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1. Socioeconomic deprivation and perinatal anxiety: an observational cohort study

Author: Best, Catherine, Ayers, Susan, Sinesi, Andrea, Meades, Rose, Cheyne, Helen, Maxwell, Margaret, McNicol, Stacey, Williams, Louise R, Alderdice, Fiona, Jomeen, Julie, and Shakespeare, Judy
Published: 2024
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2. When is the best time to screen for perinatal anxiety? A longitudinal cohort study

Author: Ayers, Susan, Sinesi, Andrea, Coates, Rose, Cheyne, Helen, Maxwell, Margaret, Best, Catherine, McNicol, Stacey, Williams, Louise R., Uddin, Nazihah, Shakespeare, Judy, and Alderdice, Fiona
Published: 2024
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3. The experience of fathers during the covid-19 UK maternity care restrictions

Author: Andrews, Kathryn, Ayers, Susan, and Williams, Louise R
Published: 2022
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4. Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women : multicentre randomised controlled trial

Author: Hagen, Suzanne, Elders, Andrew, Stratton, Susan, Sergenson, Nicole, Bugge, Carol, Dean, Sarah, Hay-Smith, Jean, Kilonzo, Mary, Dimitrova, Maria, Abdel-Fattah, Mohamed, Agur, Wael, Booth, Jo, Glazener, Cathryn, Guerrero, Karen, McDonald, Alison, Norrie, John, Williams, Louise R, and McClurg, Doreen
Published: 2020

5. Barriers and facilitators to implementing perinatal mental health care in health and social care settings: a systematic review

Author: Clark, Elaine, Frame, Evelyn, Gilbody, Simon, Hann, Agnes, McMullen, Sarah, Rosan, Camilla, Salmon, Debra, Sinesi, Andrea, Thompson, Claire, Williams, Louise R, Webb, Rebecca, Uddin, Nazihah, Ford, Elizabeth, Easter, Abigail, Shakespeare, Judy, Roberts, Nia, Alderdice, Fiona, Coates, Rose, Hogg, Sally, Cheyne, Helen, and Ayers, Susan
Published: 2021
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6. Women's experiences and views of routine assessment for anxiety in pregnancy and after birth: A qualitative study.

Author: Yuill, Cassandra, Sinesi, Andrea, Meades, Rose, Williams, Louise R., Delicate, Amy, Cheyne, Helen, Maxwell, Margaret, Shakespeare, Judy, Alderdice, Fiona, Leonard, Rachael, Ayers, Susan, Best, Catherine, Constantinou, Georgia, Gilbody, Simon, Holly, Jennifer, Jomeen, Julie, Salmon, Debra, Thompson, Clare, Uddin, Nazihah, and Walker, J. J.
Subjects: MENTAL illness, CONSCIOUSNESS raising, PERINATAL period, POSTPARTUM anxiety, CONTINUUM of care
Abstract: Background: Anxiety in pregnancy and postnatally is highly prevalent but under‐recognized. To identify perinatal anxiety, assessment tools must be acceptable to women who are pregnant or postnatal. Methods: A qualitative study of women's experiences of anxiety and mental health assessment during pregnancy and after birth and views on the acceptability of perinatal anxiety assessment. Semi‐structured interviews were conducted with 41 pregnant or postnatal women. Results were analysed using Sekhon et al.'s acceptability framework, as well as inductive coding of new or emergent themes. Results: Women's perceptions of routine assessment for perinatal anxiety were generally favourable. Most participants thought assessment was needed and that the benefits outweighed potential negative impacts, such as unnecessary referrals to specialist services. Six themes were identified of: (1) Raising awareness; (2) Improving support; (3) Surveillance and stigma; (4) Gatekeeping; (5) Personalized care and (6) Trust. Assessment was seen as a tool for raising awareness about mental health during the perinatal period and a mechanism for normalizing discussions about mental health more generally. However, views on questionnaire assessments themselves were mixed, with some participants feeling they could become an administrative 'tick box' exercise that depersonalizes care and does not provide a space to discuss mental health problems. Conclusion: Routine assessment of perinatal anxiety was generally viewed as positive and acceptable; however, this was qualified by the extent to which it was informed and personalized as a process. Approaches to assessment should ideally be flexible, tailored across the perinatal period and embedded in continuity of care. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Evaluation of perinatal anxiety assessment measures: a cognitive interview study.

Author: Meades, Rose, Sinesi, Andrea, Williams, Louise R., Delicate, Amy, Cheyne, Helen, Maxwell, Margaret, Alderdice, Fiona, Jomeen, Julie, Shakespeare, Judy, Yuill, Cassandra, Ayers, Susan, Best, Catherine, Hann, Agnes, Salmon, Debra, Uddin, Nazihah, Walker, James, and Gilbody, Simon
Subjects: COGNITIVE interviewing, GENERALIZED anxiety disorder, ANXIETY disorders, ANXIETY, PERINATAL period, JUDGMENT (Psychology)
Abstract: Background: Anxiety in pregnancy and postpartum is highly prevalent but under-recognised. To identify perinatal anxiety, assessment tools must be acceptable, relevant, and easy to use for women in the perinatal period. Methods: To determine the acceptability and ease of use of anxiety measures to pregnant or postpartum women (n = 41) we examined five versions of four measures: the Generalised Anxiety Disorder scale (GAD) 2-item and 7-item versions; Whooley questions; Clinical Outcomes in Routine Evaluation (CORE-10); and Stirling Antenatal Anxiety Scale (SAAS). Cognitive interviews were used to examine ease of comprehension, judgement, retrieval and responding. Results: All measures were acceptable. Some items were deemed less relevant to the perinatal period e.g., difficulties sleeping. Ease of comprehension, judgement, retrieval and responding varied, with all measures having strengths and weaknesses. The SAAS and CORE-10 had the lowest mean number of problematic components. The GAD had the highest mean number of problematic components. Non-binary response options were preferred. Preferences for time frames (e.g. one week, one month) varied. Qualitative data provides in-depth information on responses to each measure. Conclusions: Findings can be used to inform clinical guidelines and research on acceptable anxiety assessment in pregnancy and after birth. [ABSTRACT FROM AUTHOR]
Published: 2024
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8. Assessment of perinatal anxiety: diagnostic accuracy of five measures.

