Search

Your search keyword '"Wimberley, Catriona"' showing total 135 results
Start Over Author "Wimberley, Catriona"
135 results on '"Wimberley, Catriona"'

3. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis

Author

Gallus, Marco, Roll, Wolfgang, Dik, Andre, Barca, Cristina, Zinnhardt, Bastian, Hicking, Gordon, Mueller, Christoph, Naik, Venu Narayanan, Anstötz, Max, Krämer, Julia, Rolfes, Leoni, Wachsmuth, Lydia, Pitsch, Julika, van Loo, Karen MJ, Räuber, Saskia, Okada, Hideho, Wimberley, Catriona, Strippel, Christine, Golombeck, Kristin S, Johnen, Andreas, Kovac, Stjepana, Groß, Catharina C, Backhaus, Philipp, Seifert, Robert, Lewerenz, Jan, Surges, Rainer, Elger, Christian E, Wiendl, Heinz, Ruck, Tobias, Becker, Albert J, Faber, Cornelius, Jacobs, Andreas H, Bauer, Jan, Meuth, Sven G, Schäfers, Michael, and Melzer, Nico

Subjects
Biomedical and Clinical Sciences, Immunology, Brain Disorders, Biomedical Imaging, Autoimmune Disease, Clinical Research, Neurodegenerative, Neurosciences, 2.1 Biological and endogenous factors, Animals, Humans, Mice, Carrier Proteins, Inflammation, Limbic Encephalitis, Positron-Emission Tomography, Receptors, GABA, Autoimmune Diseases
Abstract

Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [18F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell-mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [18F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell-mediated ALE.

Published
2023

5. Impact of cerebral blood flow and amyloid load on SUVR bias

Author

Heeman, Fiona, Yaqub, Maqsood, Hendriks, Janine, van Berckel, Bart N. M., Collij, Lyduine E., Gray, Katherine R., Manber, Richard, Wolz, Robin, Garibotto, Valentina, Wimberley, Catriona, Ritchie, Craig, Barkhof, Frederik, Gispert, Juan Domingo, Vállez García, David, Lopes Alves, Isadora, and Lammertsma, Adriaan A.

Published
2022
Full Text
View/download PDF

10. Correction to: Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain.

Author

MacAskill, Mark G., Wimberley, Catriona, Morgan, Timaeus E. F., Alcaide‑Corral, Carlos J., Newby, David E., Lucatelli, Christophe, Sutherland, Andrew, Pimlott, Sally L., and Tavares, Adriana A. S.

Subjects
*POSITRON emission tomography, *BLAND-Altman plot, *NUCLEAR medicine, *PUBLISHED articles, *RATS, *HEART
Abstract

This document is a correction notice for an article titled "Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain" published in the European Journal of Nuclear Medicine & Molecular Imaging. The correction notice addresses errors in the original article and provides the accurate information. The corrections include changes to numerical values and clarifications in the text. Additionally, some figures in the original article were incorrect and have been corrected in the notice. The publisher, Springer Nature, remains neutral and unbiased in relation to jurisdictional claims and institutional affiliations. [Extracted from the article]

Published
2024
Full Text
View/download PDF

13. [18F]DPA-714-PET-MRI reveals pronounced innate immunity in human anti-LGI1 and anti-CASPR2 limbic encephalitis.

Author

Roll, Wolfgang, Bauer, Jan, Dik, Andre, Mueller, Christoph, Backhaus, Philipp, Räuber, Saskia, Zinnhardt, Bastian, Gallus, Marco, Wimberley, Catriona, Körtvelyessy, Peter, Schindler, Philipp, Stenzel, Werner, Elger, Christian E., Becker, Albert, Lewerenz, Jan, Wiendl, Heinz, Meuth, Sven G., Schäfers, Michael, and Melzer, Nico

Subjects
EPILEPSY, ANTI-NMDA receptor encephalitis, NATURAL immunity, ENCEPHALITIS, SCIENCE education
Abstract

This document, published in the Journal of Neurology, explores the use of [18F]DPA-714-PET-MRI as a diagnostic tool for autoimmune limbic encephalitis (ALE) with specific autoantibodies. The study involved two patients with these autoantibodies, and the results showed increased tracer uptake in certain areas of the brain. The study suggests that [18F]DPA-714-PET-MRI could be a valuable tool for diagnosing ALE and assessing the immune response in the brain. However, further research is needed to fully understand its potential for clinical use in ALE. [Extracted from the article]

Published
2024
Full Text
View/download PDF

15. Comparing parametric methods for longitudinal measurement of β‐amyloid pathology with PET in elderly individuals

Author

Heeman, Fiona, primary, Hendriks, Janine, additional, Tristão‐Pereira, Catarina, additional, Collij, Lyduine E., additional, Young, Peter, additional, van Berckel, Bart N.M., additional, Visser, Pieter Jelle, additional, Hanseeuw, Bernard J, additional, Vandenberghe, Rik, additional, Garibotto, Valentina, additional, Frisoni, Giovanni B, additional, Altomare, Daniele, additional, Shekari, Mahnaz, additional, Buckley, Christopher, additional, Farrar, Gill, additional, Schmidt, Mark E, additional, Gismondi, Rossella, additional, Stephens, Andrew W., additional, Ritchie, Craig W, additional, Wimberley, Catriona, additional, Martinez‐Lage, Pablo, additional, Manber, Richard, additional, Wolz, Robin, additional, Gispert, Juan Domingo, additional, Schöll, Michael, additional, Alves, Isadora Lopes, additional, Barkhof, Frederik, additional, García, David Vállez, additional, Lammertsma, Adriaan A., additional, and Yaqub, Maqsood, additional

