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2. Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study

Author

Epperla, Narendranath, Feng, Lei, Shah, Nirav N., Fitzgerald, Lindsey, Shah, Harsh, Stephens, Deborah M., Lee, Catherine J., Ollila, Thomas, Shouse, Geoffrey, Danilov, Alexey V., David, Kevin A., Torka, Pallawi, Hashmi, Hamza, Hess, Brian, Barta, Stefan K., Romancik, Jason T., Cohen, Jonathon B., Annunzio, Kaitlin, Kittai, Adam S., Reneau, John, Zurko, Joanna, Nizamuddin, Imran A., Winter, Jane N., Gordon, Leo I., Ma, Shuo, Patel, Romil, Nastoupil, Loretta, Ahmed, Sairah, and Karmali, Reem

Published
2023
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3. Impact of race and social determinants of health on outcomes in patients with aggressive B-cell NHL treated with CAR-T therapy

Author

Karmali, Reem, Machhi, Rushad, Epperla, Narendranath, Shouse, Geoffrey, Romancik, Jason, Moyo, Tamara K., Kenkre, Vaishalee, Ollila, Thomas A., Fitzgerald, Lindsey, Hess, Brian, David, Kevin, Roy, Ishan, Zurko, Joanna, Chowdhury, Sayan Mullick, Annunzio, Kaitlin, Ferdman, Robert, Bhansali, Rahul S., Harris, Elyse I., Liu, Jieqi, Nizamuddin, Imran, Ma, Shuo, Moreira, Jonathan, Winter, Jane, Pro, Barbara, Stephens, Deborah M., Danilov, Alexey, Shah, Nirav N., Cohen, Jonathon B., Barta, Stefan K., Torka, Pallawi, and Gordon, Leo I.

Published
2024
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8. Peri–CAR-T practice patterns and survival predictors for all CAR-T patients and post–CAR-T failure in aggressive B-NHL

Author

Zurko, Joanna, Nizamuddin, Imran, Epperla, Narendranath, David, Kevin, Cohen, Jonathon B., Moyo, Tamara K., Ollila, Thomas, Hess, Brian, Roy, Ishan, Ferdman, Robert, Liu, Jieqi, Chowdhury, Sayan Mullick, Romancik, Jason, Bhansali, Rahul S., Harris, Elyse I., Sorrell, Mckenzie, Masel, Rebecca, Kittai, Adam S., Denlinger, Nathan, Sigmund, Audrey M., Fitzgerald, Lindsey, Galvez, Carlos, Ma, Shuo, Winter, Jane, Pro, Barbara, Gordon, Leo I., Danilov, Alexey, Stephens, Deborah, Shah, Nirav N., Kenkre, Vaishalee, Barta, Stefan K., Torka, Pallawi, Shouse, Geoffrey, and Karmali, Reem

Published
2023
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10. A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL

Author

Xu-Monette, Zijun Y, Zhang, Hongwei, Zhu, Feng, Tzankov, Alexandar, Bhagat, Govind, Visco, Carlo, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D, You, Hua, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés JM, Møller, Michael B, Parsons, Benjamin M, van Krieken, J Han, Piris, Miguel A, Winter, Jane N, Hagemeister, Fredrick B, Shahbaba, Babak, De Dios, Ivan, Zhang, Hong, Li, Yong, Xu, Bing, Albitar, Maher, and Young, Ken H

Subjects
Orphan Drug, Human Genome, Hematology, Cancer, Rare Diseases, Lymphoma, Biotechnology, Genetics, Generic health relevance, Good Health and Well Being, Artificial Intelligence, B-Lymphocytes, Germinal Center, High-Throughput Nucleotide Sequencing, Humans, Lymphoma, Large B-Cell, Diffuse
Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity of B-cell lymphoma. Cell-of-origin (COO) classification of DLBCL is required in routine practice by the World Health Organization classification for biological and therapeutic insights. Genetic subtypes uncovered recently are based on distinct genetic alterations in DLBCL, which are different from the COO subtypes defined by gene expression signatures of normal B cells retained in DLBCL. We hypothesize that classifiers incorporating both genome-wide gene-expression and pathogenetic variables can improve the therapeutic significance of DLBCL classification. To develop such refined classifiers, we performed targeted RNA sequencing (RNA-Seq) with a commercially available next-generation sequencing (NGS) platform in a large cohort of 418 DLBCLs. Genetic and transcriptional data obtained by RNA-Seq in a single run were explored by state-of-the-art artificial intelligence (AI) to develop a NGS-COO classifier for COO assignment and NGS survival models for clinical outcome prediction. The NGS-COO model built through applying AI in the training set was robust, showing high concordance with COO classification by either Affymetrix GeneChip microarray or the NanoString Lymph2Cx assay in 2 validation sets. Although the NGS-COO model was not trained for clinical outcome, the activated B-cell-like compared with the germinal-center B-cell-like subtype had significantly poorer survival. The NGS survival models stratified 30% high-risk patients in the validation set with poor survival as in the training set. These results demonstrate that targeted RNA-Seq coupled with AI deep learning techniques provides reproducible, efficient, and affordable assays for clinical application. The clinical grade assays and NGS models integrating both genetic and transcriptional factors developed in this study may eventually support precision medicine in DLBCL.