Author: Ayers, Susan, Coates, Rose, Sinesi, Andrea, Cheyne, Helen, Maxwell, Margaret, Best, Catherine, McNicol, Stacey, Williams, Louise R., Uddin, Nazihah, Hutton, Una, Howard, Grace, Shakespeare, Judy, Walker, James J., Alderdice, Fiona, and Jomeen, Julie
Subjects: ANXIETY disorders, GENERALIZED anxiety disorder, ANXIETY, PERINATAL period, FACTOR structure
Abstract: Background: Anxiety in pregnancy and after giving birth (the perinatal period) is highly prevalent but under-recognised. Robust methods of assessing perinatal anxiety are essential for services to identify and treat women appropriately. Aims: To determine which assessment measures are most psychometrically robust and effective at identifying women with perinatal anxiety (primary objective) and depression (secondary objective). Method: We conducted a prospective longitudinal cohort study of 2243 women who completed five measures of anxiety and depression (Generalized Anxiety Disorder scale (GAD) two- and seven-item versions; Whooley questions; Clinical Outcomes in Routine Evaluation (CORE-10); and Stirling Antenatal Anxiety Scale (SAAS)) during pregnancy (15 weeks, 22 weeks and 31 weeks) and after birth (6 weeks). To assess diagnostic accuracy a sample of 403 participants completed modules of the Mini-International Neuropsychiatric Interview (MINI). Results: The best diagnostic accuracy for anxiety was shown by the CORE-10 and SAAS. The best diagnostic accuracy for depression was shown by the CORE-10, SAAS and Whooley questions, although the SAAS had lower specificity. The same cut-off scores for each measure were optimal for identifying anxiety or depression (SAAS ≥9; CORE-10 ≥9; Whooley ≥1). All measures were psychometrically robust, with good internal consistency, convergent validity and unidimensional factor structure. Conclusions: This study identified robust and effective methods of assessing perinatal anxiety and depression. We recommend using the CORE-10 or SAAS to assess perinatal anxiety and the CORE-10 or Whooley questions to assess depression. The GAD-2 and GAD-7 did not perform as well as other measures and optimal cut-offs were lower than currently recommended. [ABSTRACT FROM AUTHOR]
Published: 2024
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9. Perceptual bias, more than age, impacts on eye movements during face processing

Author: Williams, Louise R., Grealy, Madeleine A., Kelly, Steve W., Henderson, Iona, and Butler, Stephen H.
Published: 2016
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10. Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author: Brady, Marian C, primary, Ali, Myzoon, additional, VandenBerg, Kathryn, additional, Williams, Linda J, additional, Williams, Louise R, additional, Abo, Masahiro, additional, Becker, Frank, additional, Bowen, Audrey, additional, Brandenburg, Caitlin, additional, Breitenstein, Caterina, additional, Bruehl, Stefanie, additional, Copland, David A, additional, Cranfill, Tamara B, additional, di Pietro-Bachmann, Marie, additional, Enderby, Pamela, additional, Fillingham, Joanne, additional, Galli, Federica Lucia, additional, Gandolfi, Marialuisa, additional, Glize, Bertrand, additional, Godecke, Erin, additional, Hawkins, Neil, additional, Hilari, Katerina, additional, Hinckley, Jacqueline, additional, Horton, Simon, additional, Howard, David, additional, Jaecks, Petra, additional, Jefferies, Elizabeth, additional, Jesus, Luis MT, additional, Kambanaros, Maria, additional, Kang, Eun Kyoung, additional, Khedr, Eman M, additional, Kong, Anthony Pak-Hin, additional, Kukkonen, Tarja, additional, Laganaro, Marina, additional, Lambon Ralph, Matthew A, additional, Laska, Ann Charlotte, additional, Leemann, Béatrice, additional, Leff, Alexander P, additional, Lima, Roxele R, additional, Lorenz, Antje, additional, MacWhinney, Brian, additional, Shisler Marshall, Rebecca, additional, Mattioli, Flavia, additional, Maviş, İlknur, additional, Meinzer, Marcus, additional, Nilipour, Reza, additional, Noé, Enrique, additional, Paik, Nam-Jong, additional, Palmer, Rebecca, additional, Papathanasiou, Ilias, additional, Patrício, Brígida F, additional, Martins, Isabel Pavão, additional, Price, Cathy, additional, Jakovac, Tatjana Prizl, additional, Rochon, Elizabeth, additional, Rose, Miranda L, additional, Rosso, Charlotte, additional, Rubi-Fessen, Ilona, additional, Ruiter, Marina B, additional, Snell, Claerwen, additional, Stahl, Benjamin, additional, Szaflarski, Jerzy P, additional, Thomas, Shirley A, additional, van de Sandt-Koenderman, Mieke, additional, van der Meulen, Ineke, additional, Visch-Brink, Evy, additional, Worrall, Linda, additional, and Wright, Heather Harris, additional
Published: 2022
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11. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke

Author: Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, The RELEASE Collaborators, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, and The RELEASE Collaborators
Abstract: Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language ( ≥ 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab
Published: 2022

12. Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis

Author: Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris
Abstract: Background: Stroke rehabilitation interventions are routinely personalized to address individuals' needs, goals, and challenges based on evidence from aggregated randomized controlled trials (RCT) data and meta-syntheses. Individual participant data (IPD) meta-analyses may better inform the development of precision rehabilitation approaches, quantifying treatment responses while adjusting for confounders and reducing ecological bias. Aim: We explored associations between speech and language therapy (SLT) interventions frequency (days/week), intensity (h/week), and dosage (total SLT-hours) and language outcomes for different age, sex, aphasia severity, and chronicity subgroups by undertaking prespecified subgroup network meta-analyses of the RELEASE database. Methods: MEDLINE, EMBASE, and trial registrations were systematically searched (inception-Sept2015) for RCTs, including > 10 IPD on stroke-related aphasia. We extracted demographic, stroke, aphasia, SLT, and risk of bias data. Overall-language ability, auditory comprehension, and functional communication outcomes were standardized. A one-stage, random effects, network meta-analysis approach filtered IPD into a single optimal model, examining SLT regimen and language recovery from baseline to first post-intervention follow-up, adjusting for covariates identified a-priori. Data were dichotomized by age (<=/> 65 years), aphasia severity (mild-moderate/ moderate-severe based on language outcomes' median value), chronicity (<=/> 3 months), and sex subgroups. We reported estimates of means and 95% confidence intervals. Where relative variance was high (> 50%), results were reported for completeness. Results: 959 IPD (25 RCTs) were analyzed. For working-age participants, greatest language gains from baseline occurred alongside moderate to high-intensity SLT (functional communication 3-to-4 h/week; overall-language and comprehension > 9 h/week); older participants' greatest gains occurred alongside low-intensity SLT (<=
Published: 2022

13. Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis

Author: Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Branden-burg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, MaviS, ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaf-larski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Branden-burg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, MaviS, ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaf-larski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris
Abstract: BACKGROUND AND PURPOSE: Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours/week), dosage (total hours), frequency (days/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia. METHODS: Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and >= 10 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori-defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI). RESULTS: Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with >20 to 50 hours SLT dosage (18.37 [10.58-26.16] Western Aphasia Battery-Aphasia Quotient; 5.23 [1.51-8.95] Aachen Aphasia Test-Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3-5+ days/week), and comprehension (4-5 days/week). Evidence of comprehension gains was absent for SLT <= 20 hours, <3 hours/week, and <= 3 days/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed ho
Published: 2022

14. Complex speech-language therapy interventions for stroke-related aphasia: The RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author: Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Harris Wright, Heather, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Harris Wright, Heather
Abstract: Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were used t
Published: 2022

15. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses:the RELEASE database of aphasia after stroke

Author: Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Ribeiro Lima, Roxele, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, van de Sandt - Koenderman, WME, Van Der Meulen, Ineke, Visch-Brink, Evy, Wright, Heather Harris, Brady, Marian, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Ribeiro Lima, Roxele, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, van de Sandt - Koenderman, WME, Van Der Meulen, Ineke, Visch-Brink, Evy, Wright, Heather Harris, and Brady, Marian
Abstract: Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language (≥10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or a
Published: 2022

16. Complex speech-language therapy interventions for stroke-related aphasia:The RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author: Brady, Marian C., Ali, Myzoon, Berg, Kathryn Vanden, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Macwhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavi̧s, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, Berg, Kathryn Vanden, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Macwhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavi̧s, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris
Abstract: Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were use
Published: 2022

17. sj-docx-1-wso-10.1177_17474930221097477 – Supplemental material for Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis

Author: Brady, Marian C, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J, Williams, Louise R, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A, Cranfill, Tamara B, Pietro-Bachmann, Marie di, Enderby, Pamela, Fillingham, Joanne, Lucia Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M, Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Charlotte Laska, Ann, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Harris Wright, Heather
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-docx-1-wso-10.1177_17474930221097477 for Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis by Marian C Brady, Myzoon Ali, Kathryn VandenBerg, Linda J Williams, Louise R Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A Copland, Tamara B Cranfill, Marie di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis MT Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A Lambon Ralph, Ann Charlotte Laska, Béatrice Leemann, Alexander P Leff, Roxele R Lima, Antje Lorenz, Brian MacWhinney, Rebecca Shisler Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P Szaflarski, Shirley A Thomas, Mieke van de Sandt-Koenderman, Ineke van der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright and in International Journal of Stroke
Published: 2022
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18. Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis.

