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2. High-throughput single telomere analysis using DNA microarray and fluorescent in situ hybridization.

Author

Zheng, Yun-Ling, Wu, Xingjia, Williams, Madeline, Verhulst, Simon, Lin, Jue, Takahashi, Yusuke, Ma, Jian-Xing, and Wang, Ying

Subjects
In Situ Hybridization, Fluorescence, Humans, Telomere, Oligonucleotide Array Sequence Analysis, Telomere Homeostasis, High-Throughput Screening Assays, Male, Adult, Female, Middle Aged
Abstract

The human telomere system is highly dynamic. Both short and long leucocyte average telomere lengths (aTL) are associated with an increased risk of cancer and early death, illustrating the complex relationship between TL and human health and the importance of assessing TL distributions with single TL analysis. A DNA microarray and telomere fluorescent in situ hybridization (DNA-array-FISH) approach was developed to measure the base-pair (bp) lengths of single telomeres. On average 32000 telomeres were measured per DNA sample with one microarray chip assaying 96 test DNA samples. Various telomere parameters, i.e. aTL and the frequency of short/long telomeres, were computed to delineate TL distribution. The intra-assay and inter-assay coefficient of variations of aTL ranged from 1.37% to 3.98%. The correlation coefficient (r) of aTL in repeated measurements ranged from 0.91 to 1.00, demonstrating high measurement precision. aTLs measured by DNA-array-FISH predicted aTLs measured by terminal restriction fragment (TRF) analysis with r ranging 0.87-0.99. A new accurate and high-throughput method has been developed to measure the bp lengths of single telomeres. The large number of single TL data provides an opportunity for an in-depth analysis of telomere dynamics and the complex relationship between telomere and age-related diseases.

Published
2024

5. Hawks blank VCU 2-0 in first A-10 victory

Author

Williams, Madeline

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Madeline Williams Fifth-year Katy Benton advances toward VCU defense. The Hawks huddle in preparation for a penalty shot. [...]

Published
2023

7. Publisher Correction: Marine microbial metagenomes sampled across space and time

Author

Biller, Steven J., Berube, Paul M., Dooley, Keven, Williams, Madeline, Satinsky, Brandon M., Hackl, Thomas, Hogle, Shane L., Coe, Allison, Bergauer, Kristin, Bouman, Heather A., Browning, Thomas J., Corte, Daniele De, Hassler, Christel, Hulston, Debbie, Jacquot, Jeremy E., Maas, Elizabeth W., Reinthaler, Thomas, Sintes, Eva, Yokokawa, Taichi, and Chisholm, Sallie W.

Published
2019
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8. CORRESPONDENCE

Author

Lord, Bob, Hanrahan, Dennis, Burnett, Rebecca E., Robart, Kay, Bosley, Deborah S., Staples, Jeff, Willebeek-LeMair, Jason T., Manwiller, Janice, Vidal, Genie, Fenwick, Ellen, Williams, Madeline D., Sproat, Eliza, and Yaskell, Steven

Published
1998

10. Marine microbial metagenomes sampled across space and time

Author

Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology. Department of Biology, Biller, Steven, Berube, Paul M., Dooley, Keven Douglas, Williams, Madeline Dee, Satinsky, Brandon Meyer, Hackl, Thomas, Hogle, Shane Lahman, Coe, Allison, Bergauer, Kristin, Bouman, Heather A., Browning, Thomas J., De Corte, Daniele, Hassler, Christel, Hulston, Debbie, Jacquot, Jeremy E., Maas, Elizabeth W., Reinthaler, Thomas, Sintes, Eva, Yokokawa, Taichi, Chisholm, Sallie W, Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology. Department of Biology, Biller, Steven, Berube, Paul M., Dooley, Keven Douglas, Williams, Madeline Dee, Satinsky, Brandon Meyer, Hackl, Thomas, Hogle, Shane Lahman, Coe, Allison, Bergauer, Kristin, Bouman, Heather A., Browning, Thomas J., De Corte, Daniele, Hassler, Christel, Hulston, Debbie, Jacquot, Jeremy E., Maas, Elizabeth W., Reinthaler, Thomas, Sintes, Eva, Yokokawa, Taichi, and Chisholm, Sallie W

