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202 results on '"Willrich, Maria Alice V."'

4. Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation

Author

Amer, Hatem, Fervenza, Fernando, Leung, Nelson, Tran, Cheryl, Zand, Ladan, Alkhateeb, Hassan, Go, Ronald, Hogan, William, Hook, Christopher, Pruthi, Rajiv, Sridharan, Meera, Adamski, Jill, Murray, David, Winters, Jeffrey, Alexander, Mariam, Chen, Dong, Moyer, Ann, Sethi, Sanjeev, Willrich, Maria, Heikal, Nahla, Acosta-Medina, Aldo A., Moyer, Ann M., Go, Ronald S., Willrich, Maria Alice V., Fervenza, Fernando C., Bourlon, Christianne, Winters, Jeffrey L., Spears, Grant M., and Bryant, Sandra C.

Published
2023
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8. Cerebrospinal fluid kappa free light chains in patients with tumefactive demyelination.

Author

Banks, Samantha A., Willrich, Maria Alice V., Eckel-Passow, Jeanette E., and Tobin, W. Oliver

Subjects
*IMMUNOGLOBULIN light chains, *CEREBROSPINAL fluid, *CEREBROSPINAL fluid examination, *DEMYELINATION, *MYELIN oligodendrocyte glycoprotein
Abstract

This letter discusses the use of cerebrospinal fluid kappa free light chains (KFLCs) as a biomarker for diagnosing tumefactive demyelination, a condition that can be difficult to diagnose. The study included 16 patients with tumefactive demyelinating lesions, and the results showed that KFLCs had similar sensitivity and specificity to oligoclonal bands (OCB) for diagnosing multiple sclerosis (MS). The authors suggest that KFLCs could be a useful biomarker in diagnosing tumefactive demyelination and may help avoid the need for biopsy in some cases. However, the study was limited by its size and retrospective nature. [Extracted from the article]

Published
2024
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12. Clinical specificity of two assays for immunoglobulin kappa and lambda free light chains.

Author

Farnsworth, Christopher W., Roemmich, Brittany, Spears, Grant M., Murray, David L., Dispenzieri, Angela, and Willrich, Maria Alice V.

Subjects
IMMUNOGLOBULIN light chains, PLASMA cell diseases, BLOOD protein electrophoresis, MONOCLONAL antibodies, GLOMERULAR filtration rate, SYMPTOMS, ERYTHROPOIETIN receptors
Abstract

Free light chain (FLC) assays and the ratio of κ/λ are recommended for diagnosis, prognosis and monitoring of plasma cell dyscrasias (PCD). Limited data exists on FLC clinical specificity in patients diagnosed with other conditions. We assessed the κ, λ, and κ/λ FLC ratio using the FreeLite assay and the Sebia FLC ELISA assay in 176 patients with clinical presentations of fatigue, anemia, polyclonal hypergammaglobulinemia, joint disorders, kidney disease and non PCD-cancers with no monoclonal protein observed on serum protein electrophoresis or MASS-FIX immunoglobulin isotyping. Manufacturer defined reference intervals (RI) and glomerular filtration rate (GFR) specific RI (renal RI) were utilized. For the κ/λ ratio, 68.7 % (121/176) of specimens on the FreeLite and 87.5 % (154/176) of specimens on the Sebia assay were within RI. For κ, 68.2 % (120/176) and 72.2 % (127/176) of results were outside RI for FreeLite and Sebia respectively. For λ, 37.5 % (66/176) and 84.1 % (148/176) of FreeLite and Sebia results were outside RI. With FreeLite and Sebia, patients with kidney disease (n=25) had the highest κ/λ ratios. 44 patients (25.0 %) had GFR <60 mL/min/BSA. When renal RI were applied, 13.6 % had a FLCr outside the renal RI with FreeLite, and 4.5 % with Sebia. In a cohort of patients with signs and symptoms suggestive of PCDs, but ultimately diagnosed with other conditions, Sebia FLC had improved clinical specificity relative to FreeLite, if one was using an abnormal κ/λ ratio as a surrogate for monoclonality. [ABSTRACT FROM AUTHOR]

Published
2024
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15. List of contributors

