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2. Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial

Author

Chow, Ronald, Ding, Keyue, Ganesh, Vithusha, Meyer, Ralph M., van der Linden, Yvette M., Roos, Daniel, Hartsell, William F., Hoskin, Peter, Wu, Jackson S.Y., Nabid, Abdenour, van Acht, Manouk, Wanders, Rinus, Babington, Scott, Demas, William F., Wilson, Carolyn F., Wong, Rebecca K.S., Brundage, Michael, Zhu, Liting, and Chow, Edward

Published
2018
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3. A prospective study validating the EORTC QLQ-BM22 bone metastases module in patients with painful bone metastases undergoing palliative radiotherapy

Author

Raman, Srinivas, Ding, Keyue, Chow, Edward, Meyer, Ralph M., Nabid, Abdenour, Chabot, Pierre, Coulombe, Genevieve, Ahmed, Shahida, Kuk, Joda, Dar, A. Rashid, Mahmud, Aamer, Fairchild, Alysa, Wilson, Carolyn F., Wu, Jackson S.Y., Dennis, Kristopher, DeAngelis, Carlo, Wong, Rebecca K.S., Zhu, Liting, and Brundage, Michael

Published
2016
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5. Minimal clinically important differences in the EORTC QLQ-BM22 and EORTC QLQ-C15-PAL modules in patients with bone metastases undergoing palliative radiotherapy

Author

Raman, Srinivas, Ding, Keyue, Chow, Edward, Meyer, Ralph M., Nabid, Abdenour, Chabot, Pierre, Coulombe, Genevieve, Ahmed, Shahida, Kuk, Joda, Dar, A. Rashid, Mahmud, Aamer, Fairchild, Alysa, Wilson, Carolyn F., Wu, Jackson S. Y., Dennis, Kristopher, DeAngelis, Carlo, Wong, Rebecca K. S., Zhu, Liting, and Brundage, Michael

Published
2016

6. Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial

Author

Chow, Edward, Meyer, Ralph M, Ding, Keyue, Nabid, Abdenour, Chabot, Pierre, Wong, Philip, Ahmed, Shahida, Kuk, Joda, Dar, A Rashid, Mahmud, Aamer, Fairchild, Alysa, Wilson, Carolyn F, Wu, Jackson S Y, Dennis, Kristopher, Brundage, Michael, DeAngelis, Carlo, and Wong, Rebecca K S

Published
2015
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8. Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial

Author

Ellis, Peter M, Shepherd, Frances A, Millward, Michael, Perrone, Francesco, Seymour, Lesley, Liu, Geoffrey, Sun, Sophie, Cho, Byoung Chul, Morabito, Alessandro, Leighl, Natasha B, Stockler, Martin R, Lee, Christopher W, Wierzbicki, Rafal, Cohen, Victor, Blais, Normand, Sangha, Randeep S, Favaretto, Adolfo G, Kang, Jin Hyoung, Tsao, Ming-Sound, Wilson, Carolyn F, Goldberg, Zelanna, Ding, Keyue, Goss, Glenwood D, and Bradbury, Penelope Ann

Published
2014
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10. Revisiting classification of pain from bone metastases as mild, moderate, or severe based on correlation with function and quality of life

Author

Chow, Edward, Ding, Keyue, Parulekar, Wendy R., Wong, Rebecca K. S., van der Linden, Yvette M., Roos, Daniel, Hartsell, William F., Hoskin, Peter, Wu, Jackson S. Y., Nabid, Abdenour, Ong, Francisca, van Tienhoven, Geertjan, Babington, Scott, Demas, William F., Wilson, Carolyn F., Brundage, Michael, Zhu, Liting, and Meyer, Ralph M.

Published
2016
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11. Violence Against Women: Causes and Prevention. A Literature Search and Annotated Bibliography. Second Edition. Domestic Violence Monograph Series, Number 3.

