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4. Effects of processing on the stability of molybdenum oxide ultra-thin films

Author

Martín-Luengo, Aitana Tarazaga, Köstenbauer, Harald, Winkler, Jörg, and Bonanni, Alberta

Subjects
Condensed Matter - Materials Science
Abstract

The effects of wet chemical processing conventionally employed in device fabrication standards are systematically studied on molybdenum oxide (MoOx) ultra-thin films. We have combined x-ray photoelectron spectroscopy (XPS), angle resolved XPS and x-ray reflectivity techniques to provide deep insights into the changes in composition, structure and electronic states upon treatment of films with different initial stoichiometry prepared by reactive sputtering. Our results show significant reduction effects associated with the development of gap states in MoOx, as well as changes in the composition, density and structure of the films, systematically correlated with the initial oxidation state of Mo., Comment: 16 pages, 5 figures, Appendix included

Published
2016
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11. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, Sabine, Rolke, Mathias, Korn, Stephanie, Pabel, Helmut, Hoffmann, Martin, Feimer, Jan, Rabe, Klaus, Deckelmann, Regina, Welte, Tobias, Ohbayashi, Hiroyuki, Hozawa, Soichiro, Shimoda, Terufumi, Yoshida, Makoto, Nagakura, Toshikazu, Kamei, Tadashi, Sano, Yasuyuki, Kagami, Shinichiro, Takahashi, Hisaho, Haida, Michiko, Kimura, Goro, Nakamura, Hiroyuki, To, Yasuo, Shinkai, Masaharu, Shimokawaji, Tadasuke, Kudo, Makoto, Shijyubo, Noriharu, Tochigi, Takao, Kato, Motokazu, Tanaka, Akihiko, Gon, Yasuhiro, Sasaki, Norihisa, Ohdaira, Tetsuro, Omori, Chiharu, Takahashi, Toshiki, Takeuchi, Satomi, Nakajima, Kiyotaka, Makita, Hironi, Kaneko, Masahiro, Furuta, Kenjiro, Taniguchi, Masami, Inobe, Yoshito, Miki, Hiroshi, Nakamura, Yoichi, Miyazawa, Naoki, Yano, Shuichi, Iijima, Masayuki, Yamato, Tsuyoshi, Diaz, Javier, Matsuno, Alberto, Felix, Efrain, Guerreros, Alfredo, Daly, Alejandro, Rodriguez Chariarse, Fernando, Salazar, Danilo, Castro, Socorro, Chavez, William, Estrella, Rolando, Aquino, Teresita, Atienza, Tito, Samoro, Ronnie, Isidro, Marie Grace Dawn, Kuna, Piotr, Antczak, Adam, Bednarek, Michał, Mądra-Rogacka, Danuta, Hofman, Teresa, Jutel, Marek, Pisarczyk-Bogacka, Ewa, Kot, Agata, Mróz, Robert, Czupryńska-Borkowska, Małgorzata, Żurowska-Gębala, Małgorzata, Dyczek, Andrzej, Jasieniak-Pinis, Grażyna, Wojnowski, Piotr, Trębas-Pietraś, Ewa, Dobryniewska, Małgorzata, Stobiecki, Marcin, Tarnowska-Matusiak, Marzenna, Magner, Alina, Kolczyński, Andrzej, Kachel, Tomasz, Bartuzi, Zbigniew, Majorek-Olechowska, Bernadetta, Śliwiński, Paweł, Balicka, Violetta, Hajoł, Elżbieta, Stachera, Jacek, Rachel, Marta, Michnar, Marek, Tałałaj, Jarosław, Springer, Ewa, Napora, Piotr, Grzelewski, Tomasz, Bijata-Bronisz, Renata, Świderska, Anna, Mincewicz, Grzegorz, Sankowski, Zbigniew, Fijołek, Tomasz, Kwaśniewski, Artur, Jerzyńska, Joanna, Cygler, Jerzy, Olesiejuk, Ryszard, Von Steiner, Iwona, Machowiak, Wojciech, Filipek, Krzysztof, Piskorz, Piotr, Uhryn, Ewa, Nittner-Marszalska, Marita, Rybicka-Liszewska, Elżbieta, Bodzenta-Łukaszyk, Anna, Chełmińska, Marta, Krupa-Borek, Izabella, Skucha, Wojciech, Płoszczuk, Anna, Mihaescu, Traian, Petrui, Ioan