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263 results on '"Wilson WM"'

1. Advances in coronary stent technology: current expectations and new developments

Author

Wilson WM and Cruden NLM

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

William M Wilson, Nicholas LM CrudenEdinburgh Heart Center, Royal Infirmary of Edinburgh, Edinburgh, United KingdomAbstract: The field of percutaneous coronary intervention has witnessed many advances over the last few decades that have served to make it a safe and effective treatment for patients with angina due to coronary artery disease. Although the development of drug eluting stents has significantly reduced the need for repeat revascularization procedures, in-stent restenosis, stent thrombosis, and an increase in bleeding events related to the prolonged use of dual antiplatelet therapy remain important issues. The quest for the optimal coronary stent continues with numerous recent developments that are designed to further improve clinical outcomes following percutaneous coronary intervention. This review will focus on recent advances in coronary stent technology, including bioabsorbable stents and dedicated bifurcation stents, and discuss developments on the horizon.Keywords: coronary stent, bioabsorbable stent, bifurcation stent

Published
2013

2. End-stage heart failure in congenitally corrected transposition of the great arteries:a multicentre study

Author

van Dissel, AC, Opotowsky, AR, Burchill, LJ, Aboulhosn, J, Grewal, J, Lubert, AM, Antonova, P, Shah, S, Cotts, T, John, AS, Kay, WA, DeZorzi, C, Magalski, A, Han, F, Baker, D, Kay, J, Yeung, ELZB, Vonder Muhll, I, Pylypchuk, S, Kuo, MC, Nicolarsen, J, Sarubbi, B, Fusco, F, Jameson, SM, Cramer, J, Gupta, T, Gallego, P, O'Donnell, C, Hannah, J, Dellborg, M, Kauling, RM, Ginde, S, Krieger, EV, Rodriguez, F, Dehghani, P, Kutty, S, Wong, JS, Wilson, WM, Rodriguez-Monserrate, CP, Roos-Hesselink, J, Celermajer, DS, Khairy, P, Broberg, CS, van Dissel, AC, Opotowsky, AR, Burchill, LJ, Aboulhosn, J, Grewal, J, Lubert, AM, Antonova, P, Shah, S, Cotts, T, John, AS, Kay, WA, DeZorzi, C, Magalski, A, Han, F, Baker, D, Kay, J, Yeung, ELZB, Vonder Muhll, I, Pylypchuk, S, Kuo, MC, Nicolarsen, J, Sarubbi, B, Fusco, F, Jameson, SM, Cramer, J, Gupta, T, Gallego, P, O'Donnell, C, Hannah, J, Dellborg, M, Kauling, RM, Ginde, S, Krieger, EV, Rodriguez, F, Dehghani, P, Kutty, S, Wong, JS, Wilson, WM, Rodriguez-Monserrate, CP, Roos-Hesselink, J, Celermajer, DS, Khairy, P, and Broberg, CS

Abstract

BACKGROUND AND AIMS: For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear. METHODS: This multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained. The composite primary outcome was mechanical circulatory support, heart transplantation, or death. RESULTS: From 558 patients (48% female, age at first visit 36 ± 14.2 years, median follow-up 8.7 years), the event rate of the primary outcome was 15.4 per 1000 person-years (11 mechanical circulatory support implantations, 12 transplantations, and 52 deaths). Patients experiencing the primary outcome were older and more likely to have a history of atrial arrhythmia. The primary outcome was highest in those with both moderate/severe right ventricular (RV) dysfunction and tricuspid regurgitation (n = 110, 31 events) and uncommon in those with mild/less RV dysfunction and tricuspid regurgitation (n = 181, 13 events, P < .001). Outcomes were not different based on anatomic complexity and history of tricuspid valve surgery or of subpulmonic obstruction. New CHF admission or ventricular arrhythmia was associated with the primary outcome. Individuals who underwent childhood surgery had more adverse outcomes than age- and sex-matched controls. Multivariable Cox regression analysis identified older age, prior CHF admission, and severe RV dysfunction as independent predictors for the primary outcome. CONCLUSIONS: Patients with ccTGA have variable deterioration to end-stage heart failure or death over time, commonly between their fifth and sixth decades. Predictors include arrhythmic and CHF events and severe RV dysfunction but not anatomy or need for tricuspid valve surgery.

Published
2023

3. Views of Our Readers

Author

Holdaway, Ronald M., Zurkuhlen, Paul R., Azores, Anthony L., Miller, Thomas R., Williams, John R., Iafrate, Jerry C., Shaw, William R., Oehler, Terry D., Meriam,, Harold A., Reuter, Arthur C., Middendorf, Anne Bradley, Chapman, Howard L., Diamond, Hymen, Malmsten, Albert C., Clennan, John F., Rowe, James W., Marshall, Dan, Glover, Voyle, and Wilson,, Wm. R.

Published
1977

7. Wm. C. Wilson's trade circular of wholesale prices for the spring of 1872.

Author

Henry G. Gilbert Nursery and Seed Trade Catalog Collection, Wilson, Wm. C. nurseryman, U.S. Department of Agriculture, National Agricultural Library, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, and Wilson, Wm. C. nurseryman

Subjects
Bedding plants, Catalogs, Evergreens, Floriculture, Flowers, Nursery stock
Published
1872

8. Wm. C. Wilson's trade circular of wholesale prices for the spring of 1871.

Author

Wilson, Wm. C. nurseryman, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, U.S. Department of Agriculture, National Agricultural Library, Wilson, Wm. C. nurseryman, and Henry G. Gilbert Nursery and Seed Trade Catalog Collection

Subjects
Catalogs, Nurseries (Horticulture), Nursery stock, Roses, Trees
Published
1871

9. W.C. Wilson's annual descriptive catalogue of new and selected bedding plants, for the spring of 1871, embracing roses, dahlias, fuschias, chrysanthemums, summer climbers, fruit trees, grape vines, small fruits, evergreens, shrubs, &c., &c.

