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3. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, Szewczyk, Nathaniel, Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, and Szewczyk, Nathaniel

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

4. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024

7. Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice

Author

Zhu, Shouan, primary, Liu, Huanhuan, additional, Davis, Trent, additional, Willis, Craig R.G., additional, Basu, Reetobrata, additional, Witzigreuter, Luke, additional, Bell, Stephen, additional, Szewczyk, Nathaniel, additional, Lotz, Martin K., additional, Hill, Marcheta, additional, Fajardo, Roberto J., additional, O'Connor, Patrick M., additional, Berryman, Darlene E., additional, and Kopchick, John J., additional

Published
2023
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8. Routine omics collection is a golden opportunity for European human research in space and analog environments

Author

European Space Agency, National Aeronautics and Space Administration (US), University of Nottingham, Swedish Research Council, Cope, Henry [0000-0002-4984-0567], Rutter, Lindsay [0000-0003-2123-3949], Toh, Li Shean [0000-0002-9228-6266], Herranz, Raúl [0000-0002-0246-9449], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Muratani, Masafumi [0000-0002-0276-8000], Mason, Christopher E. [0000-0002-1850-1642], Etheridge,Timothy [0000-0002-3588-8711], Szewczyk, Nathaniel [0000-0003-4425-9746], Cope, Henry, Willis, Craig R.G., MacKay, Matthew J., Rutter, Lindsay, Toh, Li Shean, Williams, Philip M., Herranz, Raúl, Borg, Joseph, Bezdan, Daniela, Giacomello, Stefania, Muratani, Masafumi, Mason, Christopher E., Etheridge,Timothy, Szewczyk, Nathaniel, European Space Agency, National Aeronautics and Space Administration (US), University of Nottingham, Swedish Research Council, Cope, Henry [0000-0002-4984-0567], Rutter, Lindsay [0000-0003-2123-3949], Toh, Li Shean [0000-0002-9228-6266], Herranz, Raúl [0000-0002-0246-9449], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Muratani, Masafumi [0000-0002-0276-8000], Mason, Christopher E. [0000-0002-1850-1642], Etheridge,Timothy [0000-0002-3588-8711], Szewczyk, Nathaniel [0000-0003-4425-9746], Cope, Henry, Willis, Craig R.G., MacKay, Matthew J., Rutter, Lindsay, Toh, Li Shean, Williams, Philip M., Herranz, Raúl, Borg, Joseph, Bezdan, Daniela, Giacomello, Stefania, Muratani, Masafumi, Mason, Christopher E., Etheridge,Timothy, and Szewczyk, Nathaniel

Abstract

Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during spaceflight is still to be fully realized in humans. Nevertheless, rapid technological advancements and ever-regular spaceflight programs mean that longitudinal, standardized, and cost-effective collection of human space omics data are firmly within reach. Here, we consider the practicality and scientific return of different sampling methods and omic types in the context of human spaceflight. We also appraise ethical and legal considerations pertinent to omics data derived from European astronauts and spaceflight participants (SFPs). Ultimately, we propose that a routine omics collection program in spaceflight and analog environments presents a golden opportunity. Unlocking this bright future of artificial intelligence (AI)-driven analyses and personalized medicine approaches will require further investigation into best practices, including policy design and standardization of omics data, metadata, and sampling methods.

Published
2022

10. The acute transcriptional response to resistance exercise: impact of age and contraction mode

Author

Deane, Colleen S., Ames, Ryan M., Phillips, Bethan E., Weedon, Michael N., Willis, Craig R.G., Boereboom, Catherine, Abdulla, Haitham, Bukhari, Syed S.I., Lund, Jonathan N., Williams, John P., Wilkinson, Daniel J., Smith, Kenneth, Gallagher, Iain J., Kadi, Fawzi, Szewczyk, Nathaniel J., Atherton, Philip J., and Etheridge, Timothy

Subjects
Male, Aging, genetic structures, Down-Regulation, Resistance Training, Healthy Volunteers, Up-Regulation, sarcopenia, Young Adult, Gene Ontology, eccentric, Humans, sense organs, RNA-Seq, Muscle, Skeletal, Transcriptome, concentric, Research Paper, Aged, Muscle Contraction
Abstract

