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2. Using Overlap Weights to Address Extreme Propensity Scores in Estimating Restricted Mean Counterfactual Survival Times

Author

Cao, Zhiqiang, Ghazi, Lama, Mastrogiacomo, Claudia, Forastiere, Laura, Wilson, F. Perry, and Li, Fan

Subjects
Statistics - Methodology
Abstract

While the inverse probability of treatment weighting (IPTW) is a commonly used approach for treatment comparisons in observational data, the resulting estimates may be subject to bias and excessively large variance when there is lack of overlap in the propensity score distributions. By smoothly down-weighting the units with extreme propensity scores, overlap weighting (OW) can help mitigate the bias and variance issues associated with IPTW. Although theoretical and simulation results have supported the use of OW with continuous and binary outcomes, its performance with right-censored survival outcomes remains to be further investigated, especially when the target estimand is defined based on the restricted mean survival time (RMST)-a clinically meaningful summary measure free of the proportional hazards assumption. In this article, we combine propensity score weighting and inverse probability of censoring weighting to estimate the restricted mean counterfactual survival times, and propose computationally-efficient variance estimators. We conduct simulations to compare the performance of IPTW, trimming, and OW in terms of bias, variance, and 95% confidence interval coverage, under various degrees of covariate overlap. Regardless of overlap, we demonstrate the advantage of OW over IPTW and trimming methods in bias, variance, and coverage when the estimand is defined based on RMST.

Published
2023

4. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis

Author

Barsotti, Gabriel C., Luciano, Randy, Kumar, Ashwani, Meliambro, Kristin, Kakade, Vijayakumar, Tokita, Joji, Naik, Abhijit, Fu, Jia, Peck, Elizabeth, Pell, John, Reghuvaran, Anand, Tanvir, E.M., Patel, Prashant, Zhang, Weijia, Li, Fan, Moeckel, Gilbert, Perincheri, Sudhir, Cantley, Lloyd, Moledina, Dennis G., Wilson, F. Perry, He, John C., and Menon, Madhav C.

Published
2024
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11. Corrigendum: Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

Author

Moledina, Dennis G., Obeid, Wassim, Smith, Rex N., Rosales, Ivy, Sise, Meghan E., Moeckel, Gilbert, Kashgarian, Michael, Kuperman, Michael, Campbell, Kirk N., Lefferts, Sean, Meliambro, Kristin, Bitzer, Markus, Perazella, Mark A., Luciano, Randy L., Pober, Jordan S., Cantley, Lloyd G., Colvin, Robert B., Wilson, F. Perry, and Parikh, Chirag R.

Subjects
Proteins, Kidney diseases -- Diagnosis, Health care industry
Abstract

In the abstract and the legend for Figure 1, the descriptions of the Olink Proteomics assays utilized were incorrect. The correct descriptions appear below. The HTML and PDF versions of [...]

Published
2024
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12. Empagliflozin in Heart Failure: Regional Nephron Sodium Handling Effects

Author

Rao, Veena S., Ivey-Miranda, Juan B., Cox, Zachary L., Moreno-Villagomez, Julieta, Maulion, Christopher, Bellumkonda, Lavanya, Chang, John, Field, M. Paul, Wiederin, Daniel R., Butler, Javed, Collins, Sean P., Turner, Jeffrey M., Wilson, F. Perry, Inzucchi, Silvio E., Wilcox, Christopher S., Ellison, David H., and Testani, Jeffrey M.

Published
2024
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14. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States

Author

Flythe, Jennifer E, Assimon, Magdalene M, Tugman, Matthew J, Chang, Emily H, Gupta, Shruti, Shah, Jatan, Sosa, Marie Anne, Renaghan, Amanda DeMauro, Melamed, Michal L, Wilson, F Perry, Neyra, Javier A, Rashidi, Arash, Boyle, Suzanne M, Anand, Shuchi, Christov, Marta, Thomas, Leslie F, Edmonston, Daniel, Leaf, David E, Walther, Carl P, Anumudu, Samaya J, Arunthamakun, Justin, Kopecky, Kathleen F, Milligan, Gregory P, McCullough, Peter A, Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L, Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D, Waikar, Sushrut S, Kibbelaar, Zoe A, Athavale, Ambarish M, Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A, Shea, Lisa, Edmonston, Daniel L, Mosher, Christopher L, Shehata, Alexandre M, Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K, Walters, Patricia, Go, Ronaldo C, Rose, Keith M, Chan, Lili, Mathews, Kusum S, Coca, Steven G, Altman, Deena R, Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A, Wang, Jing G, Mosoyan, Gohar, Nadkarni, Girish N, Pattharanitima, Pattharawin, Gallagher, Emily J, Friedman, Allon N, Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J, Parikh, Chirag R, Garibaldi, Brian T, Corona-Villalobos, Celia P, Wen, Yumeng, Menez, Steven, Malik, Rubab F, Cervantes, Carmen Elena, Gautam, Samir C, Mallappallil, Mary C, Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H Bryant, Ahoubim, Afshin, Kashani, Kianoush, Tehranian, Shahrzad, Sirganagari, Dheeraj Reddy, Guru, Pramod K, and Zhou, Yan