Abstract

Recent advances in understanding the ecology of marine systems have been greatly facilitated by the growing availability of metagenomic data, which provide information on the identity, diversity and functional potential of the microbial community in a particular place and time. Here we present a dataset comprising over 5 terabases of metagenomic data from 610 samples spanning diverse regions of the Atlantic and Pacific Oceans. One set of metagenomes, collected on GEOTRACES cruises, captures large geographic transects at multiple depths per station. The second set represents two years of time-series data, collected at roughly monthly intervals from 3 depths at two long-term ocean sampling sites, Station ALOHA and BATS. These metagenomes contain genomic information from a diverse range of bacteria, archaea, eukaryotes and viruses. The data’s utility is strengthened by the availability of extensive physical, chemical, and biological measurements associated with each sample. We expect that these metagenomes will facilitate a wide range of comparative studies that seek to illuminate new aspects of marine microbial ecosystems., Simons Foundation (Award 337262), Simons Foundation (Award 329108), Gordon and Betty Moore Foundation (Grant GBMF495), Gordon and Betty Moore Foundation (Grant GBMF4511), National Science Foundation (Grant OCE-1153588), National Science Foundation (Grant OCE-1356460), National Science Foundation (Grant DBI-0424599)

Published
2020

11. Samantha's Surprise

Author

Kapelke, Dahlia and Williams, Madeline

Subjects
Fiction by children, Children's stories, Women's issues/gender studies
Abstract

Illustration by Liz Beatty Samantha Washington could barely manage to keep her eyes open, let alone take notes during Mrs. Shokenboggin's superboring lesson. She was rambling on about Mr. Henry [...]

Published
2018

12. A tale of two families

Author

Williams, Madeline Elaine

Subjects
mental disorders, behavioral disciplines and activities
Abstract

Autism spectrum disorder (ASD) is a highly complex, heterogeneous neurodevelopmental disorder characterized by an impairment in social communication and interaction as well as stereotyped/repetitive behavior. While ASD is a highly prevalent disorder (1:68), the underlying molecular mechanisms have yet to be identified and no therapeutics to treat core symptoms exist. As the name suggests, individuals with ASD have a wide range of severity of symptoms, intelligence levels, comorbid disorders, environmental and genetic contributions, different potential etiologies, and pathologies. This human social disorder characterized by vast heterogeneity cannot be properly modelled in a mouse, a challenge that has hindered the study of ASD. Here, I present methods for examining proliferation in human neural precursor cells (NPCs) as well as a case study on two families examining ASD NPC proliferation in comparison to their sex-matched sibling controls. In comparison to their siblings, ASD patients present patient-specific proliferation phenotypes at baseline, in response to growth factors, and under environmental stressor conditions. A common phenotype emerges after exposure to methyl mercury (MeHg), both ASD patients show a reduction in sensitivity to the negative impact on DNA synthesis. In aggregate, I have created a toolset to measure patient-derived NPC proliferation, applied it to examine differences in ASD-sibling pairs, and identified both patient-specific and common patient phenotypes.

Published
2018
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13. Marine microbial metagenomes sampled across space and time

Author

Biller, Steven J., primary, Berube, Paul M., additional, Dooley, Keven, additional, Williams, Madeline, additional, Satinsky, Brandon M., additional, Hackl, Thomas, additional, Hogle, Shane L., additional, Coe, Allison, additional, Bergauer, Kristin, additional, Bouman, Heather A., additional, Browning, Thomas J., additional, De Corte, Daniele, additional, Hassler, Christel, additional, Hulston, Debbie, additional, Jacquot, Jeremy E., additional, Maas, Elizabeth W., additional, Reinthaler, Thomas, additional, Sintes, Eva, additional, Yokokawa, Taichi, additional, and Chisholm, Sallie W., additional

Published
2018
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15. Marine microbial metagenomes sampled across space and time

Author

Biller, Steven J., Berube, Paul M., Dooley, Keven, Williams, Madeline, Satinsky, Brandon M., Hackl, Thomas, Hogle, Shane L., Coe, Allison, Bergauer, Kristin, Bouman, Heather A., Browning, Thomas J., De Corte, Daniele, Hassler, Christel, Hulston, Debbie, Jacquot, Jeremy E., Maas, Elizabeth W., Reinthaler, Thomas, Sintes, Eva, Yokokawa, Taichi, Chisholm, Sallie W., Biller, Steven J., Berube, Paul M., Dooley, Keven, Williams, Madeline, Satinsky, Brandon M., Hackl, Thomas, Hogle, Shane L., Coe, Allison, Bergauer, Kristin, Bouman, Heather A., Browning, Thomas J., De Corte, Daniele, Hassler, Christel, Hulston, Debbie, Jacquot, Jeremy E., Maas, Elizabeth W., Reinthaler, Thomas, Sintes, Eva, Yokokawa, Taichi, and Chisholm, Sallie W.

