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138 results on '"Williams, Leila"'

1. Rational design of a SOCSI-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens

Author

Schlabach, Michael R., Lin, Sharon, Collester, Zachary R., Wrocklage, Christopher, Shenker, Sol, Calnan, Conor, Xu, Tianlei, Gannon, Hugh S., Williams, Leila J., Thompson, Frank, Dunbar, Paul R., LaMothe, Robert A., Garrett, Tracy E., Colletti, Nicholas, Hohmann, Anja F., Tubo, Noah J., Bullock, Caroline P., Mercier, Isabelle Le, Sofjan, Katri, Merkin, Jason J., Keegan, Sean, Kryukov, Gregory V., Dugopolski, Caroline, Stegmeier, Frank, Wong, Karrie, Sharp, Fiona A., Cadzow, Louise, and Benson, Micah J.

Subjects
T cells -- Analysis, Tumors -- Analysis, Genes -- Analysis, B cells -- Analysis, Health care industry
Abstract

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T cell therapies, large-scale in vitro and in vivo clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screens were performed, with the SOCS1 gene identified as a top T cell-enhancing target. In murine [CD8.sup.+] T cell-therapy models, SOCS1 served as a critical checkpoint in restraining the accumulation of central memory T cells in lymphoid organs as well as intermediate ([Tex.sup.int]) and effector ([Tex.sup.eff]) exhausted T cell subsets derived from progenitor exhausted T cells ([Tex.sup.prog]) in tumors. A comprehensive CRISPR tiling screen of the 50C57-coding region identified sgRNAs targeting the SH2 domain of SOCS1 as the most potent, with an sgRNA with minimal off-target cut sites used to manufacture KSQ-001, an engineered TIL therapy with SOCS1 inactivated by CRISPR/Cas9. KSQ-001 possessed increased responsiveness to cytokine signals and enhanced in vivo antitumor function in mouse models. These data demonstrate the use of CRISPR/Cas9 screens in the rational design of T cell therapies., Introduction Cell therapies using T lymphocytes possessing antitumor specificity have demonstrated robust clinical activity in hematological malignancies (1-4), with more limited success observed in solid tumors (5-7). The reduced effectiveness [...]

Published
2023
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3. Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

Author

Punt, Simone, Malu, Shruti, McKenzie, Jodi A., Manrique, Soraya Zorro, Doorduijn, Elien M., Mbofung, Rina M., Williams, Leila, Silverman, Deborah A., Ashkin, Emily L., Dominguez, Ana Lucía, Wang, Zhe, Chen, Jie Qing, Maiti, Sourindra N., Tieu, Trang N., Liu, Chengwen, Xu, Chunyu, Forget, Marie-Andrée, Haymaker, Cara, Khalili, Jahan S., Satani, Nikunj, Muller, Florian, Cooper, Laurence J. N., Overwijk, Willem W., Amaria, Rodabe N., Bernatchez, Chantale, Heffernan, Timothy P., Peng, Weiyi, Roszik, Jason, and Hwu, Patrick

Published
2021
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6. Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

Author

Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, and Peng, Weiyi

Published
2018
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7. Supplementary Table from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses

Author

Fedoriw, Andrew, primary, Shi, Leilei, primary, O'Brien, Shane, primary, Smitheman, Kimberly N., primary, Wang, Yunfei, primary, Hou, Jiakai, primary, Sherk, Christian, primary, Rajapurkar, Satyajit, primary, Laraio, Jenny, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Han, Guangchun, primary, Feng, Qin, primary, Bedford, Mark T., primary, Wang, Linghua, primary, Barbash, Olena, primary, Kruger, Ryan G., primary, Hwu, Patrick, primary, Mohammad, Helai P., primary, and Peng, Weiyi, primary

Published
2023
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8. Supplementary Figure from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses

Author

Fedoriw, Andrew, primary, Shi, Leilei, primary, O'Brien, Shane, primary, Smitheman, Kimberly N., primary, Wang, Yunfei, primary, Hou, Jiakai, primary, Sherk, Christian, primary, Rajapurkar, Satyajit, primary, Laraio, Jenny, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Han, Guangchun, primary, Feng, Qin, primary, Bedford, Mark T., primary, Wang, Linghua, primary, Barbash, Olena, primary, Kruger, Ryan G., primary, Hwu, Patrick, primary, Mohammad, Helai P., primary, and Peng, Weiyi, primary

