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36 results on '"Willis, C.R."'

5. Complex polar machinery required for proper chromosome segregation in vegetative and sporulating cells of Bacillus subtilis

Author

Kloosterman, T.G., Lenarcic, R., Willis, C.R., Roberts, D.M., Hamoen, L.W., Errington, J., Wu, L.J., and Bacterial Cell Biology & Physiology (SILS, FNWI)

Subjects
fungi, bacteria
Abstract

Chromosome segregation is an essential process of cell multiplication. In prokaryotes, segregation starts with the newly replicated sister origins of replication, oriCs, which move apart to defined positions in the cell. We have developed a genetic screen to identify mutants defective in placement of oriC during spore development in the Gram-positive bacterium Bacillus subtilis. In addition to the previously identified proteins Soj and DivIVA, our screen identified several new factors involved in polar recruitment of oriC: a reported regulator of competence ComN, and the regulators of division site selection MinD and MinJ. Previous work implicated Soj as an important regulator of oriC positioning in the cell. Our results suggest a model in which the DivIVA-interacting proteins ComN and MinJ recruit MinD to the cell pole, and that these proteins work upstream of Soj to enable oriC placement. We show that these proteins form a polar complex, which acts in parallel with but distinct from the sporulation-specific RacA pathway of oriC placement, and also functions during vegetative growth. Our study further shows that MinD has two distinct cell cycle roles, in cell division and chromosome segregation, and highlights that cells probably use multiple parallel mechanisms to ensure accurate chromosome segregation. This article is protected by copyright. All rights reserved.

Published
2016

7. Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep Infectieziekten Immunologie, Hartgring, S.A.Y., Willis, C.R., Dean, C.E., Broere, F., van Eden, W., Bijlsma, J.W.J., Lafeber, F.P.J.G., van Roon, J.A.G., Risk Assessment of Toxic and Immunomodulatory Agents, Dep Infectieziekten Immunologie, Hartgring, S.A.Y., Willis, C.R., Dean, C.E., Broere, F., van Eden, W., Bijlsma, J.W.J., Lafeber, F.P.J.G., and van Roon, J.A.G.

Published
2011

19. Polymer–Drug Interacted Systems in the Physicochemical Design of Pharmaceutical Dosage Forms I

Author

Willis, C.R. and Banker, Gilbert S.

Abstract

The applicability of a polymer-drug interacted system in the physicochemical design of pharmaceutical dosage forms has been investigated. Salts of poly(methyl vinyl ether/maleic anhydride) and methapyrilene base were prepared. In vitrorelease patterns were determined by an equilibrium dialysis procedure. Dialytic release rates of the polymer-drug salt in solution demonstrated no appreciable difference in drug availability with respect to the free drug or its hydrochloride salt. In vitrodissolution rates of the polymer-drug salt in solid form showed similar results. Polymer-drug salts formed with the 1,12-dihydroxyoctadecane hemi-ester of poly-(methyl vinyl ether/maleic anhydride) exhibited prolongation of the release of the drug from granular and tableted forms in vitro.

Published
1968
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20. Evaluation of Polymeric Materials IV.

Author

Willis, C.R., Banker, Gilbert S., and Dekay, H. George

Abstract

Experimental granulations were produced using aqueous and alcoholic solutions of polymeric celluloses, vinyls, acrylamides, pyrrolidones, oxazolidinones, and ethylene oxide condensation products. Products were compared to control formulations granulated with starch paste. Dextroamphetamine sulfate was employed in a preliminary dialysis and dissolution study in the presence of the polymers shown to be of value. The experimental products exhibited gloss equal or superior to coated tablets in many instances, and no drug binding or inhibition of release occurred. The polymer-bound granulations displayed excellent flow properties, were easily compressed into tablets of various degrees of hardness, were generally more resistant to friabilation than the control; some of the polymers produced tablets which had equal or superior disintegration times compared to the control.

Published
1965
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32. Andrographolide

Author

Cava, M.P., primary, Chan, W.R., additional, Stein, R.P., additional, and Willis, C.R., additional

Published
1965
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