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255 results on '"Wilsmann-Theis, Dagmar"'

5. Palmoplantar pustulosis – a cross-sectional analysis in Germany

Author

Wilsmann-Theis, Dagmar, Jacobi, Arnd, Frambach, Yvonne, Philipp, Sandra, Weyergraf, Ansgar, Schill, Tillmann, Steinz, Kirsten, Gerdes, Sascha, and Mössner, Rotraut

Subjects
palmoplantar pustulosis, pustular palmoplantar psoriasis, therapy, psoriasis comorbidity, psoriasis arthritis, psoriasis vulgaris
Abstract

Background: Palmoplantar pustulosis (PPP) is arecalcitrant chronic inflammatory skin disease. Datarelevant for the medical care of patients with PPP arescarce. Thus, the aim of this work was to investigatethe disease burden, clinical characteristics, andcomorbidity of PPP patients in Germany. Patientsand Methods: PPP patients were examined in a crosssectionalstudy at seven specialized psoriasis centersin Germany. Results: Of the 172 included patients withPPP, 79.1% were female and 69.8% were smokers.In addition, 25.0% suffered from psoriasis vulgaris,28.2% had documented psoriatic arthritis, and 30.2%had a family history of psoriasis. In 77 patients themean Dermatology Life Quality Index (DLQI) was 12.2± 7.7 (mean ± SD). The mean Psoriasis PalmoplantarPustulosis Area and Severity Index (PPPASI) was 12.6 ±8.6. Mean body mass index was above average at 27.1± 5.5. The PPP patients had previously received anaverage of 2.6 ± 2.1 different anti-psoriatic systemicdrugs or UV-therapies. The systemic drugs that hadbeen used most frequently were corticosteroids in40.1% of patients, followed by acitretin (37.8%), andmethotrexate (27.9%). The PPPASI was 13.4 ± 8.9 inpatients without current systemic therapy and 10.4 ±7.9 in patients with systemic therapy. Conclusion: ManyPPP patients had a concomitant diagnosis of psoriasisvulgaris and/or psoriatic arthritis or had a familyhistory of psoriasis. Despite the fact that many of thepatients were using anti-psoriatic therapies, there wasstill a high burden of disease within this PPP cohort.This insufficient control of symptoms demonstratesthe urgent need for new PPP treatments.

Published
2017

8. Usage and benefit of the Internet as a source of information on disease and therapy in dermatology

Author

Grossschaedl, Katja, primary, Vallant, Christina, additional, Dernoscheg, Marie‐Therese, additional, Richtig, Markus, additional, Öllinger, Angela, additional, Balakirski, Galina, additional, Wilsmann‐Theis, Dagmar, additional, Nguyen, Van Anh, additional, Weinlich, Georg, additional, Tsiogka, Aikaterini, additional, Koelblinger, Peter, additional, Scheffel, Joerg, additional, Richtig, Erika, additional, and Richtig, Georg, additional

Published
2023
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9. Verwendung und Nutzen des Internets als Informationsquelle für Erkrankungen und Therapien in der Dermatologie

Author

Grossschaedl, Katja, primary, Vallant, Christina, additional, Dernoscheg, Marie‐Therese, additional, Richtig, Markus, additional, Öllinger, Angela, additional, Balakirski, Galina, additional, Wilsmann‐Theis, Dagmar, additional, Nguyen, Van Anh, additional, Weinlich, Georg, additional, Tsiogka, Aikaterini, additional, Koelblinger, Peter, additional, Scheffel, Joerg, additional, Richtig, Erika, additional, and Richtig, Georg, additional

Published
2023
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11. Development of a clinical algorithm to predict phenotypic switches between atopic dermatitis and psoriasis (the "Flip‐Flop" phenomenon).

Author

Müller, Svenja, Welchowski, Thomas, Schmid, Matthias, Maintz, Laura, Herrmann, Nadine, Wilsmann‐Theis, Dagmar, Royeck, Thorben, Havenith, Regina, and Bieber, Thomas

Subjects
ATOPIC dermatitis, MEDICAL protocols, PSORIASIS, BIOTHERAPY, PHENOTYPES
Abstract

