29 results on '"Wirsich J"'
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2. The photodissociation of circumstellar CO
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Wirsich, J.
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- 1993
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3. Sources of the Ultra-High Energy Cosmic Rays (UHECRs) (Part II)
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Wirsich, J., primary
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- 2017
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4. The Chromospheric Radiation on the Circumstellar Shell of δ Andromedae
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Wirsich, J., primary
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- 1998
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5. The photodissociation of circumstellar HCN and SiS
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Wirsich, J., primary
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- 1994
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6. Dust temperatures in the circumstellar shell of TX PISCIUM
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Wirsich, J., primary
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- 1991
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7. The Chromospheric Radiation on the Circumstellar Shell of ? Andromedae
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Wirsich, J.
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We have calculated the ionization of the elements O, C, Mg, Si, S, and Fe and the dissociation of the molecules CO, OH, NH, CH, SiO, CN, C2, and H2O in the circumstellar envelope (CSE) of the red giant ? Andromedae (K3 III) due to the ultraviolet radiation of the chromosphere. This calculation is based on the penetration of the chromospheric UV radiation into the CSE and its effect on the wavelengths of absorption of the species listed. We show that O, C, Mg, Si, Fe, and SiO, which are important for dust formation, survive the harsh non-LTE environment close to the central star of ? And. Some implications for dust formation in the inner region of the CSE of ? And are presented.
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- 1998
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8. Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices
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Boutière C, Rey C, Zaaraoui W, Le Troter A, Rico A, Crespy L, Achard S, Reuter F, Pariollaud F, Wirsich J, Asquinazi P, Confort-Gouny S, Soulier E, Guye M, Pelletier J, Jean-Philippe Ranjeva, and Audoin B
9. Extinction coefficients of carbon grains in far-infrared
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Wirsich, J., primary
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- 1987
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10. Photodestruction rates in the circumstellar shell of Alpha Orionis by chromospheric radiation
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Wirsich, J., primary
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- 1988
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11. Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy.
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Wirsich J, Iannotti GR, Ridley B, Shamshiri EA, Sheybani L, Grouiller F, Bartolomei F, Seeck M, Lazeyras F, Ranjeva JP, Guye M, and Vulliemoz S
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Whole-brain functional connectivity networks (connectomes) have been characterized at different scales in humans using EEG and fMRI. Multimodal epileptic networks have also been investigated, but the relationship between EEG and fMRI defined networks on a whole-brain scale is unclear. A unified multimodal connectome description, mapping healthy and pathological networks would close this knowledge gap. Here, we characterize the spatial correlation between the EEG and fMRI connectomes in right and left temporal lobe epilepsy (rTLE/lTLE). From two centers, we acquired resting-state concurrent EEG-fMRI of 35 healthy controls and 34 TLE patients. EEG-fMRI data was projected into the Desikan brain atlas, and functional connectomes from both modalities were correlated. EEG and fMRI connectomes were moderately correlated. This correlation was increased in rTLE when compared to controls for EEG-delta/theta/alpha/beta. Conversely, multimodal correlation in lTLE was decreased in respect to controls for EEG-beta. While the alteration was global in rTLE, in lTLE it was locally linked to the default mode network. The increased multimodal correlation in rTLE and decreased correlation in lTLE suggests a modality-specific lateralized differential reorganization in TLE, which needs to be considered when comparing results from different modalities. Each modality provides distinct information, highlighting the benefit of multimodal assessment in epilepsy., Competing Interests: Competing Interests: The authors have declared that no competing interests exist., (© 2024 Massachusetts Institute of Technology.)