Published
2023
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9. Data from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses

Author

Fedoriw, Andrew, primary, Shi, Leilei, primary, O'Brien, Shane, primary, Smitheman, Kimberly N., primary, Wang, Yunfei, primary, Hou, Jiakai, primary, Sherk, Christian, primary, Rajapurkar, Satyajit, primary, Laraio, Jenny, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Han, Guangchun, primary, Feng, Qin, primary, Bedford, Mark T., primary, Wang, Linghua, primary, Barbash, Olena, primary, Kruger, Ryan G., primary, Hwu, Patrick, primary, Mohammad, Helai P., primary, and Peng, Weiyi, primary

Published
2023
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10. Supplementary Tables from The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies

Author

Varghese, Sruthy, primary, Pramanik, Snigdha, primary, Williams, Leila J., primary, Hodges, Hannah R., primary, Hudgens, Courtney W., primary, Fischer, Grant M., primary, Luo, Catherine K., primary, Knighton, Barbara, primary, Tan, Lin, primary, Lorenzi, Philip L., primary, Mackinnon, Andrew L., primary, McQuade, Jennifer L., primary, Hailemichael, Yared, primary, Roszik, Jason, primary, Peng, Weiyi, primary, and Vashisht Gopal, Y.N., primary

Published
2023
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11. Supplementary Figures from The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies

Author

Varghese, Sruthy, primary, Pramanik, Snigdha, primary, Williams, Leila J., primary, Hodges, Hannah R., primary, Hudgens, Courtney W., primary, Fischer, Grant M., primary, Luo, Catherine K., primary, Knighton, Barbara, primary, Tan, Lin, primary, Lorenzi, Philip L., primary, Mackinnon, Andrew L., primary, McQuade, Jennifer L., primary, Hailemichael, Yared, primary, Roszik, Jason, primary, Peng, Weiyi, primary, and Vashisht Gopal, Y.N., primary

Published
2023
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12. Supplementary Methods, Figure Legends, Tables S1 - S3 from Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Author

Peng, Weiyi, primary, Chen, Jie Qing, primary, Liu, Chengwen, primary, Malu, Shruti, primary, Creasy, Caitlin, primary, Tetzlaff, Michael T., primary, Xu, Chunyu, primary, McKenzie, Jodi A., primary, Zhang, Chunlei, primary, Liang, Xiaoxuan, primary, Williams, Leila J., primary, Deng, Wanleng, primary, Chen, Guo, primary, Mbofung, Rina, primary, Lazar, Alexander J., primary, Torres-Cabala, Carlos A., primary, Cooper, Zachary A., primary, Chen, Pei-Ling, primary, Tieu, Trang N., primary, Spranger, Stefani, primary, Yu, Xiaoxing, primary, Bernatchez, Chantale, primary, Forget, Marie-Andree, primary, Haymaker, Cara, primary, Amaria, Rodabe, primary, McQuade, Jennifer L., primary, Glitza, Isabella C., primary, Cascone, Tina, primary, Li, Haiyan S., primary, Kwong, Lawrence N., primary, Heffernan, Timothy P., primary, Hu, Jianhua, primary, Bassett, Roland L., primary, Bosenberg, Marcus W., primary, Woodman, Scott E., primary, Overwijk, Willem W., primary, Lizée, Gregory, primary, Roszik, Jason, primary, Gajewski, Thomas F., primary, Wargo, Jennifer A., primary, Gershenwald, Jeffrey E., primary, Radvanyi, Laszlo, primary, Davies, Michael A., primary, and Hwu, Patrick, primary

Published
2023
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13. Supplementary Figure S7 from Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Author