Author

Adeli, Khosrow, primary, Alter, David N., additional, Babady, Esther, additional, Bachmann, Lorin M., additional, Bai, Shi, additional, Block, Darci R., additional, Campbell, Sean, additional, Chambliss, Allison B., additional, Chan, Daniel W., additional, Chin, Alex C., additional, Christenson, Robert H., additional, Clarke, William, additional, Colby, Jennifer M., additional, Connelly, Margery A., additional, Cotten, Steven W., additional, Dahlin, Jayme L., additional, Deharvengt, Sophie J., additional, Delvin, Edgard, additional, Dickerson, Jane, additional, Donato, Leslie J., additional, D’Orazio, Paul, additional, Dufour, D. Robert, additional, Duh, Show-Hong, additional, Eckel, Ashley, additional, Fan, Shu-Ling, additional, Frank, Elizabeth L., additional, Franke, Deanna D.H., additional, Genzen, Jonathan R., additional, Greene, Dina N., additional, Hage, David S., additional, Harris, Neil S., additional, Henderson, Matthew P.A., additional, Higgins, Victoria, additional, Holmes, Daniel T., additional, Inker, Lesley A., additional, Jackson, Brian R., additional, Jannetto, Paul J., additional, Jung, Hou-Sung, additional, Kahn, Stephen E., additional, Kavsak, Peter A., additional, Korpi-Steiner, Nichole, additional, Langman, Loralie J., additional, Leung, Stanley T., additional, Levy, Emile, additional, Liesman, Rachael, additional, Lin, David C., additional, Lockwood, Christina M., additional, Marzinke, Mark A., additional, Master, Stephen R., additional, McCudden, Christopher R., additional, McMillin, Gwendolyn A., additional, Meeusen, Jeffrey W., additional, Melanson, Stacy E.F., additional, Merrill, Anna E., additional, Miller, W. Greg, additional, Nerenz, Robert D., additional, Nichols, James H., additional, Nieuwesteeg, Michelle, additional, Park, Jason Y., additional, Parnás, M. Laura, additional, Patel, Khushbu, additional, Pelletier, J. Peter R., additional, Pence, Morgan A., additional, Petersen, Lauren M., additional, Petrides, Athena K., additional, Pyle-Eilola, Amy L., additional, Rai, Alex J., additional, Shajani-Yi, Zahra, additional, Sokoll, Lori J., additional, Straseski, Joely A., additional, Thomas, Stefani N., additional, Thoren, Katie L., additional, Toffaletti, John, additional, Truscott, Steven M., additional, Tsongalis, Gregory J., additional, Ware, Alisha D., additional, Wiencek, Joesph R., additional, Willrich, Maria Alice V., additional, Winter, William E., additional, Woodworth, Alison, additional, and Wu, Alan H.B., additional

Published
2020
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19. Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation

Author

Acosta-Medina, Aldo A., primary, Moyer, Ann M., additional, Go, Ronald S., additional, Willrich, Maria Alice V., additional, Fervenza, Fernando C., additional, Leung, Nelson, additional, Bourlon, Christianne, additional, Winters, Jeffrey L., additional, Spears, Grant M., additional, Bryant, Sandra C., additional, and Sridharan, Meera, additional

Published
2023
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21. Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement

Author

Hegen, Harald, primary, Arrambide, Georgina, additional, Gnanapavan, Sharmilee, additional, Kaplan, Batia, additional, Khalil, Michael, additional, Saadeh, Ruba, additional, Teunissen, Charlotte, additional, Tumani, Hayrettin, additional, Villar, Luisa Maria, additional, Willrich, Maria Alice V, additional, Zetterberg, Henrik, additional, and Deisenhammer, Florian, additional

Published
2022
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22. Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, primary, Walde, Janette, additional, Berek, Klaus, additional, Arrambide, Georgina, additional, Gnanapavan, Sharmilee, additional, Kaplan, Batia, additional, Khalil, Michael, additional, Saadeh, Ruba, additional, Teunissen, Charlotte, additional, Tumani, Hayrettin, additional, Villar, Luisa M, additional, Willrich, Maria Alice V, additional, Zetterberg, Henrik, additional, and Deisenhammer, Florian, additional

Published
2022
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24. Mo1522: MULTICENTER REAL-WORLD EXPERIENCE OF USTEKINUMAB TROUGH LEVELS AND ANTIBODIES IN CROHN’S DISEASE MAINTENANCE THERAPY