Published
2020

13. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Author

Campo, Elias, Jaffe, Elaine S., Cook, James R., Quintanilla-Martinez, Leticia, Swerdlow, Steven H., Anderson, Kenneth C., Brousset, Pierre, Cerroni, Lorenzo, de Leval, Laurence, Dirnhofer, Stefan, Dogan, Ahmet, Feldman, Andrew L., Fend, Falko, Friedberg, Jonathan W., Gaulard, Philippe, Ghia, Paolo, Horwitz, Steven M., King, Rebecca L., Salles, Gilles, San-Miguel, Jesus, Seymour, John F., Treon, Steven P., Vose, Julie M., Zucca, Emanuele, Advani, Ranjana, Ansell, Stephen, Au, Wing-Yan, Barrionuevo, Carlos, Bergsagel, Leif, Chan, Wing C., Cohen, Jeffrey I., d'Amore, Francesco, Davies, Andrew, Falini, Brunangelo, Ghobrial, Irene M., Goodlad, John R., Gribben, John G., Hsi, Eric D., Kahl, Brad S., Kim, Won-Seog, Kumar, Shaji, LaCasce, Ann S., Laurent, Camille, Lenz, Georg, Leonard, John P., Link, Michael P., Lopez-Guillermo, Armando, Mateos, Maria Victoria, Macintyre, Elizabeth, Melnick, Ari M., Morschhauser, Franck, Nakamura, Shigeo, Narbaitz, Marina, Pavlovsky, Astrid, Pileri, Stefano A., Piris, Miguel, Pro, Barbara, Rajkumar, Vincent, Rosen, Steven T., Sander, Birgitta, Sehn, Laurie, Shipp, Margaret A., Smith, Sonali M., Staudt, Louis M., Thieblemont, Catherine, Tousseyn, Thomas, Wilson, Wyndham H., Yoshino, Tadashi, Zinzani, Pier-Luigi, Dreyling, Martin, Scott, David W., Winter, Jane N., and Zelenetz, Andrew D.

Published
2022
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14. Increasing Science Capital by Building Relationships between Industry and the Local Community

Author

Docking, Clare, Winter, Jane, Parvin, Joy, and Turkenburg, Maria

Abstract

In recent years, research has shown that the proportion of young people considering science for future study and careers is not significantly improved by increasing their enjoyment of science at school. Rather, it is more important to help children understand that science is done by people like them and that science is relevant to their daily lives. In a corner of North Hertfordshire in eastern England, an exciting STEM programme developed by Centre for Industry Education Collaboration (CIEC), called 'Children Challenging Industry', is helping primary-age children to become immersed in local industry and find out more about how the science they study at school is used within the manufacturing processes of industry. Through high-quality and rich school-industry partnerships, a mutually beneficial relationship can be fostered from which all parties benefit.

Published
2020

15. Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy

Author

Melody, Megan, primary, Epperla, Narendranath, additional, Shouse, Geoffrey, additional, Romancik, Jason, additional, Allen, Pamela, additional, Moyo, Tamara K., additional, Kenkre, Vaishalee, additional, Ollila, Thomas, additional, Fitzgerald, Lindsey, additional, Hess, Brian, additional, David, Kevin, additional, Herr, Megan M., additional, Odetola, Oluwatobi, additional, Lin, Adam, additional, Moreira, Jonathan, additional, Ma, Shuo, additional, Winter, Jane N., additional, Roy, Ishan, additional, Stephens, Deborah, additional, Danilov, Alexey, additional, Shah, Nirav N., additional, Barta, Stefan K., additional, Cortese, Matthew, additional, Cohen, Jonathon B., additional, Gordon, Leo I., additional, and Karmali, Reem, additional

Published
2024
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16. Take Your Science Teaching to the Next Level: STEM Volunteers in the Classroom

Author

Winter, Jane

Abstract

The logistics of finding and inviting STEM professionals (volunteers from science-based industries, universities, etc.) into the classroom can appear daunting, combined with fact-handing over control of some of the lesson. So, do the benefits make the effort worthwhile? In this article, the author describes the impact that STEM professionals could have in the primary classroom, and shares some tips for how to get started.