Subjects
Clinical Research, Cardiovascular, Clinical Trials and Supportive Activities, Kidney Disease, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Renal and urogenital, Good Health and Well Being, Aged, COVID-19, Comorbidity, Critical Illness, Female, Hospital Mortality, Humans, Intensive Care Units, Kidney Function Tests, Male, Renal Dialysis, Renal Insufficiency, Chronic, Retrospective Studies, Risk Factors, SARS-CoV-2, Treatment Outcome, United States, STOP-COVID Investigators, COVID-19 outcome, Coronavirus disease 2019, altered mental status, chronic kidney disease, clinical course, clinical trajectory, critical illness, dialysis, end-stage kidney disease, end-stage renal disease, glomerular filtration rate, in-hospital mortality, intensive care unit, prognosis, renal function, severe COVID-19, severe acute respiratory syndrome coronavirus 2, Clinical Sciences, Public Health and Health Services, Urology & Nephrology
Abstract

Rationale & objectiveUnderlying kidney disease is an emerging risk factor for more severe coronavirus disease 2019 (COVID-19) illness. We examined the clinical courses of critically ill COVID-19 patients with and without pre-existing chronic kidney disease (CKD) and investigated the association between the degree of underlying kidney disease and in-hospital outcomes.Study designRetrospective cohort study.Settings & participants4,264 critically ill patients with COVID-19 (143 patients with pre-existing kidney failure receiving maintenance dialysis; 521 patients with pre-existing non-dialysis-dependent CKD; and 3,600 patients without pre-existing CKD) admitted to intensive care units (ICUs) at 68 hospitals across the United States.Predictor(s)Presence (vs absence) of pre-existing kidney disease.Outcome(s)In-hospital mortality (primary); respiratory failure, shock, ventricular arrhythmia/cardiac arrest, thromboembolic events, major bleeds, and acute liver injury (secondary).Analytical approachWe used standardized differences to compare patient characteristics (values>0.10 indicate a meaningful difference between groups) and multivariable-adjusted Fine and Gray survival models to examine outcome associations.ResultsDialysis patients had a shorter time from symptom onset to ICU admission compared to other groups (median of 4 [IQR, 2-9] days for maintenance dialysis patients; 7 [IQR, 3-10] days for non-dialysis-dependent CKD patients; and 7 [IQR, 4-10] days for patients without pre-existing CKD). More dialysis patients (25%) reported altered mental status than those with non-dialysis-dependent CKD (20%; standardized difference=0.12) and those without pre-existing CKD (12%; standardized difference=0.36). Half of dialysis and non-dialysis-dependent CKD patients died within 28 days of ICU admission versus 35% of patients without pre-existing CKD. Compared to patients without pre-existing CKD, dialysis patients had higher risk for 28-day in-hospital death (adjusted HR, 1.41 [95% CI, 1.09-1.81]), while patients with non-dialysis-dependent CKD had an intermediate risk (adjusted HR, 1.25 [95% CI, 1.08-1.44]).LimitationsPotential residual confounding.ConclusionsFindings highlight the high mortality of individuals with underlying kidney disease and severe COVID-19, underscoring the importance of identifying safe and effective COVID-19 therapies in this vulnerable population.

Published
2021

15. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19

Author

Deng, Jie, Atta, Mo, Bagnasco, Serena M., Ko, Albert, Iwasaki, Akiko, Farhadian, Shelli, Nelson, Allison, Casanovas-Massana, Arnau, White, Elizabeth B., Schulz, Wade, Coppi, Andreas, Young, Patrick, Nunez, Angela, Shepard, Denise, Matos, Irene, Strong, Yvette, Anastasio, Kelly, Brower, Kristina, Kuang, Maxine, Chiorazzi, Michael, Bermejo, Santos, Vijayakumar, Pavithra, Geng, Bertie, Fournier, John, Minasyan, Maksym, Muenker, M. Catherine, Moore, Adam J., Nadkarni, Girish, Menez, Steven, Coca, Steven G., Moledina, Dennis G., Wen, Yumeng, Chan, Lili, Thiessen-Philbrook, Heather, Obeid, Wassim, Garibaldi, Brian T., Azeloglu, Evren U., Ugwuowo, Ugochukwu, Sperati, C. John, Arend, Lois J., Rosenberg, Avi Z., Kaushal, Madhurima, Jain, Sanjay, Wilson, F. Perry, and Parikh, Chirag R.