Published
2023
Full Text
View/download PDF

17. Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

Author

Caprioglio, Camilla, Ribaldi, Federica, Visser, Leonie N. C., Minguillon, Carolina, Collij, Lyduine E., Grau-Rivera, Oriol, Zeyen, Philip, Molinuevo, José Luis, Gispert, Juan Domingo, Garibotto, Valentina, Moro, Christian, Walker, Zuzana, Edison, Paul, Demonet, Jean-François, Barkhof, Frederik, Scheltens, Philip, Alves, Isadora Lopes, Gismondi, Rossella, Farrar, Gill, Stephens, Andrew W., Jessen, Frank, Frisoni, Giovanni B., Altomare, Daniele, Abdelnour, Carla, Aguilera, Nuria, Aksman, Leon, Alarcón-Martín, Emilio, Alegret, Montse, Alonso-Lana, Silvia, Andersen, Pia, Arab, Majd, Aspö, Malin, Bader, Ilona, Bader, Ilse, Banton, Nigel, Barnes, Rodrigo, Barrie, Dawn, Battle, Mark, Belén Collado, Ana, Bellet, Julie, Berkhof, Johannes, Biger, Marine, Birck, Cindy, Bischof, Gerard, Boada, Mercè, Boellaard, Ronald, Bogdanovic, Nenad, Bollack, Ariane, Bombois, Stéphanie, Borg, Stefan, Borjesson-Hanson, Anne, Boskov, Vladimir, Boutantin, Justine, Boutoleau-Bretonniere, Claire, Bouwman, Femke, Breuilh, Laetitia, Bringman, Eva, Brunel, Baptiste, Bucci, Marco, Buckley, Chris, Buendía, Mar, Bullich, Santi, Calvet, Anna, Cañada, Laia, Cañada, Marta, Cardoso, Jorge, Carlier, Jasmine, Carre, Elise, Carrie, Isabelle, Cassagnaud, Pascaline, Cassol, Emmanuelle, Castilla-Martí, Miguel, Cazalon, Elodie, Chaarriau, Tiphaine, Chaigeau, Rachel, Chalmers, Taylor, Clerc, Marie-Thérèse, Clerigue, Montserrat, Cognat, Emmanuel, Coll, Nina, Collij, Lyduine E, Connely, Peter, Cordier, Elodie, Costes, Corine, Coulange, Camille, Courtemanche, Hélène, Creisson, Eric, Crinquette, Charlotte, Cuevas, Rosario, Cufi, Marie-Noëlle, Dardenne, Sophie, de Arriba, Maria, de Costa Luis, Casper, de Gier, Yvonne, de Verbizier Lonjon, Delphine, Dekker, Veronique, Dekyndt, Bérengère, Delbeuck, Xavier, Delrieu, Julien, Deramecourt, Vincent, Desclaux, Françoise, Diaz, Carlos, Diego, Susana, Djafar, Mehdi, Dölle, Britta, Doull, Laura, Dricot, Laurence, Drzezga, Alexander, Dubois, Bruno, Dumont, Julien, Dumur, Jean, Dumurgier, Julien, Dvorak, Martin, Ecay, Mirian, Escher, Claus, Estanga, Ainara, Esteban, Ester, Fanjaud, Guy, Fauria, Karine, Felez Sanchez, Marta, Feukam Talla, Patrick, Ford, Lisa, Frisoni, Giovanni B, Fuster, David, Gabelle, Audrey, Gaubert, Sinead, Gauci, Cédric, Geldhof, Christine, Georges, Jean, Ghika, Joseph, González, Elena, Goovaerts, Valerie, Goulart, Denis Mariano, Grasselli, Caroline, Gray, Katherine, Greensmith, Martin, Grozn, Laure, Guillemaud, Céline, Gunn, Fiona, Guntur Ramkumar, Prasad, Hagman, Göran, Hansseuw, Bernard, Heeman, Fiona, Hendriks, Janine, Himmelmann, Jakob, Hitzel, Anne, Hives, Florent, Hoenig, Merle, Hourrègue, Claire, Hudson, Justine, Huguet, Jordi, Ibarria, Marta, Iidow, Ifrah, Indart, Sandrine, Ingala, Silvia, Ivanoiu, Adrian, Jacquemont, Charlotte, Jelic, Vesna, Jiao, Jieqing, Jofresa, Sara, Jonsson, Cathrine, Kaliukhovich, Dzmitry, Kern, Silke, Kivipelto, Miia, Knezevic, Iva, Kuchcinski, Grégory, Laforce, Manon, Lafuente, Asunción, Lala, Françoise, Lammertsma, Adriaan, Lax, Michelle, Lebouvier, Thibaud, Lee, Ho-Yun, Lee, Lean, Leeuwis, Annebet, Lefort, Amandine, Legrand, Jean-François, Leroy, Mélanie, Lesoil Markowski, Constance, Levy, Marcel, Lhommel , Renaud, Lopes, Renaud, Lopes Alves, Isadora, Lorenzini, Luigi, Lorette, Adrien, Luckett, Emma, Lundin, Marie, Mackowiak, Marie-Anne, Malotaux, Vincent, Manber, Richard, Manyakov, Nikolay, Markiewicz, Pawel, Marne, Paula, Marquié, Marta, Martín, Elvira, Martínez, Joan, Martinez Lage, Pablo, Mastenbroek, Sophie