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462 results on '"Williams, Kaye J."'

1. Dose escalation of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer : a study protocol for a phase 1b TiTE-CRM clinical trial (CRAIN) in UK secondary care centres

Author

Hoskin, Peter, Lee, Marina, Dunkley, Denise, Danh, Mary, Wickens, Robin, Saunders, Geoff, Northey, Josh, Crabb, Simon, McFarlane, Vicky, Sadozye, Azmat, Cooper, Rachel, Mathew, Tony, Haslett, Kate, Reeves, Kim, Reed, Rachel, Bigos, Kamilla, Williams, Kaye J., Rowling, Emily, Choudhury, Ananya, Dancer, Sonia, Smith, Deb, and Griffiths, Gareth

Published
2024
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2. PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models

Author

Wong, Chun Wai, Evangelou, Christos, Sefton, Kieran N., Leshem, Rotem, Zhang, Wei, Gopalan, Vishaka, Chattrakarn, Sorayut, Fernandez Carro, Macarena Lucia, Uzuner, Erez, Mole, Holly, Wilcock, Daniel J., Smith, Michael P., Sergiou, Kleita, Telfer, Brian A., Isaac, Dervla T., Liu, Chang, Perl, Nicholas R., Marie, Kerrie, Lorigan, Paul, Williams, Kaye J., Rao, Patricia E., Nagaraju, Raghavendar T., Niepel, Mario, and Hurlstone, Adam F. L.

Published
2023
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8. Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles.

Author

Spadea, Alice, Tirella, Annalisa, Rios de la Rosa, Julio Manuel, Lallana, Enrique, Mehibel, Manal, Telfer, Brian, Tirelli, Nicola, Lawrence, Margaret Jayne, Williams, Kaye J., Stratford, Ian J., and Ashford, Marianne

Subjects
GENE expression, SMALL interfering RNA, PANCREATIC cancer, HYALURONIC acid, GENE therapy, GENE silencing
Abstract

Background/Objectives: Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target effects. An additional challenge is the presence of hypoxic regions in tumors, where the Hypoxia Inducible Factor (HIF) transcriptional system drives the expression of pro-survival and drug resistance genes, leading to radio- and chemo-resistance. This study aims to explore the efficacy of targeted nanoparticle (NP)-based small interfering RNA (siRNA) therapies in downregulating these genes to enhance treatment outcomes in pancreatic cancer, a tumor type characterized by high CD44 expression and hypoxia. Methods: We utilized hyaluronic acid (HA)-displaying nanoparticles composed of positively charged chitosan (CS) complexed with siRNA to target and knock down HIF-1α in pancreatic cancer cells. Two NP formulations were prepared using either low molecular weight (LMW) or high molecular weight (HMW) CS. These formulations were evaluated for their internalization by cells and their effectiveness in gene silencing, both in vitro and in vivo. Results: The study found that the molecular weight (MW) of CS influenced the interaction between HA and CD44, as well as the release of siRNA upon internalization. The LMW CS formulation shows faster uptake kinetics, while HMW CS is more effective in gene knockdown across different cell lines in vitro. In vivo, both were able to significantly knockdown HIF-1α and some of its downstream genes. Conclusions: The results suggest that HMW and LMW CS-based NPs exhibit distinct characteristics, showing that both MWs have potential for targeted pancreatic cancer therapy by influencing different aspects of delivery and gene silencing, particularly in the hypoxic tumor microenvironment. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Supplementary Figure 3 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Author

Cawthorne, Christopher, primary, Burrows, Natalie, primary, Gieling, Roben G., primary, Morrow, Christopher J., primary, Forster, Duncan, primary, Gregory, Jamil, primary, Radigois, Marc, primary, Smigova, Alison, primary, Babur, Muhammad, primary, Simpson, Kathryn, primary, Hodgkinson, Cassandra, primary, Brown, Gavin, primary, McMahon, Adam, primary, Dive, Caroline, primary, Hiscock, Duncan, primary, Wilson, Ian, primary, and Williams, Kaye J., primary

Published
2023
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21. Supplementary Figure 4 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Author

Cawthorne, Christopher, primary, Burrows, Natalie, primary, Gieling, Roben G., primary, Morrow, Christopher J., primary, Forster, Duncan, primary, Gregory, Jamil, primary, Radigois, Marc, primary, Smigova, Alison, primary, Babur, Muhammad, primary, Simpson, Kathryn, primary, Hodgkinson, Cassandra, primary, Brown, Gavin, primary, McMahon, Adam, primary, Dive, Caroline, primary, Hiscock, Duncan, primary, Wilson, Ian, primary, and Williams, Kaye J., primary

Published
2023
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22. Supplementary Figure 1 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Author

Cawthorne, Christopher, primary, Burrows, Natalie, primary, Gieling, Roben G., primary, Morrow, Christopher J., primary, Forster, Duncan, primary, Gregory, Jamil, primary, Radigois, Marc, primary, Smigova, Alison, primary, Babur, Muhammad, primary, Simpson, Kathryn, primary, Hodgkinson, Cassandra, primary, Brown, Gavin, primary, McMahon, Adam, primary, Dive, Caroline, primary, Hiscock, Duncan, primary, Wilson, Ian, primary, and Williams, Kaye J., primary

Published
2023
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23. Data from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Author

Cawthorne, Christopher, primary, Burrows, Natalie, primary, Gieling, Roben G., primary, Morrow, Christopher J., primary, Forster, Duncan, primary, Gregory, Jamil, primary, Radigois, Marc, primary, Smigova, Alison, primary, Babur, Muhammad, primary, Simpson, Kathryn, primary, Hodgkinson, Cassandra, primary, Brown, Gavin, primary, McMahon, Adam, primary, Dive, Caroline, primary, Hiscock, Duncan, primary, Wilson, Ian, primary, and Williams, Kaye J., primary