Published
2021

19. Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms

Author

Albitar, Maher, Zhang, Hong, Goy, Andre, Xu-Monette, Zijun Y., Bhagat, Govind, Visco, Carlo, Tzankov, Alexandar, Fang, Xiaosheng, Zhu, Feng, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D., Hagemeister, Fredrick B., Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Parsons, Benjamin M., van Krieken, J. Han, Piris, Miguel A., Winter, Jane N., Li, Yong, Xu, Bing, and Young, Ken H.

Published
2022
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21. PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: a study from the International DLBCL Consortium Program

Author

Li, Ling, Sun, Ruifang, Miao, Yi, Tran, Thai, Adams, Lisa, Roscoe, Nathan, Xu, Bing, Manyam, Ganiraju C., Tan, Xiaohong, Zhang, Hongwei, Xiao, Min, Tzankov, Alexandar, Visco, Carlo, Dybkaer, Karen, Bhagat, Govind, Tam, Wayne, Hsi, Eric D., van Krieken, J.Han, You, Hua, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J.M., Møller, Michael B., Piris, Miguel A., Zhang, Mingzhi, Winter, Jane N., Medeiros, L.Jeffrey, Rassidakis, George Z., Vaupel, Christine A., Li, Yong, Dakappagari, Naveen, Xu-Monette, Zijun Y., and Young, Ken H.

Published
2019
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22. Ibrutinib Maintenance Following Frontline Treatment in Patients with Mantle Cell Lymphoma

Author

Karmali, Reem, primary, Abramson, Jeremy S, additional, Stephens, Deborah M., additional, Barnes, Jeffrey A., additional, Winter, Jane N, additional, Ma, Shuo, additional, Gao, Juehua, additional, Kaplan, Jason, additional, Petrich, Adam M, additional, Mi, Xinlei, additional, Hochberg, Ephraim P., additional, Takvorian, Ronald W., additional, Nelson, Valerie, additional, Gordon, Leo I., additional, and Pro, Barbara, additional

Published
2023
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23. Tumor-infiltrating normal B cells revealed by immunoglobulin repertoire clonotype analysis are highly prognostic and crucial for antitumor immune responses in DLBCL

Author

Xu-Monette, Zijun Y., primary, Li, Yong, additional, Snyder, Thomas, additional, Yu, Tiantian, additional, Lu, Tingxun, additional, Tzankov, Alexandar, additional, Visco, Carlo, additional, Bhagat, Govind, additional, Qian, Wenbin, additional, Dybkaer, Karen, additional, Chiu, April, additional, Tam, Wayne, additional, Zu, Youli, additional, Hsi, Eric D., additional, Hagemeister, Fredrick B., additional, Wang, Yingjun, additional, Go, Heounjeong, additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J.M., additional, Moller, Michael B., additional, Parsons, Benjamin M., additional, Fan, Xiangshan, additional, van Krieken, J.Han, additional, Piris, Miguel A., additional, Winter, Jane N., additional, Au, Qingyan, additional, Kirsch, Ilan, additional, Zhang, Mingzhi, additional, Shaughnessy, John, additional, Xu, Bing, additional, and Young, Ken H., additional

Published
2023
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24. Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma

Author

Wang, Xiaoxiao, Cao, Xin, Sun, Ruifang, Tang, Charlene, Tzankov, Alexandar, Zhang, Jun, Manyam, Ganiraju C., Xiao, Min, Miao, Yi, Jabbar, Kausar, Tan, Xiaohong, Pang, Yuyang, Visco, Carlo, Xie, Yan, Dybkaer, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L., Hsi, Eric D., Choi, William W.L., van Krieken, J. Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J.M., Møller, Michael B., Parsons, Ben M., Winter, Jane N., Piris, Miguel A., Li, Shaoying, Miranda, Roberto N., Medeiros, L. Jeffrey, Li, Yong, Xu-Monette, Zijun Y., and Young, Ken H.