E, Maureille, Aurélien, Meersmans, Karen, Mett, Anja, Milne, Joseph, Minguillón, Carolina, Modat, Marc, Montrreal, Laura, Müller, Theresa, Muniz, Graciela, Mutsarts, Henk Jan, Nilsson, Ted, Ninerola, Aida, Nordberg, Agneta, Novaes, Wilse, Nuno Carmelo Pires Silva, Joao, Operto, Greg, Orellana, Adela, Ousset, Pierre-Jean, Outteryck, Olivier, Pallardy, Amandine, Palombit, Alessandro, Pancho, Ana, Pappon, Martin, Paquet, Claire, Pariente, Jérémie, Pasquier, Florence, Payoux, Pierre, Peaker, Harry, Pelejà, Esther, Pennetier, Delphine, Pérez-Cordón, Alba, Perissinotti, Andrés, Perrenoud, Matthieu Paul, Petit, Sandrine, Petyt, Grégory, Pfeil, Julia, Pirotte, Blanche, Pla, Sandra, Plaza Wuthrich, Sonia, Poitrine, Lea, Pollet, Marianne, Poncelet, Jean-Benoit, Prior, John, Pruvo, Jean-Pierre, Putallaz, Pauline, Queneau, Mathieu, Quenon , Lisa, Rădoi, Andreea, Rafiq, Marie, Ramage, Fiona, Ramis, Maribel, Reinwald, Michael, Rios, Gonzalo, Ritchie, Craig, Rodriguez, Elena, Rollin, Adeline, Rouaud, Olivier, Sacuiu, Simona, Saint-Aubert, Laure, Sala, Arianna, Salabert, Anne-Sophie, Saldias, Jon, Salvadó, Gemma, Sanabria, Angela, Sannemann, Lena, Sastre, Nathalie, Savina, Daniela, Savitcheva, Irina, Schaeverbeke, Jolien, Schildermans, Carine, Schmidt, Mark, Schöll, Michael, Schuermans, Jeroen, Semah, Franck, Shekari, Mahnaz, Skoog, Ingmar, Sotolongo-Grau, Oscar, Stephens, Andrew, Stewart, Tiffany, Stutzmann, Jennyfer, Tait, Murray, Tárraga, Lluis, Tartari, Juan Pablo, Tysen-backstrom, Ann-christine, Valero, Sergi, Vallez Garcia, David, van Berckel, Bart N M, van Essen, Martijn, Van Laere, Koen, van Leur, Jeroen, van Maurik, Ingrid S, Vandenberghe, Rik, Vellas, Bruno, Virolinen, Jukka, Visser, Pieter Jelle, Walles, Håkan, Wallin, Emilia, Whitelaw, Grant, Wimberley, Catriona, Win , Zarni, Wink, Alle Meije, Wolz, Robin, Woodside, John, Yaqub, Maqsood, Zettergren, Anna, Medical Psychology, APH - Personalized Medicine, APH - Quality of Care, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, CCA - Cancer Treatment and quality of life, CCA - Imaging and biomarkers, Neurology, Dekyndt, Bérengère, Delbeuck, Xavier, Delrieu, Julien, Demonet, Jean-François, Deramecourt, Vincent, Desclaux, Françoise, Diaz, Carlos, Diego, Susana, Djafar, Mehdi, Dölle, Britta, Doull, Laura, Dricot, Laurence, Drzezga, Alexander, Dubois, Bruno, Dumont, Julien, Dumur, Jean, Dumurgier, Julien, Dvorak, Martin, Ecay, Mirian, Edison, Paul, Escher, Claus, Estanga, Ainara, Esteban, Ester, Fanjaud, Guy, Farrar, Gill, Fauria, Karine, Felez Sanchez, Marta, Feukam Talla, Patrick, Ford, Lisa, Frisoni, Giovanni B, Fuster, David, Gabelle, Audrey, Garibotto, Valentina, Gaubert, Sinead, Gauci, Cédric, Geldhof, Christine, Georges, Jean, Ghika, Joseph, Gismondi, Rossella, Gispert, Juan Domingo, González, Elena, Goovaerts, Valerie, Goulart, Denis Mariano, Grasselli, Caroline, Grau-Rivera, Oriol, Gray, Katherine, Greensmith, Martin, Grozn, Laure, Guillemaud, Céline, Gunn, Fiona, Guntur Ramkumar, Prasad, Hagman, Göran, Hansseuw, Bernard, Heeman, Fiona, Hendriks, Janine, Himmelmann, Jakob, Hitzel, Anne, Hives, Florent, Hoenig, Merle, Hourrègue, Claire, Hudson, Justine, Huguet, Jordi, Ibarria, Marta, Iidow, Ifrah, Indart, Sandrine, Ingala, Silvia, Ivanoiu, Adrian, Jacquemont, Charlotte, Jelic, Vesna, Jessen, Frank, Jiao, Jieqing, Jofresa, Sara, Jonsson, Cathrine, Kaliukhovich, Dzmitry, Kern, Silke, Kivipelto, Miia, Knezevic, Iva, Kuchcinski, Grégory, Laforce, Manon, Lafuente, Asunción, Lala, Françoise, Lammertsma, Adriaan, Lax, Michelle, Lebouvier, Thibaud, Lee, Ho-Yun, Lee, Lean, Leeuwis, Annebet, Lefort, Amandine, Legrand, Jean-François, Leroy, Mélanie, Lesoil