Abstract

Recent advances in understanding the ecology of marine systems have been greatly facilitated by the growing availability of metagenomic data, which provide information on the identity, diversity and functional potential of the microbial community in a particular place and time. Here we present a dataset comprising over 5 terabases of metagenomic data from 610 samples spanning diverse regions of the Atlantic and Pacific Oceans. One set of metagenomes, collected on GEOTRACES cruises, captures large geographic transects at multiple depths per station. The second set represents two years of time-series data, collected at roughly monthly intervals from 3 depths at two long-term ocean sampling sites, Station ALOHA and BATS. These metagenomes contain genomic information from a diverse range of bacteria, archaea, eukaryotes and viruses. The data's utility is strengthened by the availability of extensive physical, chemical, and biological measurements associated with each sample. We expect that these metagenomes will facilitate a wide range of comparative studies that seek to illuminate new aspects of marine microbial ecosystems.

Published
2018
Full Text
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19. Disability Democracy: The Origins of Blind-Led Organizing in the United States, 1829-1935

Author

Williams, Madeline J.

Subjects
blind history, disability studies, history of technology, intersectionality, social movements, United States history, American history, Disability studies, Science history
Abstract

This dissertation considers the emergence, activities, and legacies of blind-led organizing in the late-nineteenth and early-twentieth-century United States as a vehicle for deepening understanding of the long history of political and social movement building around disability. Rooted in analysis of archival, digital, legal, material-object, and published sources, it considers how blind-led organizing—some of the first political work around disability led by disabled people themselves—and its fruits were shaped at every stage by the historical contexts in which organizers operated. The dissertation draws on the frameworks and methodological resources of U.S. history and intersectional disability studies. In the 1830s, residential blind schools formed as a strand of U.S.-American nationalism and Christian reform during key years in the United States’ ascent as a major expansionist settler-empire on the North American continent. Though this was not the intent of the sighted founders of the schools, who feared that bonds formed between blind people might encourage their isolation, the schools became incubators of blind sociality, and, by extension, blind politics. A small blind elite emerged from the schools as the first generations of pupils graduated from them. Most members of the blind elite were white men, the cohort most served by the schools in this period. The blind elite fostered the development and innovation of technologies tailored to blind people’s access needs—especially tools for blind writing like point types (including braille) and typewriters—in a world designed and run by nonblind people. They engaged collective self-help and middle-class-cultivation strategies, which they disseminated through alumni groups, social clubs, and benevolent societies. Generally pervasive economic inequality, structural barriers to blind workers’ employment, and anti-blind prejudice collided to deepen the likelihood of blind people’s poverty—and thus the likelihood of discursive connections between blindness and poverty. Alongside sighted people, middle-class blind organizers created and maintained workshops which employed blind people who might have otherwise been excluded from participation in the labor market and paid them extremely low wages to conduct repetitive and monotonous work. This and other assistance to blind people poorer than themselves functioned as a strategy to decouple cultural associations between blindness and poverty during a period in which poverty was deeply stigmatized. By the late nineteenth century, these trends in blind sociality fused with developments in association building and Progressive politics. Through their associations, graduates of the schools brought the skills they had learned in the blind schools to newly blinded adults too old for institutional instruction by engaging mutual aid work and ongoing education programs. In step with wider trends in Progressive organizing, there were more opportunities for white blind women in association leadership and membership than ever before. Under a coalescing Jim Crow regime and a rising mainstream eugenics movement, these organizations tended to prioritize the needs and concerns of white people from all classes over nonwhite blind people, though there were exceptions, including white organizers working across the color line and at least one Black- and blind-led Progressive Era association, which operated out of Baltimore. Like many other Progressive Era organizers, blind organizers took advantage of new opportunities for direct democratic participation in state politics. They considered their political advocacy to be fundamentally compatible with their ongoing mutual aid activities. Over the course of several years and through complex political campaigns, blind-led associations coalesced around the common issue of the blind pension, or a small monetary grant from the state which the associations framed as key to covering the extra and unfair costs which blind workers faced in their quest for employment and a modicum of economic security. The pension campaigns were particularly successful in the North, Midwest, and West—regions with the strongest traditions of Progressive Era direct democratic work. While blind-led organizing faced new challenges during the conservative and professionalized climate of the 1920s, blind pension laws would enjoy an unexpected afterlife in the New Deal era. The pensions provided the model for a federalized “Aid to the Blind” program, which was elaborated in the Social Security Act of 1935. Due to the legacies of blind-led organizing, blind people were the only working-age adults specified in the Act, which represented one of the first policies of federal provisions for disabled civilians in the United States.

