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The early life and professional career of Dr. Satoru Takeuchi, a noted Japanese librarian, educator, and author, are explored here within the context of Japanese library education since World War II. Professor Takeuchi, now retired from the University of Library and Information Science (ULIS) in Tsukuba, Japan, has been an influential educator, administrator, and author in Japan for well over 40 years. He has written and translated books on children's literature, storytelling, library architecture, ethics, and comparative study of libraries and librarianship. His recent analyses of the work of S. R. Ranganathan have been very influential among library education faculty and students throughout the world. This article provides a brief look at a different cultural situation for LIS education, one that is both similar to but still different from the North American centric view. It shows how one individual was greatly influenced by the North American model but made his own adaptations based on Japanese traditions and culture.

The enzyme UDP-glucose: glycoprotein glucosyltransferase (UGGT) is the gatekeeper of protein folding within the endoplasmic reticulum (ER). One-third of the human proteome traverses the ER where folding and maturation are facilitated by a complex protein homeostasis network. Both glycan modifications and disulfide bonds are of key importance in the maturation of these ER proteins. The actions of UGGT are intimately linked to the glycan code for folding and maturation of secretory proteins in the ER. UGGT selectively glucosylates the N-linked glycan of misfolded proteins so that they can reenter the lectin-folding chaperone cycle and be retained within the ER for further attempts at folding. An intriguing aspect of UGGT function is its interaction with its poorly understood cochaperone, the 15 kDa selenoprotein known as SELENOF or SEP15. This small protein contains a rare selenocysteine residue proposed to act as an oxidoreductase toward UGGT substrates. AlphaFold2 predictions of the UGGT1/SEP15 complex provide insight into this complex at a structural level. The predicted UGGT1/SEP15 interaction interface was validated by mutagenesis and coimmunoprecipitation experiments. These results serve as a springboard for models of the integrated action of UGGT1 and SEP15. [ABSTRACT FROM AUTHOR]

Preparation of samples for nuclear magnetic resonance (NMR) characterization of larger proteins requires enrichment with less abundant, NMR-active, isotopes such as 13C and 15N. This is routine for proteins that can be expressed in bacterial culture where low-cost isotopically enriched metabolic substrates can be used. However, it can be expensive for glycosylated proteins expressed in mammalian culture where more costly isotopically enriched amino acids are usually used. We describe a simple, relatively inexpensive procedure in which standard commercial media is supplemented with 13C-enriched glucose to achieve labeling of all glycans plus all alanines of the N-terminal domain of the highly glycosylated protein, CEACAM1. We demonstrate an ability to detect partially occupied N -glycan sites, sites less susceptible to processing by an endoglycosidase, and some unexpected truncation of the amino acid sequence. The labeling of both the protein (through alanines) and the glycans in a single culture requiring no additional technical expertise past standard mammalian expression requirements is anticipated to have several applications, including structural and functional screening of the many glycosylated proteins important to human health. [ABSTRACT FROM AUTHOR]

Explores problems in the design and evaluation of programs by which special libraries market their services, and identifies potentially useful approaches and quantifiable measures for market structure analysis, design decision-making, and marketing program evaluation. Eleven references and a list of nine use studies with survey instruments are appended. (EJS)

Presents historical review of issues and trends in training of professionals for subject-oriented libraries and argues that resistance by library education programs to practitioner demands for specialization has limited librarians to a narrow range of work in the "Information Society" and created unnecessary divisions within the information profession at large. (CD)

Examines the roles of intergovernmental organizations, with a focus on UNESCO, in the development of international information policy initiatives and international information transfer systems within the last 40 years. Recommendations are made for continuing work in this area. The needs and contributions of special librarians around the world are also considered. (10 references) (MES)

Examination of appropriateness of productivity measurements to assess performance of special libraries defines the concept, discusses problems in their use, and gives guidelines for implementation. Results of use of productivity measurements in Library of Congress and State Department library are reported, and productivity measurements are compared with other evaluation tools. (17 references) (MES)

Defines inter-governmental organizations (IGOs) and examines their characteristics. The nature of their information systems (publications, internal documents, archival records, library information centers, and bibliographic information networks) are discussed. Problems with acquiring information from IGOs and sources for accessing publications are described. (12 references) (MES)

No abstract available for this article. [ABSTRACT FROM PUBLISHER]

Presents a guide to the professional literature on international and comparative librarianship. 'The Beneficiaries of Library and Information Policy in British and Ex-British Africa: Steps From the White Women's League to the Electronic Library,' by Edward A. Olden; 'Building Information Systems in the Islamic World,' edited by Ziauddin Sardar; 'Formulating a National Policy for Library and Information Services: The Malaysian Experience,' by Oli Mohamed.