Markowski, Constance, Levy, Marcel, Lhommel, Renaud, Lopes, Renaud, Lopes Alves, Isadora, Lorenzini, Luigi, Lorette, Adrien, Luckett, Emma, Lundin, Marie, Mackowiak, Marie-Anne, Malotaux, Vincent, Manber, Richard, Manyakov, Nikolay, Markiewicz, Pawel, Marne, Paula, Marquié, Marta, Martín, Elvira, Martínez, Joan, Martinez Lage, Pablo, Mastenbroek, Sophie E, Maureille, Aurélien, Meersmans, Karen, Mett, Anja, Milne, Joseph, Minguillón, Carolina, Modat, Marc, Molinuevo, José Luis, Montrreal, Laura, Moro, Christian, Müller, Theresa, Muniz, Graciela, Mutsarts, Henk Jan, Nilsson, Ted, Ninerola, Aida, Nordberg, Agneta, Novaes, Wilse, Nuno Carmelo Pires Silva, Joao, Operto, Greg, Orellana, Adela, Ousset, Pierre-Jean, Outteryck, Olivier, Pallardy, Amandine, Palombit, Alessandro, Pancho, Ana, Pappon, Martin, Paquet, Claire, Pariente, Jérémie, Pasquier, Florence, Payoux, Pierre, Peaker, Harry, Abdelnour, Carla, Pelejà, Esther, Pennetier, Delphine, Pérez-Cordón, Alba, Perissinotti, Andrés, Perrenoud, Matthieu Paul, Petit, Sandrine, Petyt, Grégory, Pfeil, Julia, Pirotte, Blanche, Pla, Sandra, Aguilera, Nuria, Plaza Wuthrich, Sonia, Poitrine, Lea, Pollet, Marianne, Poncelet, Jean-Benoit, Prior, John, Pruvo, Jean-Pierre, Putallaz, Pauline, Queneau, Mathieu, Quenon, Lisa, Rădoi, Andreea, Aksman, Leon, Rafiq, Marie, Ramage, Fiona, Ramis, Maribel, Reinwald, Michael, Rios, Gonzalo, Ritchie, Craig, Rodriguez, Elena, Rollin, Adeline, Rouaud, Olivier, Sacuiu, Simona, Alarcón-Martín, Emilio, Saint-Aubert, Laure, Sala, Arianna, Salabert, Anne-Sophie, Saldias, Jon, Salvadó, Gemma, Sanabria, Angela, Sannemann, Lena, Sastre, Nathalie, Savina, Daniela, Savitcheva, Irina, Alegret, Montse, Schaeverbeke, Jolien, Scheltens, Philip, Schildermans, Carine, Schmidt, Mark, Schöll, Michael, Schuermans, Jeroen, Semah, Franck, Shekari, Mahnaz, Skoog, Ingmar, Sotolongo-Grau, Oscar, Alonso-Lana, Silvia, Stephens, Andrew, Stewart, Tiffany, Stutzmann, Jennyfer, Tait, Murray, Tárraga, Lluis, Tartari, Juan Pablo, Tysen-Backstrom, Ann-Christine, Valero, Sergi, Vallez Garcia, David, van Berckel, Bart N M, Altomare, Daniele, van Essen, Martijn, Van Laere, Koen, van Leur, Jeroen, van Maurik, Ingrid S, Vandenberghe, Rik, Vellas, Bruno, Virolinen, Jukka, Visser, Pieter Jelle, Walker, Zuzana, Walles, Håkan, Andersen, Pia, Wallin, Emilia, Whitelaw, Grant, Wimberley, Catriona, Win, Zarni, Wink, Alle Meije, Wolz, Robin, Woodside, John, Yaqub, Maqsood, Zettergren, Anna, Zeyen, Philip, Arab, Majd, Aspö, Malin, Bader, Ilona, Bader, Ilse, Banton, Nigel, Barkhof, Frederik, Barnes, Rodrigo, Barrie, Dawn, Battle, Mark, Belén Collado, Ana, Bellet, Julie, Berkhof, Johannes, Biger, Marine, Birck, Cindy, Bischof, Gerard, Boada, Mercè, Boellaard, Ronald, Bogdanovic, Nenad, Bollack, Ariane, Bombois, Stéphanie, Borg, Stefan, Borjesson-Hanson, Anne, Boskov, Vladimir, Boutantin, Justine, Boutoleau-Bretonniere, Claire, Bouwman, Femke, Breuilh, Laetitia, Bringman, Eva, Brunel, Baptiste, Bucci, Marco, Buckley, Chris, Buendía, Mar, Bullich, Santi, Calvet, Anna, Cañada, Laia, Cañada, Marta, Caprioglio, Camilla, Cardoso, Jorge, Carlier, Jasmine, Carre, Elise, Carrie, Isabelle, Cassagnaud, Pascaline, Cassol, Emmanuelle, Castilla-Martí, Miguel, Cazalon, Elodie, Chaarriau, Tiphaine, Chaigeau, Rachel, Chalmers, Taylor, Clerc, Marie-Thérèse, Clerigue, Montserrat, Cognat, Emmanuel, Coll, Nina, Collij, Lyduine E, Connely, Peter, Cordier, Elodie, Costes, Corine, Coulange, Camille, Courtemanche, Hélène, Creisson, Eric, Crinquette, Charlotte, Cuevas, Rosario, Cufi, Marie-Noëlle, Dardenne, Sophie, de Arriba, Maria, de Costa Luis, Casper, de Gier, Yvonne, de Verbizier Lonjon, Delphine, and Dekker, Veronique