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- 2024
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12. Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
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Egan MK, Larsen R, Wirsich J, Sutton BP, and Sadaghiani S
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Purpose: Simultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about EEG data quality and safety when used with newer multi-band (MB) fMRI sequences. Here, we measure the relative heating of a MB protocol compared with a standard single-band (SB) protocol considered to be safe. We also evaluated EEG quality recorded concurrently with the MB protocol on humans., Materials and Methods: We compared radiofrequency (RF)-related heating at multiple electrodes and magnetic field magnitude, B1+RMS, of a MB fMRI sequence with whole-brain coverage (TR = 440 ms, MB factor = 4) against a previously recommended, safe SB sequence using a phantom outfitted with a 64-channel EEG cap. Next, 9 human subjects underwent eyes-closed resting state EEG-fMRI using the MB sequence. Additionally, in three of the subjects resting state EEG was recorded also during the SB sequence and in an fMRI-free condition to directly compare EEG data quality across scanning conditions. EEG data quality was assessed by the ability to remove gradient and cardioballistic artifacts along with a clean spectrogram., Results: The heating induced by the MB sequence was lower than that of the SB sequence by a factor of 0.73 ± 0.38. This is consistent with an expected heating ratio of 0.64, calculated from the square of the ratio of B1+RMS values of the sequences. In the resting state EEG data, gradient and cardioballistic artifacts were successfully removed using traditional template subtraction. All subjects showed an individual alpha peak in the spectrogram with a posterior topography characteristic of eyes-closed EEG. The success of artifact rejection for the MB sequence was comparable to that in traditional SB sequences., Conclusions: Our study shows that B1+RMS is a useful indication of the relative heating of fMRI protocols. This observation indicates that simultaneous EEG-fMRI recordings using this MB sequence can be safe in terms of RF-related heating, and that EEG data recorded using this sequence is of acceptable quality after traditional artifact removal techniques., Competing Interests: The authors have declared that no competing interests exist.
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- 2021
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13. The relationship between EEG and fMRI connectomes is reproducible across simultaneous EEG-fMRI studies from 1.5T to 7T.
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Wirsich J, Jorge J, Iannotti GR, Shamshiri EA, Grouiller F, Abreu R, Lazeyras F, Giraud AL, Gruetter R, Sadaghiani S, and Vulliémoz S
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- Adolescent, Adult, Brain physiology, Connectome methods, Electroencephalography methods, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Nerve Net physiology, Reproducibility of Results, Young Adult, Brain diagnostic imaging, Connectome standards, Databases, Factual standards, Electroencephalography standards, Magnetic Resonance Imaging standards, Nerve Net diagnostic imaging
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Both electroencephalography (EEG) and functional Magnetic Resonance Imaging (fMRI) are non-invasive methods that show complementary aspects of human brain activity. Despite measuring different proxies of brain activity, both the measured blood-oxygenation (fMRI) and neurophysiological recordings (EEG) are indirectly coupled. The electrophysiological and BOLD signal can map the underlying functional connectivity structure at the whole brain scale at different timescales. Previous work demonstrated a moderate but significant correlation between resting-state functional connectivity of both modalities, however there is a wide range of technical setups to measure simultaneous EEG-fMRI and the reliability of those measures between different setups remains unknown. This is true notably with respect to different magnetic field strengths (low and high field) and different spatial sampling of EEG (medium to high-density electrode coverage). Here, we investigated the reproducibility of the bimodal EEG-fMRI functional connectome in the most comprehensive resting-state simultaneous EEG-fMRI dataset compiled to date including a total of 72 subjects from four different imaging centers. Data was acquired from 1.5T, 3T and 7T scanners with simultaneously recorded EEG using 64 or 256 electrodes. We demonstrate that the whole-brain monomodal connectivity reproducibly correlates across different datasets and that a moderate crossmodal correlation between EEG and fMRI connectivity of r ≈ 0.3 can be reproducibly extracted in low- and high-field scanners. The crossmodal correlation was strongest in the EEG-β frequency band but exists across all frequency bands. Both homotopic and within intrinsic connectivity network (ICN) connections contributed the most to the crossmodal relationship. This study confirms, using a considerably diverse range of recording setups, that simultaneous EEG-fMRI offers a consistent estimate of multimodal functional connectomes in healthy subjects that are dominantly linked through a functional core of ICNs across spanning across the different timescales measured by EEG and fMRI. This opens new avenues for estimating the dynamics of brain function and provides a better understanding of interactions between EEG and fMRI measures. This observed level of reproducibility also defines a baseline for the study of alterations of this coupling in pathological conditions and their role as potential clinical markers., (Copyright © 2021. Published by Elsevier Inc.)
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- 2021
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14. Modular slowing of resting-state dynamic functional connectivity as a marker of cognitive dysfunction induced by sleep deprivation.