Author: Brady, Marian C, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J, Williams, Louise R, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A, Cranfill, Tamara B, Pietro-Bachmann, Marie di, Enderby, Pamela, Fillingham, Joanne, Lucia Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, and Godecke, Erin
Subjects: APHASIC persons, STROKE, APHASIA, MEDICAL rehabilitation, STROKE rehabilitation
Abstract: Background: Stroke rehabilitation interventions are routinely personalized to address individuals' needs, goals, and challenges based on evidence from aggregated randomized controlled trials (RCT) data and meta-syntheses. Individual participant data (IPD) meta-analyses may better inform the development of precision rehabilitation approaches, quantifying treatment responses while adjusting for confounders and reducing ecological bias. Aim: We explored associations between speech and language therapy (SLT) interventions frequency (days/week), intensity (h/week), and dosage (total SLT-hours) and language outcomes for different age, sex, aphasia severity, and chronicity subgroups by undertaking prespecified subgroup network meta-analyses of the RELEASE database. Methods: MEDLINE, EMBASE, and trial registrations were systematically searched (inception-Sept2015) for RCTs, including ⩾ 10 IPD on stroke-related aphasia. We extracted demographic, stroke, aphasia, SLT, and risk of bias data. Overall-language ability, auditory comprehension, and functional communication outcomes were standardized. A one-stage, random effects, network meta-analysis approach filtered IPD into a single optimal model, examining SLT regimen and language recovery from baseline to first post-intervention follow-up, adjusting for covariates identified a-priori. Data were dichotomized by age (⩽/> 65 years), aphasia severity (mild–moderate/ moderate–severe based on language outcomes' median value), chronicity (⩽/> 3 months), and sex subgroups. We reported estimates of means and 95% confidence intervals. Where relative variance was high (> 50%), results were reported for completeness. Results: 959 IPD (25 RCTs) were analyzed. For working-age participants, greatest language gains from baseline occurred alongside moderate to high-intensity SLT (functional communication 3-to-4 h/week; overall-language and comprehension > 9 h/week); older participants' greatest gains occurred alongside low-intensity SLT (⩽ 2 h/week) except for auditory comprehension (> 9 h/week). For both age-groups, SLT-frequency and dosage associated with best language gains were similar. Participants ⩽ 3 months post-onset demonstrated greatest overall-language gains for SLT at low intensity/moderate dosage (⩽ 2 SLT-h/week; 20-to-50 h); for those > 3 months, post-stroke greatest gains were associated with moderate-intensity/high-dosage SLT (3–4 SLT-h/week; ⩾ 50 hours). For moderate–severe participants, 4 SLT-days/week conferred the greatest language gains across outcomes, with auditory comprehension gains only observed for ⩾ 4 SLT-days/week; mild–moderate participants' greatest functional communication gains were associated with similar frequency (⩾ 4 SLT-days/week) and greatest overall-language gains with higher frequency SLT (⩾ 6 days/weekly). Males' greatest gains were associated with SLT of moderate (functional communication; 3-to-4 h/weekly) or high intensity (overall-language and auditory comprehension; (> 9 h/weekly) compared to females for whom the greatest gains were associated with lower-intensity SLT (< 2 SLT-h/weekly). Consistencies across subgroups were also evident; greatest overall-language gains were associated with 20-to-50 SLT-h in total; auditory comprehension gains were generally observed when SLT > 9 h over ⩾ 4 days/week. Conclusions: We observed a treatment response in most subgroups' overall-language, auditory comprehension, and functional communication language gains. For some, the maximum treatment response varied in association with different SLT-frequency, intensity, and dosage. Where differences were observed, working-aged, chronic, mild–moderate, and male subgroups experienced their greatest language gains alongside high-frequency/intensity SLT. In contrast, older, moderate–severely impaired, and female subgroups within 3 months of aphasia onset made their greatest gains for lower-intensity SLT. The acceptability, clinical, and cost effectiveness of precision aphasia rehabilitation approaches based on age, sex, aphasia severity, and chronicity should be evaluated in future clinical RCTs. [ABSTRACT FROM AUTHOR]
Published: 2022
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19. Predictors of poststroke aphasia recovery : A systematic review - informed individual participant data meta-analysis

Author: The Rehabilitation and Recovery of People with Aphasia after Stroke (RELEASE) Collaborators, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A.Lambon, Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Whinney, Brian Mac, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Tampere University, Department of Otology and Oral Diseases, and Welfare Sciences
Subjects: 515 Psychology, 3112 Neurosciences, behavioral disciplines and activities
Abstract: BACKGROUND AND PURPOSE: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. METHODS: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. RESULTS: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (
Published: 2021

20. Barriers and facilitators to implementing perinatal mental health care in health and social care settings: a systematic review

Author: Webb, Rebecca, primary, Uddin, Nazihah, additional, Ford, Elizabeth, additional, Easter, Abigail, additional, Shakespeare, Judy, additional, Roberts, Nia, additional, Alderdice, Fiona, additional, Coates, Rose, additional, Hogg, Sally, additional, Cheyne, Helen, additional, Ayers, Susan, additional, Clark, Elaine, additional, Frame, Evelyn, additional, Gilbody, Simon, additional, Hann, Agnes, additional, McMullen, Sarah, additional, Rosan, Camilla, additional, Salmon, Debra, additional, Sinesi, Andrea, additional, Thompson, Claire, additional, and Williams, Louise R, additional
Published: 2021
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21. Predictors of Poststroke Aphasia Recovery A Systematic Review-Informed Individual Participant Data Meta-Analysis

Author: Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.
Abstract: Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants' age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4-165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3-26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0-20.9], +6.1 correct on AAT Token Test [CI, 3.2-8.9]; +9.3 Boston Naming Test points [CI, 4.7-13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5-1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9-24.4]; +5.3 correct on AAT Token Test [CI, 1.7-8.8]; +11.1 Boston Naming Test points [CI, 5.7-16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7-1.4]) conferred the greatest absolute change-from-baseline across each language doma
Published: 2021

22. Basic versus biofeedback-mediated intensive pelvic floor muscle training for women with urinary incontinence: the OPAL RCT

Author: Hagen, Suzanne, primary, Bugge, Carol, additional, Dean, Sarah G, additional, Elders, Andrew, additional, Hay-Smith, Jean, additional, Kilonzo, Mary, additional, McClurg, Doreen, additional, Abdel-Fattah, Mohamed, additional, Agur, Wael, additional, Andreis, Federico, additional, Booth, Joanne, additional, Dimitrova, Maria, additional, Gillespie, Nicola, additional, Glazener, Cathryn, additional, Grant, Aileen, additional, Guerrero, Karen L, additional, Henderson, Lorna, additional, Kovandzic, Marija, additional, McDonald, Alison, additional, Norrie, John, additional, Sergenson, Nicole, additional, Stratton, Susan, additional, Taylor, Anne, additional, and Williams, Louise R, additional
Published: 2020
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23. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke.