Published
2023
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16. Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study.

Author

Hsu, Raymond K, Hsu, Chi-Yuan, McCulloch, Charles E, Yang, Jingrong, Anderson, Amanda H, Chen, Jing, Feldman, Harold I, He, Jiang, Liu, Kathleen D, Navaneethan, Sankar D, Porter, Anna C, Rahman, Mahboob, Tan, Thida C, Wilson, F Perry, Xie, Dawei, Zhang, Xiaoming, Go, Alan S, and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators

Subjects
Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, acute kidney injury, chronic kidney disease, epidemiology, risk factor, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Abstract

Background:Observational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression. However, prior reports lacked uniform collection of important confounders such as proteinuria and pre-AKI kidney function trajectory, and may be susceptible to ascertainment bias, as patients may be more likely to undergo kidney function testing after AKI. Methods:We studied 444 adults with CKD who participated in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study and were concurrent members of a large integrated healthcare delivery system. We estimated glomerular filtration rate (eGFR) trajectories using serum creatinine measurements from (i) the CRIC research protocol (yearly) and (ii) routine clinical care. We used linear mixed effects models to evaluate the associations of AKI with acute absolute change in eGFR and post-AKI eGFR slope, and explored whether these varied by source of creatinine results. Models were adjusted for demographic characteristics, diabetes status and albuminuria. Results:During median follow-up of 8.5 years, mean rate of eGFR loss was -0.31 mL/min/1.73 m2/year overall, and 73 individuals experienced AKI (55% Stage 1). A significant interaction existed between AKI and source of serum creatinine for acute absolute change in eGFR level after discharge; in contrast, AKI was independently associated with a faster rate of eGFR decline (mean additional loss of -0.67 mL/min/1.73 m2/year), which was not impacted by source of serum creatinine. Conclusions:AKI is independently associated with subsequent steeper eGFR decline regardless of the serum creatinine source used, but the strength of association is smaller than observed in prior studies after taking into account key confounders such as pre-AKI eGFR slope and albuminuria.

Published
2020

18. Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study

Author

Miano, Todd A., Hennessy, Sean, Yang, Wei, Dunn, Thomas G., Weisman, Ariel R., Oniyide, Oluwatosin, Agyekum, Roseline S., Turner, Alexandra P., Ittner, Caroline A. G., Anderson, Brian J., Wilson, F. Perry, Townsend, Raymond, Reilly, John P., Giannini, Heather M., Cosgriff, Christopher V., Jones, Tiffanie K., Meyer, Nuala J., and Shashaty, Michael G. S.

Published
2022
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19. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery

Author

Mansour, Sherry G, Zhang, William R, Moledina, Dennis G, Coca, Steven G, Jia, Yaqi, Thiessen-Philbrook, Heather, McArthur, Eric, Inoue, Kazunori, Koyner, Jay L, Shlipak, Michael G, Wilson, F Perry, Garg, Amit X, Ishibe, Shuta, Parikh, Chirag R, and Consortium, TRIBE-AKI

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Clinical Research, Kidney Disease, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Aged, Biomarkers, Cardiac Surgical Procedures, Creatinine, Endpoint Determination, Female, Humans, Kidney, Male, Middle Aged, Neovascularization, Physiologic, Outcome Assessment, Health Care, Postoperative Complications, Prospective Studies, Receptors, Vascular Endothelial Growth Factor, Risk Assessment, United States, Vascular Endothelial Growth Factor A, TRIBE-AKI Consortium, AKI duration, Acute kidney injury, VEGF-A, angiogenesis, angiogenic growth factor, biomarker, cardiac surgery, cytokine, mortality, placental growth factor, soluble VEGF receptor 1, vascular endothelial growth factor A, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale & objectiveThe process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.Study designProspective cohort.Setting & participants1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.ExposuresPlasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.OutcomesAKI, long AKI duration (≥7 days), and 1-year all-cause mortality.Analytical approachMultivariable logistic regression.ResultsFollowing cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).LimitationsAngiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.ConclusionsHigher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality.