Subjects
Male, Adult, metabolism [Brain], Positron-Emission Tomography, diagnosis [Alzheimer Disease], diagnostic imaging [Cognitive Dysfunction], Humans, metabolism [Amyloid beta-Peptides], ddc:610, Prospective Studies, Disclosure, General Medicine, Aged
Abstract

ImportanceIndividuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+ undergo amyloid-positron emission tomography (PET) as part of research studies and frequently wish to know their amyloid status; however, the disclosure of a positive amyloid-PET result might have psychological risks.ObjectiveTo assess the psychological outcomes of the amyloid-PET result disclosure in individuals with SCD+ and explore which variables are associated with a safer disclosure in individuals who are amyloid positive.Design, Setting, and ParticipantsThis prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). The setting was 5 European memory clinics, and participants included patients with SCD+ who underwent amyloid-PET. Statistical analysis was performed from July to October 2022.ExposuresDisclosure of amyloid-PET result.Main Outcomes and MeasuresPsychological outcomes were defined as (1) disclosure related distress, assessed using the Impact of Event Scale–Revised (IES-R; scores of at least 33 indicate probable presence of posttraumatic stress disorder [PTSD]); and (2) anxiety and depression, assessed using the Hospital Anxiety and Depression scale (HADS; scores of at least 15 indicate probable presence of severe mood disorder symptoms).ResultsAfter disclosure, 27 patients with amyloid-positive SCD+ (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median [IQR] education: 15 [13 to 17] years, median [IQR] Mini-Mental State Examination [MMSE] score, 29 [28 to 30]) had higher median (IQR) IES-R total score (10 [2 to 14] vs 0 [0 to 2]; P P P P P = .06) and Depression (–1.0 [–2.0 to 0.0] vs –1.0 [–3.0 to 0.0]; P = .46) deltas (score after disclosure – scores at baseline). In patients with amyloid-positive SCD+, despite the small sample size, higher education was associated with lower disclosure-related distress (ρ = –0.43; P = .02) whereas the presence of study partner was associated with higher disclosure-related distress (W = 7.5; P = .03). No participants with amyloid-positive SCD+ showed probable presence of PTSD or severe anxiety or depression symptoms at follow-up.Conclusions and RelevanceThe disclosure of a positive amyloid-PET result to patients with SCD+ was associated with a bigger psychological change, yet such change did not reach the threshold for clinical concern.

Published
2023
Full Text
View/download PDF

20. 2 TSPO PET imaging of inflammation with [18F]LW223 predicts functional outcome following myocardial infarction

Author

MacAskill, Jen, primary, Reid, Victoria, additional, Alcaide-Corral, Carlos, additional, Morgan, Timaeus, additional, De Albuquerque, Ana Clara Juan, additional, Thomson, Adrian, additional, Fujisawa, Takeshi, additional, Mills, Nicholas, additional, Knyzeliene, Agne, additional, Balogh, Viktoria, additional, Wimberley, Catriona, additional, Dweck, Marc, additional, Gray, Gillian, additional, Newby, David, additional, Lucatelli, Christophe, additional, Pimlott, Sally, additional, Sutherland, Andrew, additional, and Tavares, Adriana, additional

Published
2023
Full Text
View/download PDF

25. Additional file 1 of Impact of cerebral blood flow and amyloid load on SUVR bias

Author

Heeman, Fiona, Yaqub, Maqsood, Hendriks, Janine, van Berckel, Bart N. M., Collij, Lyduine E., Gray, Katherine R., Manber, Richard, Wolz, Robin, Garibotto, Valentina, Wimberley, Catriona, Ritchie, Craig, Barkhof, Frederik, Gispert, Juan Domingo, Vállez García, David, Lopes Alves, Isadora, and Lammertsma, Adriaan A.

Subjects
mental disorders
Abstract

Additional file 1. Impact of cerebral blood flow and amyloid load on SUVR bias.

Published
2022
Full Text
View/download PDF

27. Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism

Author

MacAskill, Mark G., primary, Stadulyte, Agne, additional, Williams, Lewis, additional, Morgan, Timaeus E.F., additional, Sloan, Nikki L., additional, Alcaide-Corral, Carlos J., additional, Walton, Tashfeen, additional, Wimberley, Catriona, additional, McKenzie, Chris-Anne, additional, Spath, Nick, additional, Mungall, William, additional, BouHaidar, Ralph, additional, Dweck, Marc R., additional, Gray, Gillian A., additional, Newby, David E., additional, Lucatelli, Christophe, additional, Sutherland, Andrew, additional, Pimlott, Sally L., additional, and Tavares, Adriana A.S., additional

Published
2020
Full Text
View/download PDF

28. Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain.

Author

MacAskill, Mark G., Wimberley, Catriona, Morgan, Timaeus E. F., Alcaide-Corral, Carlos J., Newby, David E., Lucatelli, Christophe, Sutherland, Andrew, Pimlott, Sally L., and Tavares, Adriana A. S.

