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5. Examining the acceptability and feasibility of the Compassionate Mindful Resilience (CMR) programme in adult patients with chronic kidney disease:The COSMIC study protocol

Author

Wilson, A. (Anna), McKeaveney, C. (Clare), Carswell, C. (Claire), Atkinson, K. (Karen), Burton, S. (Stephanie), McVeigh, C. (Clare), Graham-Wisener, L. (Lisa), Jääskeläinen, E. (Erika), Johnston, W. (William), O’Rourke, D. (Daniel), Reid, J. (Joanne), Rej, S. (Sohem), Walsh, I. (Ian), McArdle, M. (Michael), Noble, H. (Helen), Wilson, A. (Anna), McKeaveney, C. (Clare), Carswell, C. (Claire), Atkinson, K. (Karen), Burton, S. (Stephanie), McVeigh, C. (Clare), Graham-Wisener, L. (Lisa), Jääskeläinen, E. (Erika), Johnston, W. (William), O’Rourke, D. (Daniel), Reid, J. (Joanne), Rej, S. (Sohem), Walsh, I. (Ian), McArdle, M. (Michael), and Noble, H. (Helen)

Abstract

Kidney disease is often progressive, and patients experience diminished health-related quality of life. In addition, the impact of the coronavirus (COVID-19) pandemic, and its associated restrictions, has brought many additional burdens. It is therefore essential that effective and affordable systems are explored to improve the psychological health of this group that can be delivered safely during the COVID-19 pandemic. The aim of this study is to support a new service development project in partnership with the UK’s leading patient support charity Kidney Care UK by implementing the four-session Compassionate Mindful Resilience (CMR) programme, developed by MindfulnessUK, and explore its effectiveness for patients with stage 4 or 5 chronic kidney disease or have received a kidney transplant. The study will utilise a quasi-experimental, pretest/posttest design to measure the effect of the CMR programme on anxiety, depression, self-compassion, the ability to be mindful, wellbeing, and resilience, using pre- and posttests, alongside a qualitative exploration to explore factors influencing the feasibility, acceptability, and suitability of the intervention, with patients (and the Mindfulness Teacher) and their commitment to practice. Outcomes from this study will include an evidence-based mindfulness and compassion programme for use with people with kidney disease, which is likely to have applicability across other chronic diseases.

Published
2022

7. Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MILESTONE) study

Author

Santosh, P. (Paramala), Singh, J. (Jatinder), Adams, L. (Laura), Mastroianni, M. (Mathilde), Heaney, N. (Natalie), Lievesley, K. (Kate), Sagar-Ouriaghli, I. (Ilyas), Allibrio, G. (Giovanni), Appleton, R. (Rebecca), Davidović, N. (Nikolina), de Girolamo, G. (Giovanni), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Franić, T. (Tomislav), Gatherer, C. (Charlotte), Gerritsen, S.E. (Suzanne), Gheza, E. (Elisa), Madan, J. (Jason), Manenti, L. (Lidia), Maras, A. (Athanasios), Margari, F. (Francesco), McNicholas, F. (Fiona), Pastore, A. (Adriana), Paul, M. (Moli), Purper-Ouakil, D. (Diane), Rinaldi, F. (Francesco), Sakar, V. (Vehbi), Schulze, U. (Ulrike), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tremmery, S. (Sabine), Tuffrey, A. (Amanda), Tuomainen, H. (Helena), Verhulst, F.C. (Frank), Warwick, J. (Jane), Wilson, A. (Anna), Wolke, D. (Dieter), Fiori, F. (Federico), Singh, S.P. (Swaran), Santosh, P. (Paramala), Singh, J. (Jatinder), Adams, L. (Laura), Mastroianni, M. (Mathilde), Heaney, N. (Natalie), Lievesley, K. (Kate), Sagar-Ouriaghli, I. (Ilyas), Allibrio, G. (Giovanni), Appleton, R. (Rebecca), Davidović, N. (Nikolina), de Girolamo, G. (Giovanni), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Franić, T. (Tomislav), Gatherer, C. (Charlotte), Gerritsen, S.E. (Suzanne), Gheza, E. (Elisa), Madan, J. (Jason), Manenti, L. (Lidia), Maras, A. (Athanasios), Margari, F. (Francesco), McNicholas, F. (Fiona), Pastore, A. (Adriana), Paul, M. (Moli), Purper-Ouakil, D. (Diane), Rinaldi, F. (Francesco), Sakar, V. (Vehbi), Schulze, U. (Ulrike), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tremmery, S. (Sabine), Tuffrey, A. (Amanda), Tuomainen, H. (Helena), Verhulst, F.C. (Frank), Warwick, J. (Jane), Wilson, A. (Anna), Wolke, D. (Dieter), Fiori, F. (Federico), and Singh, S.P. (Swaran)