Published
2019

22. Multiscale PHATE identifies multimodal signatures of COVID-19

Author

Kuchroo, Manik, Huang, Jessie, Wong, Patrick, Grenier, Jean-Christophe, Shung, Dennis, Tong, Alexander, Lucas, Carolina, Klein, Jon, Burkhardt, Daniel B., Gigante, Scott, Godavarthi, Abhinav, Rieck, Bastian, Israelow, Benjamin, Simonov, Michael, Mao, Tianyang, Oh, Ji Eun, Silva, Julio, Takahashi, Takehiro, Odio, Camila D., Casanovas-Massana, Arnau, Fournier, John, Farhadian, Shelli, Dela Cruz, Charles S., Ko, Albert I., Hirn, Matthew J., Wilson, F. Perry, Hussin, Julie G., Wolf, Guy, Iwasaki, Akiko, and Krishnaswamy, Smita

Published
2022
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25. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19

Author

Ko, Albert, Iwasaki, Akiko, Farhadian, Shelli, Nelson, Allison, Casanovas-Massana, Arnau, White, Elizabeth B., Schulz, Wade, Coppi, Andreas, Young, Patrick, Nunez, Angela, Shepard, Denise, Matos, Irene, Strong, Yvette, Anastasio, Kelly, Brower, Kristina, Kuang, Maxine, Chiorazzi, Michael, Bermejo, Santos, Vijayakumar, Pavithra, Geng, Bertie, Fournier, John, Minasyan, Maksym, Muenker, M. Catherine, Moore, Adam J., Nadkarni, Girish, Menez, Steven, Moledina, Dennis G., Thiessen-Philbrook, Heather, Wilson, F. Perry, Obeid, Wassim, Simonov, Michael, Yamamoto, Yu, Corona-Villalobos, Celia P., Chang, Crystal, Garibaldi, Brian T., Clarke, William, Dela Cruz, Charles, Coca, Steven G., and Parikh, Chirag R.

Published
2022
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26. Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF)

Author

Ghazi, Lama, Desai, Nihar R., Simonov, Michael, Yamamoto, Yu, O'Connor, Kyle D., Riello, Ralph J., Huang, Joanna, Olufade, Temitope, McDermott, James, Inzucchi, Silvio E., Velazquez, Eric J., Wilson, F. Perry, and Ahmad, Tariq

Published
2022
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30. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

Author

Moledina, Dennis G., Obeid, Wassim, Smith, Rex N., Rosales, Ivy, Sise, Meghan E., Moeckel, Gilbert, Kashgarian, Michael, Kuperman, Michael, Campbell, Kirk N., Lefferts, Sean, Meliambro, Kristin, Bitzer, Markus, Perazella, Mark A., Luciano, Randy L., Pober, Jordan S., Cantley, Lloyd G., Colvin, Robert B., Wilson, F. Perry, and Parikh, Chirag R.

Subjects
Nephritis -- Diagnosis -- Development and progression, Biological markers -- Physiological aspects -- Health aspects -- Identification and classification, Chemokines -- Physiological aspects -- Health aspects -- Identification and classification, Health care industry
Abstract

BACKGROUND. Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis- specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be delayed, missed, or incorrectly assumed. Here, we identify and validate urinary CXCL9, an IFN-[gamma]-induced chemokine involved in lymphocyte chemotaxis, as a diagnostic biomarker for AIN. METHODS. In a prospectively enrolled cohort with pathologist-adjudicated histological diagnoses, termed the discovery cohort, we tested the association of 180 immune proteins measured by an aptamer- based assay with AIN and validated the top protein, CXCL9, using sandwich immunoassay. We externally validated these findings in 2 cohorts with biopsy- confirmed diagnoses, termed the validation cohorts, and examined mRNA expression differences in kidney tissue from patients with AIN and individuals in the control group. RESULTS. In aptamer-based assay, urinary CXCL9 was 7.6-fold higher in patients with AIN than in individuals in the control group (P = 1.23 * [10.sup.-5]). Urinary CXCL9 measured by sandwich immunoassay was associated with AIN in the discovery cohort (n = 204; 15% AIN) independently of currently available clinical tests for AIN (adjusted odds ratio for highest versus lowest quartile: 6.0 [1.8-20]). Similar findings were noted in external validation cohorts, where CXCL9 had an AUC of 0.94 (0.86-1.00) for AIN diagnosis. CXCL9 mRNA expression was 3.9-fold higher in kidney tissue from patients with AIN (n = 19) compared with individuals in the control group (n = 52; P = 5.8 * [10.sup.-6]). CONCLUSION. We identified CXCL9 as a diagnostic biomarker for AIN using aptamer- based urine proteomics, confirmed this association using sandwich immunoassays in discovery and external validation cohorts, and observed higher expression of this protein in kidney biopsies from patients with AIN. FUNDING. This study was supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awards K23DK117065 (DGM), K08DK113281 (KM), R01DK128087 (DGM), R01DK126815 (DGM and LGC), R01DK126477 (KNC), UH3DK114866 (CRP, DGM, and FPW), R01DK130839 (MES), and P30DK079310 (the Yale O'Brien Center). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health., Introduction Sudden loss of kidney function, termed acute kidney injury (AKI), is common, affecting 1 in 5 hospitalized patients and is associated with adverse long-term outcomes, including chronic kidney disease, [...]