Dorin, Savu, Angelica, Apti, Ghiulten, Toma, Claudia, Trailescu, Ana, Sokurenko, Sergei, Trofimov, Vasiliy, Leshchenko, Igor, Shaporova, Natalia, Ilyashevich, Inna, Stitsenko, Irina, Vizel, Alexander, Ilkovich, Yulia, Tikhanov, Dmitrii, Goncharova, Svetlana, Ezhov, Andrey, Ignatova, Galina, Izmozherova, Nadezhda, Berdnikova, Nadezhda, Goryachkina, Ludmila, Popova, Veronika, Bolieva, Laura, Rebrov, Andrey, Nosov, Vladimir, Magnitskaya, Olga, Nedogoda, Sergey, Abrosimov, Vladimir, Molotkov, Artem, Reshedko, Galina, Smirnov, Mikhail, Osipenko, Marina, Pavlysh, Elena, Myasoedova, Svetlana, Lenskaya, Liudmila, Chistyakov, Valery, Vishneva, Elena, Uon, Liliya, Zateyschikova, Anna, Laleko, Svetlana, Pak, Tatiana, Bruning, Axel, Naidoo, Visvakuren, Reddy, Jeevren, Van Zyl Smit, Richard, Park, Hae-Sim, Cho, Young Joo, Cho, Sang-Heon, Lee, Sang Haak, Lee, Byung Jae, Kim, Ju Sang, Cho, You Sook, Park, Choon-Sik, Kim, Mi-Kyeong, Koh, Young-Il, Kim, Joo-Hee, Lee, Sook Young, Lee, Sang Pyo, Park, Jung Won, Yoo, Kwang Ha, Yoon, Hyoungkyu, Lee, Jaechun, Hur, Gyu-Young, Lee, Soo Keol, Kim, HeeKyoo, Ramos Barbón, David, Laffond Yges, Elena, Martínez Moragón, Eva, Arias Guillen, Miguel, Saura Vinuesa, Alberto, Sánchez-Toril López, Fernando, Velasco Garrido, José Luis, García-Cosio Piqueras, Borja, Pérez de Llano, Luis, Valero Santiago, Antonio Luis, Rubio, Myriam Calle, Bjermer, Leif, Lundbäck, Bo, Gemicioglu, Bilun, Bavbek, Sevim, Ediger, Dane, Erdinc, Munevver, Hanta, Ismail, Nayci, Sibel, Arinc, Sibel, Iashyna, Liudmyla, Mostovoy, Yuriy, Ostrovskyy, Mykola, Kuryk, Lesia, Lemko, Ivan, Ospanova, Tetyana, Moskalenko, Liubov, Korzh, Oleksii, Blazhko, Viktor, Krakhmalova, Olena, Romaniuk, Liliia, Dytyatkovs'ka, Yevgeniya, Yakovenko, Oleh, Gavrysyuk, Volodymyr, Burhan, Hassan, Saralaya, Dinesh, Scott, Stephen, Morice, Alyn, Jackson-Voyzey, Ewart, Win, Thida, Nasser, Shuab, Harrison, Richard, Chaudhuri, Rekha, Nordstrom, Monica, De, Pradip, Masoli, Matthew, Mansur, Adel, Gunstone, Anthony, Niven, Robert, Harrison, Timothy, Babu, Suresh, Bhuchar, Subodh, Kureishy, Shahrukh, Zwetchkenbaum, John, Kaplan, Lawrence, Bleecker, Eugene, Reyes, Santiago, Fakih, Faisal, Heuer, Marvin, Klein, Ryan, Marcus, Michael, Hussain, Iftikhar, Tanus, Tonny, Raissy, Hengameh, Alpizar, Sady, Rodriguez, Hector, Gleich, Gerald, Bridges, Tracy, Pouzar, Joe, Steven, Gary, Matz, Jonathan, Krstevska, Shana, Ziworitin, Dama, Kaplan, Adolfo, Sublett, James, DeAngelo, James, Darter, Amy, Agaiby, John, Hagan, John, Davis, Enrique, Siri, Dareen, Mcevoy, Charlene, Dharma, Chrisette, Karimjee, Najmuddin, Kelsen, Steven, Frade, Manuel, Silverthorn, Amy, Kline, Joel, Averill, Francis, Ruiz, Jose, Robinette, Emory, Shaikh, Zeeshan, Aguilar, Carlos, Nish, William, Alvarez, German, Ismail, Younus, Parikh, Purvi, Leong, Mila, Murphy, Dennis, Garcia, Francisco, Goldsobel, Alan, Blanco, Antonio, Campbell, Edward, Perez, Guido, Chupp, Geoffrey, Bates, Toby, Perez, Vandely, Wenzel, Sally, Shenoy, Kartik, Katial, Rohit, Bernstein, David, Parikh, Neil, Sims, William, Ferguson, Gary, Pham, David, George, Anu, Beasley, Richard, Perez, Gilberto, Garver, Robert, Garcia-Portela, Miriam, Wong, Stephen, Soong, Weily, Guillot, Richard, Hudes, Golda, Arif, Ahmed, Binker, Josefa, Villareal, Manuel, Ziegner, Ulrike, Ojile, Joseph, Goswami, Sanjeev, Piniella, Carlos, Segal, Ilia, Zafra, Heidi, Lee, Mitchell, Tarpay, Martha, Panuto, John, Merchant, Rajan, Springsteen, Peter, Scialla, Timothy, Shapero, Paul, Allen, Karen, Moss, Mark, Cruz, Humberto, Rumbyrt, Jeffrey, Boyd, Amy, Nathan, Robert, Bernstein, Jonathan, Jacobs, Joshua, Ginchansky, Elliot, Johnston, Janice, Baxter, Barbara, Johnson II, Thomas, Apaliski, Stephen, Corder, Clinton, Fuentes, David, Diaz, Joseph, Ngo, Chau, Le, Lan, Busse, William W, Bleecker, Eugene R, Ferguson, Gary T, Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell

Published
2019
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12. Treatment of Metaphyseal Defects in Plated Proximal Humerus Fractures with a New Augmentation Technique—A Biomechanical Cadaveric Study

Author

Zhelev, Daniel, primary, Hristov, Stoyan, additional, Zderic, Ivan, additional, Ivanov, Stoyan, additional, Visscher, Luke, additional, Baltov, Asen, additional, Ribagin, Simeon, additional, Stoffel, Karl, additional, Kralinger, Franz, additional, Winkler, Jörg, additional, Richards, R. Geoff, additional, Varga, Peter, additional, and Gueorguiev, Boyko, additional

Published
2023
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19. A Novel Technique for Treatment of Metaphyseal Voids in Proximal Humerus Fractures in Elderly Patients

Author

Hristov, Stoyan, Visscher, Luke, Winkler, Jörg, Zhelev, Daniel, Ivanov, Stoyan, Veselinov, Deyan, Baltov, Asen, Varga, Peter, Berk, Till, Stoffel, Karl, Kralinger, Franz, Gueorguiev, Boyko, University of Zurich, and Gueorguiev, Boyko

Subjects
Bone Cements, 610 Medicine & health, General Medicine, 2700 General Medicine, augmentation, bone cement, defect, fracture, proximal humerus, Humerus, Fracture Fixation, Internal, 10021 Department of Trauma Surgery, Shoulder Fractures, Humans, Polymethyl Methacrylate, Bone Plates, Aged, Retrospective Studies
Abstract

Background and Objectives: The treatment of proximal humerus fractures in elderly patients is challenging, with reported high complication rates mostly related to implant failure involving screw cut-out and penetration. Metaphyseal defects are common in osteoporotic bone and weaken the osteosynthesis construct. A novel technique for augmentation with polymethylmethacrylate (PMMA) bone cement was developed for the treatment of patients in advanced age with complex proximal humerus fractures and metaphyseal voids, whereby the cement was allowed to partially cure for 5–7 min after mixing to achieve medium viscosity, and then it was manually placed into the defect through the traumatic lateral window with a volume of 4–6 mL per patient. The aim of this retrospective clinical study was to assess this technique versus autologous bone graft augmentation and no augmentation. Materials and Methods: The outcomes of 120 patients with plated Neer three- and four-part fractures, assigned to groups of 63 cases with no augmentation, 28 with bone graft augmentation and 29 with cement augmentation, were assessed in this study. DASH, CS, pain scores and range of motion were analyzed at 3, 6 and 12 months. Statistical analysis was performed with factors for treatment and age groups, Neer fracture types and follow-up periods, and with the consideration of age as a covariate. Results: DASH and CS improved following cement augmentation at three and six months compared to bone grafting, being significant when correcting for age as a covariate (p ≤ 0.007). While the age group had a significant effect on both these scores with worsened values at a higher age for non-augmented and grafted patients (p ≤ 0.044), this was not the case for cement augmented patients (p ≥ 0.128). Cement augmentation demonstrated good clinical results at 12 months with a mean DASH of 10.21 and mean CS percentage of 84.83% versus the contralateral side, not being significantly different among the techniques (p ≥ 0.372), despite the cement augmented group representing the older population with more four-part fractures. There were no concerning adverse events specifically related to the novel technique. Conclusions: This study has detailed a novel technique for the treatment of metaphyseal defects with PMMA cement augmentation in elderly patients with complex proximal humerus fractures and follow-up to one year, whereby the cement was allowed to partially cure to achieve medium viscosity, and then it was manually placed into the defect through the traumatic lateral window. The results demonstrate clinically equivalent short-term results to 6 months compared to augmentation with bone graft or no augmentation—despite the patient group being older and with a higher rate of more severe fracture patterns. The technique appears to be safe with no specifically related adverse events and can be added in the surgeon’s armamentarium for the treatment of these difficult to manage fractures.