Background: Atopic dermatitis (AD) and psoriasis vulgaris (PV) are almost mutually exclusive diseases with different immune polarizations, mechanisms and therapeutic targets. Switches to the other disease ("Flip‐Flop" [FF] phenomenon) can occur with or without systemic treatment and are often referred to as paradoxical reactions under biological therapy. Methods: The objective was to develop a diagnostic algorithm by combining clinical criteria of AD and PV to identify FF patients. The algorithm was prospectively validated in patients enrolled in the CK‐CARE registry in Bonn, Germany. Afterward, algorithm refinements were implemented based on machine learning. Results: Three hundred adult Caucasian patients were included in the validation study (n = 238 with AD, n = 49 with PV, n = 13 with FF; mean age 41.2 years; n = 161 [53.7%] female). The total FF scores of the PV and AD groups differed significantly from the FF group in the validation data (p <.001). The predictive mean generalized Youden‐Index of the initial model was 78.9% [95% confidence interval 72.0%–85.6%] and the accuracy was 89.7%. Disease group‐specific sensitivity was 100% (FF), 95.0% (AD), and 61.2% (PV). The specificity was 89.2% (FF), 100% (AD), and 100% (PV), respectively. Conclusion: The FF algorithm represents the first validated tool to identify FF patients. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Efficacy and Safety of Methotrexate in Psoriasis Vulgaris Long-Term Treatment: A Real-World Observation Study.

Author

Wilsmann-Theis, Dagmar, Funk, Rhena, Mössner, Rotraut, Bieber, Thomas, and Wenzel, Jörg

Subjects
*PSORIASIS, *DRUG efficacy, *PSORIATIC arthritis, *SCIENTIFIC observation, *RETROSPECTIVE studies, *ACQUISITION of data, *GASTROINTESTINAL diseases, *METHOTREXATE, *SEVERITY of illness index, *MEDICAL records, *DISEASE prevalence, *DESCRIPTIVE statistics, *FATIGUE (Physiology), *PATIENT safety, *ALANINE aminotransferase
Abstract

Background: Methotrexate (MTX) in the therapy of psoriasis vulgaris (PV) is a well and long-established treatment option. Aims: To assess the long-term experience of individual patients in the real world with regard to the efficacy and safety of MTX in PV therapy. Patients and Methods: In a retrospective study, MTX as a weekly used monotherapy in PV was examined. Clinical data including the Psoriasis Area Severity Index (PASI), prevalence of psoriatic-arthritis (PsA), Investigator Global Assessment (IGA), laboratory parameters, occurrence of adverse events (AEs), dosing of MTX and characteristics of patients treated for at least 24 months were collected. Results: A total of 55 patients with 247 patient-years under MTX therapy were included. The mean PASI reduction was 51.2% with a significant (P < 0.001) improvement in the skin condition in the first 6 months of treatment, remaining stable thereafter. The mean MTX dose increased from 11.8 ± 3.7 mg to 12.9 ± 3.8 mg in the first year of therapy, with a constant mean dose in the following years. In 247 patient-years, no serious AE was documented. Gastrointestinal side effects or fatigue were commonly detected. The liver parameter alanine aminotransferase/ glutamatepyruvate transaminase (ALT/GPT) (baseline 35.8 ± 22.0 U/L) increased after 3 years of therapy (42.0 ± 22.4 U/L; P = 0.013) without clinical significance. Conclusion: In this patient collective, MTX in low doses was effective and safe in long-term therapy. The improved skin condition was steady and reached by an unvarying dose. New data showed a better efficacy of MTX in higher doses; however, additional data must be collected on the long-term efficacy and safety of MTX with a higher dose regime. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Prospective double-blind study on the value of musculoskeletal ultrasound by dermatologists as a screening instrument for psoriatic arthritis.

Author

Grobelski, Jakub, Wilsmann-Theis, Dagmar, Karakostas, Pantelis, Behning, Charlotte, Brossart, Peter, and Schäfer, Valentin S

Subjects
*PSORIATIC arthritis, *DERMATOLOGISTS, *PREDICTIVE tests, *MEDICAL screening, *BLIND experiment, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *RESEARCH funding, *SENSITIVITY & specificity (Statistics), *LONGITUDINAL method
Abstract