Peng, Weiyi, primary, Chen, Jie Qing, primary, Liu, Chengwen, primary, Malu, Shruti, primary, Creasy, Caitlin, primary, Tetzlaff, Michael T., primary, Xu, Chunyu, primary, McKenzie, Jodi A., primary, Zhang, Chunlei, primary, Liang, Xiaoxuan, primary, Williams, Leila J., primary, Deng, Wanleng, primary, Chen, Guo, primary, Mbofung, Rina, primary, Lazar, Alexander J., primary, Torres-Cabala, Carlos A., primary, Cooper, Zachary A., primary, Chen, Pei-Ling, primary, Tieu, Trang N., primary, Spranger, Stefani, primary, Yu, Xiaoxing, primary, Bernatchez, Chantale, primary, Forget, Marie-Andree, primary, Haymaker, Cara, primary, Amaria, Rodabe, primary, McQuade, Jennifer L., primary, Glitza, Isabella C., primary, Cascone, Tina, primary, Li, Haiyan S., primary, Kwong, Lawrence N., primary, Heffernan, Timothy P., primary, Hu, Jianhua, primary, Bassett, Roland L., primary, Bosenberg, Marcus W., primary, Woodman, Scott E., primary, Overwijk, Willem W., primary, Lizée, Gregory, primary, Roszik, Jason, primary, Gajewski, Thomas F., primary, Wargo, Jennifer A., primary, Gershenwald, Jeffrey E., primary, Radvanyi, Laszlo, primary, Davies, Michael A., primary, and Hwu, Patrick, primary

Published
2023
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14. Supplementary Methods from The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies

Author

Varghese, Sruthy, primary, Pramanik, Snigdha, primary, Williams, Leila J., primary, Hodges, Hannah R., primary, Hudgens, Courtney W., primary, Fischer, Grant M., primary, Luo, Catherine K., primary, Knighton, Barbara, primary, Tan, Lin, primary, Lorenzi, Philip L., primary, Mackinnon, Andrew L., primary, McQuade, Jennifer L., primary, Hailemichael, Yared, primary, Roszik, Jason, primary, Peng, Weiyi, primary, and Vashisht Gopal, Y.N., primary

Published
2023
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15. Data from Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Author

Peng, Weiyi, primary, Chen, Jie Qing, primary, Liu, Chengwen, primary, Malu, Shruti, primary, Creasy, Caitlin, primary, Tetzlaff, Michael T., primary, Xu, Chunyu, primary, McKenzie, Jodi A., primary, Zhang, Chunlei, primary, Liang, Xiaoxuan, primary, Williams, Leila J., primary, Deng, Wanleng, primary, Chen, Guo, primary, Mbofung, Rina, primary, Lazar, Alexander J., primary, Torres-Cabala, Carlos A., primary, Cooper, Zachary A., primary, Chen, Pei-Ling, primary, Tieu, Trang N., primary, Spranger, Stefani, primary, Yu, Xiaoxing, primary, Bernatchez, Chantale, primary, Forget, Marie-Andree, primary, Haymaker, Cara, primary, Amaria, Rodabe, primary, McQuade, Jennifer L., primary, Glitza, Isabella C., primary, Cascone, Tina, primary, Li, Haiyan S., primary, Kwong, Lawrence N., primary, Heffernan, Timothy P., primary, Hu, Jianhua, primary, Bassett, Roland L., primary, Bosenberg, Marcus W., primary, Woodman, Scott E., primary, Overwijk, Willem W., primary, Lizée, Gregory, primary, Roszik, Jason, primary, Gajewski, Thomas F., primary, Wargo, Jennifer A., primary, Gershenwald, Jeffrey E., primary, Radvanyi, Laszlo, primary, Davies, Michael A., primary, and Hwu, Patrick, primary

Published
2023
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16. Figures S1-S9 from The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

Author

Huang, Lu, primary, Malu, Shruti, primary, McKenzie, Jodi A., primary, Andrews, Miles C., primary, Talukder, Amjad H., primary, Tieu, Trang, primary, Karpinets, Tatiana, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Williams, Leila J., primary, Wang, Zhe, primary, Mbofung, Rina M., primary, Wang, Zhi-Qiang, primary, Davis, Richard Eric, primary, Lo, Roger S., primary, Wargo, Jennifer A., primary, Davies, Michael A., primary, Bernatchez, Chantale, primary, Heffernan, Timothy, primary, Amaria, Rodabe N., primary, Korkut, Anil, primary, Peng, Weiyi, primary, Roszik, Jason, primary, Lizée, Gregory, primary, Woodman, Scott E., primary, and Hwu, Patrick, primary

Published
2023
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17. Supplementary information from The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