Author: Williams, Louise R, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A, Cranfill, Tamara B, Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, and Hawkins, Neil
Subjects: *DATABASES, *STROKE, *SPEECH therapy, *SYSTEMATIC reviews, *AUDITORY perception, *FUNCTIONAL status, *LANGUAGE & languages, *APHASIA, *DATABASE management, *DISABILITIES, *COMMUNICATION, *WRITTEN communication, *MEDICAL research, *DISEASE risk factors, *DISEASE complications
Abstract: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Data were collated by systematically identifying existing, eligible studies in any language (≥10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants' median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ability overall (n = 2699; 80 datasets), naming (n = 2886; 75 datasets), auditory comprehension (n = 2750; 71 datasets), functional communication (n = 1591; 29 datasets), reading (n = 770; 12 datasets) and writing (n = 724; 13 datasets). Information on SLT interventions were described by theoretical approach, therapy target, mode of delivery, setting and provider. Therapy regimen was described according to intensity (1882 IPD; 60 datasets), frequency (2057 IPD; 66 datasets), duration (1960 IPD; 64 datasets) and dosage (1978 IPD; 62 datasets). Our international IPD archive demonstrates the application of big data principles in the context of aphasia research; our rigorous methodology for data acquisition and cleaning can serve as a template for the establishment of similar databases in other research areas. [ABSTRACT FROM AUTHOR]
Published: 2022
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24. RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author: Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Whinney, Brian Mac, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, İlknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris
Subjects: Stroke, IPD, Meta-analysis, Complex intervention, Aphasia, Clinical Medicine, Medical and Health Sciences
Abstract: Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)
Published: 2020

25. RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author: Brady, Marian, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda, Williams, Louise R, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, and Bruehl, Stefanie
Abstract: Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use metaand network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)
Published: 2019
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26. Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke

Author: RELEASE Collaboration, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis Mt, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon-Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, RELEASE Collaboration, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis Mt, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon-Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris
Abstract: Purpose: Speech and language pathology (SLP) for aphasia is a complex intervention delivered to a heterogeneous population within diverse settings. Simplistic descriptions of participants and interventions in research hinder replication, interpretation of results, guideline and research developments through secondary data analyses. This study aimed to describe the availability of participant and intervention descriptors in existing aphasia research datasets. Method: We systematically identified aphasia research datasets containing ≥10 participants with information on time since stroke and language ability. We extracted participant and SLP intervention descriptions and considered the availability of data compared to historical and current reporting standards. We developed an extension to the Template for Intervention Description and Replication checklist to support meaningful classification and synthesis of the SLP interventions to support secondary data analysis. Result: Of 11, 314 identified records we screened 1131 full texts and received 75 dataset contributions. We extracted data from 99 additional public domain datasets. Participant age (97.1%) and sex (90.8%) were commonly available. Prior stroke (25.8%), living context (12.1%) and socio-economic status (2.3%) were rarely available. Therapy impairment target, frequency and duration were most commonly available but predominately described at group level. Home practice (46.3%) and tailoring (functional relevance 46.3%) were inconsistently available. Conclusion: Gaps in the availability of participant and intervention details were significant, hampering clinical implementation of evidence into practice and development of our field of research. Improvements in the quality and consistency of participant and intervention data reported in aphasia research are required to maximise clinical implementation, replication in research and the generation of insights from secondary data analysis. Systematic review registratio
Published: 2020

27. Who participates in aphasia research? An analysis of the REhabilitation and recovery of peopLE with Aphasia after StrokE (RELEASE) data set

Author: Ali, Myzoon, primary, Elders, Andrew, additional, Godwin, Jon, additional, Karachalia Sandri, Anastasia, additional, Williams, Linda J, additional, Williams, Louise R, additional, VandenBerg, Kathryn, additional, Abel, Stefanie, additional, Abo, Masahiro, additional, Becker, Frank, additional, Bowen, Audrey, additional, Brandenburg, Caitlin, additional, Breitenstein, Caterina, additional, Copland, David, additional, Cranfill, Tamara, additional, Di Pietro-Bachmann, Marie, additional, Enderby, Pam, additional, Fillingham, Joanne, additional, Galli, Federica, additional, Gandolfi, Marialuisa, additional, Glize, Bertrand, additional, Godecke, Erin, additional, Hilari, Katerina, additional, Hinckley, Jacqueline, additional, Horton, Simon, additional, Howard, David, additional, Jaecks, Petra, additional, Jefferies, Beth, additional, Jesus, Luis, additional, Kambanaros, Maria, additional, Khedr, Eman, additional, Kong, Anthony PH, additional, Kukkonen, Tarja, additional, Kyoung Kang, Eun, additional, Lambon Ralph, Matthew, additional, Laganaro, Marina, additional, Laska, Ann-Charlotte, additional, Leemann, Béatrice, additional, Leff, Alexander, additional, Lorenz, Antje, additional, MacWhinney, Brian, additional, Mattioli, Flavia, additional, Maviş, İlknur, additional, Meinzer, Marcus, additional, Noé Sebastián, Enrique, additional, Nilipour, Reza, additional, Paik, Nam-Jong, additional, Palmer, Rebecca, additional, Papathanasiou, Ilias, additional, Patricio, Brigida, additional, Pavão Martins, Isabel, additional, Price, Cathy, additional, Prizl Jakovac, Tatjana, additional, Rochon, Elizabeth, additional, Rose, Miranda L, additional, Rosso, Charlotte, additional, Ribeiro Lima, Roxele, additional, Rubi-Fessen, Ilona, additional, Ruiter, Marina, additional, Shisler Marshall, Rebecca, additional, Small, Steve, additional, Snell, Claerwen, additional, Stahl, Benjamin, additional, Szaflarski, Jerzy P, additional, Thomas, Shirley, additional, Van Der Meulen, Ineke, additional, Van De Sandt-Koenderman, Mieke, additional, Visch-Brink, Evy, additional, Worrall, Linda, additional, Wright, Heather Harris, additional, and Brady, Marian C, additional
Published: 2018
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28. Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the RELEASE Collaboration.