Author

Ramos, Guilherme Piovezani, primary, Tharayil, Vivek, additional, Kurdi, Ahmed T., additional, Bali, Aman S., additional, Rolak, Stacey C., additional, Fredrick, Thomas W., additional, Neto, Manuel B. Braga, additional, Vinsard, Daniela Guerrero, additional, Urquhart, Siri A., additional, Dunleavy, Katie A., additional, Bakhshi, Zeinab, additional, Tariq, Raseen, additional, Becker, Michelle, additional, Johnson, Amanda M., additional, Pasha, Shabana F., additional, Hashash, Jana G., additional, Harmsen, William S., additional, Willrich, Maria Alice V., additional, and Loftus, Edward V., additional

Published
2022
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25. sj-pdf-6-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-6-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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26. sj-pdf-2-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-2-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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27. sj-pdf-19-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-19-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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28. sj-pdf-8-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-8-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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29. sj-pdf-9-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-9-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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30. sj-pdf-7-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-7-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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31. sj-pdf-4-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-4-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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32. sj-pdf-3-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-3-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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33. sj-pdf-5-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-5-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Published
2022
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34. Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement.

Author

Hegen, Harald, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa Maria, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
IMMUNOGLOBULIN light chains, CEREBROSPINAL fluid, MULTIPLE sclerosis, MONOCLONAL gammopathies, IMMUNOGLOBULIN G, DIFFERENTIAL diagnosis
Abstract

Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. The gold standard to determine intrathecal IgG synthesis is the detection of CSF-restricted oligoclonal bands (OCBs). However, advances in laboratory methods brought up κ-free light chains (FLCs) as a new biomarker, which are produced in excess over intact immunoglobulins and accumulate in CSF in the case of central nervous system-derived inflammation. Overwhelming evidence showed a high diagnostic accuracy of intrathecal κ-FLC synthesis in MS with sensitivity and specificity of approximately 90% similar to OCB. κ-FLCs have advantages as its detection is fast, easy, cost-effective, reliable, rater-independent and returning quantitative results which might also improve the value of predicting MS disease activity. An international panel of experts in MS and CSF diagnostics developed a consensus of all participants. Six recommendations are given for establishing standard CSF evaluation in patients suspected of having MS. The panel recommended to include intrathecal κ-FLC synthesis in the next revision of MS diagnostic criteria as an additional tool to measure intrathecal immunoglobulin synthesis. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis.

Author

Hegen, Harald, Walde, Janette, Berek, Klaus, Arrambide, Georgina, Gnanapavan, Sharmilee, Kaplan, Batia, Khalil, Michael, Saadeh, Ruba, Teunissen, Charlotte, Tumani, Hayrettin, Villar, Luisa M, Willrich, Maria Alice V, Zetterberg, Henrik, and Deisenhammer, Florian

Subjects
IMMUNOGLOBULIN light chains, CEREBROSPINAL fluid, MULTIPLE sclerosis, MONOCLONAL gammopathies
Abstract

Background: Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. Objective: To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. Methods: PubMed was searched for studies that assessed diagnostic sensitivity and specificity of κ-FLC index and OCB to discriminate CIS/MS patients from control subjects. Two reviewers following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines performed study eligibility assessment and data extraction. Findings from studies were analyzed with bivariate mixed models. Results: A total of 32 studies were included in the meta-analysis to evaluate diagnostic value of κ-FLC index. Sensitivity and specificity ranged from 52% to 100% (weighted average: 88%) and 69% to 100% (89%) for κ-FLC index and from 37% to 100% (85%) and 74% to 100% (92%) for OCB. Mean difference of sensitivity and specificity between κ-FLC index and OCB was 2 and −4 percentage points. Diagnostic accuracy determined by mixed models revealed no significant difference between κ-FLC index and OCB. A discriminatory cut-off for κ-FLC index was determined at 6.1. Conclusion: The findings indicate that κ-FLC index has similar diagnostic accuracy in MS as OCB. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Certolizumab Trough Levels and Antibodies in Crohn Disease: A Single-Center Experience

Author

Ramos, Guilherme Piovezani, primary, Al-Bawardy, Badr, additional, Braga Neto, Manuel Bonfim, additional, Bledsoe, Adam C, additional, Quinn, Kevin P, additional, Heron, Valérie, additional, Willrich, Maria Alice V, additional, Johnson, Amanda, additional, Chedid, Victor G, additional, Coelho-Prabhu, Nayantara, additional, Kisiel, John B, additional, Papadakis, Konstantinos A, additional, Pardi, Darrell, additional, Kane, Sunanda, additional, Tremaine, William J, additional, Raffals, Laura, additional, Bruining, David H, additional, Faubion, William A, additional, Harmsen, William S, additional, and Loftus, Edward V, additional