Author

Huang, Lu, primary, Malu, Shruti, primary, McKenzie, Jodi A., primary, Andrews, Miles C., primary, Talukder, Amjad H., primary, Tieu, Trang, primary, Karpinets, Tatiana, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Williams, Leila J., primary, Wang, Zhe, primary, Mbofung, Rina M., primary, Wang, Zhi-Qiang, primary, Davis, Richard Eric, primary, Lo, Roger S., primary, Wargo, Jennifer A., primary, Davies, Michael A., primary, Bernatchez, Chantale, primary, Heffernan, Timothy, primary, Amaria, Rodabe N., primary, Korkut, Anil, primary, Peng, Weiyi, primary, Roszik, Jason, primary, Lizée, Gregory, primary, Woodman, Scott E., primary, and Hwu, Patrick, primary

Published
2023
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18. Figure S1 from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Melendez, Brenda, primary, McKenzie, Jodi A., primary, Chen, Yuan, primary, Jackson, Heather L., primary, Voo, Kui S., primary, Mbofung, Rina M., primary, Leahey, Sara Elizabeth, primary, Wang, Jian, primary, Lizee, Gregory, primary, Tawbi, Hussein A., primary, Davies, Michael A., primary, Hoos, Axel, primary, Smothers, James, primary, Srinivasan, Roopa, primary, Paul, Elaine M., primary, Yanamandra, Niranjan, primary, and Hwu, Patrick, primary

Published
2023
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19. Table S1 from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Melendez, Brenda, primary, McKenzie, Jodi A., primary, Chen, Yuan, primary, Jackson, Heather L., primary, Voo, Kui S., primary, Mbofung, Rina M., primary, Leahey, Sara Elizabeth, primary, Wang, Jian, primary, Lizee, Gregory, primary, Tawbi, Hussein A., primary, Davies, Michael A., primary, Hoos, Axel, primary, Smothers, James, primary, Srinivasan, Roopa, primary, Paul, Elaine M., primary, Yanamandra, Niranjan, primary, and Hwu, Patrick, primary

Published
2023
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20. Supplementary Table S2 from The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

Author

Huang, Lu, primary, Malu, Shruti, primary, McKenzie, Jodi A., primary, Andrews, Miles C., primary, Talukder, Amjad H., primary, Tieu, Trang, primary, Karpinets, Tatiana, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Williams, Leila J., primary, Wang, Zhe, primary, Mbofung, Rina M., primary, Wang, Zhi-Qiang, primary, Davis, Richard Eric, primary, Lo, Roger S., primary, Wargo, Jennifer A., primary, Davies, Michael A., primary, Bernatchez, Chantale, primary, Heffernan, Timothy, primary, Amaria, Rodabe N., primary, Korkut, Anil, primary, Peng, Weiyi, primary, Roszik, Jason, primary, Lizée, Gregory, primary, Woodman, Scott E., primary, and Hwu, Patrick, primary

Published
2023
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21. Supplementary Figure legends from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Melendez, Brenda, primary, McKenzie, Jodi A., primary, Chen, Yuan, primary, Jackson, Heather L., primary, Voo, Kui S., primary, Mbofung, Rina M., primary, Leahey, Sara Elizabeth, primary, Wang, Jian, primary, Lizee, Gregory, primary, Tawbi, Hussein A., primary, Davies, Michael A., primary, Hoos, Axel, primary, Smothers, James, primary, Srinivasan, Roopa, primary, Paul, Elaine M., primary, Yanamandra, Niranjan, primary, and Hwu, Patrick, primary

Published
2023
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22. Predicting End-of-Year Achievement Test Performance: A Comparison of Assessment Methods

Author

Kettler, Ryan J., Elliott, Stephen N., Kurz, Alexander, Zigmond, Naomi, Lemons, Christopher J., Kloo, Amanda, Shrago, Jacqueline, Beddow, Peter A., Williams, Leila, Bruen, Charles, Lupp, Lynda, Farmer, Jeanie, and Mosiman, Melanie

Abstract

Motivated by the multiple-measures clause of recent federal policy regarding student eligibility for alternate assessments based on modified academic achievement standards (AA-MASs), this study examined how scores or combinations of scores from a diverse set of assessments predicted students' end-of-year proficiency status on statewide achievement tests. Scores from 388 eighth-grade students, both with and without disabilities, from 3 states were compared for the predictive validity of test inferences from a set of brief online screening tests, teachers' ratings of performance, and students' previous year's achievement tests. The research team developed screening tests in reading and mathematics that were found to be internally consistent and added predictive value to the identification of students who would perform at a level below proficient on state achievement tests of reading and mathematics. Although achievement results from the previous year were more predictive of future achievement results, scores from the online screening tests and from Performance Screening Guides could be used as supplements to typical achievement tests. Implications of these findings for educators in the 17 states currently using AA-MAS tests for students with disabilities are discussed, and needed future research is identified.

