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1. Combined strategy of upfront CTCA and optimal treatment for stable chest pain: rationale and design of the CLEAR-CAD trial

Author

Verpalen, Victor A, Coerkamp, Casper F, Hinderks, Mark J, Meeder, Joan G, Winter, Michiel M, Arkenbout, E Karin, Vis, Jeroen C, Habets, Jesse, Smulders, Martijn W, Mihl, Casper, van Ofwegen-Hanekamp, Clara E E, van der Spoel, Tycho I G, Tanis, Wilco, van Gelder, Rogier E, van der Wielen, Marloes L J, Somsen, G Aernout, Kikkert, Wouter J, Carati, Luc F, el Barzouhi, Abdelilah, van Bergen, Paul F M M, Dedic, Admir, Prokop, Mathias, Stallmann, Hein P, Beele, Xavier D Y, Quarles van Ufford, Henriëtte M E, Nijveldt, Robin, Dijkgraaf, Marcel G W, Damman, Peter, Planken, R Nils, and Henriques, José P S

Published
2024
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2. Digital consults in heart failure care: a randomized controlled trial

Author

Man, Jelle P., Koole, Maarten A. C., Meregalli, Paola G., Handoko, M. Louis, Stienen, Susan, de Lange, Frederik J., Winter, Michiel M., Schijven, Marlies P., Kok, Wouter E. M., Kuipers, Dorianne I., van der Harst, Pim, Asselbergs, Folkert W., Zwinderman, Aeilko H., Dijkgraaf, Marcel G. W., Chamuleau, Steven A. J., and Schuuring, Mark J.

Published
2024
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9. Computer versus cardiologist: Is a machine learning algorithm able to outperform an expert in diagnosing a phospholamban p.Arg14del mutation on the electrocardiogram?

Author

Bleijendaal, Hidde, Ramos, Lucas A., Lopes, Ricardo R., Verstraelen, Tom E., Baalman, Sarah W.E., Oudkerk Pool, Marinka D., Tjong, Fleur V.Y., Melgarejo-Meseguer, Francisco M., Gimeno-Blanes, F. Javier, Gimeno-Blanes, Juan R., Amin, Ahmad S., Winter, Michiel M., Marquering, Henk A., Kok, Wouter E.M., Zwinderman, Aeilko H., Wilde, Arthur A.M., and Pinto, Yigal M.

Published
2021
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10. Digital consults to optimize guideline-directed therapy: design of a pragmatic multicenter randomized controlled trial

Author

Gezonde Vaten, Circulatory Health, Team Onderzoek, Man, Jelle P, Dijkgraaf, Marcel G W, Handoko, M Louis, de Lange, Frederik J, Winter, Michiel M, Schijven, Marlies P, Stienen, Susan, Meregalli, Paola, Kok, Wouter E M, Kuipers, Dorianne I, van der Harst, Pim, Koole, Maarten A C, Chamuleau, Steven A J, Schuuring, Mark J, Gezonde Vaten, Circulatory Health, Team Onderzoek, Man, Jelle P, Dijkgraaf, Marcel G W, Handoko, M Louis, de Lange, Frederik J, Winter, Michiel M, Schijven, Marlies P, Stienen, Susan, Meregalli, Paola, Kok, Wouter E M, Kuipers, Dorianne I, van der Harst, Pim, Koole, Maarten A C, Chamuleau, Steven A J, and Schuuring, Mark J

Published
2024

11. Beyond validation: getting wearable activity trackers into cardiovascular care—a discussion paper.

Author

Straiton, Nicola, Moons, Philip, Verstrael, Axel, Liu, Mark, and Winter, Michiel M

Subjects
EVIDENCE-based nursing, RISK assessment, CARDIOVASCULAR diseases, PHYSICAL fitness mobile apps, MEDICAL care, WEARABLE technology, CARDIOVASCULAR diseases risk factors, CARDIOVASCULAR disease nursing, PHYSICAL activity, CARDIOVASCULAR system
Abstract

This paper addresses the challenge of integrating wearable activity trackers (WATs) into cardiovascular disease care. Despite evidence supporting the use of trackers for monitoring and promoting physical activity, implementation challenges persist in clinical settings. The paper emphasizes the lack of systematic, evidence-based implementation approaches for integrating trackers. It underscores the urgent need for stakeholder collaboration between clinicians, patients, implementation scientists, researchers, health and technology partners, and the use of proven implementation science methodologies. This is crucial for bridging the gap and ensuring effective translation of WATs into cardiovascular care, meeting the increasing demand from patients and clinicians. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Digital consults to optimize guideline‐directed therapy: design of a pragmatic multicenter randomized controlled trial