Author: Rose, Miranda L, Ali, Myzoon, Elders, Andrew, Godwin, Jon, Karachalia Sandri, Anastasia, Williams, Linda J, Williams, Louise R, VandenBerg, Kathryn, Abel, Stefanie, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Copland, David, Cranfill, Tamara, Di Pietro-Bachmann, Marie, Enderby, Pam, Fillingham, Joanne, and Galli, Federica
Subjects: APHASIA, CONFERENCES & conventions, SPEECH therapy, THERAPEUTICS
Abstract: The article focuses on rehabilitation of people with aphasia. Topics discussed include examining effect of speech and language therapy on people with aphasia; improving patients quality of life; and supporting data synthesis and meta-analyses in interventions for people with aphasia facilitates replication in clinic.
Published: 2018
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29. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke

Author: National Institute for Health Research (NIHR) Health Services and Delivery Research Tavistock Trust for Aphasia Chief Scientist Office Scottish Government Health and Social Care Directorates, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, The RELEASE Collaborators, National Institute for Health Research (NIHR) Health Services and Delivery Research Tavistock Trust for Aphasia Chief Scientist Office Scottish Government Health and Social Care Directorates, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, and The RELEASE Collaborators
Abstract: Williams, L. R., Ali, M., VandenBerg, K., Williams, L. J., Abo, M., Becker, F., . . . Brady, M. C. (2021). Utilising a systematic review-based approach to create a database of individual participant data for meta-and network meta-analyses: The RELEASE database of aphasia after stroke. Aphasiology. Advance online publication. https://doi.org/10.1080/02687038.2021.1897081

30. Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the release collaboration

Author: National Institute for Health Research, Health Services and Delivery Research Programme Chief Scienctist Office, Scottish Government Health and Social Care Directorates EU Cooperation in Science and Technology Tavistock Trust for Aphasia, Rose, Miranda L., Ali, Myzoon, Elders, Andrew, Godwin, Jon, Sandri, Anastasia Karachalia, Williams, Linda J., Williams, Louise R., VandenBerg, Kathryn, Abel, Stefanie, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Copland, David, Cranfill, Tamara, Di Pietro-Bachmann, Marie, Enderby, Pam, Fillingham, Joanne, Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Beth, Jesus, Luis, Kambanaros, Maria, Khedr, Eman, Kong, Anthony P. H., Kukkonen, Tarja, Kang, Eun K, Ralph, Matthew L, Laganaro, Marina, Laska, Ann-Charlotte, Leeman, Béatrice, Leff, Alexander, Lorenz, Antje, MacWhinney, Brian, Mattiolo, Flavia, Maviş, İlknur, Meinzer, Marcus, Noé Sebastián, Enrique, Nilipour, Reza, O'Halloran, Robyn, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel P, Pierce, John, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rosso, Charlotte, Ribeiro, Roxele L, Rubi-Fessen, Ilona, Ruiter, Marina, Marshall, Rebecca S, Small, Steve, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley, Togher, Leanne, Van Der Meulen, Ineke, Van De Sandt-Koenderman, Mieke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, National Institute for Health Research, Health Services and Delivery Research Programme Chief Scienctist Office, Scottish Government Health and Social Care Directorates EU Cooperation in Science and Technology Tavistock Trust for Aphasia, Rose, Miranda L., Ali, Myzoon, Elders, Andrew, Godwin, Jon, Sandri, Anastasia Karachalia, Williams, Linda J., Williams, Louise R., VandenBerg, Kathryn, Abel, Stefanie, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Copland, David, Cranfill, Tamara, Di Pietro-Bachmann, Marie, Enderby, Pam, Fillingham, Joanne, Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Beth, Jesus, Luis, Kambanaros, Maria, Khedr, Eman, Kong, Anthony P. H., Kukkonen, Tarja, Kang, Eun K, Ralph, Matthew L, Laganaro, Marina, Laska, Ann-Charlotte, Leeman, Béatrice, Leff, Alexander, Lorenz, Antje, MacWhinney, Brian, Mattiolo, Flavia, Maviş, İlknur, Meinzer, Marcus, Noé Sebastián, Enrique, Nilipour, Reza, O'Halloran, Robyn, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel P, Pierce, John, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rosso, Charlotte, Ribeiro, Roxele L, Rubi-Fessen, Ilona, Ruiter, Marina, Marshall, Rebecca S, Small, Steve, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley, Togher, Leanne, Van Der Meulen, Ineke, Van De Sandt-Koenderman, Mieke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, and Brady, Marian C
Abstract: Rose, M. L., Ali, M., Elders, A., Godwin, J., Karachalia Sandri, A., Williams, L. J., . . . Brady, M. C. (2018). Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the RELEASE collaboration. Aphasiology, 32(sup1), 183-186. https://www.tandfonline.com/doi/full/10.1080/02687038.2018.1487021

31. RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author: Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Pavão Martins, Isabel, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Pavão Martins, Isabel, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris
Abstract: Brady, M. C., Ali, M., VandenBerg, K., Williams, L. J., Williams, L. R., Abo, M., ... & Bruehl, S. (2020). RELEASE: a protocol for a systematic review based, individual participant data, meta-and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. Aphasiology, 34(2), 137-157. https://www.tandfonline.com/doi/full/10.1080/02687038.2019.1643003

32. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Author: Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.
Abstract: Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language (>= 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants' median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab

33. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Author: Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.
Abstract: Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language (>= 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants' median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab

34. Prevalence and treatment of perinatal anxiety: diagnostic interview study - ERRATUM.

Author: Ayers S, Sinesi A, Meades R, Cheyne H, Maxwell M, Best C, McNicol S, Williams LR, Hutton U, Howard G, Shakespeare J, Alderdice F, and Jomeen J
Published: 2025
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35. Prevalence and treatment of perinatal anxiety: diagnostic interview study.