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Lombardo D, Cassé-Perrot C, Ranjeva JP, Le Troter A, Guye M, Wirsich J, Payoux P, Bartrés-Faz D, Bordet R, Richardson JC, Felician O, Jirsa V, Blin O, Didic M, and Battaglia D
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- Adult, Brain diagnostic imaging, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction etiology, Humans, Male, Nerve Net diagnostic imaging, Sleep Deprivation diagnostic imaging, Time Factors, Attention physiology, Brain physiopathology, Cognitive Dysfunction physiopathology, Connectome, Memory, Short-Term physiology, Nerve Net physiopathology, Psychomotor Performance physiology, Sleep Deprivation physiopathology, Visual Perception physiology
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Dynamic Functional Connectivity (dFC) in the resting state (rs) is considered as a correlate of cognitive processing. Describing dFC as a flow across morphing connectivity configurations, our notion of dFC speed quantifies the rate at which FC networks evolve in time. Here we probe the hypothesis that variations of rs dFC speed and cognitive performance are selectively interrelated within specific functional subnetworks. In particular, we focus on Sleep Deprivation (SD) as a reversible model of cognitive dysfunction. We found that whole-brain level (global) dFC speed significantly slows down after 24h of SD. However, the reduction in global dFC speed does not correlate with variations of cognitive performance in individual tasks, which are subtle and highly heterogeneous. On the contrary, we found strong correlations between performance variations in individual tasks -including Rapid Visual Processing (RVP, assessing sustained visual attention)- and dFC speed quantified at the level of functional sub-networks of interest. Providing a compromise between classic static FC (no time) and global dFC (no space), modular dFC speed analyses allow quantifying a different speed of dFC reconfiguration independently for sub-networks overseeing different tasks. Importantly, we found that RVP performance robustly correlates with the modular dFC speed of a characteristic frontoparietal module., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2020
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15. Concurrent EEG- and fMRI-derived functional connectomes exhibit linked dynamics.
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Wirsich J, Giraud AL, and Sadaghiani S
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- Adolescent, Adult, Brain diagnostic imaging, Female, Humans, Male, Nerve Net diagnostic imaging, Young Adult, Brain physiology, Connectome methods, Electroencephalography methods, Magnetic Resonance Imaging methods, Nerve Net physiology
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Long-range connectivity has become the most studied feature of human functional Magnetic Resonance Imaging (fMRI), yet the spatial and temporal relationship between its whole-brain dynamics and electrophysiological connectivity remains largely unknown. FMRI-derived functional connectivity exhibits spatial reconfigurations or time-varying dynamics at infraslow (<0.1Hz) speeds. Conversely, electrophysiological connectivity is based on cross-region coupling of fast oscillations (~1-100Hz). It is unclear whether such fast oscillation-based coupling varies at infraslow speeds, temporally coinciding with infraslow dynamics across the fMRI-based connectome. If so, does the association of fMRI-derived and electrophysiological dynamics spatially vary over the connectome across the functionally distinct electrophysiological oscillation bands? In two concurrent electroencephalography (EEG)-fMRI resting-state datasets, oscillation-based coherence in all canonical bands (delta through gamma) indeed reconfigured at infraslow speeds in tandem with fMRI-derived connectivity changes in corresponding region-pairs. Interestingly, irrespective of EEG frequency-band the cross-modal tie of connectivity dynamics comprised a large proportion of connections distributed across the entire connectome. However, there were frequency-specific differences in the relative strength of the cross-modal association. This association was strongest in visual to somatomotor connections for slower EEG-bands, and in connections involving the Default Mode Network for faster EEG-bands. Methodologically, the findings imply that neural connectivity dynamics can be reliably measured by fMRI despite heavy susceptibility to noise, and by EEG despite shortcomings of source reconstruction. Biologically, the findings provide evidence that contrast with known territories of oscillation power, oscillation coupling in all bands slowly reconfigures in a highly distributed manner across the whole-brain connectome., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2020
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16. Multi-timescale hybrid components of the functional brain connectome: A bimodal EEG-fMRI decomposition.
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Wirsich J, Amico E, Giraud AL, Goñi J, and Sadaghiani S
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Concurrent electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) bridge brain connectivity across timescales. During concurrent EEG-fMRI resting-state recordings, whole-brain functional connectivity (FC) strength is spatially correlated across modalities. However, cross-modal investigations have commonly remained correlational, and joint analysis of EEG-fMRI connectivity is largely unexplored. Here we investigated if there exist (spatially) independent FC networks linked between modalities. We applied the recently proposed hybrid connectivity independent component analysis (connICA) framework to two concurrent EEG-fMRI resting-state datasets (total 40 subjects). Two robust components were found across both datasets. The first component has a uniformly distributed EEG frequency fingerprint linked mainly to intrinsic connectivity networks (ICNs) in both modalities. Conversely, the second component is sensitive to different EEG frequencies and is primarily linked to intra-ICN connectivity in fMRI but to inter-ICN connectivity in EEG. The first hybrid component suggests that connectivity dynamics within well-known ICNs span timescales, from millisecond range in all canonical frequencies of FC
EEG to second range of FCfMRI . Conversely, the second component additionally exposes linked but spatially divergent neuronal processing at the two timescales. This work reveals the existence of joint spatially independent components, suggesting that parts of resting-state connectivity are co-expressed in a linked manner across EEG and fMRI over individuals., (© 2020 Massachusetts Institute of Technology.)- Published
- 2020
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17. Intrinsic connectome organization across temporal scales: New insights from cross-modal approaches.