Published
2018
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25. Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial

Author

Armand, Philippe, Nagler, Arnon, Weller, Edie A, Devine, Steven M, Avigan, David E, Chen, Yi-Bin, Kaminski, Mark S, Holland, H Kent, Winter, Jane N, Mason, James R, Fay, Joseph W, Rizzieri, David A, Hosing, Chitra M, Ball, Edward D, Uberti, Joseph P, Lazarus, Hillard M, Mapara, Markus Y, Gregory, Stephanie A, Timmerman, John M, Andorsky, David, Or, Reuven, Waller, Edmund K, Rotem-Yehudar, Rinat, and Gordon, Leo I

Subjects
Rare Diseases, Cancer, Hematology, Biotechnology, Transplantation, Clinical Research, Stem Cell Research, Lymphoma, Prevention, Evaluation of treatments and therapeutic interventions, 6.2 Cellular and gene therapies, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Chile, Combined Modality Therapy, Disease-Free Survival, Drug Administration Schedule, Fatigue, Female, Hematopoietic Stem Cell Transplantation, Humans, Immune Tolerance, India, Israel, Lymphocyte Count, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Neutropenia, Programmed Cell Death 1 Receptor, Transplantation, Autologous, Treatment Outcome, United States, Young Adult, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeThe Programmed Death-1 (PD-1) immune checkpoint pathway may be usurped by tumors, including diffuse large B-cell lymphoma (DLBCL), to evade immune surveillance. The reconstituting immune landscape after autologous hematopoietic stem-cell transplantation (AHSCT) may be particularly favorable for breaking immune tolerance through PD-1 blockade.Patients and methodsWe conducted an international phase II study of pidilizumab, an anti-PD-1 monoclonal antibody, in patients with DLBCL undergoing AHSCT, with correlative studies of lymphocyte subsets. Patients received three doses of pidilizumab beginning 1 to 3 months after AHSCT.ResultsSixty-six eligible patients were treated. Toxicity was mild. At 16 months after the first treatment, progression-free survival (PFS) was 0.72 (90% CI, 0.60 to 0.82), meeting the primary end point. Among the 24 high-risk patients who remained positive on positron emission tomography after salvage chemotherapy, the 16-month PFS was 0.70 (90% CI, 0.51 to 0.82). Among the 35 patients with measurable disease after AHSCT, the overall response rate after pidilizumab treatment was 51%. Treatment was associated with increases in circulating lymphocyte subsets including PD-L1E-bearing lymphocytes, suggesting an on-target in vivo effect of pidilizumab.ConclusionThis is the first demonstration of clinical activity of PD-1 blockade in DLBCL. Given these results, PD-1 blockade after AHSCT using pidilizumab may represent a promising therapeutic strategy in this disease.

Published
2013

26. Living with locally advanced rectal cancer : an exploration of the everydayness of living with rectal cancer

Author

Winter, Jane, Addington-Hall, Julia, and Hopkinson, Jane

Subjects
361, RT Nursing, RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Abstract

Advances in treatment and prolonged survival times mean that increasingly individuals are living with advanced cancer, yet services remain disease orientated. This thesis has documented the process of undertaking a longitudinal qualitative study to explore the everydayness of living with locally advanced rectal cancer. The study has identified how this can influence individual’s day to day lives when the focus of care moves away from cure, but prior to the transition to ‘end of life’ care. The aim was to obtain data in which to situate local service development based on those aspects which were accorded primacy by the participants. This interpretive study used a longitudinal qualitative approach which was informed by phenomenology. The philosophical works of Heidegger, Merleau Ponty and Van Manen were influential in this work which involved ten participants, with locally advanced rectal cancer. Successive interviews with ten individuals were undertaken over a two year period. The 38 interviews were analysed using a combination of frameworks offered by Miles and Huberman and Saldana. Individuals during much of this time concentrated on maintaining normality in their everyday lives. The drive for stasis and focus on day to day living allowed the individual to remain in the present and distance a future which was associated with illness and annihilation. Crucial to this was the ability to self-manage. This allowed space to create a self-definition of health. Uncertainty during this time was life affirming. Avoiding those who may challenge this, was desirable for as long as possible. As illness progressed there was an inverse relationship between the ‘boundness’ of the body and the ‘boundness’ of the individual. Insights from this study raise the need for further research and exploration of alternative models of supportive care whilst focusing on the wellness of individuals and self-management within their daily lives.