Author: Ayers S, Sinesi A, Meade R, Cheyne H, Maxwell M, Best C, McNicol S, Williams LR, Hutton U, Howard G, Shakespeare J, Alderdice F, and Jomeen J
Abstract: Background: Anxiety affects around one in five women during pregnancy and after birth. However, there is no systematic information on the proportion of women with perinatal anxiety disorders who want or receive treatment., Aims: To examine (a) the prevalence of anxiety disorders during pregnancy and after birth in a population-based sample, and (b) the proportion of women with anxiety disorders who want treatment and receive treatment., Method: This study conducted 403 diagnostic interviews in early pregnancy ( n = 102), mid-pregnancy ( n = 99), late pregnancy ( n = 102) or postpartum ( n = 100). Participants also completed self-report measures of previous/current mental health problems and desire for treatment at every time point., Results: The prevalence of anxiety disorders over all time points combined was 19.9% (95% CI 16.1-24.1), with greatest prevalence in early pregnancy (25.5%, 95% CI 17.4-35.1). The most prevalent disorders were obsessive-compulsive disorder (8.2%, 95% CI 5.7-11.3) and generalised anxiety disorder (5.7%, 95% CI 3.7-8.4). The majority of women with anxiety disorders did not want professional help or treatment (79.8%). Most women with anxiety disorders who did want treatment (20.2%) were receiving treatment. The majority of participants with anxiety disorders had a history of mental health problems (64.6%)., Conclusions: Prevalence rates overall are consistent with previous research, lending validity to the findings. However, findings challenge the assumption that everyone with a psychological disorder wants treatment. These findings highlight the importance of relationship-based care, where individual needs and contextual barriers to treatment can be explored.
Published: 2024
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36. Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author: Brady MC, Ali M, VandenBerg K, Williams LJ, Williams LR, Abo M, Becker F, Bowen A, Brandenburg C, Breitenstein C, Bruehl S, Copland DA, Cranfill TB, di Pietro-Bachmann M, Enderby P, Fillingham J, Galli FL, Gandolfi M, Glize B, Godecke E, Hawkins N, Hilari K, Hinckley J, Horton S, Howard D, Jaecks P, Jefferies E, Jesus LMT, Kambanaros M, Kang EK, Khedr EM, Kong APH, Kukkonen T, Laganaro M, Lambon Ralph MA, Laska AC, Leemann B, Leff AP, Lima RR, Lorenz A, MacWhinney B, Shisler Marshall R, Mattioli F, Maviş İ, Meinzer M, Nilipour R, Noé E, Paik NJ, Palmer R, Papathanasiou I, Patrício BF, Martins IP, Price C, Jakovac TP, Rochon E, Rose ML, Rosso C, Rubi-Fessen I, Ruiter MB, Snell C, Stahl B, Szaflarski JP, Thomas SA, van de Sandt-Koenderman M, van der Meulen I, Visch-Brink E, Worrall L, and Wright HH
Abstract: Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority., Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain., Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data., Setting: Participant data were collected in research and clinical settings., Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke., Main Outcome Measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication., Data Sources and Participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted., Review Methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were used to generate hypotheses., Results: We retrieved 5928 individual participant data from 174 data sets across 28 countries, comprising 75 electronic (3940 individual participant data), 47 randomised controlled trial (1778 individual participant data) and 91 speech and language therapy intervention (2746 individual participant data) data sets. The median participant age was 63 years (interquartile range 53–72 years). We identified 53 unavailable, but potentially eligible, randomised controlled trials (46 of these appeared to include speech and language therapy). Relevant individual participant data were filtered into each analysis. Statistically significant predictors of recovery included age (functional communication, individual participant data: 532, n = 14 randomised controlled trials) and sex (overall language ability, individual participant data: 482, n = 11 randomised controlled trials; functional communication, individual participant data: 532, n = 14 randomised controlled trials). Older age and being a longer time since aphasia onset predicted poorer recovery. A negative relationship between baseline severity score and change from baseline ( p < 0.0001) may reflect the reduced improvement possible from high baseline scores. The frequency, duration, intensity and dosage of speech and language therapy were variously associated with auditory comprehension, naming and functional communication recovery. There were insufficient data to examine spontaneous recovery. The greatest overall gains in language ability [14.95 points (95% confidence interval 8.7 to 21.2 points) on the Western Aphasia Battery-Aphasia Quotient] and functional communication [0.78 points (95% confidence interval 0.48 to 1.1 points) on the Aachen Aphasia Test-Spontaneous Communication] were associated with receiving speech and language therapy 4 to 5 days weekly; for auditory comprehension [5.86 points (95% confidence interval 1.6 to 10.0 points) on the Aachen Aphasia Test-Token Test], the greatest gains were associated with receiving speech and language therapy 3 to 4 days weekly. The greatest overall gains in language ability [15.9 points (95% confidence interval 8.0 to 23.6 points) on the Western Aphasia Battery-Aphasia Quotient] and functional communication [0.77 points (95% confidence interval 0.36 to 1.2 points) on the Aachen Aphasia Test-Spontaneous Communication] were associated with speech and language therapy participation from 2 to 4 (and more than 9) hours weekly, whereas the highest auditory comprehension gains [7.3 points (95% confidence interval 4.1 to 10.5 points) on the Aachen Aphasia Test-Token Test] were associated with speech and language therapy participation in excess of 9 hours weekly (with similar gains notes for 4 hours weekly). While clinically similar gains were made alongside different speech and language therapy intensities, the greatest overall gains in language ability [18.37 points (95% confidence interval 10.58 to 26.16 points) on the Western Aphasia Battery-Aphasia Quotient] and auditory comprehension [5.23 points (95% confidence interval 1.51 to 8.95 points) on the Aachen Aphasia Test-Token Test] were associated with 20–50 hours of speech and language therapy. Network meta-analyses on naming and the duration of speech and language therapy interventions across language outcomes were unstable. Relative variance was acceptable (< 30%). Subgroups may benefit from specific interventions., Limitations: Data sets were graded as being at a low risk of bias but were predominantly based on highly selected research participants, assessments and interventions, thereby limiting generalisability., Conclusions: Frequency, intensity and dosage were associated with language gains from baseline, but varied by domain and subgroup., Future Work: These exploratory findings require confirmatory study designs to test the hypotheses generated and to develop more tailored speech and language therapy interventions., Study Registration: This study is registered as PROSPERO CRD42018110947., Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme and will be published in full in Health and Social Care Delivery Research ; Vol. 10, No. 28. See the NIHR Journals Library website for further project information. Funding was also provided by The Tavistock Trust for Aphasia., (Copyright © King’s Printer and Controller of HMSO 2022. This work was produced by Brady et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.)
Published: 2022
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37. Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women: multicentre randomised controlled trial.