Subjects
*TRANSLOCATOR proteins, *RADIOACTIVE tracers, *MYOCARDIAL infarction, *EMISSION-computed tomography, *HEART, *BRAIN
Abstract

Purpose: To provide a comprehensive assessment of the novel 18 kDa translocator protein (TSPO) radiotracer, [18F]LW223, kinetics in the heart and brain when using a simplified imaging approach. Methods: Naive adult rats and rats with surgically induced permanent coronary artery ligation received a bolus intravenous injection of [18F]LW223 followed by 120 min PET scanning with arterial blood sampling throughout. Kinetic modelling of PET data was applied to estimated rate constants, total volume of distribution (VT) and binding potential transfer corrected (BPTC) using arterial or image-derived input function (IDIF). Quantitative bias of simplified protocols using IDIF versus arterial input function (AIF) and stability of kinetic parameters for PET imaging data of different length (40–120 min) were estimated. Results: PET outcome measures estimated using IDIF significantly correlated with those derived with invasive AIF, albeit with an inherent systematic bias. Truncation of the dynamic PET scan duration to less than 100 min reduced the stability of the kinetic modelling outputs. Quantification of [18F]LW223 uptake kinetics in the brain and heart required the use of different outcome measures, with BPTC more stable in the heart and VT more stable in the brain. Conclusion: Modelling of [18F]LW223 PET showed the use of simplified IDIF is acceptable in the rat and the minimum scan duration for quantification of TSPO expression in rats using kinetic modelling with this radiotracer is 100 min. Carefully assessing kinetic outcome measures when conducting a systems level as oppose to single-organ centric analyses is crucial. This should be taken into account when assessing the emerging role of the TSPO heart-brain axis in the field of PET imaging. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

29. Qualification of the Seven Dementias Platform UK PET-MR Scanners for Multicentre Trials

Author

Krokos, Georgios, primary, MacKewn, Jane, additional, Pike, Lucy, additional, Hallett, William, additional, Markiewicz, Pawel, additional, Barnes, Anna, additional, Rega, Marilena, additional, Fryer, Tim D., additional, Manavaki, Roido, additional, Anton-Rodriguez, Jose M., additional, Howell, Elizabeth, additional, Wimberley, Catriona, additional, Clark, Tim, additional, Macnaught, Gillian, additional, Marsden, Paul, additional, and Matthews, Julian C., additional

Published
2019
Full Text
View/download PDF

30. Assessment of simplified methods for quantification of [18F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate

Author

Van Camp, Nadja, primary, Balbastre, Yaël, additional, Herard, Anne-Sophie, additional, Lavisse, Sonia, additional, Tauber, Clovis, additional, Wimberley, Catriona, additional, Guillermier, Martine, additional, Berniard, Aurélie, additional, Gipchtein, Pauline, additional, Jan, Caroline, additional, Badin, Romina Aron, additional, Delzescaux, Thierry, additional, Hantraye, Philippe, additional, and Bonvento, Gilles, additional

Published
2019
Full Text
View/download PDF

31. Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism.

Author

MacAskill, Mark G., Stadulyte, Agne, Williams, Lewis, Morgan, Timaeus E. F., Sloan, Nikki L., Alcaide- Corral, Carlos J., Walton, Tashfeen, Wimberley, Catriona, McKenzie, Chris-Anne, Spath, Nick, Mungall, William, BouHaidar, Ralph, Dweck, Marc R., Gray, Gillian A., Newby, David E., Lucatelli, Christophe, Sutherland, Andrew, Pimlott, Sally L., and Tavares, Adriana A. S.

Published
2021
Full Text
View/download PDF

32. Impact of Endothelial 18-kDa Translocator Protein on the Quantification of 18F-DPA-714

Author

Wimberley, Catriona, Lavisse, Sonia, Brulon, Vincent, Peyronneau, Marie-Anne, Leroy, Claire, Bodini, Benedetta, Remy, Philippe, Stankoff, Bruno, Buvat, Irène, and Bottlaender, Michel

Subjects
PET, 18F-DPA-714, TSPO, quantification, neuroinflammation
Abstract

18F-DPA-714 is a second-generation tracer for PET imaging of the 18-kDa translocator protein (TSPO), a marker of neuroinflammation. Analysis and interpretation of TSPO PET are challenging, especially because of the basal expression of TSPO. The aim of this study was to evaluate a compartmental model that accounts for the effect of endothelial TSPO binding on the quantification of 18F-DPA-714 PET scans from a cohort of healthy subjects. Methods: Fifteen healthy subjects (9 high-affinity binders and 6 mixed-affinity binders) underwent 18F-DPA-714 PET scans with arterial blood sampling and metabolite analysis. The kinetic parameters were quantified using a 2-tissue compartmental model (2TC) as well as a 2TC with an extra, irreversible, compartment for endothelial binding (2TC-1K). These regional parameters and messenger RNA (mRNA) expression specific to endothelial cells were correlated with regional TSPO mRNA expression. Results: The 2TC-1K model was more appropriate than the 2TC for 81% of fits. The total volume of distribution was significantly reduced by 21% ± 12% across all regions with the 2TC-1K, compared with the 2TC. The endothelial binding parameter Kb varied highly across brain regions. Kb strongly and significantly correlated with all 3 probes extracted for TSPO mRNA expression (r = 0.80, r = 0.79, and r = 0.90), but no correlation was seen with the other binding parameters from the 2TC-1K. For the 2TC, there was a lower but significant correlation between the volume of distribution and one of the TSPO mRNA probes (r = 0.65). A strong, significant correlation was seen between mRNA for TSPO and genes specific to endothelial cells. Conclusion: Accounting for endothelial TSPO in the kinetic model improved the fit of PET data. The high correlation between Kb and TSPO mRNA suggests that the 2TC-1K model reveals more biologic information about the regional density of TSPO than the 2TC. The correlation between TSPO and endothelial cell mRNA supports the relationship between the regional variation of Kb and endothelial TSPO. These results can improve the estimation of binding parameter estimates from 18F-DPA-714 PET, especially in diseases that induce vascular change.