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Sadaghiani S and Wirsich J
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The discovery of a stable, whole-brain functional connectivity organization that is largely independent of external events has drastically extended our view of human brain function. However, this discovery has been primarily based on functional magnetic resonance imaging (fMRI). The role of this whole-brain organization in fast oscillation-based connectivity as measured, for example, by electroencephalography (EEG) and magnetoencephalography (MEG) is only beginning to emerge. Here, we review studies of intrinsic connectivity and its whole-brain organization in EEG, MEG, and intracranial electrophysiology with a particular focus on direct comparisons to connectome studies in fMRI. Synthesizing this literature, we conclude that irrespective of temporal scale over four orders of magnitude, intrinsic neurophysiological connectivity shows spatial similarity to the connectivity organization commonly observed in fMRI. A shared structural connectivity basis and cross-frequency coupling are possible mechanisms contributing to this similarity. Acknowledging that a stable whole-brain organization governs long-range coupling across all timescales of neural processing motivates researchers to take "baseline" intrinsic connectivity into account when investigating brain-behavior associations, and further encourages more widespread exploration of functional connectomics approaches beyond fMRI by using EEG and MEG modalities., Competing Interests: Competing Interests: The authors have declared that no competing interests exist., (© 2019 Massachusetts Institute of Technology.)
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- 2020
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18. Impact of Zika Virus on adult human brain structure and functional organization.
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Bido-Medina R, Wirsich J, Rodríguez M, Oviedo J, Miches I, Bido P, Tusen L, Stoeter P, and Sadaghiani S
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Objective: To determine the impact of Zika virus (ZIKV) infection on brain structure and functional organization of severely affected adult patients with neurological complications that extend beyond Guillain-Barré Syndrome (GBS)-like manifestations and include symptoms of the central nervous system (CNS)., Methods: In this first case-control neuroimaging study, we obtained structural and functional magnetic resonance images in nine rare adult patients in the subacute phase, and healthy age- and sex-matched controls. ZIKV patients showed atypical descending and rapidly progressing peripheral nervous system (PNS) manifestations, and importantly, additional CNS presentations such as perceptual deficits. Voxel-based morphometry was utilized to evaluate gray matter volume, and resting state functional connectivity and Network Based Statistics were applied to assess the functional organization of the brain., Results: Gray matter volume was decreased bilaterally in motor areas (supplementary motor cortex, specifically Frontal Eye Fields) and beyond (left inferior frontal sulcus). Additionally, gray matter volume increased in right middle frontal gyrus. Functional connectivity increased in a widespread network within and across temporal lobes., Interpretation: We provide preliminary evidence for a link between ZIKV neurological complications and changes in adult human brain structure and functional organization, comprising both motor-related regions potentially secondary to prolonged PNS weakness, and nonsomatomotor regions indicative of PNS-independent alternations. The latter included the temporal lobes, particularly vulnerable in a range of neurological conditions. While future studies into the ZIKV-related neuroinflammatory mechanisms in adults are urgently needed, this study indicates that ZIKV infection can lead to an impact on the brain.
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- 2018
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19. Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation.
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Wirsich J, Rey M, Guye M, Bénar C, Lanteaume L, Ridley B, Confort-Gouny S, Cassé-Perrot C, Soulier E, Viout P, Rouby F, Lefebvre MN, Audebert C, Truillet R, Jouve E, Payoux P, Bartrés-Faz D, Bordet R, Richardson JC, Babiloni C, Rossini PM, Micallef J, Blin O, and Ranjeva JP
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- Adult, Brain diagnostic imaging, Brain physiopathology, Brain Mapping, Electroencephalography, Humans, Magnetic Resonance Imaging, Male, Nerve Net diagnostic imaging, Nerve Net physiopathology, Sleep Deprivation diagnostic imaging, Brain drug effects, Donepezil pharmacology, Nerve Net drug effects, Nootropic Agents pharmacology, Sleep physiology, Sleep Deprivation physiopathology
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Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer's disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative 'PharmaCog'. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.
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- 2018
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20. Complementary contributions of concurrent EEG and fMRI connectivity for predicting structural connectivity.