Author: Hagen S, Elders A, Stratton S, Sergenson N, Bugge C, Dean S, Hay-Smith J, Kilonzo M, Dimitrova M, Abdel-Fattah M, Agur W, Booth J, Glazener C, Guerrero K, McDonald A, Norrie J, Williams LR, and McClurg D
Subjects: Female, Humans, Middle Aged, Pelvic Floor physiopathology, Quality of Life, Treatment Outcome, Urinary Incontinence physiopathology, Electromyography methods, Exercise Therapy methods, Neurofeedback methods, Urinary Incontinence therapy
Abstract: Objective: To assess the effectiveness of pelvic floor muscle training (PFMT) plus electromyographic biofeedback or PFMT alone for stress or mixed urinary incontinence in women., Design: Parallel group randomised controlled trial., Setting: 23 community and secondary care centres providing continence care in Scotland and England., Participants: 600 women aged 18 and older, newly presenting with stress or mixed urinary incontinence between February 2014 and July 2016: 300 were randomised to PFMT plus electromyographic biofeedback and 300 to PFMT alone., Interventions: Participants in both groups were offered six appointments with a continence therapist over 16 weeks. Participants in the biofeedback PFMT group received supervised PFMT and a home PFMT programme, incorporating electromyographic biofeedback during clinic appointments and at home. The PFMT group received supervised PFMT and a home PFMT programme. PFMT programmes were progressed over the appointments., Main Outcome Measures: The primary outcome was self-reported severity of urinary incontinence (International Consultation on Incontinence Questionnaire-urinary incontinence short form (ICIQ-UI SF), range 0 to 21, higher scores indicating greater severity) at 24 months. Secondary outcomes were cure or improvement, other pelvic floor symptoms, condition specific quality of life, women's perception of improvement, pelvic floor muscle function, uptake of other urinary incontinence treatment, PFMT self-efficacy, adherence, intervention costs, and quality adjusted life years., Results: Mean ICIQ-UI SF scores at 24 months were 8.2 (SD 5.1, n=225) in the biofeedback PFMT group and 8.5 (SD 4.9, n=235) in the PFMT group (mean difference -0.09, 95% confidence interval -0.92 to 0.75, P=0.84). Biofeedback PFMT had similar costs (mean difference £121 ($154; €133), -£409 to £651, P=0.64) and quality adjusted life years (-0.04, -0.12 to 0.04, P=0.28) to PFMT. 48 participants reported an adverse event: for 23 this was related or possibly related to the interventions., Conclusions: At 24 months no evidence was found of any important difference in severity of urinary incontinence between PFMT plus electromyographic biofeedback and PFMT alone groups. Routine use of electromyographic biofeedback with PFMT should not be recommended. Other ways of maximising the effects of PFMT should be investigated., Trial Registration: ISRCTN57756448., Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form. All authors declare grant funding for the trial from National Institute for Health Research (NIHR), Health Technology Assessment programme. In addition, outside the submitted work WA reports: personal fees from UCB Pharma, Pfizer, Bard, Boston Scientific, Neomedic, Johnson and Johnson, SEP Pharma/Contura, NHS Ayrshire and Arran, London Medical Education Academy, Central Legal Office NHS Scotland, Oaklaw Consultancy, various law firms acting on behalf of mesh manufacturers, patient claimants, and defendant clinicians; grants from Olympus, NIHR, University of Stirling, University of Aberdeen; grants and non-financial support from Astellas Pharmaceuticals; personal fees and non-financial support from Chief Scientist Office, NHS Research Scotland, and NHS Ayrshire and Arran. KG reports personal fees and non-financial support from Contura, outside the submitted work. MAF reports outside the submitted work: being a speaker, consultant and/or surgical trainer for a number of industrial companies (Astellas, Ethicon, Bard, Pfizer, AMS, Coloplast, and others); receiving travel expenses and received personal honorariums and sponsorship towards attending scientific conferences and educational meetings; research grant from Coloplast; sponsorship for trainees attending or presenting at pharmaceutical sponsored educational/ leadership workshops and scientific conferences; being previous chairman of the Scottish Pelvic Floor Network, which received sponsorship by various industrial companies. JN reports outside the submitted work membership of the following NIHR boards: Commissioning Priority Review Decision-making committee (2015); Health Technology Assessment (HTA) Commissioning Board (2010-2016); HTA Commissioning Sub-Board (Expression of Interest) (2014); HTA Funding Boards Policy Group (2016-2019); HTA General Board (2016-2019); HTA Post-Board funding teleconference (2016-2019); NIHR Clinical Trials Unit Standing Advisory Committee (2018-present); NIHR HTA and Efficacy and Mechanism Evaluation Editorial Board (2014-2019); Pre-exposure Prophylaxis Impact Review Panel (2017)., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2020
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