Author

Wisconsin Univ., Madison. Univ. Extension. Women's Education Resources., National Clearinghouse on Domestic Violence, Rockville, MD., Wilson, Carolyn F., and Clarenbach, Kathryn F.

Abstract

A review of current literature about the causes and prevention of violence against women is presented. The materials focus on the common theme of recognizing the victimization of women at all levels of society and include the following topics: (1) the history of violence and subordination of women, (2) sex role socialization, (3) sexism and the law, (4) women's movement responses to the trauma of abuse, and (5) government responses. The annotated bibliography highlights literature dealing with medical aspects, psychological and psychiatric studies, and sociological perspectives. (JAC)

Published
1980

12. Developing Joint Graduate Programs for Librarians.

Author

Marchant, Maurice P. and Wilson, Carolyn F.

Abstract

Results of questionnaire survey of research library directors concerning M.L.S. joint degree programs indicate that respondents favored joint programs with 15 percent reduced coursework; areas of interest for nonlibrary science degree are hard sciences, other professions, foreign languages; graduates have edge in placement, slightly higher beginning salary, more rapid advancement opportunities. (EJS)

Published
1983

13. Genetic biomarkers associated with changes in quality of life and pain following palliative radiotherapy in patients with bone metastases

Author

Furfari, Anthony, primary, Wan, Bo Angela, additional, Ding, Keyue, additional, Wong, Andrew, additional, Zhu, Liting, additional, Bezjak, Andrea, additional, Wong, Rebecca, additional, Wilson, Carolyn F., additional, DeAngelis, Carlo, additional, Azad, Azar, additional, Chow, Edward, additional, and Charames, George S., additional

Published
2017
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14. Genetic biomarkers associated with response to palliative radiotherapy in patients with painful bone metastases

Author

Furfari, Anthony, primary, Wan, Bo Angela, additional, Ding, Keyue, additional, Wong, Andrew, additional, Zhu, Liting, additional, Bezjak, Andrea, additional, Wong, Rebecca, additional, Wilson, Carolyn F., additional, DeAngelis, Carlo, additional, Azad, Azar, additional, Chow, Edward, additional, and Charames, George S., additional

Published
2017
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15. Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases

Author

Furfari, Anthony, primary, Wan, Bo Angela, additional, Ding, Keyue, additional, Wong, Andrew, additional, Zhu, Liting, additional, Bezjak, Andrea, additional, Wong, Rebecca, additional, Wilson, Carolyn F., additional, DeAngelis, Carlo, additional, Azad, Azar, additional, Chow, Edward, additional, and Charames, George S., additional

Published
2017
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16. Gender differences in pain and patient reported outcomes: a secondary analysis of the NCIC CTG SC. 23 randomized trial

Author

Chow, Selina, primary, Ding, Keyue, additional, Wan, Bo Angela, additional, Brundage, Michael, additional, Meyer, Ralph M., additional, Nabid, Abdenour, additional, Chabot, Pierre, additional, Coulombe, Genevieve, additional, Ahmed, Shahida, additional, Kuk, Joda, additional, Dar, A. Rashid, additional, Mahmud, Aamer, additional, Fairchild, Alysa, additional, Wilson, Carolyn F., additional, Y. Wu, Jackson S., additional, Dennis, Kristopher, additional, DeAngelis, Carlo, additional, S. Wong, Rebecca K., additional, Zhu, Liting, additional, and Chow, Edward, additional

Published
2017
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17. Minimal clinically important differences in the EORTC QLQ-C30 and brief pain inventory in patients undergoing re-irradiation for painful bone metastases

Author

Raman, Srinivas, primary, Ding, Keyue, additional, Chow, Edward, additional, Meyer, Ralph M., additional, van der Linden, Yvette M., additional, Roos, Daniel, additional, Hartsell, William F., additional, Hoskin, Peter, additional, Wu, Jackson S. Y., additional, Nabid, Abdenour, additional, Haas, Rick, additional, Wiggenraad, Ruud, additional, Babington, Scott, additional, Demas, William F., additional, Wilson, Carolyn F., additional, Wong, Rebecca K. S., additional, Zhu, Liting, additional, and Brundage, Michael, additional