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Wirsich J, Ridley B, Besson P, Jirsa V, Bénar C, Ranjeva JP, and Guye M
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- Adult, Brain diagnostic imaging, Diffusion Magnetic Resonance Imaging methods, Female, Humans, Male, Models, Theoretical, Nerve Net diagnostic imaging, Young Adult, Brain anatomy & histology, Brain physiology, Connectome methods, Electroencephalography methods, Magnetic Resonance Imaging methods, Nerve Net anatomy & histology, Nerve Net physiology
- Abstract
While averaged dynamics of brain function are known to estimate the underlying structure, the exact relationship between large-scale function and structure remains an unsolved issue in network neuroscience. These complex functional dynamics, measured by EEG and fMRI, are thought to arise from a shared underlying structural architecture, which can be measured by diffusion MRI (dMRI). While simulation and data transformation (e.g. graph theory measures) have been proposed to refine the understanding of the underlying function-structure relationship, the potential complementary and/or independent contribution of EEG and fMRI to this relationship is still poorly understood. As such, we explored this relationship by analyzing the function-structure correlation in fourteen healthy subjects with simultaneous resting-state EEG-fMRI and dMRI acquisitions. We show that the combination of EEG and fMRI connectivity better explains dMRI connectivity and that this represents a genuine model improvement over fMRI-only models for both group-averaged connectivity matrices and at the individual level. Furthermore, this model improves the prediction within each resting-state network. The best model fit to underlying structure is mediated by fMRI and EEG-δ connectivity in combination with Euclidean distance and interhemispheric connectivity with more local contributions of EEG-γ at the scale of resting-state networks. This highlights that the factors mediating the relationship between functional and structural metrics of connectivity are context and scale dependent, influenced by topological, geometric and architectural features. It also suggests that fMRI studies employing simultaneous EEG measures may characterize additional and essential parts of the underlying neuronal activity of the resting-state, which might be of special interest for both clinical studies and the investigation of resting-state dynamics., (Copyright © 2017 Elsevier Inc. All rights reserved.)
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- 2017
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21. Simultaneous Intracranial EEG-fMRI Shows Inter-Modality Correlation in Time-Resolved Connectivity Within Normal Areas but Not Within Epileptic Regions.
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Ridley B, Wirsich J, Bettus G, Rodionov R, Murta T, Chaudhary U, Carmichael D, Thornton R, Vulliemoz S, McEvoy A, Wendling F, Bartolomei F, Ranjeva JP, Lemieux L, and Guye M
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- Adult, Brain physiopathology, Brain Mapping, Epilepsy physiopathology, Female, Humans, Male, Multimodal Imaging, Nerve Net physiopathology, Seizures physiopathology, Young Adult, Brain diagnostic imaging, Electroencephalography methods, Epilepsy diagnostic imaging, Magnetic Resonance Imaging methods, Nerve Net diagnostic imaging, Seizures diagnostic imaging
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For the first time in research in humans, we used simultaneous icEEG-fMRI to examine the link between connectivity in haemodynamic signals during the resting-state (rs) and connectivity derived from electrophysiological activity in terms of the inter-modal connectivity correlation (IMCC). We quantified IMCC in nine patients with drug-resistant epilepsy (i) within brain networks in 'healthy' non-involved cortical zones (NIZ) and (ii) within brain networks involved in generating seizures and interictal spikes (IZ1) or solely spikes (IZ2). Functional connectivity (h
2 ) estimates for 10 min of resting-state data were obtained between each pair of electrodes within each clinical zone for both icEEG and fMRI. A sliding window approach allowed us to quantify the variability over time of h2 (vh2 ) as an indicator of connectivity dynamics. We observe significant positive IMCC for h2 and vh2 , for multiple bands in the NIZ only, with the strongest effect in the lower icEEG frequencies. Similarly, intra-modal h2 and vh2 were found to be differently modified as a function of different epileptic processes: compared to NIZ, [Formula: see text] was higher in IZ1, but lower in IZ2, while [Formula: see text] showed the inverse pattern. This corroborates previous observations of inter-modal connectivity discrepancies in pathological cortices, while providing the first direct invasive and simultaneous comparison in humans. We also studied time-resolved FC variability multimodally for the first time, finding that IZ1 shows both elevated internal [Formula: see text] and less rich dynamical variability, suggesting that its chronic role in epileptogenesis may be linked to greater homogeneity in self-sustaining pathological oscillatory states.- Published
- 2017
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22. Brain sodium MRI in human epilepsy: Disturbances of ionic homeostasis reflect the organization of pathological regions.