Abstract

OBJECTIVE: Young people moving from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS) are faced with significant challenges. To improve this state of affairs, there needs to be a recognition of the problem and initiatives and an urgent requirement for appropriate tools for measuring readiness and outcomes at the transfer boundary (16-18 years of age in Europe). The objective of this study was to develop and

Published
2020
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8. Training of adult psychiatrists and child and adolescent psychiatrists in europe

Author

Singh, S.P. (Swaran), Madan, J. (Jason), Warwick, J. (Jane), Wolke, D. (Dieter), Appleton, R. (Rebecca), Canaway, A. (Alastair), Griffin, J.D. (James), De Girolamo, G. (Giovanni), Santosh, P. (Paramala), Sagar-Ouriaghli, I. (Ilyas), Heaney, N. (Natalie), Maurice, V. (Virginie), Van Bodegom, L. (Larissa), Overbeek, M. (Mathilde), Kooymans, E. (Esther), Schulze, U. (Ulrike), Saam, M. (Melanie), Breuninger, U. (Ulrike), Gronostaj, A. (Aleksandra), Franić, T. (Tomislav), Davidović, N. (Nikolina), Verhulst, F.C. (Frank), Gerritsen, S.E. (Suzanne), Lievesley, K. (Kate), Tuffrey, A. (Amanda), Wilson, A. (Anna), Gatherer, C. (Charlotte), Walker, L. (Leanne), Russet, F. (Frederick), Humbertclaude, V. (Veronique), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Hendrickx, G. (Gaelle), Kovač, V. (Vlatka), McNicholas, F. (Fiona), Maras, A. (Athanasios), Paramala, S. (Santosh), Paul, M. (Moli), Schulze, U.M.E. (Ulrike M. E.), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tuomainen, H. (Helena), Singh, S.P. (Swaran P.), Tremmery, S. (Sabine), Purper-Ouakil, D. (Diane), Singh, S.P. (Swaran), Madan, J. (Jason), Warwick, J. (Jane), Wolke, D. (Dieter), Appleton, R. (Rebecca), Canaway, A. (Alastair), Griffin, J.D. (James), De Girolamo, G. (Giovanni), Santosh, P. (Paramala), Sagar-Ouriaghli, I. (Ilyas), Heaney, N. (Natalie), Maurice, V. (Virginie), Van Bodegom, L. (Larissa), Overbeek, M. (Mathilde), Kooymans, E. (Esther), Schulze, U. (Ulrike), Saam, M. (Melanie), Breuninger, U. (Ulrike), Gronostaj, A. (Aleksandra), Franić, T. (Tomislav), Davidović, N. (Nikolina), Verhulst, F.C. (Frank), Gerritsen, S.E. (Suzanne), Lievesley, K. (Kate), Tuffrey, A. (Amanda), Wilson, A. (Anna), Gatherer, C. (Charlotte), Walker, L. (Leanne), Russet, F. (Frederick), Humbertclaude, V. (Veronique), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Hendrickx, G. (Gaelle), Kovač, V. (Vlatka), McNicholas, F. (Fiona), Maras, A. (Athanasios), Paramala, S. (Santosh), Paul, M. (Moli), Schulze, U.M.E. (Ulrike M. E.), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tuomainen, H. (Helena), Singh, S.P. (Swaran P.), Tremmery, S. (Sabine), and Purper-Ouakil, D. (Diane)