Published
2017
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18. Patient Reported Outcomes After Radiation Therapy for Bone Metastases as a Function of Age: A Secondary Analysis of the NCIC CTG SC—Twenty-Three Randomized Trial

Author

Chow, Selina, primary, Ding, Keyue, additional, Wan, Bo Angela, additional, Brundage, Michael, additional, Meyer, Ralph M., additional, Nabid, Abdenour, additional, Chabot, Pierre, additional, Coulombe, Genevieve, additional, Ahmed, Shahida, additional, Kuk, Joda, additional, Dar, A. Rashid, additional, Mahmud, Aamer, additional, Fairchild, Alysa, additional, Wilson, Carolyn F., additional, Wu, Jackson S. Y., additional, Dennis, Kristopher, additional, DeAngelis, Carlo, additional, Wong, Rebecca K. S., additional, Zhu, Liting, additional, and Chow, Edward, additional

Published
2017
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19. Effect of Radiotherapy on Painful Bone Metastases

Author

McDonald, Rachel, primary, Ding, Keyue, additional, Brundage, Michael, additional, Meyer, Ralph M., additional, Nabid, Abdenour, additional, Chabot, Pierre, additional, Coulombe, Genevieve, additional, Ahmed, Shahida, additional, Kuk, Joda, additional, Dar, A. Rashid, additional, Mahmud, Aamer, additional, Fairchild, Alysa, additional, Wilson, Carolyn F., additional, Wu, Jackson S. Y., additional, Dennis, Kristopher, additional, DeAngelis, Carlo, additional, Wong, Rebecca K. S., additional, Zhu, Liting, additional, Chan, Stephanie, additional, and Chow, Edward, additional

Published
2017
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20. B06-C Improved Pain and Quality of Life as Early as Day 10 Following Radiotherapy for Painful Bone Metastases: A Secondary Analysis of the NCIC CTG SC.23 Randomized Trial

Author

McDonald, Rachel, primary, Ding, Keyue, additional, Brundage, Michael, additional, Meyer, Ralph M., additional, Nabid, Abdenour, additional, Chabot, Pierre, additional, Coulombe, Genevieve, additional, Ahmed, Shahida, additional, Kuk, Joda, additional, Dar, A Rashid, additional, Mahmud, Aamer, additional, Fairchild, Alysa, additional, Wilson, Carolyn F., additional, Wu, Jackson SY., additional, Dennis, Kristopher, additional, DeAngelis, Carlo, additional, Wong, Rebecca KS., additional, Zhu, Liting, additional, and Chow, Edward, additional

Published
2016
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21. 250: Minimal Clinically Important Differences in the EORTC QLQ-BM22 and EORTC QLQ-C15-Pal Modules in Patients with Bone Metastases

Author

Raman, Srinivas, primary, Ding, Keyue, additional, Chow, Edward, additional, Meyer, Ralph, additional, Nabid, Abdenour, additional, Chabot, Pierre, additional, Coulombe, Genevieve, additional, Ahmed, Shahida, additional, Kuk, Joda, additional, Dar, A Rashid, additional, Mahmud, Aamer, additional, Fairchild, Alysa, additional, Wilson, Carolyn F., additional, Wu, Jackson S.Y., additional, Dennis, Kristopher, additional, DeAngelis, Carlo, additional, Wong, Rebecca K.S., additional, Zhu, Liting, additional, and Brundage, Michael, additional

Published
2016
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22. Prophylactic dexamethasone for radiation-induced bone-pain flare – Authors' reply

Author

Chow, Edward, primary, Meyer, Ralph M, additional, Ding, Keyue, additional, Nabid, Abdenour, additional, Chabot, Pierre, additional, Wong, Philip, additional, Ahmed, Shahida, additional, Kuk, Joda, additional, Dar, A Rashid, additional, Mahmud, Aamer, additional, Fairchild, Alysa, additional, Wilson, Carolyn F, additional, Wu, Jackson S Y, additional, Dennis, Kristopher, additional, Brundage, Michael, additional, DeAngelis, Carlo, additional, and Wong, Rebecca K S, additional

Published
2016
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23. Patient Reported Outcomes After Radiation Therapy for Bone Metastases as a Function of Age: A Secondary Analysis of the NCIC CTG SC—Twenty-Three Randomized Trial.