Published
2023
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33. Mechanistic Differences between Torsemide and Furosemide

Author

Rao, Veena S., Cox, Zachary L., Ivey-Miranda, Juan B., Neville, Daniel, Balkcom, Natasha, Moreno-Villagomez, Julieta, Ramos-Mastache, Daniela, Maulion, Christopher, Bellumkonda, Lavanya, Tang, W.H. Wilson, Collins, Sean P., Velazquez, Eric J., Mentz, Robert J., Wilson, F. Perry, Turner, Jeffrey M., Wilcox, Christopher S., Ellison, David H., Fang, James C., and Testani, Jeffrey M.

Published
2025
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34. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study

Author

Moledina, Dennis G., Simonov, Michael, Yamamoto, Yu, Alausa, Jameel, Arora, Tanima, Biswas, Aditya, Cantley, Lloyd G., Ghazi, Lama, Greenberg, Jason H., Hinchcliff, Monique, Huang, Chenxi, Mansour, Sherry G., Martin, Melissa, Peixoto, Aldo, Schulz, Wade, Subair, Labeebah, Testani, Jeffrey M., Ugwuowo, Ugochukwu, Young, Patrick, and Wilson, F. Perry

Published
2021
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35. A neutrophil activation signature predicts critical illness and mortality in COVID-19

Author

Meizlish, Matthew L., Pine, Alexander B., Bishai, Jason D., Goshua, George, Nadelmann, Emily R., Simonov, Michael, Chang, C-Hong, Zhang, Hanming, Shallow, Marcus, Bahel, Parveen, Owusu, Kent, Yamamoto, Yu, Arora, Tanima, Atri, Deepak S., Patel, Amisha, Gbyli, Rana, Kwan, Jennifer, Won, Christine H., Dela Cruz, Charles, Price, Christina, Koff, Jonathan, King, Brett A., Rinder, Henry M., Wilson, F. Perry, Hwa, John, Halene, Stephanie, Damsky, William, van Dijk, David, Lee, Alfred I., and Chun, Hyung J.

Published
2021
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36. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States

Author

Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Kashani, Kianoush, Tehranian, Shahrzad, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Thakkar, Jyotsana, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner M.B., Avasare, Rupali S., Zonies, David, Leaf, David E., Gupta, Shruti, Sise, Meghan E., Newman, Erik T., Abu Omar, Samah, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta, Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V., Ali, Muhammad Imran, Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Reagan, Ronald, Chang, Steven Y., Beutler, Rebecca M., Monica, Santa, Schulze, Carl E., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Kunczt, Alissa, Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Dy, Rajany, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, Hayer, Patrick O’, Meloche, Chelsea, Feroze, Rafey, Kaakati, Rayan, Perry, Danny, Bitar, Abbas, Anderson, Elizabeth, Padalia, Kishan J., Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Mariyam Joy, Christina, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Weiner, Daniel E., Jose, Aju, Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, Ugwuowo, Ugochukwu, Assimon, Magdalene M., Shah, Jatan, Renaghan, Amanda DeMauro, Wilson, F. Perry, and Edmonston, Daniel

Published
2021
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39. Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Go, Alan S., Townsend, Raymond R., Anderson, Amanda H., Xie, Dawei, Wang, Xue, Baudier, Robin L., Orlandi, Paula, Appel, Lawrence J., Dember, Laura M., He, Jiang, Kusek, John W., Lash, James P., Navaneethan, Sankar D., Ojo, Akinlolu, Rahman, Mahboob, Roy, Jason, Scialla, Julia J., Sondheimer, James H., Steigerwalt, Susan P., Wilson, F. Perry, Wolf, Myles, and Feldman, Harold I.