Abstract

Background: Profound clinical, conceptual and ideological differences between child and adult mental health service models contribute to transition-related discontinuity of care. Many of these may be related to psychiatry training. Methods: A systematic review on General Adult Psychiatry (GAP) and Child and Adult Psychiatry (CAP) training in Europe, with a particular focus on transition as a theme in GAP and CAP training. Results: Thirty-four full-papers, six abstracts and seven additional full text documents were identified. Important variations between countries were found across several domains including assessment of trainees, clinical and educational supervision, psychotherapy training and continuing medical education. Three models of training were identified: i) a generalist common training programme; ii) totally separate training programmes; iii) mixed types. Only two national training programs (UK and Ireland) were identified to have addressed transition as a topic, both involving CAP exclusively. Conclusion: Three models of training in GAP and CAP across Europe are identified, suggesting that the harmonization is not yet realised and a possible barrier to improving transitional care. Training in transition has only recently been considered. It is timely, topical and important to develop evidence-based training approaches on transitional care across Europe into both CAP and GAP training.

Published
2019
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9. The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Author

Redin, C. (Claire), Brand, H. (Harrison), Collins, R.L. (Ryan L.), Kammin, T. (Tammy), Mitchell, E. (Elyse), Hodge, J.C. (Jennelle C.), Hanscom, C. (Carrie), Pillalamarri, V. (Vamsee), Seabra, C.M. (Catarina M.), Abbott, M.-A. (Mary-Alice), Abdul-Rahman, O.A. (Omar), Aberg, E. (Erika), Adley, R. (Rhett), Alcaraz-Estrada, S.L. (Sofia L.), Alkuraya, F.S. (Fowzan S), An, Y. (Yu), Anderson, M.-A. (Mary-Anne), Antolik, C. (Caroline), Anyane-Yeboa, K. (Kwame), Atkin, J.F. (Joan), Bartell, T. (Tina), Bernstein, J.A. (Jonathan A.), Beyer, E. (Elizabeth), Blumenthal, I. (Ian), Bongers, E. (Ernie), Brilstra, E.H. (Eva H.), Brown, C.W. (Chester W.), Brüggenwirth, H.T. (Hennie), Callewaert, L., Chiang, C. (Colby), Corning, K. (Ken), Cox, H. (H.), Cuppen, E. (Edwin), Currall, B.B. (Benjamin B.), Cushing, T. (Tom), David, D. (Dezso), Deardorff, M.A. (Matthew), Dheedene, A. (Annelies), D'Hooghe, M. (Marc), Vries, B. (Boukje) de, Earl, D.L. (Dawn L.), Ferguson, H.L. (Heather L.), Fisher, H. (Heather), Fitzpatrick, D.R. (David R.), Gerrol, P. (Pamela), Giachino, D. (Daniela), Glessner, J.T. (Joseph T.), Gliem, T. (Troy), Grady, M. (Margo), Graham, B.H. (Brett H.), Griffis, C. (Cristin), Gripp, K.W. (Karen), Gropman, A.L. (Andrea L.), Hanson-Kahn, A. (Andrea), Harris, D.J. (David J.), Hayden, M.A. (Mark A.), Hill, R. (Rosamund), Hochstenbach, R. (Ron), Hoffman, J.D. (Jodi D.), Hopkin, R., Hubshman, M.W. (Monika W.), Innes, M., Irons, M. (Mira), Irving, M. (Melita), Jacobsen, J.C. (Jessie