Objectives This study evaluated musculoskeletal ultrasound (MSUS) use by dermatologists previously trained on a novel handheld, chip-based ultrasound device (HHUD) to screen for early PsA. Methods Twelve dermatologists were recruited to screen psoriasis patients for PsA using the novel HHUD in one major hospital in Bonn (Germany) and six private practices in surrounding regions. Patient screening was based on medical history, clinical examination, and the GEPARD questionnaire paired with an MSUS examination of up to three painful joints. All screened patients were then referred to rheumatologists, who determined the final diagnosis. The screening effect of MSUS was assessed according to its sensitivity and specificity before and after its application. Results Between 1 October 2020 and 26 May 2021, a total of 140 psoriasis patients with arthralgia participated in this study. PsA was diagnosed in 19 (13.6%) cases. Before applying MSUS, dermatologists' screening sensitivity and specificity were recorded as 88.2% and 54.4%, respectively, while after applying MSUS the sensitivity and specificity changed to 70.6% and 90.4%, respectively. MSUS led to a change of PsA suspicion in 46 cases, with PsA no longer being suspected in 45 of them. Conclusion This study was able to demonstrate that PsA screening using MSUS by previously trained dermatologists can lead to more precise PsA detection and potentially decreased rheumatologist referral rates. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Prospektive, doppel-blinde Studie zur Wertigkeit des muskuloskelettalen Ultraschalls durch Dermatologen in der Früherkennung von Psoriasis Arthritis anhand portabler Ultraschallgeräte: Die PsoSone Studie

Author

Schäfer, Valentin, Grobelski, Jakub, Wilsmann-Theis, Dagmar, Karakostas, Pantelis, Brossart, Peter, Behning, Charlotte, and Recker, Florian

Subjects
Medicine and health
Abstract

Einleitung: Das Ziel der Studie war die prospektive Untersuchung des muskuloskelettalen Ultraschalls (MSUS) durch Dermatologen als Screening Instrument zur Früherkennung von Psoriasis Arthritis (PsA) unter Anwendung portabler, chip-basierter Ultraschallgeräte (HHUD). Methoden: Zwölf [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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25. Psoriasis Arthritis oder doch nur Arthrose? Eine Analyse aus dem Psoriasis Arthritis Zentrum Bonn

Author

Schäfer, Valentin, Ziob, Jana, Behning, Charlotte, Brossart, Peter, Bieber, Thomas, and Wilsmann-Theis, Dagmar

Subjects
Medicine and health
Abstract

Einleitung: Dermatologen sind in ihrem klinischen Alltag häufig mit Krankheitsbildern konfrontiert, welche auf eine rheumatologische Erkrankung hinweisen. Zu den häufigsten zählt die Psoriasis Arthritis (PsA), an welcher bis zu 40% der Psoriasis-Patienten leiden. Doch auch andere [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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29. Generalisierte pustulöse Psoriasis: Überblick zum Status quo und Ergebnisse einer Diskussionsrunde

Author

Reich, Kristian, primary, Augustin, Matthias, additional, Gerdes, Sascha, additional, Ghoreschi, Kamran, additional, Kokolakis, Georgios, additional, Mößner, Rotraut, additional, Mrowietz, Ulrich, additional, Navarini, Alexander A., additional, Pinter, Andreas, additional, Schäkel, Knut, additional, Staubach, Petra, additional, Sticherling, Michael, additional, Thaçi, Diamant, additional, and Wilsmann‐Theis, Dagmar, additional

Published
2022
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30. Generalized pustular psoriasis: overview of the status quo and results of a panel discussion

Author

Reich, Kristian, primary, Augustin, Matthias, additional, Gerdes, Sascha, additional, Ghoreschi, Kamran, additional, Kokolakis, Georgios, additional, Mößner, Rotraut, additional, Mrowietz, Ulrich, additional, Navarini, Alexander A., additional, Pinter, Andreas, additional, Schäkel, Knut, additional, Staubach, Petra, additional, Sticherling, Michael, additional, Thaçi, Diamant, additional, and Wilsmann‐Theis, Dagmar, additional

Published
2022
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34. Etablierung und Validierung eines didaktischen muskuloskelettalen Ultraschallkurses für Dermatologen unter Verwendung eines innovativen Hand‐Ultraschallsystems – die MUDE‐Studie (Muskuloskelettaler Ultraschall für Dermatologen)

Author

Grobelski, Jakub, primary, Recker, Florian, additional, Wilsmann‐ Theis, Dagmar, additional, Hartung, Wolfgang, additional, Karakostas, Pantelis, additional, Brossart, Peter, additional, and Schäfer, Valentin Sebastian, additional

Published
2021
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39. Documentation of psoriasis in routine care – expert consensus on a German data set