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Ridley B, Marchi A, Wirsich J, Soulier E, Confort-Gouny S, Schad L, Bartolomei F, Ranjeva JP, Guye M, and Zaaraoui W
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- Adult, Epilepsy physiopathology, Female, Humans, Male, Middle Aged, Protons, Sodium cerebrospinal fluid, Young Adult, Cerebral Cortex diagnostic imaging, Cerebral Cortex metabolism, Cerebral Cortex physiopathology, Electrocorticography methods, Epilepsy diagnostic imaging, Epilepsy metabolism, Homeostasis physiology, Magnetic Resonance Imaging methods, Sodium metabolism
- Abstract
In light of technical advancements supporting exploration of MR signals other than
1 H, sodium (23 Na) has received attention as a marker of ionic homeostasis and cell viability. Here, we evaluate for the first time the possibility that23 Na-MRI is sensitive to pathological processes occurring in human epilepsy. A normative sample of 27 controls was used to normalize regions of interest (ROIs) from 1424 unique brain locales on quantitative23 Na-MRI and high-resolution1 H-MPRAGE images. ROIs were based on intracerebral electrodes in ten patients undergoing epileptic network mapping. The stereo-EEG gold standard was used to define regions as belonging to primarily epileptogenic, secondarily irritative and to non-involved regions. Estimates of total sodium concentration (TSC) on23 Na-MRI and cerebrospinal fluid (CSF) on1 H imaging were extracted for each patient ROI, and normalized against the same region in controls. ROIs with disproportionate CSF contributions (ZCSF ≥1.96) were excluded. TSC levels were found to be elevated in patients relative to controls except in one patient, who suffered non-convulsive seizures during the scan, in whom we found reduced TSC levels. In the remaining patients, an ANOVA (F1100 = 12.37, p<0.0001) revealed a highly significant effect of clinically-defined zones (F1100 = 11.13, p<0.0001), with higher normalized TSC in the epileptogenic zone relative to both secondarily irritative (F1100 = 11, p=0.0009) and non-involved regions (F1100 = 17.8, p<0.0001). We provide the first non-invasive, in vivo evidence of a chronic TSC elevation alongside ZCSF levels within the normative range, associated with the epileptogenic region even during the interictal period in human epilepsy, and the possibility of reduced TSC levels due to seizure. In line with modified homeostatic mechanisms in epilepsy - including altered mechanisms underlying ionic gating, clearance and exchange - we provide the first indication of23 Na-MRI as an assay of altered sodium concentrations occurring in epilepsy associated with the organization of clinically relevant divisions of pathological cortex., (Copyright © 2017 Elsevier Inc. All rights reserved.)- Published
- 2017
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23. Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices.
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Boutière C, Rey C, Zaaraoui W, Le Troter A, Rico A, Crespy L, Achard S, Reuter F, Pariollaud F, Wirsich J, Asquinazi P, Confort-Gouny S, Soulier E, Guye M, Pelletier J, Ranjeva JP, and Audoin B
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- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis complications, Muscle Spasticity etiology, Connectome methods, Motor Cortex, Multiple Sclerosis therapy, Muscle Spasticity therapy, Outcome Assessment, Health Care, Theta Rhythm physiology, Transcranial Magnetic Stimulation methods
- Abstract
Background: Intermittent theta burst stimulation (iTBS) of the primary motor cortex improves transiently lower limbs spasticity in multiple sclerosis (MS). However, the cerebral mechanisms underlying this effect have never been investigated., Objective: To assess whether modulation of spasticity induced by iTBS is underlined by functional reorganization of the primary motor cortices., Methods: A total of 17 patients with MS suffering from lower limbs spasticity were randomized to receive real iTBS or sham iTBS during the first half of a 5-week indoor rehabilitation programme. Spasticity was assessed using the Modified Ashworth Scale and the Visual Analogue Scale at baseline, after the stimulation session and at the end of the rehabilitation programme. Resting-state functional magnetic resonance imaging (fMRI) was performed at the three time points, and brain functional networks topology was analysed using graph-theoretical approach., Results: At the end of stimulation, improvement of spasticity was greater in real iTBS group than in sham iTBS group ( p = 0.026). iTBS had a significant effect on the balance of the connectivity degree between the stimulated and the homologous primary motor cortex ( p = 0.005). Changes in inter-hemispheric balance were correlated with improvement of spasticity (rho = 0.56, p = 0.015)., Conclusion: This longitudinal resting-state fMRI study evidences that functional reorganization of the primary motor cortices may underlie the effect of iTBS on spasticity in MS.