C.), Janssens, S. (Sandra), Jewett, T. (Tamison), Johnson, J.P. (John P.), Jongmans, M.C.J. (Marjolijn), Kahler, S.G. (Stephen G.), Koolen, D.A. (David), Korzelius, J. (Jerome), Kroisel, P. (Peter), Lacassie, Y. (Yves), Lawless, W. (William), Lemyre, E. (Emmanuelle), Leppig, K. (Kathy), Levin, A.V. (Alex V.), Li, H. (Haibo), Li, H. (Hong), Liao, E.C. (Eric C.), Lim, C. (Cynthia), Lose, E.J. (Edward J.), Lucente, D. (Diane), MacEra, M.J. (Michael J.), Manavalan, P. (Poornima), Mandrile, G. (Giorgia), Marcelis, C.L.M. (Carlo), Margolin, L. (Lauren), Mason, T. (Tamara), Masser-Frye, D. (Diane), McClellan, M.W. (Michael W.), Zepeda Mendoza, C.J. (Cinthya J.), Menten, B., Middelkamp, S. (Sjors), Mikami, L.R. (Liya R.), Moe, E. (Emily), Mohammed, S. (Shabaz), Mononen, T. (Tarja), Mortenson, M.E. (Megan E.), Moya, G. (Graciela), Nieuwint, A.W. (Aggie W.), Ordulu, Z. (Zehra), Parkash, S. (Sandhya), Pauker, S.P. (Susan P.), Pereira, S. (Shahrin), Perrin, D. (Danielle), Phelan, K. (Katy), Piña Aguilar, R.E. (Raul E.), Poddighe, P. (Pino), Pregno, G. (Giulia), Raskin, S. (Salmo), Reis, L. (Linda), Rhead, W. (William), Rita, D. (Debra), Renkens, I. (Ivo), Roelens, F. (Filip), Ruliera, J. (Jayla), Rump, P. (Patrick), Schilit, S.L.P. (Samantha L.P.), Shaheen, R. (Ranad), Sparkes, R. (Rebecca), Spiegel, E. (Erica), Stevens, B. (Blair), Stone, M.R. (Matthew R.), Tagoe, J. (Julia), Thakuria, J.V. (Joseph V.), Bon, B. (Bregje) van, van de Kamp, J.M. (Jiddeke M.), Van Der Burgt, I. (Ineke), Essen, T. (Ton) van, Ravenswaaij-Arts, C.M.A. (Conny) van, Van Roosmalen, M.J. (Markus J.), Vergult, S. (Sarah), Volker-Touw, C.M.L. (Catharina M.L.), Warburton, D. (Dorothy), Waterman, M.J. (Matthew J.), Wiley, S. (Susan), Wilson, A. (Anna), Yerena-De Vega, M.D.L.C.A. (Maria De La Concepcion A), Zori, R.T. (Roberto T.), Levy, B. (Brynn), Brunner, H.G. (Han), Leeuw, N. (Nicole) de, Kloosterman, W.P. (Wigard), Thorland, E.C. (Erik C.), Morton, C.C. (Cynthia), Gusella, J.F. (James), Talkowski, M.E. (Michael E.), Redin, C. (Claire), Brand, H. (Harrison), Collins, R.L. (Ryan L.), Kammin, T. (Tammy), Mitchell, E. (Elyse), Hodge, J.C. (Jennelle C.), Hanscom, C. (Carrie), Pillalamarri, V. (Vamsee), Seabra, C.M. (Catarina M.), Abbott, M.-A. (Mary-Alice), Abdul-Rahman, O.A. (Omar), Aberg, E. (Erika), Adley, R. (Rhett), Alcaraz-Estrada, S.L. (Sofia L.), Alkuraya, F.S. (Fowzan S), An, Y. (Yu), Anderson, M.-A. (Mary-Anne), Antolik, C. (Caroline), Anyane-Yeboa, K. (Kwame), Atkin, J.F. (Joan), Bartell, T. (Tina), Bernstein, J.A. (Jonathan A.), Beyer, E. (Elizabeth), Blumenthal, I. (Ian), Bongers, E. (Ernie), Brilstra, E.H. (Eva H.), Brown, C.W. (Chester W.), Brüggenwirth, H.T. (Hennie), Callewaert, L., Chiang, C. (Colby), Corning, K. (Ken), Cox, H. (H.), Cuppen, E. (Edwin), Currall, B.B. (Benjamin B.), Cushing, T. (Tom), David, D. (Dezso), Deardorff, M.A. (Matthew), Dheedene, A. (Annelies), D'Hooghe, M. (Marc), Vries, B. (Boukje) de, Earl, D.L. (Dawn L.), Ferguson, H.L. (Heather L.), Fisher, H. (Heather), Fitzpatrick, D.R. (David