Author

Otten, Marina, primary, Mrowietz, Ulrich, additional, Kiedrowski, Ralph Michael, additional, Otto, Ramona, additional, Altenburg, Andreas, additional, Aschoff, Roland, additional, Beissert, Stefan, additional, Beiteke, Ulrike, additional, Bonnekoh, Bernd, additional, Hoffmann, Matthias, additional, Körber, Andreas, additional, Maaßen, Dirk, additional, Mössner, Rotraut, additional, Navarini, Alexander, additional, Petering, Holger, additional, Ramaker‐Brunke, Jutta, additional, Rosenbach, Thomas, additional, Schwichtenberg, Uwe, additional, Sticherling, Michael, additional, Sondermann, Wiebke, additional, Thaci, Diamant, additional, Timmel, Andreas, additional, Tsianakas, Athanasios, additional, Werfel, Thomas, additional, Wilsmann‐Theis, Dagmar, additional, and Augustin, Matthias, additional

Published
2021
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40. Dokumentation der Psoriasis in der Routineversorgung – Expertenkonsens zu einem deutschen Datensatz

Author

Otten, Marina, primary, Mrowietz, Ulrich, additional, Kiedrowski, Ralph Michael, additional, Otto, Ramona, additional, Altenburg, Andreas, additional, Aschoff, Roland, additional, Beissert, Stefan, additional, Beiteke, Ulrike, additional, Bonnekoh, Bernd, additional, Hoffmann, Matthias, additional, Körber, Andreas, additional, Maaßen, Dirk, additional, Mössner, Rotraut, additional, Navarini, Alexander, additional, Petering, Holger, additional, Ramaker‐Brunke, Jutta, additional, Rosenbach, Thomas, additional, Schwichtenberg, Uwe, additional, Sticherling, Michael, additional, Sondermann, Wiebke, additional, Thaci, Diamant, additional, Timmel, Andreas, additional, Tsianakas, Athanasios, additional, Werfel, Thomas, additional, Wilsmann‐Theis, Dagmar, additional, and Augustin, Matthias, additional

Published
2021
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41. Interpersonal experiences of stigmatization and sexual impairments, quality of life and depression in patients with psoriasis: the mediating role of social avoidance

Author

Da Silva, Neuza, Augustin, Matthias, Wilsmann-Theis, Dagmar, Staubach-Renz, Petra, von Stülpnagel, Catharina, and Sommer, Rachel

Subjects
ddc: 610, Medicine and health
Abstract

Background: Plaque-type psoriasis or intertriginous psoriasis affects the anogenital area in 29–40% of cases, resulting in significant quality of life (QoL) impairments and higher rates of depression. Patients with anogenital psoriasis also reported impaired sexual experiences because of [for full text, please go to the a.m. URL]

Published
2021

42. Einrichtung und Validierung eines didaktischen muskuloskelettalem Ultraschallkurses für Dermatologen mit Anwendung eines innovativen portablen Ultraschallsystems - die MUDE Studie (Muskuloskelettaler Ultraschall für Dermatologen)

Author

Grobelski, Jakub, Recker, Florian, Karakostas, Pantelis, Wilsmann-Theis, Dagmar, Hartung, Wolfgang, Brossart, Peter, and Schäfer, Valentin

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Der Ultraschall schmerzhafter Gelenke spielt eine wichtige Rolle in der Früherkennung der Arthritis, wie beispielsweise der Psoriasis Arthritis. Pathologische Gelenkbefunde in der klinischen Untersuchung können übersehen werden, vor allem, wenn sie von ungeübten Untersuchern[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021

43. Influenza Vaccination in Psoriatic Patients - Epidemiology and Patient Perceptions: A German Multicenter Study (Vac-Pso)

Author

Kromer, Christian, Wellmann, Phoebe, Siemer, Ralf, Klein, Selina, Mohr, Johannes, Pinter, Andreas, Wilsmann-Theis, Dagmar Irmgard, and Mößner, Rotraut

Subjects
ddc:000, ddc:610, ddc:510
Abstract

The risk of developing severe complications from an influenza virus infection is increased in patients with chronic inflammatory diseases such as psoriasis (PsO) and atopic dermatitis (AD). However, low influenza vaccination rates have been reported. The aim of this study was to determine vaccination rates in PsO compared to AD patients and explore patient perceptions of vaccination. A multicenter cross-sectional study was performed in 327 and 98 adult patients with PsO and AD, respectively. Data on vaccination, patient and disease characteristics, comorbidity, and patient perceptions was collected with a questionnaire. Medical records and vaccination certificates were reviewed. A total of 49.8% of PsO and 32.7% of AD patients were vaccinated at some point, while in season 2018/2019, 30.9% and 13.3% received an influenza vaccination, respectively. There were 96.6% and 77.6% of PsO and AD patients who had an indication for influenza vaccination due to age, immunosuppressive therapy, comorbidity, occupation, and/or pregnancy. Multivariate regression analysis revealed higher age (p < 0.001) and a history of bronchitis (p = 0.023) as significant predictors of influenza vaccination in PsO patients. Considering that most patients had an indication for influenza vaccination, the rate of vaccinated patients was inadequately low.