Published
2023
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24. Supplementary Figure 2 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Author

Cawthorne, Christopher, primary, Burrows, Natalie, primary, Gieling, Roben G., primary, Morrow, Christopher J., primary, Forster, Duncan, primary, Gregory, Jamil, primary, Radigois, Marc, primary, Smigova, Alison, primary, Babur, Muhammad, primary, Simpson, Kathryn, primary, Hodgkinson, Cassandra, primary, Brown, Gavin, primary, McMahon, Adam, primary, Dive, Caroline, primary, Hiscock, Duncan, primary, Wilson, Ian, primary, and Williams, Kaye J., primary

Published
2023
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28. Supplementary Figure Legends from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941

Author

Cawthorne, Christopher, primary, Burrows, Natalie, primary, Gieling, Roben G., primary, Morrow, Christopher J., primary, Forster, Duncan, primary, Gregory, Jamil, primary, Radigois, Marc, primary, Smigova, Alison, primary, Babur, Muhammad, primary, Simpson, Kathryn, primary, Hodgkinson, Cassandra, primary, Brown, Gavin, primary, McMahon, Adam, primary, Dive, Caroline, primary, Hiscock, Duncan, primary, Wilson, Ian, primary, and Williams, Kaye J., primary

Published
2023
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30. Supplementary Figure 1 from The Clinically Active PARP Inhibitor AG014699 Ameliorates Cardiotoxicity but Does Not Enhance the Efficacy of Doxorubicin, despite Improving Tumor Perfusion and Radiation Response in Mice

Author

Ali, Majid, primary, Kamjoo, Marzieh, primary, Thomas, Huw D., primary, Kyle, Suzanne, primary, Pavlovska, Ivanda, primary, Babur, Muhammed, primary, Telfer, Brian A., primary, Curtin, Nicola J., primary, and Williams, Kaye J., primary

Published
2023
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34. Supplementary Tables 1-2 from The Clinically Active PARP Inhibitor AG014699 Ameliorates Cardiotoxicity but Does Not Enhance the Efficacy of Doxorubicin, despite Improving Tumor Perfusion and Radiation Response in Mice

Author

Ali, Majid, primary, Kamjoo, Marzieh, primary, Thomas, Huw D., primary, Kyle, Suzanne, primary, Pavlovska, Ivanda, primary, Babur, Muhammed, primary, Telfer, Brian A., primary, Curtin, Nicola J., primary, and Williams, Kaye J., primary

Published
2023
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39. Data from Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish

Author

Henderson, Fiona, primary, Johnston, Hannah R., primary, Badrock, Andrew P., primary, Jones, Emrys A., primary, Forster, Duncan, primary, Nagaraju, Raghavendar T., primary, Evangelou, Christos, primary, Kamarashev, Jivko, primary, Green, Michael, primary, Fairclough, Michael, primary, Ramirez, Irene Barinaga-Rementeria, primary, He, Shuning, primary, Snaar-Jagalska, B. Ewa, primary, Hollywood, Katherine, primary, Dunn, Warwick B., primary, Spaink, Herman P., primary, Smith, Michael P., primary, Lorigan, Paul, primary, Claude, Emmanuelle, primary, Williams, Kaye J., primary, McMahon, Adam W., primary, and Hurlstone, Adam, primary

Published
2023
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40. Supplementary Figure 2 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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41. Supplementary Video from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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42. Supplementary Figure 6 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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43. Table S3 from Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish

Author

Henderson, Fiona, primary, Johnston, Hannah R., primary, Badrock, Andrew P., primary, Jones, Emrys A., primary, Forster, Duncan, primary, Nagaraju, Raghavendar T., primary, Evangelou, Christos, primary, Kamarashev, Jivko, primary, Green, Michael, primary, Fairclough, Michael, primary, Ramirez, Irene Barinaga-Rementeria, primary, He, Shuning, primary, Snaar-Jagalska, B. Ewa, primary, Hollywood, Katherine, primary, Dunn, Warwick B., primary, Spaink, Herman P., primary, Smith, Michael P., primary, Lorigan, Paul, primary, Claude, Emmanuelle, primary, Williams, Kaye J., primary, McMahon, Adam W., primary, and Hurlstone, Adam, primary

Published
2023
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44. Supplementary Figure 9 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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45. Supplementary Figure 8 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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46. Supplementary Data from Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish

Author

Henderson, Fiona, primary, Johnston, Hannah R., primary, Badrock, Andrew P., primary, Jones, Emrys A., primary, Forster, Duncan, primary, Nagaraju, Raghavendar T., primary, Evangelou, Christos, primary, Kamarashev, Jivko, primary, Green, Michael, primary, Fairclough, Michael, primary, Ramirez, Irene Barinaga-Rementeria, primary, He, Shuning, primary, Snaar-Jagalska, B. Ewa, primary, Hollywood, Katherine, primary, Dunn, Warwick B., primary, Spaink, Herman P., primary, Smith, Michael P., primary, Lorigan, Paul, primary, Claude, Emmanuelle, primary, Williams, Kaye J., primary, McMahon, Adam W., primary, and Hurlstone, Adam, primary

Published
2023
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47. Supplementary Tables from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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48. Supplementary Data from Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo?

Author

Ali, Majid, primary, Telfer, Brian A., primary, McCrudden, Cian, primary, O'Rourke, Martin, primary, Thomas, Huw D., primary, Kamjoo, Marzieh, primary, Kyle, Suzanne, primary, Robson, Tracy, primary, Shaw, Chris, primary, Hirst, David G., primary, Curtin, Nicola J., primary, and Williams, Kaye J., primary

Published
2023
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49. Supplementary Material from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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50. Supplementary Figure 4 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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