Published
2021
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42. Optimizing the Design and Analysis of Future AKI Trials

Author

Legrand, Matthieu, Bagshaw, Sean M., Koyner, Jay L., Schulman, Ivonne H., Mathis, Michael R., Bernholz, Juliane, Coca, Steven, Gallagher, Martin, Gaudry, Stéphane, Liu, Kathleen D., Mehta, Ravindra L., Pirracchio, Romain, Ryan, Abigail, Steubl, Dominik, Stockbridge, Norman, Erlandsson, Fredrik, Turan, Alparslan, Wilson, F. Perry, Zarbock, Alexander, Bokoch, Michael P., Casey, Jonathan D., Rossignol, Patrick, and Harhay, Michael O.

Published
2022
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43. Serial direct sodium removal in patients with heart failure and diuretic resistance

Author

Rao, Veena S., primary, Ivey‐Miranda, Juan B., additional, Cox, Zachary L., additional, Moreno‐Villagomez, Julieta, additional, Ramos‐Mastache, Daniela, additional, Neville, Daniel, additional, Balkcom, Natasha, additional, Asher, Jennifer L., additional, Bellumkonda, Lavanya, additional, Bigvava, Tamar, additional, Shaburishvili, Tamaz, additional, Bartunek, Jozef, additional, Wilson, F. Perry, additional, Finkelstein, Fredrick, additional, Maulion, Christopher, additional, Turner, Jeffrey M., additional, and Testani, Jeffrey M., additional

Published
2024
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44. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

Author

Moledina, Dennis G., primary, Obeid, Wassim, additional, Smith, Rex N., additional, Rosales, Ivy, additional, Sise, Meghan E., additional, Moeckel, Gilbert, additional, Kashgarian, Michael, additional, Kuperman, Michael, additional, Campbell, Kirk N., additional, Lefferts, Sean, additional, Meliambro, Kristin, additional, Bitzer, Markus, additional, Perazella, Mark A., additional, Luciano, Randy L., additional, Pober, Jordan S., additional, Cantley, Lloyd G., additional, Colvin, Robert B., additional, Wilson, F. Perry, additional, and Parikh, Chirag R., additional

Published
2024
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50. Protein N-Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease

Author

Veličković, Dušan, Shapiro, John P., Parikh, Samir V., Rovin, Brad, Toto, Robert D., Vazquez, Miguel A., Poggio, Emilio D., O'Toole, John F., Sedor, John R., Alexandrov, Theodore, Jain, Sanjay, Bitzer, Markus, Hodgin, Jeffrey, Veličković, Marija, Sharma, Kumar, Anderton, Christopher R., Adeyi, Oyedele A., Alakwaa, Fadhl, Alexandrov, Theodore, Allen, Jamie L., Alpers, Charles E., Alvear, Alison Bunio, Ambekar, Akhil, Ancheta, Joed, Anderton, Christopher R., Angus, Sophia A., Anjani, Kavya, Appelbaum, Paul S., Ardayfio, Joseph, Arora, Tanima, Ascani, Heather K., Asghari, Mahla, El-Achkar, Tarek M., Athar, Humra, Atta, Mohamed G., Aulisio, Mark P., Aw, Stephanie J., Azeloglu, Evren U., Bagne, Cathy A., Balderes, Olivia, Balis, Ulysses G.J., Barasch, Jonathan, Barisoni, Laura, Barwinska, Daria, Basta, Jeannine, Bebiak, Jack, Beck, Laurence H., Berge, Jerica M., Berglund, Ashley C., Bernard, Lauren, Berry, Brooke, Beyda, David H., Bhanushali, Jini Ashok, Bitzer, Markus, Bjornstad, Petter, Blanc, Victoria M., Blank, Kristina N., Bledsoe, Sharon B., Bogen, Steve, Bomback, Andrew S., Bonevich, Nikole, Border, Samuel, Börner, Katy, Bowen, William S., Boys, Charlotte, Bracamonte, Erika R., Bream, Peter R., Brosius, Frank C., Brown, Keith D., Budiman, Tifanny, Bueckle, Andreas, Bui, J.T., James, T., Burg, Ashley R., Burgess, Adam, Bush, Lakeshia, Bush, William S., Cai, Qi, Calixte, Marie Florence, Cameron-Wheeler, Tashas, Campbell, Kirk N, Campbell, Taneisha, Campbell, Catherine, Campos, Baltazar, Canetta, Pietro A., Cantley, Lloyd G, Caramori, M. Luiza, Carmona-Powell, Eunice, Carson, Jonas M, Chan, Lili, Chen, Sarah W, Chen, Yijiang, Cheng, Ying-Hua, Bejarano, Maria Chilo, Choe, Kisurb, Cimino, James G., Coca, Steven G., Coleman, Alyson, Colley, Madeline E., Collie, Mary M., Colona, Mia R., Commander, Clayton W., Conlon, Kristine, Conser, Ninive, Cooperman, Leslie, Corona-Villalobos, Celia P., Crawford, Dana C., Creger, Nathan, Cuevas-Rios, Yarieli, D'Agati, Vivette ., Dagher, Pierre c., de Boer, Ian H., de Caestecker, M.P, de Cos, Marina, Gonçalves, Joana P., Dekker, Matthew, Demeke, Dawit, Dighe, Ashveena L, Ding, Yanli, Djambazova, Katerina V., Donohoe, Isabel, Dowd, Frederick, Drawz, P.E., Dufresne, Martin, Dull, Rachel, Dunn, Kenneth W., Duran, Daniel Damian, Eadon, Michael T, Eddy, Sean, Elder, Michele M, Fallegger, Robin, Farrow, Melissa A, Ferkowicz, Michael, Fine, Derek M., Flanagan, Siobhan M., Fogo, Agnes B., Fox, Monica L., Frey, Renee, Froment, Anne, Gaba, Ron C., Gadegbeku, Crystal A, Gaut, Joseph P., Gehlenborg, Nils, Geraghty, Molly C, Ghag, Reetika, Gilliam, Matthew, Ginley, Brandon, Gisch, Debora, Gordon, Ronald E., Gorman, Brittney L., Greka, Anna, Grewenow, Stephanie M., Gurung, Bhupendra Kumar, Guthrie, Leah, Hacohen, Nir, Haddad, Samuel, Hall, Daniel E., Hansen, Jens, Harindhanavudhi, Tasma, Hartman, John, Hayashi, Lynda, Haydak, Jonathan, He, John Cijiang, He, Yongqun, Hedayati, S. Susan, Henderson, Dori, Henderson, Joel M, Hendricks, Allen R, Henshaw, Asari, Herlitz, Leal, Hernandez, Jeanine, Herr, Bruce W., Himmelfarb, Jonathan, Hodgin, Jeffrey B., Hoofnagle, Andrew N, Horowitz, Carol R., Hsieh, E.W.Y., Huynh, Courtney, Iyengar, Ravi, Jain, Sanjay, Janowczyk, Andrew, Jeffers, Vivian, Jefferson, Nichole M., Jennette, J Charles, Johansen, Camille, Jolly, Stacey, Jones, Christopher J., Jones, Jennifer L., Jones, Kiasha, Joyeux, Cienn N., Ju, Wenjun, Judd, Audra M., Kakade, Vijayakumar R, Kakarla, Dhatri, Kaspari, Rachel R., Kaushal, Madhurima, Keefe, Nicole, Keller, Mark S., Kelley, Sara S., Kellum, John A., Kelly, K. J., Kelly, Tanika N., Kermani, Asra, Kiryluk, Krzysztof, Klett, Susan, Knight, Richard A., Knoten, Amanda, Koch, Gina, Koewler, Robert, Kretzler, Matthias, Kruse, Angela R.S., Küchenhoff, Leonie, Lake, Blue B., Lardenoije, Roy, Larson, Astrid, Larson, Brandon G, Lash, James