Author

Chow, Selina, Ding, Keyue, Wan, Bo Angela, Brundage, Michael, Meyer, Ralph M., Nabid, Abdenour, Chabot, Pierre, Coulombe, Genevieve, Ahmed, Shahida, Kuk, Joda, Dar, A. Rashid, Mahmud, Aamer, Fairchild, Alysa, Wilson, Carolyn F., Wu, Jackson S. Y., Dennis, Kristopher, DeAngelis, Carlo, Wong, Rebecca K. S., Zhu, Liting, and Chow, Edward

Abstract

Purpose: To explore the age difference in response and patient-reported outcomes in patients with cancer having bone metastases undergoing palliative radiotherapy. Methods: Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life (QOL) Bone Metastases module (QLQ-BM22), EORTC QOL Core-15-Palliative (QLQ-C15-PAL), and Dexamethasone Symptom Questionnaire (DSQ) before a single 8-Gy radiation treatment, on days 10 and 42 after treatment. Patient demographics, performance status, analgesic consumption, BM22, C15, and DSQ were compared with multivariant analysis between patients under 75 years and 75 years and older. Multiple linear regression models were used to assess the differences between age-groups, adjusting for baseline demographics and primary disease sites. Results: There were 298 patients (170 male) with 209 (70%) less than 75 years of age. Most common primary cancer sites include lung, prostate, and breast. At baseline, younger patients had better performance status, consumed more analgesic, and reported worse scores in nausea, insomnia, and functional interference, while older patients more commonly had prostate cancer. There were no significant differences in the incidence of radiation-induced pain flare; response to radiation; changes from baseline for BM22, C15-PAL; and DSQ, nor overall survival at day 42 between the 2 groups. Responders to radiation in the elderly group reported better improvement in physical and emotional domains when compared with nonresponders. Conclusions: In patients with cancer having bone metastases undergoing palliative radiotherapy, there was no significant difference in general with age in response to radiation and patient-reported outcomes. Palliative radiotherapy should be offered to elderly patients when needed. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Revisiting classification of pain from bone metastases as mild, moderate, or severe based on correlation with function and quality of life

Author

Chow, Edward, primary, Ding, Keyue, additional, Parulekar, Wendy R., additional, Wong, Rebecca K. S., additional, van der Linden, Yvette M., additional, Roos, Daniel, additional, Hartsell, William F., additional, Hoskin, Peter, additional, Wu, Jackson S. Y., additional, Nabid, Abdenour, additional, Ong, Francisca, additional, van Tienhoven, Geertjan, additional, Babington, Scott, additional, Demas, William F., additional, Wilson, Carolyn F., additional, Brundage, Michael, additional, Zhu, Liting, additional, and Meyer, Ralph M., additional

Published
2015
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25. Impact of Reirradiation of Painful Osseous Metastases on Quality of Life and Function: A Secondary Analysis of the NCIC CTG SC.20 Randomized Trial

Author

Chow, Edward, primary, Meyer, Ralph M., additional, Chen, Bingshu E., additional, van der Linden, Yvette M., additional, Roos, Daniel, additional, Hartsell, William F., additional, Hoskin, Peter, additional, Wu, Jackson S.Y., additional, Nabid, Abdenour, additional, Tissing-Tan, Caroline J.A., additional, Oei, Bing, additional, Babington, Scott, additional, Demas, William F., additional, Wilson, Carolyn F., additional, Wong, Rebecca K.S., additional, and Brundage, Michael, additional

Published
2014
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26. NCIC CTG BR.26: A phase III randomized, double blind, placebo controlled trial of dacomitinib versus placebo in patients with advanced/metastatic non-small cell lung cancer (NSCLC) who received prior chemotherapy and an EGFR TKI.