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- 2017
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24. Alien Hand, Restless Brain: Salience Network and Interhemispheric Connectivity Disruption Parallel Emergence and Extinction of Diagonistic Dyspraxia.
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Ridley B, Beltramone M, Wirsich J, Le Troter A, Tramoni E, Aubert S, Achard S, Ranjeva JP, Guye M, and Felician O
- Abstract
Diagonistic dyspraxia (DD) is by far the most spectacular manifestation reported by sufferers of acute corpus callosum (CC) injury (so-called "split-brain"). In this form of alien hand syndrome, one hand acts at cross purposes with the other "against the patient's will". Although recent models view DD as a disorder of motor control, there is still little information regarding its neural underpinnings, due to widespread connectivity changes produced by CC insult, and the obstacle that non-volitional movements represent for task-based functional neuroimaging studies. Here, we studied patient AM, the first report of DD in patient with complete developmental CC agenesis. This unique case also offers the opportunity to study the resting-state connectomics of DD in the absence of diffuse changes subsequent to CC injury or surgery. AM developed DD following status epilepticus (SE) which resolved over a 2-year period. Whole brain functional connectivity (FC) was compared (Crawford-Howell [CH]) to 16 controls during the period of acute DD symptoms (Time 1) and after remission (Time 2). Whole brain graph theoretical models were also constructed and topological efficiency examined. At Time 1, disrupted FC was observed in inter-hemispheric and intra-hemispheric right edges, involving frontal superior and midline structures. Graph analysis indicated disruption of the efficiency of salience and right frontoparietal (FP) networks. At Time 2, after remission of diagnostic dyspraxia symptoms, FC and salience network changes had resolved. In sum, longitudinal analysis of connectivity in AM indicates that DD behaviors could result from disruption of systems that support the experience and control of volitional movements and the ability to generate appropriate behavioral responses to salient stimuli. This also raises the possibility that changes to large-scale functional architecture revealed by resting-state functional magnetic resonance imaging (fMRI) (rs-fMRI) may provide relevant information on the evolution of behavioral syndromes in addition to that provided by structural and task-based functional imaging.
- Published
- 2016
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25. Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy.
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Wirsich J, Perry A, Ridley B, Proix T, Golos M, Bénar C, Ranjeva JP, Bartolomei F, Breakspear M, Jirsa V, and Guye M
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- Adult, Brain diagnostic imaging, Brain Mapping, Connectome, Diffusion Magnetic Resonance Imaging, Epilepsy, Temporal Lobe diagnostic imaging, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways diagnostic imaging, Neural Pathways physiopathology, Oxygen blood, Young Adult, Brain pathology, Epilepsy, Temporal Lobe pathology, Neural Pathways pathology
- Abstract
The in vivo structure-function relationship is key to understanding brain network reorganization due to pathologies. This relationship is likely to be particularly complex in brain network diseases such as temporal lobe epilepsy, in which disturbed large-scale systems are involved in both transient electrical events and long-lasting functional and structural impairments. Herein, we estimated this relationship by analyzing the correlation between structural connectivity and functional connectivity in terms of analytical network communication parameters. As such, we targeted the gradual topological structure-function reorganization caused by the pathology not only at the whole brain scale but also both in core and peripheral regions of the brain. We acquired diffusion (dMRI) and resting-state fMRI (rsfMRI) data in seven right-lateralized TLE (rTLE) patients and fourteen healthy controls and analyzed the structure-function relationship by using analytical network communication metrics derived from the structural connectome. In rTLE patients, we found a widespread hypercorrelated functional network. Network communication analysis revealed greater unspecific branching of the shortest path (search information) in the structural connectome and a higher global correlation between the structural and functional connectivity for the patient group. We also found evidence for a preserved structural rich-club in the patient group. In sum, global augmentation of structure-function correlation might be linked to a smaller functional repertoire in rTLE patients, while sparing the central core of the brain which may represent a pathway that facilitates the spread of seizures.
- Published
- 2016
- Full Text
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26. Corrigendum: Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study.
- Author
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Faget-Agius C, Boyer L, Wirsich J, Ranjeva JP, Richieri R, Soulier E, Confort-Gouny S, Auquier P, Guye M, and Lançon C
- Published
- 2016
- Full Text
- View/download PDF
27. Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study.