Author

Man, Jelle P., primary, Dijkgraaf, Marcel G.W., additional, Handoko, M. Louis, additional, de Lange, Frederik J., additional, Winter, Michiel M., additional, Schijven, Marlies P., additional, Stienen, Susan, additional, Meregalli, Paola, additional, Kok, Wouter E.M., additional, Kuipers, Dorianne I., additional, van der Harst, Pim, additional, Koole, Maarten A.C., additional, Chamuleau, Steven A.J., additional, and Schuuring, Mark J., additional

Published
2023
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16. Digital consults to optimize guideline‐directed therapy: design of a pragmatic multicenter randomized controlled trial.

Author

Man, Jelle P., Dijkgraaf, Marcel G.W., Handoko, M. Louis, de Lange, Frederik J., Winter, Michiel M., Schijven, Marlies P., Stienen, Susan, Meregalli, Paola, Kok, Wouter E.M., Kuipers, Dorianne I., van der Harst, Pim, Koole, Maarten A.C., Chamuleau, Steven A.J., and Schuuring, Mark J.

Subjects
PATIENT satisfaction, VENTRICULAR ejection fraction, PATIENT education, MEDICAL care costs, PATIENT safety, HEART failure
Abstract

Aims: Many heart failure (HF) patients do not receive optimal guideline‐directed medical therapy (GDMT) despite clear benefit on morbidity and mortality outcomes. Digital consults (DCs) have the potential to improve efficiency on GDMT optimization to serve the growing HF population. The investigator‐initiated ADMINISTER trial was designed as a pragmatic multicenter randomized controlled open‐label trial to evaluate efficacy and safety of DC in patients on HF treatment. Methods and results: Patients (n = 150) diagnosed with HF with a reduced ejection fraction will be randomized to DC or standard care (1:1). The intervention group receives multifaceted DCs including (i) digital data sharing (e.g. exchange of pharmacotherapy use and home‐measured vital signs), (ii) patient education via an e‐learning, and (iii) digital guideline recommendations to treating clinicians. The consults are performed remotely unless there is an indication to perform the consult physically. The primary outcome is the GDMT prescription rate score, and secondary outcomes include time till full GDMT optimization, patient and clinician satisfaction, time spent on healthcare, and Kansas City Cardiomyopathy Questionnaire. Results will be reported in accordance to the CONSORT statement. Conclusions: The ADMINISTER trial will offer the first randomized controlled data on GDMT prescription rates, time till full GDMT optimization, time spent on healthcare, quality of life, and patient and clinician satisfaction of the multifaceted patient‐ and clinician‐targeted DC for GDMT optimization. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial

Author

van den Berk, Inge A H, primary, Kanglie, Maadrika M N P, additional, van Engelen, Tjitske S R, additional, Altenburg, Josje, additional, Annema, Jouke T, additional, Beenen, Ludo F M, additional, Boerrigter, Bart, additional, Bomers, Marije K, additional, Bresser, Paul, additional, Eryigit, Elvin, additional, Groenink, Maarten, additional, Hochheimer, Suzanne M R, additional, Holleman, Frits, additional, Kooter, Jos A J, additional, van Loon, Ramon B, additional, Keijzers, Mitran, additional, van der Lee, Ivo, additional, Luijendijk, Paul, additional, Meijboom, Lilian J, additional, Middeldorp, Saskia, additional, Schijf, Laura J, additional, Soetekouw, Robin, additional, Sprengers, Ralf W, additional, Montauban van Swijndregt, Alexander D, additional, de Monyé, Wouter, additional, Ridderikhof, Milan L, additional, Winter, Michiel M, additional, Bipat, Shandra, additional, Dijkgraaf, Marcel G W, additional, Bossuyt, Patrick M M, additional, Prins, Jan M, additional, and Stoker, Jaap, additional

Published
2022
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24. PO-631-03 DEEP LEARNING FOR THE IDENTIFICATION OF PATIENTS WITH A HIGH RISK FOR IDIOPATHIC VENTRICULAR FIBRILLATION

Author

Bleijendaal, Hidde, primary, Boersma, Jussi, additional, Lopes, Ricardo Ricci, additional, van der Ree, Martijn H., additional, Meijborg, Veronique M.F., additional, Amin, Ahmad S., additional, Winter, Michiel M., additional, Marquering, Henk, additional, Schomaker, Lambert, additional, zwinderman, Aeilko H., additional, Pinto, Yigal M., additional, Wilde, Arthur A.M., additional, and Postema, Pieter G., additional

Published
2022
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25. Artificial Intelligence in Patients with Congenital Heart Disease: Where Do We Stand?

