1. Pre-transplant donor-specific HLA antibodies and risk for poor first-year renal transplant outcomes: results from the Swiss Transplant Cohort Study
- Author
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Wehmeier, Caroline, Amico, Patrizia, Sidler, Daniel, Wirthm��ller, Urs, Hadaya, Karine, Ferrari-Lacraz, Sylvie, Golshayan, D��la, Aubert, Vincent, Schnyder, Aurelia, Sunic, Kata, Schachtner, Thomas, Nilsson, Jakob, and Schaub, Stefan
- Subjects
body regions ,surgical procedures, operative ,610 Medicine & health - Abstract
The aim of this study was to analyze first year renal outcomes in a nationwide prospective multicenter cohort comprising 2215 renal transplants, with a special emphasis on the presence of pre-transplant donor-specific HLA antibodies (DSA). All transplants had a complete virtual crossmatch and DSA were detected in 19% (411/2215). The investigated composite endpoint was a poor first-year outcome defined as (i) allograft failure or (ii) death or (iii) poor allograft function (eGFR ���25��ml/min/1.73��m2 ) at one year. Two hundred and twenty-one (221/2215; 10%) transplants showed a poor first-year outcome. Rejection (24/70; 34%) was the most common reason for graft failure. First-year patient's death was rare (48/2215; 2%). There were no statistically significant differences between DSA-positive and DSA-negative transplants regarding composite and each individual endpoint, as well as reasons for graft failure and death. DSA-positive transplants experienced more frequently rejection episodes, mainly antibody-mediated rejection (both P��
- Published
- 2021
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