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2. Peripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies—A Case Series

Author

Dörner, Marc, Schreiber, Frank, Vielhaber, Stefan, Schelle, Thomas, Grimm, Alexander, Schreiber, Stefanie, Stephanik, Heike, Tempelmann, Claus, Winter, Natalie, Stahl, Jan-Hendrik, Wittlinger, Julia, Willikens, Sophia, Kramer, Magdalena, and Heinze, Hans-Jochen

Subjects
lcsh:R5-920, amyotrophic lateral sclerosis, peripheral nerve imaging, magnetic resonance neurography, nerve ultrasound, immune-mediated neuropathies, Case Report, ddc:610, lcsh:Medicine (General)
Abstract

Background: Diagnosis of immune-mediated neuropathies and their differentiation from amyotrophic lateral sclerosis (ALS) can be challenging, especially at early disease stages. Accurate diagnosis is, however, important due to the different prognosis and available treatment options. We present one patient with a left-sided dorsal flexor paresis and initial suspicion of ALS and another with multifocal sensory deficits. In both, peripheral nerve imaging was the key for diagnosis. Methods: We performed high-resolution nerve ultrasound (HRUS) and 7T or 3T magnetic resonance neurography (MRN). Results: In both patients, HRUS revealed mild to severe, segmental or inhomogeneous, nerve enlargement at multiple sites, as well as an area increase of isolated fascicles. MRN depicted T2 hyperintense nerves with additional contrast-enhancement. Discussion: Peripheral nerve imaging was compatible with the respective diagnosis of an immune-mediated neuropathy, i.e., multifocal motor neuropathy (MMN) in patient 1 and multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) in patient 2. Peripheral nerve imaging, especially HRUS, should play an important role in the diagnostic work-up for immune-mediated neuropathies and their differentiation from ALS.

Published
2020
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4. Nerve Ultrasound as Helpful Tool in Polyneuropathies

Author

Kramer, Magdalena, primary, Grimm, Alexander, additional, Winter, Natalie, additional, Dörner, Marc, additional, Grundmann-Hauser, Kathrin, additional, Stahl, Jan-Hendrik, additional, Wittlinger, Julia, additional, Kegele, Josua, additional, Kronlage, Cornelius, additional, and Willikens, Sophia, additional

Published
2021
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6. Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies

Author

Grimm, Anna-Sophie, primary, Schubert, Charlotte, additional, Grimm, Alexander, additional, Stahl, Jan-Hendrik, additional, Küpper, Hanna, additional, Horber, Veronka, additional, Kegele, Josua, additional, Willikens, Sophia, additional, Wittlinger, Julia, additional, Serna-Higuita, Lina, additional, Winter, Natalie, additional, and Groeschel, Samuel, additional

Published
2020
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