Published
2014
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23. 255 ExPRESSTM: An accelerated process for the manufacture of KSQ-001, a CRISPR/Cas9-edited eTILTMproduct

Author

Lin, Sharon, primary, Williams, Leila, additional, Ghose, Mitali, additional, Gannon, Hugh, additional, Calnan, Conor, additional, Pizzo, Angelina, additional, Kao, Pei-Lun, additional, Brady, Mallory, additional, Sofjan, Katri, additional, Dodson, Anne, additional, Shenker, Sol, additional, Schlabach, Michael, additional, Sharp, Fiona, additional, Stegmeier, Frank, additional, Benson, Micah, additional, and Wong, Karrie, additional

Published
2022
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24. 297 Manufacture of KSQ-001, a CRISPR/Cas9-engineered TIL (eTIL) therapy, for the treatment of head and neck squamous cell carcinoma

Author

Wong, Karrie, primary, Williams, Leila, additional, Constant, Nick, additional, Ghose, Mitali, additional, Lin, Sharon, additional, Thompson, Frank, additional, Calnan, Conor, additional, Sharp, Fiona, additional, Donnelly, Sean, additional, Quinn, Charles, additional, Hanna, Glenn, additional, Stegmeier, Frank, additional, and Benson, Micah, additional

Published
2022
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25. RNA editing derived epitopes function as cancer antigens to elicit immune responses

Author

Zhang, Minying, Fritsche, Jens, Roszik, Jason, Williams, Leila J., Peng, Xinxin, Chiu, Yulun, Tsou, Chih-Chiang, Hoffgaard, Franziska, Goldfinger, Valentina, Schoor, Oliver, Talukder, Amjad, Forget, Marie A., Haymaker, Cara, Bernatchez, Chantale, Han, Leng, Tsang, Yiu-Huen, Kong, Kathleen, Xu, Xiaoyan, Scott, Kenneth L., Singh-Jasuja, Harpreet, Lizee, Greg, Liang, Han, Weinschenk, Toni, Mills, Gordon B., and Hwu, Patrick

Published
2018
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26. LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade

Author

Hickman, Amber, primary, Koetsier, Joost, additional, Kurtanich, Trevin, additional, Nielsen, Michael C., additional, Winn, Glenn, additional, Wang, Yunfei, additional, Bentebibel, Salah-Eddine, additional, Shi, Leilei, additional, Punt, Simone, additional, Williams, Leila, additional, Haymaker, Cara, additional, Chesson, Charles B., additional, Fa’ak, Faisal, additional, Dominguez, Ana L., additional, Jones, Richard, additional, Kuiatse, Isere, additional, Caivano, Amy R., additional, Khounlo, Sayadeth, additional, Warier, Navin D., additional, Marathi, Upendra, additional, Market, Robert V., additional, Biediger, Ronald J., additional, Craft, John W., additional, Hwu, Patrick, additional, Davies, Michael A., additional, Woodside, Darren G., additional, Vanderslice, Peter, additional, Diab, Adi, additional, Overwijk, Willem W., additional, and Hailemichael, Yared, additional

Published
2022
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27. HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

Author

Mbofung, Rina M., McKenzie, Jodi A., Malu, Shruti, Zhang, Min, Peng, Weiyi, Liu, Chengwen, Kuiatse, Isere, Tieu, Trang, Williams, Leila, Devi, Seram, Ashkin, Emily, Xu, Chunyu, Huang, Lu, Zhang, Minying, Talukder, Amjad H., Tripathi, Satyendra C., Khong, Hiep, Satani, Nikunj, Muller, Florian L., Roszik, Jason, Heffernan, Timothy, Allison, James P., Lizee, Gregory, Hanash, Sam M., Proia, David, Amaria, Rodabe, Davis, R. Eric, and Hwu, Patrick

Published
2017
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28. Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses

Author

Fedoriw, Andrew, primary, Shi, Leilei, additional, O'Brien, Shane, additional, Smitheman, Kimberly N., additional, Wang, Yunfei, additional, Hou, Jiakai, additional, Sherk, Christian, additional, Rajapurkar, Satyajit, additional, Laraio, Jenny, additional, Williams, Leila J., additional, Xu, Chunyu, additional, Han, Guangchun, additional, Feng, Qin, additional, Bedford, Mark T., additional, Wang, Linghua, additional, Barbash, Olena, additional, Kruger, Ryan G., additional, Hwu, Patrick, additional, Mohammad, Helai P., additional, and Peng, Weiyi, additional