R.), Gerrol, P. (Pamela), Giachino, D. (Daniela), Glessner, J.T. (Joseph T.), Gliem, T. (Troy), Grady, M. (Margo), Graham, B.H. (Brett H.), Griffis, C. (Cristin), Gripp, K.W. (Karen), Gropman, A.L. (Andrea L.), Hanson-Kahn, A. (Andrea), Harris, D.J. (David J.), Hayden, M.A. (Mark A.), Hill, R. (Rosamund), Hochstenbach, R. (Ron), Hoffman, J.D. (Jodi D.), Hopkin, R., Hubshman, M.W. (Monika W.), Innes, M., Irons, M. (Mira), Irving, M. (Melita), Jacobsen, J.C. (Jessie C.), Janssens, S. (Sandra), Jewett, T. (Tamison), Johnson, J.P. (John P.), Jongmans, M.C.J. (Marjolijn), Kahler, S.G. (Stephen G.), Koolen, D.A. (David), Korzelius, J. (Jerome), Kroisel, P. (Peter), Lacassie, Y. (Yves), Lawless, W. (William), Lemyre, E. (Emmanuelle), Leppig, K. (Kathy), Levin, A.V. (Alex V.), Li, H. (Haibo), Li, H. (Hong), Liao, E.C. (Eric C.), Lim, C. (Cynthia), Lose, E.J. (Edward J.), Lucente, D. (Diane), MacEra, M.J. (Michael J.), Manavalan, P. (Poornima), Mandrile, G. (Giorgia), Marcelis, C.L.M. (Carlo), Margolin, L. (Lauren), Mason, T. (Tamara), Masser-Frye, D. (Diane), McClellan, M.W. (Michael W.), Zepeda Mendoza, C.J. (Cinthya J.), Menten, B., Middelkamp, S. (Sjors), Mikami, L.R. (Liya R.), Moe, E. (Emily), Mohammed, S. (Shabaz), Mononen, T. (Tarja), Mortenson, M.E. (Megan E.), Moya, G. (Graciela), Nieuwint, A.W. (Aggie W.), Ordulu, Z. (Zehra), Parkash, S. (Sandhya), Pauker, S.P. (Susan P.), Pereira, S. (Shahrin), Perrin, D. (Danielle), Phelan, K. (Katy), Piña Aguilar, R.E. (Raul E.), Poddighe, P. (Pino), Pregno, G. (Giulia), Raskin, S. (Salmo), Reis, L. (Linda), Rhead, W. (William), Rita, D. (Debra), Renkens, I. (Ivo), Roelens, F. (Filip), Ruliera, J. (Jayla), Rump, P. (Patrick), Schilit, S.L.P. (Samantha L.P.), Shaheen, R. (Ranad), Sparkes, R. (Rebecca), Spiegel, E. (Erica), Stevens, B. (Blair), Stone, M.R. (Matthew R.), Tagoe, J. (Julia), Thakuria, J.V. (Joseph V.), Bon, B. (Bregje) van, van de Kamp, J.M. (Jiddeke M.), Van Der Burgt, I. (Ineke), Essen, T. (Ton) van, Ravenswaaij-Arts, C.M.A. (Conny) van, Van Roosmalen, M.J. (Markus J.), Vergult, S. (Sarah), Volker-Touw, C.M.L. (Catharina M.L.), Warburton, D. (Dorothy), Waterman, M.J. (Matthew J.), Wiley, S. (Susan), Wilson, A. (Anna), Yerena-De Vega, M.D.L.C.A. (Maria De La Concepcion A), Zori, R.T. (Roberto T.), Levy, B. (Brynn), Brunner, H.G. (Han), Leeuw, N. (Nicole) de, Kloosterman, W.P. (Wigard), Thorland, E.C. (Erik C.), Morton, C.C. (Cynthia), Gusella, J.F. (James), and Talkowski, M.E. (Michael E.)

Abstract

Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyotypes and demonstrated complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the limitations of conventional cytogenetic approaches. At least 33.9% of BCAs resulted in gene disruption that likely contributed to the developmental phenotype, 5.2% were associated with pathogenic genomic imbalances, and 7.3% disrupted topologically associated domains (TADs) encompassing known syndromic loci. Remarkably, BCA br

Published
2017
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