- Author
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Faget-Agius C, Boyer L, Wirsich J, Ranjeva JP, Richieri R, Soulier E, Confort-Gouny S, Auquier P, Guye M, and Lançon C
- Subjects
- Adolescent, Adult, Brain pathology, Cerebral Cortex pathology, Cerebral Cortex ultrastructure, Gray Matter pathology, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neurons metabolism, Quality of Life, Radiography, Schizophrenia pathology, Surveys and Questionnaires, Temporal Lobe pathology, Temporal Lobe ultrastructure, Brain ultrastructure, Gray Matter ultrastructure, Magnetic Resonance Imaging, Schizophrenia diagnostic imaging
- Abstract
The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the secondary visual cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p < 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.
- Published
- 2015
- Full Text
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28. Nodal approach reveals differential impact of lateralized focal epilepsies on hub reorganization.
- Author
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Ridley BG, Rousseau C, Wirsich J, Le Troter A, Soulier E, Confort-Gouny S, Bartolomei F, Ranjeva JP, Achard S, and Guye M
- Subjects
- Adult, Aged, Female, Functional Laterality, Humans, Male, Middle Aged, Nerve Net physiopathology, Young Adult, Brain physiopathology, Brain Mapping methods, Epilepsies, Partial physiopathology, Magnetic Resonance Imaging methods
- Abstract
The impact of the hemisphere affected by impairment in models of network disease is not fully understood. Among such models, focal epilepsies are characterised by recurrent seizures generated in epileptogenic areas also responsible for wider network dysfunction between seizures. Previous work focusing on functional connectivity within circumscribed networks suggests a divergence of network integrity and compensatory capacity between epilepsies as a function of the laterality of seizure onset. We evaluated the ability of complex network theory to reveal changes in focal epilepsy in global and nodal parameters using graph theoretical analysis of functional connectivity data obtained with resting-state fMRI. Graphs of functional connectivity networks were derived from 19 right and 13 left focal epilepsy patients and 15 controls. Topological metrics (degree, local efficiency, global efficiency and modularity) were computed for a whole-brain, atlas-defined network. We also calculated a hub disruption index for each graph metric, measuring the capacity of the brain network to demonstrate increased connectivity in some nodes for decreased connectivity in others. Our data demonstrate that the patient group as a whole is characterised by network-wide pattern of reorganization, even while global parameters fail to distinguish between groups. Furthermore, multiple metrics indicate that epilepsies with differently lateralized epileptic networks are asymmetric in their burden on functional brain networks; with left epilepsy patients being characterised by reduced efficiency and modularity, while in right epilepsy patients we provide the first evidence that functional brain networks are characterised by enhanced connectivity and efficiency at some nodes whereas reduced in others., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
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29. Single-trial EEG-informed fMRI reveals spatial dependency of BOLD signal on early and late IC-ERP amplitudes during face recognition.
- Author
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Wirsich J, Bénar C, Ranjeva JP, Descoins M, Soulier E, Le Troter A, Confort-Gouny S, Liégeois-Chauvel C, and Guye M
- Subjects
- Adult, Electroencephalography, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult, Evoked Potentials physiology, Face, Functional Neuroimaging methods, Multimodal Imaging methods, Pattern Recognition, Visual physiology, Recognition, Psychology physiology, Visual Pathways physiology
- Abstract
Simultaneous EEG-fMRI has opened up new avenues for improving the spatio-temporal resolution of functional brain studies. However, this method usually suffers from poor EEG quality, especially for evoked potentials (ERPs), due to specific artifacts. As such, the use of EEG-informed fMRI analysis in the context of cognitive studies has particularly focused on optimizing narrow ERP time windows of interest, which ignores the rich diverse temporal information of the EEG signal. Here, we propose to use simultaneous EEG-fMRI to investigate the neural cascade occurring during face recognition in 14 healthy volunteers by using the successive ERP peaks recorded during the cognitive part of this process. N170, N400 and P600 peaks, commonly associated with face recognition, were successfully and reproducibly identified for each trial and each subject by using a group independent component analysis (ICA). For the first time we use this group ICA to extract several independent components (IC) corresponding to the sequence of activation and used single-trial peaks as modulation parameters in a general linear model (GLM) of fMRI data. We obtained an occipital-temporal-frontal stream of BOLD signal modulation, in accordance with the three successive IC-ERPs providing an unprecedented spatio-temporal characterization of the whole cognitive process as defined by BOLD signal modulation. By using this approach, the pattern of EEG-informed BOLD modulation provided improved characterization of the network involved than the fMRI-only analysis or the source reconstruction of the three ERPs; the latter techniques showing only two regions in common localized in the occipital lobe., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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