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We used transcriptomics to compare age-related molecular responses to acute CON and ECC exercise. Eight young (21±1 y) and eight older (70±1 y) exercise-naïve male volunteers had vastus lateralis biopsies collected at baseline and 5 h post unilateral CON and contralateral ECC exercise. RNA was subjected to next-generation sequencing and differentially expressed (DE) genes tested for pathway enrichment using Gene Ontology (GO). The young transcriptional response to CON and ECC was highly similar and older adults displayed moderate contraction-specific profiles, with no GO enrichment. Age-specific responses to ECC revealed 104 DE genes unique to young, and 170 DE genes in older muscle, with no GO enrichment. Following CON, 15 DE genes were young muscle-specific, whereas older muscle uniquely expressed 147 up-regulated genes enriched for cell adhesion and blood vessel development, and 28 down-regulated genes involved in mitochondrial respiration, amino acid and lipid metabolism. Thus, older age is associated with contraction-specific regulation often without clear functional relevance, perhaps reflecting a degree of stochastic age-related dysregulation.

Published
2019

12. Network analysis of human muscle adaptation to aging and contraction

Author

Willis, Craig R.G., Ames, Ryan M., Deane, Colleen S., Phillips, Bethan E., Boereboom, Catherine L., Abdulla, Haitham, Bukhari, Syed S.I., Lund, Jonathan N, Williams, John P., Wilkinson, Daniel J., Smith, Kenneth, Kadi, Fawzi, Szewczyk, Nathaniel J., Atherton, Philip J., Etheridge, Timothy, Willis, Craig R.G., Ames, Ryan M., Deane, Colleen S., Phillips, Bethan E., Boereboom, Catherine L., Abdulla, Haitham, Bukhari, Syed S.I., Lund, Jonathan N, Williams, John P., Wilkinson, Daniel J., Smith, Kenneth, Kadi, Fawzi, Szewczyk, Nathaniel J., Atherton, Philip J., and Etheridge, Timothy

Abstract

Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we employed a network-driven pipeline to identify putative molecular drivers of muscle aging and contraction mode responses. RNA-sequencing data was generated from young (21±1 y) and older (70±1 y) human skeletal muscle before and following acute unilateral concentric and contralateral eccentric contractions. Application of weighted gene co-expression network analysis identified 33 distinct gene clusters ('modules') with an expression profile regulated by aging, contraction and/or linked to muscle strength. These included two contraction 'responsive' modules (related to 'cell adhesion' and 'transcription factor' processes) that also correlated with the magnitude of post-exercise muscle strength decline. Module searches for 'hub' genes and enriched transcription factor binding sites established a refined set of candidate module-regulatory molecules (536 hub genes and 60 transcription factors) as possible contributors to muscle aging and/or contraction responses. Thus, network-driven analysis can identify new molecular candidates of functional relevance to muscle aging and contraction mode adaptations., Funding Agencies:EPSRC/BBSRC Innovation Fellowship EP/S001352/1Bournemouth University Medical Research Council UK (MRC) MR/P021220/1 MR/K00414X/1Arthritis Research UK via the MRC-ARUK Centre for Musculoskeletal Aging Research 19891Biotechnology and Biological Sciences Research Council (BBSRC) BB/J014400/1 BB/M009122/1 BB/N015894/1Swedish Research Council for Sport Science dnr 2016/125 dnr 2017/143National Institute for Health Research, Nottingham Biomedical Research Centre

Published
2020
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13. Network analysis of human muscle adaptation to aging and contraction

Author

Willis, Craig R.G., primary, Ames, Ryan M., additional, Deane, Colleen S., additional, Phillips, Bethan E., additional, Boereboom, Catherine L., additional, Abdulla, Haitham, additional, Bukhari, Syed S.I., additional, Lund, Jonathan N., additional, Williams, John P., additional, Wilkinson, Daniel J., additional, Smith, Kenneth, additional, Kadi, Fawzi, additional, Szewczyk, Nathaniel J., additional, Atherton, Philip J., additional, and Etheridge, Timothy, additional

Published
2020
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