Published
2010

27. XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53

Author

Deng, Manman, Zhang, Mingzhi, Xu-Monette, Zijun Y., Pham, Lan V., Tzankov, Alexandar, Visco, Carlo, Fang, Xiaosheng, Bhagat, Govind, Zhu, Feng, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D., Choi, William W. L., Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Parsons, Benjamin M., van Krieken, J. Han, Piris, Miguel A., Winter, Jane N., Hagemeister, Fredrick, Alinari, Lapo, Li, Yong, Andreeff, Michael, Xu, Bing, and Young, Ken H.

Published
2020
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29. Potatoes to Plastics: A Resource for Building Science Capital

Author

Winter, Jane

Abstract

In this article, Jane Winter describes a pilot project that uses a simple and engaging science activity to raise children's science capital, as well as increasing understanding of the potential of science to combat world problems. "Potatoes to plastics" is a Centre for Industry Education Collaboration (CIEC) project, aimed at key stage 2 children (ages 7-11). This activity highlights how science can be used to develop solutions to real-world problems by using a waste product to make a valuable (and biodegradable) material.

Published
2018

30. Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma

Author

Xu-Monette, Zijun Y., Li, Ling, Byrd, John C., Jabbar, Kausar J., Manyam, Ganiraju C., Maria de Winde, Charlotte, van den Brand, Michiel, Tzankov, Alexandar, Visco, Carlo, Wang, Jing, Dybkaer, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L., Hsi, Eric D., Choi, William W.L., Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J.M., Møller, Michael B., Parsons, Ben M., Winter, Jane N., Wang, Michael, Hagemeister, Frederick B., Piris, Miguel A., Han van Krieken, J., Medeiros, L.Jeffrey, Li, Yong, van Spriel, Annemiek B., and Young, Ken H.

Published
2016
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32. Supplementary Tables from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Author

Xu-Monette, Ziju Y., primary, Xiao, Min, primary, Au, Qingyan, primary, Padmanabhan, Raghav, primary, Xu, Bing, primary, Hoe, Nicholas, primary, Rodríguez-Perales, Sandra, primary, Torres-Ruiz, Raul, primary, Manyam, Ganiraju C., primary, Visco, Carlo, primary, Miao, Yi, primary, Tan, Xiaohong, primary, Zhang, Hongwei, primary, Tzankov, Alexandar, primary, Wang, Jing, primary, Dybkær, Karen, primary, Tam, Wayne, primary, You, Hua, primary, Bhagat, Govind, primary, Hsi, Eric D., primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Piris, Miguel A., primary, van Krieken, J. Han, primary, Winter, Jane N., primary, Westin, Jason R., primary, Pham, Lan V., primary, Medeiros, L. Jeffrey, primary, Rassidakis, George Z., primary, Li, Yong, primary, Freeman, Gordon J., primary, and Young, Ken H., primary

Published
2023
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33. Data from Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents

Author

Deng, Manman, primary, Xu-Monette, Zijun Y., primary, Pham, Lan V., primary, Wang, Xudong, primary, Tzankov, Alexandar, primary, Fang, Xiaosheng, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, You, Hua, primary, Huh, Jooryung, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, Hagemeister, Fredrick, primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Liu, Phillip, primary, and Young, Ken H., primary

Published
2023
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34. Data from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Author

Xu-Monette, Ziju Y., primary, Xiao, Min, primary, Au, Qingyan, primary, Padmanabhan, Raghav, primary, Xu, Bing, primary, Hoe, Nicholas, primary, Rodríguez-Perales, Sandra, primary, Torres-Ruiz, Raul, primary, Manyam, Ganiraju C., primary, Visco, Carlo, primary, Miao, Yi, primary, Tan, Xiaohong, primary, Zhang, Hongwei, primary, Tzankov, Alexandar, primary, Wang, Jing, primary, Dybkær, Karen, primary, Tam, Wayne, primary, You, Hua, primary, Bhagat, Govind, primary, Hsi, Eric D., primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Piris, Miguel A., primary, van Krieken, J. Han, primary, Winter, Jane N., primary, Westin, Jason R., primary, Pham, Lan V., primary, Medeiros, L. Jeffrey, primary, Rassidakis, George Z., primary, Li, Yong, primary, Freeman, Gordon J., primary, and Young, Ken H., primary