Published
2022

21. Prognostic Relevance of Cardiopulmonary Exercise Testing for Patients with Chronic Thromboembolic Pulmonary Hypertension

Author

Ewert, Ralf, primary, Ittermann, Till, additional, Schmitt, Delia, additional, Pfeuffer-Jovic, Elena, additional, Stucke, Johannes, additional, Tausche, Kristin, additional, Halank, Michael, additional, Winkler, Jörg, additional, Hoheisel, Andreas, additional, Stubbe, Beate, additional, Heine, Alexander, additional, Seyfarth, Hans-Jürgen, additional, Opitz, Christian, additional, Habedank, Dirk, additional, Wensel, Roland, additional, and Held, Matthias, additional

Published
2022
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22. A Novel Technique for Treatment of Metaphyseal Voids in Proximal Humerus Fractures in Elderly Patients

Author

Hristov, Stoyan; https://orcid.org/0000-0002-6118-315X, Visscher, Luke; https://orcid.org/0000-0002-0031-0805, Winkler, Jörg, Zhelev, Daniel, Ivanov, Stoyan; https://orcid.org/0000-0003-4711-2766, Veselinov, Deyan, Baltov, Asen, Varga, Peter, Berk, Till; https://orcid.org/0000-0001-9582-1810, Stoffel, Karl; https://orcid.org/0000-0003-4431-3626, Kralinger, Franz, Gueorguiev, Boyko; https://orcid.org/0000-0001-9795-115X, Hristov, Stoyan; https://orcid.org/0000-0002-6118-315X, Visscher, Luke; https://orcid.org/0000-0002-0031-0805, Winkler, Jörg, Zhelev, Daniel, Ivanov, Stoyan; https://orcid.org/0000-0003-4711-2766, Veselinov, Deyan, Baltov, Asen, Varga, Peter, Berk, Till; https://orcid.org/0000-0001-9582-1810, Stoffel, Karl; https://orcid.org/0000-0003-4431-3626, Kralinger, Franz, and Gueorguiev, Boyko; https://orcid.org/0000-0001-9795-115X

Abstract

Background and Objectives: The treatment of proximal humerus fractures in elderly patients is challenging, with reported high complication rates mostly related to implant failure involving screw cut-out and penetration. Metaphyseal defects are common in osteoporotic bone and weaken the osteosynthesis construct. A novel technique for augmentation with polymethylmethacrylate (PMMA) bone cement was developed for the treatment of patients in advanced age with complex proximal humerus fractures and metaphyseal voids, whereby the cement was allowed to partially cure for 5-7 min after mixing to achieve medium viscosity, and then it was manually placed into the defect through the traumatic lateral window with a volume of 4-6 mL per patient. The aim of this retrospective clinical study was to assess this technique versus autologous bone graft augmentation and no augmentation. Materials and Methods: The outcomes of 120 patients with plated Neer three- and four-part fractures, assigned to groups of 63 cases with no augmentation, 28 with bone graft augmentation and 29 with cement augmentation, were assessed in this study. DASH, CS, pain scores and range of motion were analyzed at 3, 6 and 12 months. Statistical analysis was performed with factors for treatment and age groups, Neer fracture types and follow-up periods, and with the consideration of age as a covariate. Results: DASH and CS improved following cement augmentation at three and six months compared to bone grafting, being significant when correcting for age as a covariate (p ≤ 0.007). While the age group had a significant effect on both these scores with worsened values at a higher age for non-augmented and grafted patients (p ≤ 0.044), this was not the case for cement augmented patients (p ≥ 0.128). Cement augmentation demonstrated good clinical results at 12 months with a mean DASH of 10.21 and mean CS percentage of 84.83% versus the contralateral side, not being significantly different among the techniques (p ≥ 0.3