Author

Ellis, Peter Michael, primary, Liu, Geoffrey, additional, Millward, Michael, additional, Perrone, Francesco, additional, Shepherd, Frances A., additional, Sun, Sophie, additional, Cho, Byoung Chul, additional, Morabito, Alessandro, additional, Stockler, Martin R., additional, Wierzbicki, Rafal, additional, Cohen, Victor, additional, Blais, Normand, additional, Sangha, Randeep S., additional, Favaretto, Adolfo G., additional, Kang, Jin Hyoung, additional, Wilson, Carolyn F., additional, O'Connell, Joseph, additional, Ding, Keyue, additional, Goss, Glenwood D., additional, and Bradbury, Penelope Ann, additional

Published
2014
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27. Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial

Author

Bramwell, Vivien HC, primary, Tuck, Alan B, additional, Chapman, Judith-Anne W, additional, Anborgh, Pieter H, additional, Postenka, Carl O, additional, Al-Katib, Waleed, additional, Shepherd, Lois E, additional, Han, Lei, additional, Wilson, Carolyn F, additional, Pritchard, Kathleen I, additional, Pollak, Michael N, additional, and Chambers, Ann F, additional

Published
2014
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28. A randomized trial of single versus multiple fractions (Fx) for re-irradiation (RE-RT) of painful bone metastases (PBM): NCIC CTG SC.20.

Author

Chow, Edward, primary, van der Linden, Yvette, additional, Roos, Daniel, additional, Hartsell, William F., additional, Hoskin, Peter, additional, Wu, Jackson S.Y., additional, Brundage, Michael, additional, Nabid, Abdenour, additional, Wilson, Carolyn F., additional, Meyer, Ralph M., additional, Chen, Bingshu E, additional, and Wong, Rebecca, additional

Published
2013
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29. Randomized Trial of Tamoxifen Versus Combined Tamoxifen and Octreotide LAR Therapy in the Adjuvant Treatment of Early-Stage Breast Cancer in Postmenopausal Women: NCIC CTG MA.14

Author

Pritchard, Kathleen I., primary, Shepherd, Lois E., additional, Chapman, Judith-Anne W., additional, Norris, Brian D., additional, Cantin, Jacques, additional, Goss, Paul E., additional, Dent, Susan F., additional, Walde, David, additional, Vandenberg, Ted A., additional, Findlay, Brian, additional, O'Reilly, Susan E., additional, Wilson, Carolyn F., additional, Han, Lei, additional, Piura, Ettie, additional, Whelan, Timothy J., additional, and Pollak, Michael N., additional

Published
2011
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31. A Comparison of Two Meperidine/Hydroxyzine Sedation Regimens for the Uncooperative Pediatric Dental Patient.

Author

Cathers, Justin W., Wilson, Carolyn F. G., Webb, Michael D., Alvarez, Marta E. D., Schiffman, Teresa, and Taylor, Samuel

Subjects
*SEDATIVES, *PEDIATRICS, *DENTAL care, *PHYSICAL diagnosis, *EDEMA, *PAIN
Abstract

Purpose: The purpose of this study was to compare the safety and efficacy of submucosal-administered meperidine (SM) and oral-administered meperidine (OM). Both regimens were used in conjunction with oral hydroxyzine for the sedation of children for dental treatment. Methods: Twenty preschool-age children, with previous histories of uncooperative behavior, were randomly assigned to first receive a sedation regimen of either SM (0.5 mg/Ib), or OM (1 mg/lb), both with oral hydroxyzine (0.5 mg/lb). A cross-over design was utilized so that each child received both regimens. Safety was monitored through vital signs and side effects. Efficacy was measured with Houpt and Frankl behavior ratings. Results: Vital signs remained stable during both treatments. Differences noted were clinically insignificant. The major side effects reported during submucosal injection included pain (58%) and edema (26%). All blinded behavior ratings, in both sedation regimens, significantly improved from presedation Frankl ratings. No significant differences existed between treatments. Success was 63% in the SM group and 80% in the OM group. The percentages were not statistically significant (P=.219). Conclusions: Both methods of administration were found to be safe and effective for sedating uncooperative pediatric dental patients. Neither was significantly more effective or safer than the other. [ABSTRACT FROM AUTHOR]