Published
2023
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35. Supplementary Tables 1-5 and Supplementary Figures 1-8 from Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents

Author

Deng, Manman, primary, Xu-Monette, Zijun Y., primary, Pham, Lan V., primary, Wang, Xudong, primary, Tzankov, Alexandar, primary, Fang, Xiaosheng, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, You, Hua, primary, Huh, Jooryung, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, Hagemeister, Fredrick, primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Liu, Phillip, primary, and Young, Ken H., primary

Published
2023
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36. EBV-positive DLBCL frequently harbors somatic mutations associated with clonal hematopoiesis of indeterminate potential

Author

Li, Yong, primary, Xu-Monette, Zijun Y., additional, Abramson, Jeremy, additional, Sohani, Aliyah R., additional, Bhagat, Govind, additional, Tzankov, Alexandar, additional, Visco, Carlo, additional, Zhang, Shanxiang, additional, Dybkaer, Karen, additional, Pan, Zenggang, additional, Xu, Min, additional, Tam, Wayne, additional, Zu, Youli, additional, Hsi, Eric D., additional, Hagemeister, Fredrick B., additional, Go, Heounjeong, additional, van Krieken, J. Han, additional, Winter, Jane N., additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J. M., additional, Møller, Michael B., additional, Piris, Miguel A., additional, Wang, Yingjun, additional, Zhang, Mingzhi, additional, and Young, Ken H., additional

Published
2023
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37. Supplementary Figures 1-3 from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Author

Xu-Monette, Ziju Y., primary, Xiao, Min, primary, Au, Qingyan, primary, Padmanabhan, Raghav, primary, Xu, Bing, primary, Hoe, Nicholas, primary, Rodríguez-Perales, Sandra, primary, Torres-Ruiz, Raul, primary, Manyam, Ganiraju C., primary, Visco, Carlo, primary, Miao, Yi, primary, Tan, Xiaohong, primary, Zhang, Hongwei, primary, Tzankov, Alexandar, primary, Wang, Jing, primary, Dybkær, Karen, primary, Tam, Wayne, primary, You, Hua, primary, Bhagat, Govind, primary, Hsi, Eric D., primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Piris, Miguel A., primary, van Krieken, J. Han, primary, Winter, Jane N., primary, Westin, Jason R., primary, Pham, Lan V., primary, Medeiros, L. Jeffrey, primary, Rassidakis, George Z., primary, Li, Yong, primary, Freeman, Gordon J., primary, and Young, Ken H., primary

Published
2023
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38. Supplemental Tables 1-9 from A Three-Arm Randomized Phase II Study of Bendamustine/Rituximab with Bortezomib Induction or Lenalidomide Continuation in Untreated Follicular Lymphoma: ECOG-ACRIN E2408

Author

Evens, Andrew M., primary, Hong, Fangxin, primary, Habermann, Thomas M., primary, Advani, Ranjana H., primary, Gascoyne, Randy D., primary, Witzig, Thomas E., primary, Quon, Andrew, primary, Ranheim, Erik A., primary, Ansell, Stephen M., primary, Cheema, Puneet Singh, primary, Dy, Philip A., primary, O'Brien, Timothy E., primary, Winter, Jane N., primary, Cescon, Terrence P., primary, Chang, Julie E., primary, and Kahl, Brad S., primary

Published
2023
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39. Supplmentary Documents including Methods, Tables, and Legends for Supplementary Figures, and Supplementary Figure S1-S5 from Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma

Author

Xu-Monette, Zijun Y., primary, Deng, Qipan, primary, Manyam, Ganiraju C., primary, Tzankov, Alexander, primary, Li, Ling, primary, Xia, Yi, primary, Wang, Xiao-xiao, primary, Zou, Dehui, primary, Visco, Carlo, primary, Dybkær, Karen, primary, Li, Jun, primary, Zhang, Li, primary, Liang, Han, primary, Montes-Moreno, Santiago, primary, Chiu, April, primary, Orazi, Attilio, primary, Zu, Youli, primary, Bhagat, Govind, primary, Richards, Kristy L., primary, Hsi, Eric D., primary, Choi, William W.L., primary, van Krieken, J. Han, primary, Huh, Jooryung, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Parsons, Ben M., primary, Møller, Michael B., primary, Wang, Sa A., primary, Miranda, Roberto N., primary, Piris, Miguel A., primary, Winter, Jane N., primary, Medeiros, L. Jeffrey, primary, Li, Yong, primary, and Young, Ken H., primary