Published
2017

33. Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism.

Author

MacAskill, Mark G., Stadulyte, Agne, Williams, Lewis, Morgan, Timaeus E. F., Sloan, Nikki L., Alcaide-Corral, Carlos J., Walton, Tashfeen, Wimberley, Catriona, McKenzie, Chris-Anne, Spath, Nick, Mungall, William, BouHaidar, Ralph, Dweck, Marc R., Gray, Gillian A., Newby, David E., Lucatelli, Christophe, Sutherland, Andrew, Pimlott, Sally L., and Tavares, Adriana A. S.

Published
2020
Full Text
View/download PDF

34. Assessment of simplified methods for quantification of [ 18 F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate.

Author

Van Camp, Nadja, Balbastre, Yaël, Herard, Anne-Sophie, Lavisse, Sonia, Tauber, Clovis, Wimberley, Catriona, Guillermier, Martine, Berniard, Aurélie, Gipchtein, Pauline, Jan, Caroline, Badin, Romina Aron, Delzescaux, Thierry, Hantraye, Philippe, and Bonvento, Gilles

Abstract

The 18 kDa translocator protein (TSPO) is the main molecular target to image neuroinflammation by positron emission tomography (PET). However, TSPO-PET quantification is complex and none of the kinetic modelling approaches has been validated using a voxel-by-voxel comparison of TSPO-PET data with the actual TSPO levels of expression. Here, we present a single case study of binary classification of in vivo PET data to evaluate the statistical performance of different TSPO-PET quantification methods. To that end, we induced a localized and adjustable increase of TSPO levels in a non-human primate brain through a viral-vector strategy. We then performed a voxel-wise comparison of the different TSPO-PET quantification approaches providing parametric [18F]-DPA-714 PET images, with co-registered in vitro three-dimensional TSPO immunohistochemistry (3D-IHC) data. A data matrix was extracted from each brain hemisphere, containing the TSPO-IHC and TSPO-PET data for each voxel position. Each voxel was then classified as false or true, positive or negative after comparison of the TSPO-PET measure to the reference 3D-IHC method. Finally, receiver operating characteristic curves (ROC) were calculated for each TSPO-PET quantification method. Our results show that standard uptake value ratios using cerebellum as a reference region (SUVCBL) has the most optimal ROC score amongst all non-invasive approaches. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

36. Longitudinal positron emission tomography imaging of glial cell activation in a mouse model of mesial temporal lobe epilepsy: Toward identification of optimal treatment windows

Author

Nguyen, Duc-Loc, primary, Wimberley, Catriona, additional, Truillet, Charles, additional, Jego, Benoit, additional, Caillé, Fabien, additional, Pottier, Géraldine, additional, Boisgard, Raphaël, additional, Buvat, Irène, additional, and Bouilleret, Viviane, additional

Published
2018
Full Text
View/download PDF

37. Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination

Author

Vodovar, Dominique, primary, Duchêne, Adeline, additional, Wimberley, Catriona, additional, Leroy, Claire, additional, Pottier, Géraldine, additional, Dauvilliers, Yves, additional, Giaume, Christian, additional, Lin, Jian-Sheng, additional, Mouthon, Franck, additional, Tournier, Nicolas, additional, and Charvériat, Mathieu, additional

Published
2018
Full Text
View/download PDF

38. Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities

Author

Rizzo, Gaia, primary, Veronese, Mattia, additional, Tonietto, Matteo, additional, Bodini, Benedetta, additional, Stankoff, Bruno, additional, Wimberley, Catriona, additional, Lavisse, Sonia, additional, Bottlaender, Michel, additional, Bloomfield, Peter S, additional, Howes, Oliver, additional, Zanotti-Fregonara, Paolo, additional, Turkheimer, Federico E, additional, and Bertoldo, Alessandra, additional

Published
2017
Full Text
View/download PDF

41. Biological parameter estimation for longitudinal imaging in the rodent brain

Author

Wimberley, Catriona

Abstract

The thesis investigates kinetic modelling and parameter estimation techniques for longitudinal imaging studies in pre-clinical PET (positron emission tomography) of the rodent brain. Pre-clinical PET imaging is useful for investigating animal models of disease, and it is possible to follow evolution toward pathology with longitudinal imaging studies. Longitudinal studies require experimental methods that avoid blood sampling. It's also necessary to have methods that will allow the generation of parametric maps and give statistically robust and accurate parameter estimates. The work presented in this thesis aimed to develop, explore and validate parameter estimation methods for longitudinal studies using extensive kinetic modelling and simulation based approaches. Two biological targets were investigated, the D2 dopamine system, and the translocator protein (TSPO), useful for PET imaging as an indicator of neuroinflammation. The first part of the work achieved a robust and accurate data driven method for following changes in parameter estimates or creating parametric maps of the D2 dopamine system with 11C-raclopride. The method was validated for estimating Bavail and appKD in a broad range of experimental conditions. The second part of the thesis focused on the characterisation of TSPO ligands. The binding properties of two lead radiotracers (18F-PBR111 and 18F-PBR102) were compared in a well validated model of neuroinflammation, and found to be similar. The binding parameters of 18F-PBR111 were further characterised in an animal model of epileptogenesis. The studies presented in this thesis explored, developed and validated extensive kinetic modelling techniques and image processing tools for longitudinal imaging studies. The techniques will reliably estimate stable and accurate kinetic parameters, create parametric maps, and be able to detect small changes locally. This will allow researchers to study the progression through all stages of neurodegenerative diseases.