Published
2021
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44. A Cross Sectional Evaluation of Light Chain N-Glycosylation By MASS-FIX in Plasma Cell Disorders

Author

Mellors, Patrick, primary, Dasari, Surendra, additional, Kohlhagen, Mindy, additional, Arendt, Bonnie Kaye, additional, Gertz, Morie A., additional, Kumar, Shaji K., additional, Buadi, Francis K., additional, Willrich, Maria Alice V., additional, Lust, John A., additional, Kapoor, Prashant, additional, Lacy, Martha Q., additional, Dingli, David, additional, Hwa, Yi L., additional, Fonder, Amie, additional, Hobbs, Miriam A., additional, Hayman, Suzanne R., additional, Kourelis, Taxiarchis, additional, Warsame, Rahma M, additional, Muchtar, Eli, additional, Leung, Nelson, additional, Go, Ronald S., additional, Lin, Yi, additional, Gonsalves, Wilson I, additional, Siddiqui, Mustaqeem A., additional, Kyle, Robert A., additional, Rajkumar, S. Vincent, additional, Murray, David L., additional, and Dispenzieri, Angela, additional

Published
2020
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45. Determination of Relapse Risk By Complement Gene Variants after Eculizumab Discontinuation in Complement-Mediated Thrombotic Microangiopathy: A Retrospective Review

Author

Acosta-Medina, Aldo A., primary, Moyer, Ann M., additional, Go, Ronald S., additional, Willrich, Maria Alice V., additional, Alkhateeb, Hassan B., additional, Bourlon De Los Rios, Christianne, additional, Chen, Dong, additional, Fervenza, Fernando C., additional, Heikal, Nahla M., additional, Leung, Nelson, additional, Marshall, Ariela L., additional, Tran, Cheryl L., additional, Winters, Jeffrey L., additional, and Sridharan, Meera, additional

Published
2020
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46. MASS-FIX for the Diagnosis of Plasma Cell Disorders: A Single Institution Experience of 4118 Patients

Author

Mellors, Patrick, primary, Dasari, Surendra, additional, Kohlhagen, Mindy, additional, Arendt, Bonnie Kaye, additional, Gertz, Morie A., additional, Kumar, Shaji K., additional, Buadi, Francis K., additional, Willrich, Maria Alice V., additional, Lust, John A., additional, Kapoor, Prashant, additional, Lacy, Martha Q., additional, Dingli, David, additional, Hwa, Yi L., additional, Fonder, Amie, additional, Hobbs, Miriam A., additional, Hayman, Suzanne R., additional, Kourelis, Taxiarchis, additional, Warsame, Rahma M, additional, Muchtar, Eli, additional, Leung, Nelson, additional, Go, Ronald S., additional, Lin, Yi, additional, Gonsalves, Wilson I, additional, Siddiqui, Mustaqeem, additional, Kyle, Robert A., additional, Rajkumar, S. Vincent, additional, Murray, David L., additional, and Dispenzieri, Angela, additional

Published
2020
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48. Performance of perpendicular drop versus tangent skimming gating of M-protein in proficiency testing challenges

Author

Willrich, Maria Alice V., primary, Long, Thomas A., additional, Bashleben, Christine, additional, Fink, Susan L., additional, Rudolf, Joseph W., additional, Peterson, Daniel, additional, Wener, Mark H., additional, Baltaro, Richard J., additional, Genzen, Jonathan R., additional, Ansari, Mohammad Qasim, additional, Rhoads, Daniel D., additional, and Linden, Michael A., additional

Published
2020
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49. Distinct Cutoff Values of Adalimumab Trough Levels Are Associated With Different Therapeutic Outcomes in Patients With Inflammatory Bowel Disease

Author

Park, Sang Hyoung, primary, Al-Bawardy, Badr, additional, Aniwan, Satimai, additional, Kane, Sunanda V, additional, Coelho-Prabhu, Nayantara, additional, Papadakis, Konstantinos A, additional, Kisiel, John B, additional, Bruining, David H, additional, Faubion, William A, additional, Raffals, Laura E, additional, Pardi, Darrell S, additional, Tremaine, William J, additional, Stephens, Michael C, additional, Tung, Jeanne, additional, Khanna, Sahil, additional, Willrich, Maria Alice V, additional, and Loftus, Edward V, additional

Published
2019
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