Author

Oudkerk Pool, Marinka D., Kauw, Dirkjan, Bleijendaal, Hidde, Mulder, Barbara J. M., Pinto, Yigal, Bouma, Berto J., Winter, Michiel M., Graduate School, Cardiology, Amsterdam Cardiovascular Sciences, ACS - Heart failure & arrhythmias, APH - Personalized Medicine, APH - Aging & Later Life, and ACS - Pulmonary hypertension & thrombosis

Abstract

Life expectancy of patients with congenital heart disease (CHD) has increased in recent decades; however, late complications remain frequent and difficult to predict. Progress in data science has spurred the development of decision support systems and could aid physicians in predicting clinical deterioration and in the management of CHD patients. Newly developed artificial intelligence (AI) algorithms have shown performances comparable to humans in clinical diagnostics using statistical and computational algorithms and are expected to partly surpass human intelligence in the near future. Although much research on AI has been performed in patients with acquired heart disease, little data is available with respect to research on AI in patients with CHD. Learning algorithms in patients with CHD have shown to be promising in the interpretation of ECG, cardiac imaging, and the prediction of surgical outcome. However, current learning algorithms are not accurate enough to be implemented into daily clinical practice. Data on AI possibilities remain scarce in patients with CHD, and studies on large data sets are warranted to increase sensitivity, specificity, accuracy, and clinical relevance of these algorithms.

Published
2020
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34. Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial

Author

van den Berk, Inge A H, Kanglie, Maadrika M N P, van Engelen, Tjitske S R, Altenburg, Josje, Annema, Jouke T, Beenen, Ludo F M, Boerrigter, Bart, Bomers, Marije K, Bresser, Paul, Eryigit, Elvin, Groenink, Maarten, Hochheimer, Suzanne M R, Holleman, Frits, Kooter, Jos A J, van Loon, Ramon B, Keijzers, Mitran, van der Lee, Ivo, Luijendijk, Paul, Meijboom, Lilian J, Middeldorp, Saskia, Schijf, Laura J, Soetekouw, Robin, Sprengers, Ralf W, Montauban van Swijndregt, Alexander D, de Monyé, Wouter, Ridderikhof, Milan L, Winter, Michiel M, Bipat, Shandra, Dijkgraaf, Marcel G W, Bossuyt, Patrick M M, Prins, Jan M, and Stoker, Jaap

Abstract

BackgroundChest CT displays chest pathology better than chest X-ray (CXR). We evaluated the effects on health outcomes of replacing CXR by ultra-low-dose chest-CT (ULDCT) in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the emergency department.MethodsPragmatic, multicentre, non-inferiority randomised clinical trial in patients suspected of non-traumatic pulmonary disease at the emergency department. Between 31 January 2017 and 31 May 2018, every month, participating centres were randomly allocated to using ULDCT or CXR. Primary outcome was functional health at 28 days, measured by the Short Form (SF)-12 physical component summary scale score (PCS score), non-inferiority margin was set at 1 point. Secondary outcomes included hospital admission, hospital length of stay (LOS) and patients in follow-up because of incidental findings.Results2418 consecutive patients (ULDCT: 1208 and CXR: 1210) were included. Mean SF-12 PCS score at 28 days was 37.0 for ULDCT and 35.9 for CXR (difference 1.1; 95% lower CI: 0.003). After ULDCT, 638/1208 (52.7%) patients were admitted (median LOS of 4.8 days; IQR 2.1–8.8) compared with 659/1210 (54.5%) patients after CXR (median LOS 4.6 days; IQR 2.1–8.8). More ULDCT patients were in follow-up because of incidental findings: 26 (2.2%) versus 4 (0.3%).ConclusionsShort-term functional health was comparable between ULDCT and CXR, as were hospital admissions and LOS, but more incidental findings were found in the ULDCT group. Our trial does not support routine use of ULDCT in the work-up of patients suspected of non-traumatic pulmonary disease at the emergency department.Trial registration numberNTR6163.

