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12 results on '"Winn, Jennifer S."'

1. Validation of a Molecular Diagnostic Test for Circulating Tumor DNA by Next-Gen Sequencing

Author

Fernandez, Sandra V., primary, Tan, Yin Fei, additional, Rao, Shilpa, additional, Fittipaldi, Patricia, additional, Sheriff, Fathima, additional, Borghaei, Hossein, additional, Dotan, Efrat, additional, Winn, Jennifer S., additional, Edelman, Martin J., additional, Treat, Joseph, additional, Judd, Julia, additional, Alpaugh, R. Katherine, additional, Wang, Y. Lynn, additional, Yu, Jian Q., additional, Wasik, Mariusz, additional, and Baldwin, Don A., additional

Published
2023
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2. E2112: Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Hormone Receptor–Positive Advanced Breast Cancer. A Trial of the ECOG-ACRIN Cancer Research Group

Author

Connolly, Roisin M., primary, Zhao, Fengmin, additional, Miller, Kathy D., additional, Lee, Min-Jung, additional, Piekarz, Richard L., additional, Smith, Karen L., additional, Brown-Glaberman, Ursa A., additional, Winn, Jennifer S., additional, Faller, Bryan A., additional, Onitilo, Adedayo A., additional, Burkard, Mark E., additional, Budd, George T., additional, Levine, Ellis G., additional, Royce, Melanie E., additional, Kaufman, Peter A., additional, Thomas, Alexandra, additional, Trepel, Jane B., additional, Wolff, Antonio C., additional, and Sparano, Joseph A., additional

Published
2021
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3. Genetic Variants and Tumor Immune Microenvironment: Clues for Targeted Therapies in Inflammatory Breast Cancer (IBC)

Author

Gong, Yulan, primary, Nagarathinam, Rajeswari, additional, Arisi, Maria F., additional, Gerratana, Lorenzo, additional, Winn, Jennifer S., additional, Slifker, Michael, additional, Pei, Jianming, additional, Cai, Kathy Q., additional, Hasse, Zachary, additional, Obeid, Elias, additional, Noriega, Julio, additional, Sebastiano, Christopher, additional, Ross, Eric, additional, Alpaugh, Katherine, additional, Cristofanilli, Massimo, additional, and Fernandez, Sandra V., additional

Published
2021
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4. Genetic Variants and Tumor Immune Microenvironment: Clues for Targeted Therapies in Inflammatory Breast Cancer (IBC)

Author

Gong, Yulan, Nagarathinam, Rajeswari, Arisi, Maria F., Gerratana, Lorenzo, Winn, Jennifer S, Slifker, Michael, Pei, Jianming, Cai, Kathy Q, Hasse, Zachary, Obeid, Elias, Noriega, Julio, Sebastiano, Christopher, Ross, Eric, Alpaugh, Katherine, Cristofanilli, Massimo, Fernandez, Sandra V, Gong, Yulan, Nagarathinam, Rajeswari, Arisi, Maria F., Gerratana, Lorenzo, Winn, Jennifer S, Slifker, Michael, Pei, Jianming, Cai, Kathy Q, Hasse, Zachary, Obeid, Elias, Noriega, Julio, Sebastiano, Christopher, Ross, Eric, Alpaugh, Katherine, Cristofanilli, Massimo, and Fernandez, Sandra V

Abstract

To better understand the etiology of inflammatory breast cancer (IBC) and identify potential therapies, we studied genomic alterations in IBC patients. Targeted, next-generation sequencing (NGS) was performed on cell-free DNA (cfDNA) (n = 33) and paired DNA from tumor tissues (n = 29) from 32 IBC patients. We confirmed complementarity between cfDNA and tumor tissue genetic profiles. We found a high incidence of germline variants in IBC patients that could be associated with an increased risk of developing the disease. Furthermore, 31% of IBC patients showed deficiencies in the homologous recombination repair (HRR) pathway (BRCA1, BRCA2, PALB2, RAD51C, ATM, BARD1) making them sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We also characterized the tumor-infiltrating lymphocytes (TILs) in tumor tissue biopsies by studying several markers (CD4, CD8, FoxP3, CD20, PD-1, and PD-L1) through immunohistochemistry (IHC) staining. In 7 of 24 (29%) patients, tumor biopsies were positive for PD-L1 and PD-1 expression on TILs, making them sensitive to PD-1/PD-L1 blocking therapies. Our results provide a rationale for considering PARP inhibitors and PD-1/PDL1 blocking immunotherapy in qualifying IBC patients.

Published
2021

5. Abstract GS4-02: E2112: Randomized phase 3 trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer. A trial of the ECOG-ACRIN cancer research group

Author

Connolly, Roisin M, primary, Zhao, Fengmin, additional, Miller, Kathy D, additional, Lee, Min-Jung, additional, Piekarz, Richard L, additional, Smith, Karen L, additional, Brown-Glaberman, Ursa, additional, Winn, Jennifer S, additional, Faller, Bryan A, additional, Onitilo, Adedayo A, additional, Burkard, Mark E, additional, Budd, George T, additional, Levine, Ellis G, additional, Royce, Melanie E, additional, Kaufman, Peter A, additional, Thomas, Alexandra, additional, Trepel, Jane B, additional, Wolff, Antonio C, additional, and Sparano, Joseph A, additional

Published
2021
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8. Abstract P5-03-11: Germline and somatic variants in patients with inflammatory breast cancer (IBC) detected using cell-free DNA

Author

Winn, Jennifer S., primary, Hasse, Zachary, additional, Pei, Jianming, additional, Slifker, Michael, additional, Arisi-Fernandez, Sebastian M., additional, Talarchek, Jacqueline N., additional, Obeid, Elias, additional, Devarajan, Karthik, additional, Wu, Hong, additional, Gong, Yulan, additional, Cristofanilli, Massimo, additional, Alpaugh, R.Katherine, additional, and Fernandez, Sandra Viviana, additional

Published
2020
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9. Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer

Author

Winn, Jennifer S., primary, Hasse, Zachary, additional, Slifker, Michael, additional, Pei, Jianming, additional, Arisi-Fernandez, Sebastian M., additional, Talarchek, Jacqueline N., additional, Obeid, Elias, additional, Baldwin, Donald A., additional, Gong, Yulan, additional, Ross, Eric, additional, Cristofanilli, Massimo, additional, Alpaugh, R. Katherine, additional, and Fernandez, Sandra V., additional

Published
2020
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