charlene, Arteaga, Carmen, Morgan, Alasdair G, Manning, Cameron, Backhouse, Ellen, Hamilton, Iona, Job, Dominic, Marshall, Ian, Doubal, Fergus N, and Wardlaw, Joanna M

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-2-eso-10.1177_2396987320929617 for Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 by Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhouse, Iona Hamilton, Dominic Job, Ian Marshall, Fergus N Doubal and Joanna M Wardlaw in European Stroke Journal

Published
2020
Full Text
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50. sj-pdf-1-eso-10.1177_2396987320929617 - Supplemental material for Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Author

Clancy, Una, Garcia, Daniela Jaime, Stringer, Michael S, Thrippleton, Michael J, Valdés-Hernández, Maria C, Wiseman, Stewart, Hamilton, Olivia KL, Chappell, Francesca M, Brown, Rosalind, Blair, Gordon W, Hewins, Will, Sleight, Emilie, Ballerini, Lucia, Bastin, Mark E, Maniega, Susana Munoz, MacGillivray, Tom, Hetherington, Kirstie, Hamid, Charlene, Arteaga, Carmen, Morgan, Alasdair G, Manning, Cameron, Backhouse, Ellen, Hamilton, Iona, Job, Dominic, Marshall, Ian, Doubal, Fergus N, and Wardlaw, Joanna M

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-eso-10.1177_2396987320929617 for Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 by Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhouse, Iona Hamilton, Dominic Job, Ian Marshall, Fergus N Doubal and Joanna M Wardlaw in European Stroke Journal

Published
2020
Full Text
View/download PDF

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