Published
2022

23. Humidity-driven degradation of sputtered molybdenum oxide and molybdenum–titanium-oxide thin films.

Author

Goetz, Selina, Edinger, Stefan, Linke, Christian, Franzke, Enrico, Winkler, Jörg, Valtiner, Markus, and Dimopoulos, Theodoros

Abstract

Molybdenum oxide (MoO3) has become a popular material in its implementation as a hole-selective layer in organic light emitting diodes and solar cells, by virtue of its favourable optical and electronic properties. However, care must be taken concerning the stability of MoO3 against water, especially for layers that are amorphous, with a considerable amount of oxygen vacancies. The present study investigates the degradation of sputtered molybdenum oxide-based thin films when exposed to controlled and elevated humidity. The investigation is mainly based on infrared spectroscopy analysis, supported by atomic force and scanning electron microscopy, X-ray diffraction and energy dispersive X-ray spectroscopy. Detrimental modifications are observed in amorphous MoO3 films due to the adsorption of water and hydrolysis. These modifications depend strongly on the humidity level and even lead to the film's crystallization under specific conditions. In the following, a stable alternative to MoO3 is presented in the form of a mixed molybdenum–titanium-oxide (MTO), which was previously shown to maintain the favourable optical and electronic properties of MoO3. The spectroscopic analysis demonstrates that the water adsorption and subsequent hydrolysis is dramatically reduced in MTO, preserving a compact layer over the observed time period of 30 days at elevated humidity. [ABSTRACT FROM AUTHOR]

Published
2023
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25. LaRA 2: parallel and vectorized program for sequence���structure alignment of RNA sequences

Author

Winkler, Jörg, Urgese, Gianvito, Ficarra, Elisa, and Reinert, Knut

Subjects
FOS: Computer and information sciences, Parallel computing, Base Sequence, Sequence Analysis, RNA, QH301-705.5, Bioinformatics, Computer applications to medicine. Medical informatics, R858-859.7, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, RNA secondary structure, Integer linear program, Structural alignment, Algorithms, RNA, Humans, Nucleic Acid Conformation, Sequence Alignment, Software, Biology (General), 000 Informatik, Informationswissenschaft, allgemeine Werke::000 Informatik, Wissen, Systeme::004 Datenverarbeitung, Informatik, Sequence Analysis
Abstract

Background The function of non-coding RNA sequences is largely determined by their spatial conformation, namely the secondary structure of the molecule, formed by Watson–Crick interactions between nucleotides. Hence, modern RNA alignment algorithms routinely take structural information into account. In order to discover yet unknown RNA families and infer their possible functions, the structural alignment of RNAs is an essential task. This task demands a lot of computational resources, especially for aligning many long sequences, and it therefore requires efficient algorithms that utilize modern hardware when available. A subset of the secondary structures contains overlapping interactions (called pseudoknots), which add additional complexity to the problem and are often ignored in available software. Results We present the SeqAn-based software LaRA 2 that is significantly faster than comparable software for accurate pairwise and multiple alignments of structured RNA sequences. In contrast to other programs our approach can handle arbitrary pseudoknots. As an improved re-implementation of the LaRA tool for structural alignments, LaRA 2 uses multi-threading and vectorization for parallel execution and a new heuristic for computing a lower boundary of the solution. Our algorithmic improvements yield a program that is up to 130 times faster than the previous version. Conclusions With LaRA 2 we provide a tool to analyse large sets of RNA secondary structures in relatively short time, based on structural alignment. The produced alignments can be used to derive structural motifs for the search in genomic databases.