Author

Wilson, Wm. C. nurseryman, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, U.S. Department of Agriculture, National Agricultural Library, Wilson, Wm. C. nurseryman, and Henry G. Gilbert Nursery and Seed Trade Catalog Collection

Subjects
Bedding plants, Catalogs, Floriculture, Flowers, Nursery stock
Published
1871

10. W.C. Wilson's annual catalogue of new and selected bedding plants, roses, dahlies, fuschias, chrysanthemums, summer climbers, fruit trees, grape vines, small fruits, evergreens, shrubs, &c., &c.

Author

Henry G. Gilbert Nursery and Seed Trade Catalog Collection, Wilson, Wm. C. nurseryman, U.S. Department of Agriculture, National Agricultural Library, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, and Wilson, Wm. C. nurseryman

Subjects
Bedding plants, Catalogs, Floriculture, Flowers, Nursery stock
Published
1869

13. Reply Briefs

Author

Evans, Don and Wilson, Wm. R.

Published
1982

25. In vivo measurement of extracellular serotonin in the ventral hippocampus during treadmill running

Author

Wilson Wm and Marsden Ca

Subjects
Pharmacology, medicine.medical_specialty, Microdialysis, business.industry, Anatomy, Hippocampal formation, Psychiatry and Mental health, Treadmill running, Endocrinology, In vivo, Internal medicine, medicine, Extracellular, Hippocampus (mythology), Serotonin, Treadmill, business
Abstract

The present study used the microdialysis technique to investigate the effect of treadmill running, without the use of an electric grid, on extracellular serotonin in the ventral hippocampus of male Lister hooded rat. Extracellular hippocampal serotonin was measured during 60min of treadmill running at 20m/min and compared with control animals who were placed on the stationary treadmill for 60min. The exercised animals had been habituated to the treadmill and trained for 4-5 weeks so as to be able to run for 60min, while the control animals had been placed on the stationary treadmill as frequently and for the same length of time as the exercising group. Extracellular hippocampal serotonin was higher (p < 0.05) during the first 40min of exercise than after 40min of being placed on the stationary treadmill, but this increase occurred only in those animals that learned more slowly and ran a shorter distance (1030+/-30m) and not in those that learned more rapidly and ran further (1150+/-20m).

Published
1996
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30. Immunogenicity in dogs of three recombinant antigens (TSA, LeIF and LmSTI1) potential vaccine candidates for canine visceral leishmaniasis

Author

Fujiwara, Ricardo RTF, Vale, André AMV, Silva, João JCF França da, Costa, Roberto RTd da, Quetz, Josiane JdS Silva, Filho, Olindo OAM Martins, Reis, Alexandre ABR, Oliveira, Rodrigo RCO, Coelho, George GLM Machado, Bueno, Lilian LLB, Bethony, Jeffrey JMB, Frank, Glen GF, Nascimento, Evaldo EN, Genaro, Odair OG, Mayrink, Wilson WM, Reed, Steven SR, and Neto, Antonio ACN

Abstract

Control of canine visceral leishmaniasis (VL) remains a difficult and serious problem mostly because there is no reliable and effective vaccine available to prevent this disease. A mixture of three recombinant leishmanial antigens (TSA, LeIF and LmSTI1) encoded by three genes highly conserved in the Leishmania genus have been shown to induce excellent protection against infection in both murine and simian models of cutaneous leishmaniasis. A human clinical trial with these antigens is currently underway. Because of the high degree of conservation, these antigens might be useful vaccine candidates for VL as well. In the present study, using the dog model of the visceral disease, we evaluated the immunogenicity of these three antigens formulated with two different adjuvants, MPL-SE® and AdjuPrime®. The results were compared with a whole parasite vaccine formulated with BCG as the adjuvant. In order to investigate if sensitization with the recombinant antigens would result in recognition of the corresponding native parasite antigens upon infection, the animals were exposed for four weeks after the termination of the immunization protocol with the recombinant antigens to a low number of L. chagasi promastigotes, an etiological agent of VL. Immune response was evaluated by quantitative ELISA in the animal sera before and after exposure to the viable parasites. Both antigen specific IgG1 and IgG2 antibody levels were measured. Immunization of dogs with the recombinant antigens formulated in either MPL-SE® or AdjuPrime® resulted in high antibody levels particularly to LmSTI1. In addition, this immunization although to low levels, resulted in the development of antibody response to the whole parasite lysate. Importantly, experimental exposure with low numbers of culture forms of L. chagasi promastigotes caused a clear boost in the immune response to both the recombinant antigens and the corresponding native molecules. The boost response was predominantly of the IgG2 isotype in animals primed with the recombinant antigens plus MPL-SE®. In contrast, animals primed with the recombinant antigens formulated in AdjuPrime® as well as animals vaccinated with crude antigen preparation responded with mixed IgG1/IgG2 isotypes. These results point to the possible use of this antigen cocktail formulated with the adjuvant MPL-SE® in efficacy field trials against canine VL.

Published
2005
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32. The Diet Factor in Pellagra.

Author

Wilson, WM. H.

Abstract

This subject has been dealt with by so many investigators and, within recent years in the United States, in such minute detail that it would seem surprising that no definite conclusion has yet been reached as to the cause of the disease or the actual part played by the diet in bringing about the condition. [ABSTRACT FROM PUBLISHER]

Published
1921
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