Published
2023

26. Careful, Careful.

Author

Williams, Madeline Rose

Subjects
ANIMAL cemeteries
Published
2016

27. Employee buys Ballard Sales ice equipment firm.

Author

Williams, Madeline

Subjects
SALE of business enterprises
Abstract

Reports that Ballard Sales Incorporated, an ice machine and equipment distributor in Fort Worth, Texas, has been purchased by Lee Norton, an employee at Ballard from owner Frances Fournier. Business background of Ballard; Brief information on Fournier's business transactions; Background information on Norton.

Published
1998

28. Law, politics and the price of volunteering.

Author

Williams, Madeline

Subjects
CITIZENS' associations
Abstract

Focuses on lawyers who defy the risks and opt to argue cases in which their may be a conflict of interests, particularly if the presiding judge and the defending attorney personally acquainted state, with emphasis on Estil Vance Junior, who represented I-CARE (Citizens Advocates for Responsible Expansion). Details on the case; Significance of the fact that the presiding judge in the case was a former law partner of Vance.

Published
1998

29. Retired Carter Blood chief realizes goal with North Texas...

Author

Williams, Madeline

Subjects
BLOOD banks, HEALTH facilities
Abstract

Looks at the construction of the Carter BloodCare Center, combining the Medical Doctor Margie Peschel's Fort Worth Carter Blood Center and Dallas blood bank. Purpose of the mergers; Significant advances at the Carter Blood Center; Themesong of Peschel; Background information on Peschel; Positions held; Her achievements.

Published
1997

30. Banking bust was tough but valuable experience, bankers say.

Author

Williams, Madeline

Subjects
BANKERS, EMPLOYMENT
Abstract

Opinion. Comments on the experience of bankers who survived the industry's dark days with their careers still in place. Details on four bank executives who experience a series of bank failures.

Published
1997

31. Pharmaceutical giants, physicians, partner with clinical researchers.

Author

Williams, Madeline

Subjects
CLINICAL drug trials
Abstract

States that pharmaceutical companies and physicians in Fort Worth, Texas, to test the effectiveness of drugs developed. Factors which contributed to physicians and pharmaceutical companies joining forces; Reference to Andrew O. Nelson, an employee of The Phoenix, a research management company in New Jersey; Advantages of doctors and pharmaceutical companies joining forces.

Published
1997

32. Healing hands: After 59 years, Dr. Carlton has no plans to retire.

Author

Williams, Madeline

Subjects
CARLTON, Catherine
Abstract

Profiles Dr. Catherine Carlton, who has been practicing osteopathic medicine at the same location in Fort Worth, Texas for almost 60 years. History behind Carlton's practice; Statements from Carlton.

Published
1997

33. From cattle drive to high-tech: Cowtown cuts trail of progress.

Author

Williams, Madeline

Subjects
HIGH technology industries
Abstract

Presents information on the economic progress of `Cowtown' in Texas. What has contributed to the country's economic success; Details on the most profitable industries in Cowtown.

Published
1997

35. Ophthalmologist sets sights on new glaucoma advances.

Author

Williams, Madeline

Subjects
SMITH, Judson
Abstract

Interviews Doctor Judson P. Smith, specialist in ophthalmology and ophthalmic surgery. Information on Smith; Comments from Smith regarding his work.