Published
2023
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41. Mobile health in cardiac patients: an overview on experiences and challenges of stakeholders involved in daily use and development

Author

Kauw, Dirkjan, primary, Huisma, Piter R, additional, Medlock, Stephanie K, additional, Koole, Maarten A C, additional, Wierda, Eric, additional, Abu-Hanna, Ameen, additional, Schijven, Marlies P, additional, Mulder, Barbara J M, additional, Bouma, Berto J, additional, Winter, Michiel M, additional, and Schuuring, Mark J, additional

Published
2020
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42. Protecting patient privacy in digital health technology: the Dutch m-Health infrastructure of Hartwacht as a learning case

Author

Wierda, Eric, primary, Blok, Sebastiaan, additional, Somsen, G Aernout, additional, van der Velde, Enno T, additional, Tulevski, Igor I, additional, Stavrov, Borut, additional, de Wildt, Maud C C, additional, van den Born, Bert J H, additional, Breukel, Laura, additional, de Mol, Bas A J M, additional, Ploem, M Corrette, additional, and Winter, Michiel M, additional

Published
2020
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45. Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial

Author

Cardiologie, Team Medisch, Circulatory Health, van Dissel, Alexandra C., Winter, Michiel M., van der Bom, Teun, Vliegen, Hubert W., van Dijk, Arie P.J., Pieper, Petronella G., Sieswerda, Gertjan T., Roos-Hesselink, Jolien W., Zwinderman, Aeilko H., Mulder, Barbara J.M., Bouma, Berto J., Cardiologie, Team Medisch, Circulatory Health, van Dissel, Alexandra C., Winter, Michiel M., van der Bom, Teun, Vliegen, Hubert W., van Dijk, Arie P.J., Pieper, Petronella G., Sieswerda, Gertjan T., Roos-Hesselink, Jolien W., Zwinderman, Aeilko H., Mulder, Barbara J.M., and Bouma, Berto J.

Published
2019

48. Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial

Author

van Dissel, Alexandra C., primary, Winter, Michiel M., additional, van der Bom, Teun, additional, Vliegen, Hubert W., additional, van Dijk, Arie P.J., additional, Pieper, Petronella G., additional, Sieswerda, Gertjan T., additional, Roos-Hesselink, Jolien W., additional, Zwinderman, Aeilko H., additional, Mulder, Barbara J.M., additional, and Bouma, Berto J., additional

Published
2019
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49. Evaluating the systemic right ventricle by CMR: the importance of consistent and reproducible delineation of the cavity

Author

van Dijk Arie PJ, Bouma Berto J, Groenink Maarten, Bernink Flip JP, Winter Michiel M, Helbing Willem A, Tijssen Jan GP, and Mulder Barbara JM

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The method used to delineate the boundary of the right ventricle (RV), relative to the trabeculations and papillary muscles in cardiovascular magnetic resonance (CMR) ventricular volume analysis, may matter more when these structures are hypertrophied than in individuals with normal cardiovascular anatomy. This study aimed to compare two methods of cavity delineation in patients with systemic RV. Methods Twenty-nine patients (mean age 34.7 ± 12.4 years) with a systemic RV (12 with congenitally corrected transposition of the great arteries (ccTGA) and 17 with atrially switched (TGA) underwent CMR. We compared measurements of systemic RV volumes and function using two analysis protocols. The RV trabeculations and papillary muscles were either included in the calculated blood volume, the boundary drawn immediately within the apparently compacted myocardial layer, or they were manually outlined and excluded. RV stroke volume (SV) calculated using each method was compared with corresponding left ventricular (LV) SV. Additionally, we compared the differences in analysis time, and in intra- and inter-observer variability between the two methods. Paired samples t-test was used to test for differences in volumes, function and analysis time between the two methods. Differences in intra- and inter-observer reproducibility were tested using an extension of the Bland-Altman method. Results The inclusion of trabeculations and papillary muscles in the ventricular volume resulted in higher values for systemic RV end diastolic volume (mean difference 28.7 ± 10.6 ml, p < 0.001) and for end systolic volume (mean difference 31.0 ± 11.5 ml, p < 0.001). Values for ejection fraction were significantly lower (mean difference -7.4 ± 3.9%, p < 0.001) if structures were included. LV SV did not differ significantly from RV SV for both analysis methods (p = NS). Including structures resulted in shorter analysis time (p < 0.001), and showed better inter-observer reproducibility for ejection fraction (p < 0.01). Conclusion The choice of method for systemic RV cavity delineation significantly affected volume measurements, given the CMR acquisition and analysis systems used. We recommend delineation outside the trabeculations for routine clinical measurements of systemic RV volumes as this approach took less time and gave more reproducible measurements.

Published
2008
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