Published
2022
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29. 624 Targeting Type I arginine methyltransferases promotes T cell mediated antitumor immune responses

Author

Shi, Leilei, primary, Fedoriw, Andrew, additional, O’Brien, Shane, additional, Smitheman, Kimberly, additional, Wang, Yunfei, additional, Hou, Jiakai, additional, Sherk, Christian, additional, Rajapurkar, Satyajit, additional, Laraio, Jenny, additional, Williams, Leila, additional, Xu, Chunyu, additional, Han, Guangchun, additional, Feng, Qin, additional, Bedford, Mark, additional, Wang, Linghua, additional, Barbash, Olena, additional, Kruger, Ryan, additional, Hwu, Patrick, additional, Mohammad, Helai, additional, and Peng, Weiyi, additional

Published
2021
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30. 186 Development of KSQ-001, an engineered TIL (eTIL) therapy for solid tumors through CRISPR/Cas9-mediated editing of SOCS1

Author

Wong, Karrie, primary, Lin, Sharon, additional, Wrocklage, Christopher, additional, Sofjan, Katri, additional, Williams, Leila, additional, Brady, Mallory, additional, Colletti, Nicholas, additional, Tubo, Noah, additional, Gannon, Hugh, additional, LaMothe, Robert, additional, Xu, Tianlei, additional, VandenBerg, Tracy, additional, Shenker, Sol, additional, Dugopolski, Caroline, additional, Stegmeier, Frank, additional, Cadzow, Louise, additional, Schlabach, Michael, additional, and Benson, Micah, additional

Published
2021
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31. 204 KSQ-004: Unbiased pair-wise discovery of SOCS1 and Regnase-1 as the top CRISPR/Cas9 dual-edit combination enhancing in vivo TIL potency against solid tumors

Author

Wong, Karrie, primary, Wrocklage, Christopher, additional, Lin, Sharon, additional, Mercier, Isabelle Le, additional, Bullock, Caroline, additional, Cadzow, Louise, additional, Hohmann, Anja, additional, Shenker, Sol, additional, Sofjan, Katri, additional, Williams, Leila, additional, Kryukov, Gregory, additional, Calnan, Conor, additional, Stegmeier, Frank, additional, Benson, Micah, additional, and Schlabach, Michael, additional

Published
2021
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32. 554 The panorama of tumor intrinsic immune regulators exhibited by genome-wide CRPISR immune screen integrated with comprehensive clinical dataset analysis

Author

Hou, Jiakai, primary, Wang, Yunfei, additional, Shi, Leilei, additional, Chen, Yuan, additional, Xu, Chunyu, additional, Saeedi, Arash, additional, Pan, Ke, additional, Bohat, Ritu, additional, Egan, Nicholas, additional, McKenzie, Jodi, additional, Mbofung, Rina, additional, Williams, Leila, additional, Yang, Zhenhuang, additional, Sun, Ming, additional, Liang, Xiaofang, additional, Ahnert, Jordi Rodon, additional, Varadarajan, Navin, additional, Yee, Cassian, additional, Chen, Yiwen, additional, Hwu, Patrick, additional, and Peng, Weiyi, additional

Published
2021
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33. Abstract 1575: The landscape of tumor intrinsic immune regulators revealed by genome-wide CRISPR immune screen integrated with comprehensive clinical data analysis

Author

Hou, Jiakai, primary, Wang, Yunfei, additional, Shi, Leilei, additional, Chen, Yuan, additional, Xu, Chunyu, additional, Saeedi, Arash, additional, Pan, Ke, additional, Bohat, Ritu, additional, Egan, Nicholas A., additional, McKenzie, Jodi A., additional, Mbofung, Rina M., additional, Williams, Leila J., additional, Yang, Zhenghuang, additional, Sun, Ming, additional, Liang, Xiaofang, additional, Ahnert, Jordi Rodon, additional, Varadarajan, Navin, additional, Yee, Cassian, additional, Chen, Yiwen, additional, Hwu, Patrick, additional, and Peng, Weiyi, additional

Published
2021
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34. The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies

Author

Varghese, Sruthy, primary, Pramanik, Snigdha, additional, Williams, Leila J., additional, Hodges, Hannah R., additional, Hudgens, Courtney W., additional, Fischer, Grant M., additional, Luo, Catherine K., additional, Knighton, Barbara, additional, Tan, Lin, additional, Lorenzi, Philip L., additional, Mackinnon, Andrew L., additional, McQuade, Jennifer L., additional, Hailemichael, Yared, additional, Roszik, Jason, additional, Peng, Weiyi, additional, and Vashisht Gopal, Y.N., additional

Published
2021
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35. Precision Antifungal Treatment Significantly Extends Voice Prosthesis Lifespan in Patients Following Total Laryngectomy

Author

Pentland, Daniel R, Stevens, Sarah, Williams, Leila, Baker, Mark, McCall, Carolyn, Makarovaite, Viktorija, Balfour, Alistair, Mühlschlegel, Fritz A., Gourlay, Campbell W., Pentland, Daniel R, Stevens, Sarah, Williams, Leila, Baker, Mark, McCall, Carolyn, Makarovaite, Viktorija, Balfour, Alistair, Mühlschlegel, Fritz A., and Gourlay, Campbell W.

Abstract

Indwelling silicone valves called voice prostheses (VPs) are the gold standard for speech rehabilitation in patients with laryngeal cancer following total laryngectomy. Reported VP lifespans amongst these patients are highly variable but when devices fail patients experience loss of voice and an increase risk of chest infection. Early failure of VP is a current clinical concern that is associated with regular hospital visits, reduced quality of life and associated medical cost. Poly-microbial biofilms comprised of both bacterial and fungal microorganisms readily colonize VPs and are linked to loss of device performance and its early failure in addition to providing a reservoir for potential infection. Our detailed analysis of poly-microbial biofilm composition on 159 early failing VPs from 48 total laryngectomy patients confirmed Candida albicans as the predominant fungal species and Staphylococcus aureus as the most common bacterial colonizer within our patient cohort. Using a combination of microbiological analysis, patient data and a high-throughput antifungal test assay mimicking in vivo conditions we established an evidence based precision antifungal treatment approach to VP management. Our approach has allowed us to implement a personalized VP management pathway, which increases device in situ lifespan by an average of 270%. Our study represents a significant step forward in both our understanding of the cause of VP failure and a new effective treatment pathway that offers tangible benefit to patients.

Published
2020

36. Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators

Author

Hou, Jiakai, primary, Wang, Yunfei, additional, Shi, Leilei, additional, Chen, Yuan, additional, Xu, Chunyu, additional, Saeedi, Arash, additional, Pan, Ke, additional, Bohat, Ritu, additional, Egan, Nicholas A., additional, McKenzie, Jodi A., additional, Mbofung, Rina M., additional, Williams, Leila J., additional, Yang, Zhenhuang, additional, Sun, Ming, additional, Liang, Xiaofang, additional, Rodon Ahnert, Jordi, additional, Varadarajan, Navin, additional, Yee, Cassian, additional, Chen, Yiwen, additional, Hwu, Patrick, additional, and Peng, Weiyi, additional

Published
2021
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39. Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

Author

Punt, Simone, primary, Malu, Shruti, additional, McKenzie, Jodi A., additional, Manrique, Soraya Zorro, additional, Doorduijn, Elien M., additional, Mbofung, Rina M., additional, Williams, Leila, additional, Silverman, Deborah A., additional, Ashkin, Emily L., additional, Dominguez, Ana Lucía, additional, Wang, Zhe, additional, Chen, Jie Qing, additional, Maiti, Sourindra N., additional, Tieu, Trang N., additional, Liu, Chengwen, additional, Xu, Chunyu, additional, Forget, Marie-Andrée, additional, Haymaker, Cara, additional, Khalili, Jahan S., additional, Satani, Nikunj, additional, Muller, Florian, additional, Cooper, Laurence J. N., additional, Overwijk, Willem W., additional, Amaria, Rodabe N., additional, Bernatchez, Chantale, additional, Heffernan, Timothy P., additional, Peng, Weiyi, additional, Roszik, Jason, additional, and Hwu, Patrick, additional