Published
2023
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40. Supplementary Figure from Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma

Author

Xu-Monette, Zijun Y., primary, Wei, Li, primary, Fang, Xiaosheng, primary, Au, Qingyan, primary, Nunns, Harry, primary, Nagy, Máté, primary, Tzankov, Alexandar, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, Hagemeister, Fredrick B., primary, Sun, Xiaoping, primary, Han, Xin, primary, Go, Heounjeong, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Albitar, Maher, primary, You, Hua, primary, and Young, Ken H., primary

Published
2023
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41. Supplementary Table 1 from Prevalence and Clinical Implications of Epstein–Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries

Author

Ok, Chi Young, primary, Li, Ling, primary, Xu-Monette, Zijun Y., primary, Visco, Carlo, primary, Tzankov, Alexander, primary, Manyam, Ganiraju C., primary, Montes-Moreno, Santiago, primary, Dybaer, Karen, primary, Chiu, April, primary, Orazi, Attilio, primary, Zu, Youli, primary, Bhagat, Govind, primary, Chen, Jiayu, primary, Richards, Kristy L., primary, Hsi, Eric D., primary, Choi, William W. L., primary, van Krieken, J. Han, primary, Huh, Jooryung, primary, Ai, Weiyun, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Farnen, John P., primary, Møller, Michael B., primary, Bueso-Ramos, Carlo E., primary, Miranda, Roberto N., primary, Winter, Jane N., primary, Piris, Miguel A., primary, Medeiros, L. Jeffrey, primary, and Young, Ken H., primary

Published
2023
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42. Supplementary Data from Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors

Author

Yap, Timothy A., primary, Winter, Jane N., primary, Giulino-Roth, Lisa, primary, Longley, Jemma, primary, Lopez, Juanita, primary, Michot, Jean-Marie, primary, Leonard, John P., primary, Ribrag, Vincent, primary, McCabe, Michael T., primary, Creasy, Caretha L., primary, Stern, Melissa, primary, Pene Dumitrescu, Teodora, primary, Wang, Xiaowei, primary, Frey, Steve, primary, Carver, Jennifer, primary, Horner, Thierry, primary, Oh, Choon, primary, Khaled, Ahmed, primary, Dhar, Arindam, primary, and Johnson, Peter W.M., primary

Published
2023
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43. Supplementary Data from Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma

Author

Xu-Monette, Zijun Y., primary, Wei, Li, primary, Fang, Xiaosheng, primary, Au, Qingyan, primary, Nunns, Harry, primary, Nagy, Máté, primary, Tzankov, Alexandar, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, Hagemeister, Fredrick B., primary, Sun, Xiaoping, primary, Han, Xin, primary, Go, Heounjeong, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Albitar, Maher, primary, You, Hua, primary, and Young, Ken H., primary

Published
2023
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44. Supplementary Figure 1 from Prevalence and Clinical Implications of Epstein–Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries

Author

Ok, Chi Young, primary, Li, Ling, primary, Xu-Monette, Zijun Y., primary, Visco, Carlo, primary, Tzankov, Alexander, primary, Manyam, Ganiraju C., primary, Montes-Moreno, Santiago, primary, Dybaer, Karen, primary, Chiu, April, primary, Orazi, Attilio, primary, Zu, Youli, primary, Bhagat, Govind, primary, Chen, Jiayu, primary, Richards, Kristy L., primary, Hsi, Eric D., primary, Choi, William W. L., primary, van Krieken, J. Han, primary, Huh, Jooryung, primary, Ai, Weiyun, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Farnen, John P., primary, Møller, Michael B., primary, Bueso-Ramos, Carlo E., primary, Miranda, Roberto N., primary, Winter, Jane N., primary, Piris, Miguel A., primary, Medeiros, L. Jeffrey, primary, and Young, Ken H., primary

Published
2023
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45. Supplementary Data from Expression of p21 Protein Predicts Clinical Outcome in DLBCL Patients Older than 60 Years Treated with R-CHOP but not CHOP: A Prospective ECOG and Southwest Oncology Group Correlative Study on E4494