Published
2022
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27. Value of Cardiopulmonary Exercise Testing in the Prognosis Assessment of Chronic Obstructive Pulmonary Disease Patients: A Retrospective, Multicentre Cohort Study

Author

Ewert, Ralf, primary, Obst, Anne, additional, Mühle, Andreas, additional, Halank, Michael, additional, Winkler, Jörg, additional, Trümper, Bernd, additional, Hoheisel, Gerhard, additional, Hoheisel, Andreas, additional, Wiersbitzky, Mark, additional, Heine, Alexander, additional, Maiwald, Alexander, additional, Gläser, Sven, additional, and Stubbe, Beate, additional

Published
2021
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30. Low-Temperature-Processed Transparent Electrodes Based on Compact and Mesoporous Titanium Oxide Layers for Flexible Perovskite Solar Cells

Author

Goetz, Selina, primary, Mehanni, Daniella, additional, Bansal, Neha, additional, Kubicek, Bernhard, additional, Wibowo, Rachmat Adhi, additional, Bauch, Martin, additional, Linke, Christian, additional, Franzke, Enrico, additional, Winkler, Jörg, additional, Meyer, Toby, additional, Narbey, Stephanie, additional, Stock, David, additional, Valtiner, Markus, additional, and Dimopoulos, Theodoros, additional

Published
2021
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42. Value of Cardiopulmonary Exercise Testing in the Prognosis Assessment of Chronic Obstructive Pulmonary Disease Patients: A Retrospective, Multicentre Cohort Study.

Author

Ewert, Ralf, Obst, Anne, Mühle, Andreas, Halank, Michael, Winkler, Jörg, Trümper, Bernd, Hoheisel, Gerhard, Hoheisel, Andreas, Wiersbitzky, Mark, Heine, Alexander, Maiwald, Alexander, Gläser, Sven, and Stubbe, Beate

Subjects
EXERCISE tests, RESEARCH, CONFIDENCE intervals, CARDIOPULMONARY system, RETROSPECTIVE studies, SEVERITY of illness index, OBSTRUCTIVE lung diseases, MEDICAL records, KAPLAN-Meier estimator, RECEIVER operating characteristic curves, OUTPATIENTS
Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases associated with high mortality. Previous studies suggested a prognostic role for peak oxygen uptake (VO2peak) assessed during cardiopulmonary exercise testing (CPET) in patients with COPD. However, most of these studies had small sample sizes or short follow-up periods, and despite their relevance, CPET parameters are not included in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) tool for assessment of severity. Objectives: We therefore aimed to assess the prognostic value of CPET parameters in a large cohort of outpatients with COPD. Methods: In this retrospective, multicentre cohort study, medical records of patients with COPD who underwent CPET during 2004–2017 were reviewed and demographics, smoking habits, GOLD grade and category, exacerbation frequency, dyspnoea score, lung function measurements, and CPET parameters were documented. Relationships with survival were evaluated using Kaplan-Meier analysis, Cox regression, and receiver operating characteristic (ROC) curves. Results: Of a total of 347 patients, 312 patients were included. Five-year and 10-year survival probability was 75% and 57%, respectively. VO2peak significantly predicted survival (hazard ratio: 0.886 [95% confidence interval: 0.830; 0.946]). The optimal VO2peak threshold for discrimination of 5-year survival was 14.6 mL/kg/min (area under ROC curve: 0.713). Five-year survival in patients with VO2peak <14.6 mL/kg/min versus ≥ 14.6 mL/kg/min was 60% versus 86% in GOLD categories A/B and 64% versus 90% in GOLD categories C/D. Conclusions: We confirm that VO2peak is a highly significant predictor of survival in COPD patients and recommend the incorporation of VO2peak into the assessment of COPD severity. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Elucidating the physical properties of the molybdenum oxide Mo4O11 and its tantalum substituted variant Mo2Ta2O11

Author

Zoller, Michael, primary, Bubnova, Rimma, additional, Biryukov, Yaroslav, additional, Haussühl, Eiken, additional, Pöttgen, Rainer, additional, Janka, Oliver, additional, Penner, Simon, additional, Praty, Corsin, additional, Fitzek, Harald, additional, Winkler, Jörg, additional, Filatov, Stanislav, additional, and Huppertz, Hubert, additional

Published
2020
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49. Ergebnisse einer Ringanalyse zur Bestimmung von organischen Stoffen in schwebstoffbürtigen Sedimenten der Elbe

Author

Stachel, Burkhard, Jankowsky, Andrea, Winkler, Jörg, Wolff, Stefan, Geller, Walter, editor, Punčochář, Pavel, editor, Bornhöft, Dirk, editor, Bouček, Jan, editor, Feldmann, Hildegard, editor, Guhr, Helmut, editor, Mohaupt, Volker, editor, Simon, Manfred, editor, Smrtˇák, Josef, editor, Spoustová, Jitka, editor, and Uhlmann, Ogarit, editor

Published
1998
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