Published
1997

36. Cathedral redo a symbol of FW renaissance.

Author

Williams, Madeline

Subjects
CATHEDRALS
Abstract

Reports on the restoration and enlargement project of the Saint Patrick's Cathedral, Fort Worth, Texas. Cost of the project; What restoration and enlargement phases include; What the plan calls for; When the project will be completed; Comments made by Art Dickenson, chairman of the fund drive.

Published
1997

37. Retireee gives words to the speech impaired.

Author

Williams, Madeline

Subjects
LANGUAGE disorders
Abstract

Presents information on a proposal by Bob Middlebrook, a retired real estate businessman, of club sponsored laminated communication boards, in efforts to assist the speech impaired. Details on the agreement of the proposal; What prompted this move by Middlebrook; Comments made by Middlebrook.

Published
1997

38. Greek grocer selling shop for high-tech hopes.

Author

Williams, Madeline

Subjects
CAREER changes, SALE of business enterprises
Abstract

Looks at the decision by Nick Phiripes, manager of `George's,' a family owned Greek grocery and import store located in Fort Worth, Texas, to sell the company and change his career. Why Phiripes made the decision; Nick's parents approval of his decision; How his wife feels about the decision.

Published
1997

39. Fort Worth's printing past: The type that ran hot and cold.

Author

Williams, Madeline

Subjects
PRINTING industry, NEWSPAPER publishing, HISTORY
Abstract

Relates the history and changes in the newspaper and printing industry of Fort Worth, Texas. Fort Worth as center of printing revolution; Invention of cold type and rotary offset press in late 1940s; Establishment of Printers Service Co. in the 1950s; Starting of Printing Center, a central printing plant, in 1972; Coming of duplicator and multicolor presses; Advent of technological innovations.

Published
1997

40. Raising barricades lead to rising profits.

Author

Williams, Madeline

Subjects
BUYERS Co.
Abstract

Relates the history of Buyers Co., a Fort Worth, Texas-based company which specializes in producing barricades and traffic control signs and devices. Owners Pam and Steven Buyers' recollections of their initial experiences in operating the company; Purpose of barricades; Educational background of the owners.

Published
1997

41. Politicking for boom times and back.

Author

Williams, Madeline

Subjects
WOODARD, Don
Abstract

Features insurance executive, political insider and author Don Woodard. Writing of the book `Black Diamonds! Black Gold!' which looks at the history of Texas oil and politics; Insurance partnership with sons; Association with political kingmaker H.B. Fuqua; Involvement in politics.

Published
1997

42. Anesthesiologist lands TCMS' prestigious Gold-Headed Cane.

Author

Williams, Madeline

Subjects
AWARDS
Abstract

Announces that Dr. Valentine `Val' Borum received the Tarrant County Medical Society's Gold-Headed Cane for outstanding contributions to the medical profession. Information on Borum's medical career; Statements from Borum.

Published
1997

43. Pulmonary specialist has heart for patients, hope for the cures.

Author

Williams, Madeline

Subjects
MEDICAL care cost control
Abstract

Profiles pulmonary specialist Dr. Roger Gleason. Statements from Gleason; Educational background of Gleason; Concerns with the upsurge of medical insurance control over medical practice.

Published
1997

44. Dropping hyphenation in an all-American move.

Author

Williams, Madeline

Subjects
DISCRIMINATION (Sociology), MASS media
Abstract

Presents opinion regarding ethnic discrimination in the media. Case of Tiger Woods; Hyphenated description of Americans; Language used for minorities; Responsibility of the media to lead the way; Sports and entertainment breaking down color barriers; End divisiveness.

Published
1997

45. Stock Show tradition driven by 101 years of `better beef'.

Author

Williams, Madeline C.

Subjects
CATTLE industry, CONFERENCES & conventions
Abstract

Presents an article written by newspaperman and historian, Mack H. Williams about the history of the 1997 Fort Worth Stock Show. Importance of cattle industry to the economy.

Published
1997

46. Gardens bloom under volunteer care.

Author

Williams, Madeline

Subjects
BOTANICAL gardens, GARDEN clubs
Abstract

Opinion. Focuses on the efforts of the Garden Club of America to improve the Fort Worth Botanic Garden in Texas. Annual operating budget; Fundraising and volunteer work by the club.

Published
1997

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