Author

Winter, Jane N., primary, Li, Shuli, primary, Aurora, Vikas, primary, Variakojis, Daina, primary, Nelson, Beverly, primary, Krajewska, Maryla, primary, Zhang, Lijun, primary, Habermann, Thomas M., primary, Fisher, Richard I., primary, Macon, William R., primary, Chhanabhai, Mukesh, primary, Felgar, Raymond E., primary, Hsi, Eric D., primary, Medeiros, L. Jeffrey, primary, Weick, James K., primary, Weller, Edie A., primary, Melnick, Ari, primary, Reed, John C., primary, Horning, Sandra J., primary, and Gascoyne, Randy D., primary

Published
2023
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46. Supplementary Data from The Novel Expanded Porphyrin, Motexafin Gadolinium, Combined with [90Y]Ibritumomab Tiuxetan for Relapsed/Refractory Non-Hodgkin's Lymphoma: Preclinical Findings and Results of a Phase I Trial

Author

Evens, Andrew M., primary, Spies, William G., primary, Helenowski, Irene B., primary, Patton, David, primary, Spies, Stewart, primary, Jovanovic, Borko D., primary, Miyata, Sarah, primary, Hamilton, Elizabeth, primary, Variakojis, Daina, primary, Chen, Jun, primary, Naumovski, Louie, primary, Rosen, Steven T., primary, Winter, Jane N., primary, Miller, Richard A., primary, and Gordon, Leo I., primary

Published
2023
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47. Supplement Figures 1 - 5 and Tables 1 - 6 from Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma

Author

Ok, Chi Young, primary, Chen, Jiayu, primary, Xu-Monette, Zijun Y., primary, Tzankov, Alexandar, primary, Manyam, Ganiraju C., primary, Li, Ling, primary, Visco, Carlo, primary, Montes-Moreno, Santiago, primary, Dybkær, Karen, primary, Chiu, April, primary, Orazi, Attilio, primary, Zu, Youli, primary, Bhagat, Govind, primary, Richards, Kristy L., primary, Hsi, Eric D., primary, Choi, William W.L., primary, van Krieken, J. Han, primary, Huh, Jooryung, primary, Zhao, Xiaoying, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Bertoni, Francesco, primary, Farnen, John P., primary, Møller, Michael B., primary, Piris, Miguel A., primary, Winter, Jane N., primary, Medeiros, L. Jeffrey, primary, and Young, Ken H., primary

Published
2023
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48. Data from Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma

Author

Ok, Chi Young, primary, Chen, Jiayu, primary, Xu-Monette, Zijun Y., primary, Tzankov, Alexandar, primary, Manyam, Ganiraju C., primary, Li, Ling, primary, Visco, Carlo, primary, Montes-Moreno, Santiago, primary, Dybkær, Karen, primary, Chiu, April, primary, Orazi, Attilio, primary, Zu, Youli, primary, Bhagat, Govind, primary, Richards, Kristy L., primary, Hsi, Eric D., primary, Choi, William W.L., primary, van Krieken, J. Han, primary, Huh, Jooryung, primary, Zhao, Xiaoying, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Bertoni, Francesco, primary, Farnen, John P., primary, Møller, Michael B., primary, Piris, Miguel A., primary, Winter, Jane N., primary, Medeiros, L. Jeffrey, primary, and Young, Ken H., primary

Published
2023
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49. Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma

Author

Bryan, Locke J., primary, Casulo, Carla, additional, Allen, Pamela B., additional, Smith, Scott E., additional, Savas, Hatice, additional, Dillehay, Gary L., additional, Karmali, Reem, additional, Pro, Barbara, additional, Kane, Kaitlyn L., additional, Bazzi, Latifa A., additional, Chmiel, Joan S., additional, Palmer, Brett A., additional, Mehta, Jayesh, additional, Gordon, Leo I., additional, and Winter, Jane N., additional

Published
2023
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50. Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP

Author

Xu-Monette, Zijun Y, Dabaja, Bouthaina S, Wang, Xiaoxiao, Tu, Meifeng, Manyam, Ganiraju C, Tzankov, Alexander, Xia, Yi, Zhang, Li, Sun, Ruifang, Visco, Carlo, Dybkaer, Karen, Yin, Lihui, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L, Hsi, Eric D, Choi, William WL, van Krieken, J Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés JM, Møller, Michael B, Parsons, Ben M, Zhao, Xiaoying, Winter, Jane N, Piris, Miguel A, McDonnell, Timothy J, Miranda, Roberto N, Li, Yong, Medeiros, L Jeffrey, and Young, Ken H

Published
2015
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