Published
2020
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42. Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., additional, Xu, Chunyu, additional, Melendez, Brenda, additional, McKenzie, Jodi A., additional, Chen, Yuan, additional, Jackson, Heather L., additional, Voo, Kui S., additional, Mbofung, Rina M., additional, Leahey, Sara Elizabeth, additional, Wang, Jian, additional, Lizee, Gregory, additional, Tawbi, Hussein A., additional, Davies, Michael A., additional, Hoos, Axel, additional, Smothers, James, additional, Srinivasan, Roopa, additional, Paul, Elaine M., additional, Yanamandra, Niranjan, additional, and Hwu, Patrick, additional

Published
2019
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45. Abstract 2372: Tumoral p53 mutations differentially mediate poor T-cell infiltration and autologous T-cell killing in preclinical models

Author

Silverman, Deborah A., primary, Ashkin, Emily, additional, Whitfield, Benjamin, additional, Punt, Simone, additional, Manrique, Soraya Zorro, additional, Wang, Yunfei, additional, Korkut, Anil, additional, Williams, Leila, additional, Zhang, Minying, additional, Kotler, Eran, additional, Oren, Moshe, additional, Maitra, Anirban, additional, and Hwu, Patrick, additional

Published
2019
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47. The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

Author

Huang, Lu, primary, Malu, Shruti, additional, McKenzie, Jodi A., additional, Andrews, Miles C., additional, Talukder, Amjad H., additional, Tieu, Trang, additional, Karpinets, Tatiana, additional, Haymaker, Cara, additional, Forget, Marie-Andrée, additional, Williams, Leila J., additional, Wang, Zhe, additional, Mbofung, Rina M., additional, Wang, Zhi-Qiang, additional, Davis, Richard Eric, additional, Lo, Roger S., additional, Wargo, Jennifer A., additional, Davies, Michael A., additional, Bernatchez, Chantale, additional, Heffernan, Timothy, additional, Amaria, Rodabe N., additional, Korkut, Anil, additional, Peng, Weiyi, additional, Roszik, Jason, additional, Lizée, Gregory, additional, Woodman, Scott E., additional, and Hwu, Patrick, additional

Published
2018
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48. Abstract 1719: Superior efficacy of neoadjuvant compared to adjuvant immune checkpoint blockade in non-small cell lung cancer

Author

Cascone, Tina, primary, Hamdi, Haifa, additional, Zhang, Fahao, additional, Poteete, Alissa, additional, Li, Lerong, additional, Hudgens, Courtney W., additional, Williams, Leila J., additional, Wu, Qiuyu, additional, Gudikote, Jayanthi, additional, Peng, Weiyi, additional, Hwu, Patrick, additional, Wang, Jing, additional, Tetzlaff, Michael, additional, William, William N., additional, and Heymach, John V., additional

Published
2018
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49. Abstract 4938: OX40 agonist antibody-based combination therapy with PI3Kβ selective inhibitor enhances T cell immunity

Author

Peng, Weiyi, primary, Xu, Chunyu, additional, Melendez, Brenda, additional, Jackson, Heather, additional, McKenzi, Jodi A., additional, Williams, Leila J., additional, Chen, Yuan, additional, Mbofung, Rina M., additional, Leahey, Sara E. Leahey E., additional, Lizee, Greg, additional, Davies, Michael A., additional, Yanamandra, Niranjan, additional, and Hwu, Patrick, additional

Published
2018
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50. The metabolic basis of resistance to Adoptive T Cell Therapy (ACT) in patients with solid tumors

Author

Peng, Weiyi, primary, Cascone, Tina, additional, McKenzie, Jodi, additional, Mbofung, Rina, additional, Punt, Simone, additional, Wang, Zhe, additional, Xu, Chunyu, additional, Williams, Leila, additional, Wang, Zhiqiang, additional, Bristow, Christopher, additional, Carugo, Alessandro, additional, Peoples, Michael, additional, Li, Lerong, additional, Karpinets, Tatiana, additional, Huang, Lu, additional, Malu, Shruti, additional, Creasy, Caitlin, additional, Leahey, Sara, additional, Chen, Jiong, additional, Bernatchez, Chantale, additional, Gopal, Vashisht, additional, Heffernan, Timothy, additional, Hu, Jianhua, additional, Wang, Jing, additional, Amaria, Rodabe, additional, Wistuba, Ignacio, additional, Woodman, Scott, additional, Roszik, Jason, additional, Davis, Eric, additional, Davies, Michael, additional, Heymach, John, additional, and Hwu, Patrick, additional

Published
2018
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