P., Laszik, Zoltan G., Lecker, Stewart H., Lee, Simon C., Lee, Sora, Lefferts, Sean, Li, Xiang, Lienczewski, Chrysta C, Limonte, Christine P, Lucarelli, Nicholas, Lukowski, Jessica, Lutnick, Brendon, Ma, Shihong, Ma, Sisi, Madabhushi, Anant, Maikhor, Shana, Mao, Weiguang, Mariani, Laura H., Markovic, Marina, Marquez, Nicole, Marshall, Jamie L., McAdams, Meredith C, McClelland, Robyn L., McCown, Phillip J., McMahon, Gearoid Michael, McMurray, Amy, Mehl, Karla, Meliambro, Kristin, Ferreira, Ricardo Melo, Mendoza, Katherine, Menez, Steven, Menon, Rajasree, Meza, Natalie, Migas, Lukasz G., Miller, R. Tyler, Mimar, Sayat, Minor, Brittany C, Mody, Priya, Moeckel, Gilbert W., Moledina, D.G., Molina-Guzman, Jenny, Monroy-Trujillo, Jose M, Morales, Alexander, Moreno, Vanessa, Mottl, Amy K., Mukatash, Tariq, Munar, Dane, Murugan, Raghavan, Nachman, Patrick H., Nadkarni, Girish N, Naglah, Ahmed, Nair, Viji, Nam, Yunbi, Narasimhan, R., Nwanne, Gerald, O'Malley, Charles, O'Toole, John F., Toro, Fernanda Ochoa, Oliver, George (Holt), Onul, Ingrid F, Otto, Edgar A., Palevsky, Paul M., Palmer, Ellen, Pamreddy, Annapurna, Parikh, Chirag R., Parikh, Samir V, Park, Christopher, Park, Harold, Paša-Tolić, Ljiljana, Patel, Jiten, Patel, Marissa, Patlis, Boris S., Paul, Anindya S., Phuong, Jimmy, Pillai, Anil, Pinkeney, Roy, Plisiewicz, Alexa, Poggio, Emilio D, Pollack, Ari, Prasad, Pottumarthi V, Pyle, Laura, Quardokus, Ellen M., Quiroga, Arabela, Ragi, Nagarjunachary, Randhawa, Parmjeet, Randle, Teresa, Rao, Via, Rauchman, Michael, Rauwolf, Nicolas J, Reamy, Rebecca, Record, Elizabeth G., Redmond, Devona, Rennke, Helmut, Renteria, Amada, Rezaei, Kasra A, Rhodes, Rosamond, Ricardo, Ana C., Rice, Samuel, Rivera, Marcelino, Roberts, Glenda V., Rosas, R., Sylvia, E., Rose, Michael P., Rosen, Seymour, Rosenberg, Avi Z., Rosenberg, Michael S., Rosengart, Matthew R., Rovin, Brad H., Roy, Neil, Roy-Chaudhury, Prabir, Rubinsky, Melissa D., Sabo, Angela R., Saez-Rodriguez, Julio, Safadi, Sami, Samari, Imane H., Sanora, Ana Celina, Sarder, Pinaki, Sarkisova, Natalya, Sarwal, Minnie M, Saul, John, Saunders, Milda R., Schaub, Jennifer A., Schmidt, IM, Scott, Raymond, Scroggins, Aaron, Sealfon, Rachel S. G., Sedor, John R., Sendrey, Dianna, Setty, Suman, Shah, Sonya, Shariff, Saad Mohammed, Sharma, Kumar, Shaw, Melissa M., Sigdel, Tara K, Silva, Paolo S., Snyder, Jaime, Snyder, Michelle L., Spates-Harden, Kassandra, Sperati, C. John, Spraggins, Jeffrey M., Srivastava, Anand, Stashevsky, Jennifer, Steck, Becky, Stillman, Isaac E, Stutzke, Christy, Subramanian, Lalita, Sun, Jennifer K., Rajan, Sandhya Sundar, Sutton, Timothy A., Taliercio, Jonathan J, Tan, Roderick, Tanevski, Jovan, Thajudeen, Bijin, Thurman, Joshua M., Tokita, Joji, Torrealba, Jose R., Toto, Robert D, Tout, Haneen, Troyanskaya, Olga G, Tsosie, Rebecca, Turner, Jeffrey M, Tuttle, Katherine R., Ugwuowo, Ugochukwu, Upadhyay, Ashish, Valerius, M. Todd, Van de Plas, Raf, Varela, German, Vazquez, Miguel A., Velickovic, Dusan, Venkatachalam, Manjeri, Verdoes, Abraham, Verma, Ashish, Victoria-Castro, Angela M., Vijayan, Anitha, Villalobos, Alexander, Viloria, Noralinda B., Vinovskis, Carissa, Vita, Tina, Waikar, Sushrut S., Wang, Ashley R., Wang, Bangchen, Wang, Nancy, Wang, Ruikang, Wangperawong, Artit, Ward, Stephen C, Warfield, Curtis, Weins, Astrid, Wen, Natasha, Wen, Yumeng, Wilcox, Adam, Williams, James C., Williams, Kayleen, Williams, Mark E., Wilson, F. Perry, Winfree, Seth, Winters, James, Wofford, Stephanie, Wolf, Susan M., Wong, Aaron, Woodhead, Gregory, Wright, Devin M., Wright, Zach, Wright, Zoe, Wrobel, Julia, Xing, Fuyong, Xu, Alan, Yadati, Pranav, Ye, Hongping, Young, Bessie A., Yu, Guanghao, Mon-Wei Yu, Samuel, Zeinoun, Gabriel, Zeitler, Evan M., Zhang, Bo, Zhang, Guanshi, and Zhang, Yi

Published
2024
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