Published
2014

45. Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies.

Author

García-Lorenzo, Daniel, Lavisse, Sonia, Leroy, Claire, Wimberley, Catriona, Bodini, Benedetta, Remy, Philippe, Veronese, Mattia, Turkheimer, Federico, Stankoff, Bruno, and Bottlaender, Michel

Abstract

There is a great need for a non-invasive methodology enabling the quantification of translocator protein overexpression in PET clinical imaging. [18F]DPA-714 has emerged as a promising translocator protein radiotracer as it is fluorinated, highly specific and returned reliable quantification using arterial input function. Cerebellum gray matter was proposed as reference region for simplified quantification; however, this method cannot be used when inflammation involves cerebellum. Here we adapted and validated a supervised clustering (supervised clustering algorithm (SCA)) for [18F]DPA-714 analysis. Fourteen healthy subjects genotyped for translocator protein underwent an [18F]DPA-714 PET, including 10 with metabolite-corrected arterial input function and three for a test–retest assessment. Two-tissue compartmental modelling provided BPND AIF estimates that were compared to either BPND LoganSCA or BPND LoganCRB generated by Logan analysis (using supervised clustering algorithm extracted reference region or cerebellum gray matter). The supervised clustering algorithm successfully extracted a pseudo-reference region with similar reliability using classes that were defined using either all subjects, or separated into HAB and MAB subjects. BPND AIF, BPND LoganSCA and BPND LoganCRB were highly correlated (ICC of 0.91 ± 0.05) but BPND LoganSCA were ∼26% higher and less variable than BPND LoganCRB. Reproducibility was good with 5% variability in the test–retest study. The clustering technique for [18F]DPA-714 provides a simple, robust and reproducible technique that can be used for all neurological diseases. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

46. Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation

Author

Reilhac, Anthonin, primary, Boisson, Frédéric, additional, Wimberley, Catriona, additional, Parmar, Arvind, additional, Zahra, David, additional, Hamze, Hasar, additional, Davis, Emma, additional, Arthur, Andrew, additional, Bouillot, Caroline, additional, Charil, Arnaud, additional, and Grégoire, Marie-Claude, additional

Published
2016
Full Text
View/download PDF

47. In Vivo Measurement of Hippocampal GABAA/cBZR Density with [18F]-Flumazenil PET for the Study of Disease Progression in an Animal Model of Temporal Lobe Epilepsy

Author

Vivash, Lucy, primary, Gregoire, Marie-Claude, additional, Bouilleret, Viviane, additional, Berard, Alexis, additional, Wimberley, Catriona, additional, Binns, David, additional, Roselt, Peter, additional, Katsifis, Andrew, additional, Myers, Damian E., additional, Hicks, Rodney J., additional, O'Brien, Terence J., additional, and Dedeurwaerdere, Stefanie, additional

Published
2014
Full Text
View/download PDF

48. OSSI-PET: Open-Access Database of Simulated [^11C]Raclopride Scans for the Inveon Preclinical PET Scanner: Application to the Optimization of Reconstruction Methods for Dynamic Studies.

Author

Garcia, Marie-Paule, Charil, Arnaud, Callaghan, Paul, Wimberley, Catriona, Busso, Florian, Gregoire, Marie-Claude, Bardies, Manuel, and Reilhac, Anthonin

Subjects
DIAGNOSTIC imaging, IMAGE reconstruction, POSITRON emission tomography, PHARMACOKINETICS, TOMOGRAPHY image quality, MONTE Carlo method, MATHEMATICAL optimization
Abstract

A wide range of medical imaging applications benefits from the availability of realistic ground truth data. In the case of positron emission tomography (PET), ground truth data is crucial to validate processing algorithms and assessing their performances. The design of such ground truth data often relies on Monte-Carlo simulation techniques. Since the creation of a large dataset is not trivial both in terms of computing time and realism, we propose the OSSI-PET database containing 350 simulated [^11C]Raclopride dynamic scans for rats, created specifically for the Inveon pre-clinical PET scanner. The originality of this database lies on the availability of several groups of scans with controlled biological variations in the striata. Besides, each group consists of a large number of realizations (i.e., noise replicates). We present the construction methodology of this database using rat pharmacokinetic and anatomical models. A first application using the OSSI-PET database is presented. Several commonly used reconstruction techniques were compared in terms of image quality, accuracy and variability of the activity estimates and of the computed kinetic parameters. The results showed that OP-OSEM3D iterative reconstruction method outperformed the other tested methods. Analytical methods such as FBP2D and 3DRP also produced satisfactory results. However, FORE followed by OSEM2D reconstructions should be avoided. Beyond the illustration of the potential of the database, this application will help scientists to understand the different sources of noise and bias that can occur at the different steps in the processing and will be very useful for choosing appropriate reconstruction methods and parameters. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results