Published
2005

32. Competing risks of death in younger and older postmenopausal breast cancer patients.

Author

Chapman JA, Pritchard KI, Goss PE, Ingle JN, Muss HB, Dent SF, Vandenberg TA, Findlay B, Gelmon KA, Wilson CF, Shepherd LE, and Pollak MN

Abstract

Aim: To show a new paradigm of simultaneously testing whether breast cancer therapies impact other causes of death., Methods: MA.14 allocated 667 postmenopausal women to 5 years of tamoxifen 20 mg/daily ± 2 years of octreotide 90 mg, given by depot intramuscular injections monthly. Event-free survival was the primary endpoint of MA.14; at median 7.9 years, the tamoxifen+octreotide and tamoxifen arms had similar event-free survival (P = 0.62). Overall survival was a secondary endpoint, and the two trial arms also had similar overall survival (P = 0.86). We used the median 9.8 years follow-up to examine by intention-to-treat, the multivariate time-to-breast cancer-specific (BrCa) and other cause (OC) mortality with log-normal survival analysis adjusted by treatment and stratification factors. We tested whether baseline factors including Insulin-like growth factor 1 (IGF1), IGF binding protein-3, C-peptide, body mass index, and 25-hydroxy vitamin D were associated with (1) all cause mortality, and if so and (2) cause-specific mortality. We also fit step-wise forward cause-specific adjusted models., Results: The analyses were performed on 329 patients allocated tamoxifen and 329 allocated tamoxifen+octreotide. The median age of MA.14 patients was 60.1 years: 447 (82%) < 70 years and 120 (18%) ≥ 70 years. There were 170 deaths: 106 (62.3%) BrCa; 55 (32.4%) OC, of which 24 were other malignancies, 31 other causes of death; 9 (5.3%) patients with unknown cause of death were excluded from competing risk assessments. BrCa and OC deaths were not significantly different by treatment arm (P = 0.40): tamoxifen patients experienced 50 BrCa and 32 OC deaths, while tamoxifen + octreotide patients experienced 56 BrCa and 23 OC deaths. Proportionately more deaths (P = 0.004) were from BrCa for patients < 70 years, where 70% of deaths were due to BrCa, compared to 54% for those ≥ 70 years of age. The proportion of deaths from OC increased with increasing body mass index (BMI) (P = 0.02). Higher pathologic T and N were associated with more BrCa deaths (P < 0.0001 and 0.002, respectively). The cumulative hazard plot for BrCa and OC mortality indicated the concurrent accrual of both types of death throughout follow-up, that is the existence of competing risks of mortality. MA.14 therapy did not impact mortality (P = 0.77). Three baseline patient and tumor characteristics were differentially associated with cause of death: older patients experienced more OC (P = 0.01) mortality; patients with T1 tumors and hormone receptor positive tumors had less BrCa mortality (respectively, P = 0.01, P = 0.06). Additionally, step-wise cause-specific models indicated that patients with node negative disease experienced less BrCa mortality (P = 0.002); there was weak evidence that, lower C-peptide (P = 0.08) was associated with less BrCa mortality, while higher BMI (P = 0.01) was associated with worse OC mortality., Conclusion: We demonstrate here a new paradigm of simultaneous testing of therapeutics directed at multiple diseases for which postmenopausal women are concurrently at risk. Octreotide LAR did not significantly impact breast cancer or other cause mortality, although different baseline factors influenced type of death.

Published
2014
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