Published
2021

44. Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany

Author

Haskamp, Stefan, Horowitz, Joseph Simon, Oji, Vinzenz, Philipp, Sandra, Sticherling, Michael, Schäkel, Knut, Schuhmann, Sarah, Prinz, Jörg C., Burkhardt, Harald, Behrens, Frank, Böhm, Beate, Köhm, Michaela, Rech, Jürgen, Simon, David, Schett, Georg, Morrison, Kirsten, Gerdes, Sascha, Assmann, Gunter, Nimeh, Ali, Schuster, Volker, Jacobi, Arnd, Weyergraf, Ansgar, Reis, André, Uebe, Steffen, Wilsmann-Theis, Dagmar, Mößner, Rotraut, and Hüffmeier, Ulrike

Published
2021
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50. Stationäre Psoriasistherapie: Quo vadis? – Eine retrospektive Studie an den Universitätskliniken Aachen, Bonn und Essen im Zeitraum von 2010 bis 2019

Author

Poortinga, Sietske, Sondermann, Wiebke, Förster, Meike, Yazdi, Amir S., Bieber, Thomas, Balakirski, Galina, and Wilsmann-Theis, Dagmar

Abstract

Einleitung: In den letzten Jahrzehnten wurde eine Reihe neuer hochwirksamer Biologika zur Psoriasistherapie zugelassen. Dies wirft die Frage auf, ob die Psoriasis immer noch eine Erkrankung darstellt, die einer stationären Behandlung bedarf. Methoden: Es erfolgte eine retrospektive Analyse stationärer Patientendaten im Zeitraum zwischen 2010 und 2019 (letzte 10 Jahren vor der COVID-19-Pandemie) aus 3 deutschen Universitätshautkliniken (Aachen, Bonn und Essen). Zu den erhobenen Daten gehörten Alter und Geschlecht der Patienten, Aufnahmediagnose, stationäre Verweildauer und Anzahl aller während des Krankenhausaufenthalts erfassten Komorbiditäten. Ergebnisse: Über den definierten Zeitraum von 10 Jahren wurden in den 3 dermatologischen Kliniken insgesamt 59.500 Patienten stationär behandelt. Bei insgesamt 7,3 % (4322) dieser Patienten wurde eine Psoriasis (L40.-) als Hauptdiagnose kodiert. Die Gesamtzahl der stationär behandelten Patienten pro Jahr stieg über die Jahre im Vergleich zu 2010 an, dabei konnte der maximale Anstieg im Vergleich zu 2010 im Jahr 2016 beobachtet werden und betrug +27 %. Auch die Anzahl der stationär behandelten Psoriasisfälle erhöhte sich über die Jahre. Der maximale Anstieg der Anzahl der stationären Psoriasispatienten im Vergleich zum Jahr 2010 fand im Jahr 2016 statt und betrug +45 %. Während es eine statistisch signifikante Verringerung der mittleren stationären Verweildauer für alle dermatologischen stationären Fälle von 6,4 ± 6,6 Tage im Jahr 2010 auf 5,1 ± 4,6 Tage im 2019 (p&lt; 0,001) gab, war die Reduktion der mittleren stationären Verweildauer bei Psoriasispatienten im Jahr 2019 im Vergleich zu 2010 (von 12,2 ± 5,5 auf 8,9 ± 3,3 Tage) statistisch signifikant höher als für die stationären Fälle insgesamt (p&lt; 0,001). Diskussion: Die vorliegenden Daten zeigen einen stabilen Bedarf an stationären Psoriasisbehandlungen in Deutschland. Weitere Analysen der stationären Psoriasisdaten nach dem Ende der COVID-19-Pandemie sind erforderlich, um den langfristigen Einfluss moderner systemischer Behandlungsoptionen auf die stationäre Psoriasisversorgung in Deutschland zu evaluieren.

Published
2023
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