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4. Exclusion zone phenomena in water -- a critical review of experimental findings and theories

Author

Elton, Daniel C., Spencer, Peter D., Riches, James D., and Williams, Elizabeth D.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Chemical Physics
Abstract

The existence of the exclusion zone (EZ), a layer of water in which plastic microspheres are repelled from hydrophilic surfaces, has now been independently demonstrated by several groups. A better understanding of the mechanisms which generate EZs would help with understanding the possible importance of EZs in biology and in engineering applications such as filtration and microfluidics. Here we review the experimental evidence for EZ phenomena in water and the major theories that have been proposed. We review experimental results from birefringence, neutron radiography, nuclear magnetic resonance, and other studies. Pollack and others have theorized that water in the EZ exists has a different structure than bulk water, and that this accounts for the EZ. We present several alternative explanations for EZs and argue that Schurr's theory based on diffusiophoresis presents a compelling alternative explanation for the core EZ phenomenon. Among other things, Schurr's theory makes predictions about the growth of the EZ with time which have been confirmed by Florea et al. and others. We also touch on several possible confounding factors that make experimentation on EZs difficult, such as charged surface groups, dissolved solutes, and adsorbed nanobubbles., Comment: 14 pgs

Published
2019
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5. Guidelines and definitions for research on epithelial–mesenchymal transition

Author

Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Brabletz, Thomas, Bronner, Marianne, Campbell, Kyra, Cano, Amparo, Casanova, Jordi, Christofori, Gerhard, Dedhar, Shoukat, Derynck, Rik, Ford, Heide L, Fuxe, Jonas, García de Herreros, Antonio, Goodall, Gregory J, Hadjantonakis, Anna-Katerina, Huang, Ruby YJ, Kalcheim, Chaya, Kalluri, Raghu, Kang, Yibin, Khew-Goodall, Yeesim, Levine, Herbert, Liu, Jinsong, Longmore, Gregory D, Mani, Sendurai A, Massagué, Joan, Mayor, Roberto, McClay, David, Mostov, Keith E, Newgreen, Donald F, Nieto, M Angela, Puisieux, Alain, Runyan, Raymond, Savagner, Pierre, Stanger, Ben, Stemmler, Marc P, Takahashi, Yoshiko, Takeichi, Masatoshi, Theveneau, Eric, Thiery, Jean Paul, Thompson, Erik W, Weinberg, Robert A, Williams, Elizabeth D, Xing, Jianhua, Zhou, Binhua P, and Sheng, Guojun

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Animals, Biomedical Research, Cell Movement, Cell Plasticity, Consensus, Developmental Biology, Epithelial-Mesenchymal Transition, Humans, Neoplasms, Terminology as Topic, EMT International Association, Medical and Health Sciences, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.

Published
2020

9. Defining the challenges and opportunities for using patient-derived models in prostate cancer research.

Author

Brennen, W. Nathaniel, Le Magnen, Clémentine, Karkampouna, Sofia, Anselmino, Nicolas, Bock, Nathalie, Choo, Nicholas, Clark, Ashlee K., Coleman, Ilsa M., Dolgos, Robin, Ferguson, Alison M., Goode, David L., Krutihof-de Julio, Marianna, Navone, Nora M., Nelson, Peter S., O'Neill, Edward, Porter, Laura H., Ranasinghe, Weranja, Sunada, Takuro, Williams, Elizabeth D., and Butler, Lisa M.

Published
2024
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10. A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells

Author

McGovern, Jacqui A., Bock, Nathalie, Shafiee, Abbas, Martine, Laure C., Wagner, Ferdinand, Baldwin, Jeremy G., Landgraf, Marietta, Lahr, Christoph A., Meinert, Christoph, Williams, Elizabeth D., Pollock, Pamela M., Denham, Jim, Russell, Pamela J., Risbridger, Gail P., Clements, Judith A., Loessner, Daniela, Holzapfel, Boris M., and Hutmacher, Dietmar W.

Published
2021
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18. Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Author

Wafai, Razan, Williams, Elizabeth D., de Souza, Emma, Simpson, Peter T., McCart Reed, Amy E., Kutasovic, Jamie R., Waltham, Mark, Snell, Cameron E., Blick, Tony, Thompson, Erik W., and Hugo, Honor J.

Published
2020
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19. Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition

Author

Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Brabletz, Thomas, Bronner, Marianne, Campbell, Kyra, Cano, Amparo, Casanova, Jordi, Christofori, Gerhard, Dedhar, Shoukat, Derynck, Rik, Ford, Heide L., Fuxe, Jonas, García de Herreros, Antonio, Goodall, Gregory J., Hadjantonakis, Anna-Katerina, Huang, Ruby Y. J., Kalcheim, Chaya, Kalluri, Raghu, Kang, Yibin, Khew-Goodall, Yeesim, Levine, Herbert, Liu, Jinsong, Longmore, Gregory D., Mani, Sendurai A., Massagué, Joan, Mayor, Roberto, McClay, David, Mostov, Keith E., Newgreen, Donald F., Nieto, M. Angela, Puisieux, Alain, Runyan, Raymond, Savagner, Pierre, Stanger, Ben, Stemmler, Marc P., Takahashi, Yoshiko, Takeichi, Masatoshi, Theveneau, Eric, Thiery, Jean Paul, Thompson, Erik W., Weinberg, Robert A., Williams, Elizabeth D., Xing, Jianhua, Zhou, Binhua P., and Sheng, Guojun

Published
2021
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24. Supplementary data from MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2

Author

Das, Rajdeep, primary, Gregory, Philip A., primary, Fernandes, Rayzel C., primary, Denis, Iza, primary, Wang, Qingqing, primary, Townley, Scott L., primary, Zhao, Shuang G., primary, Hanson, Adrienne R., primary, Pickering, Marie A., primary, Armstrong, Heather K., primary, Lokman, Noor A., primary, Ebrahimie, Esmaeil, primary, Davicioni, Elai, primary, Jenkins, Robert B., primary, Karnes, R. Jeffrey, primary, Ross, Ashley E., primary, Den, Robert B., primary, Klein, Eric A., primary, Chi, Kim N., primary, Ramshaw, Hayley S., primary, Williams, Elizabeth D., primary, Zoubeidi, Amina, primary, Goodall, Gregory J., primary, Feng, Felix Y., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, and Selth, Luke A., primary

Published
2023
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25. Supplementary Data from ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Author

Centenera, Margaret M., primary, Scott, Julia S., primary, Machiels, Jelle, primary, Nassar, Zeyad D., primary, Miller, Deanna C., primary, Zinonos, Irene, primary, Dehairs, Jonas, primary, Burvenich, Ingrid J.G., primary, Zadra, Giorgia, primary, Chetta, Paolo M., primary, Bango, Clyde, primary, Evergren, Emma, primary, Ryan, Natalie K., primary, Gillis, Joanna L., primary, Mah, Chui Yan, primary, Tieu, Terence, primary, Hanson, Adrienne R., primary, Carelli, Ryan, primary, Bloch, Katarzyna, primary, Panagopoulos, Vasilios, primary, Waelkens, Etienne, primary, Derua, Rita, primary, Williams, Elizabeth D., primary, Evdokiou, Andreas, primary, Cifuentes-Rius, Anna, primary, Voelcker, Nicolas H., primary, Mills, Ian G., primary, Tilley, Wayne D., primary, Scott, Andrew M., primary, Loda, Massimo, primary, Selth, Luke A., primary, Swinnen, Johannes V., primary, and Butler, Lisa M., primary

Published
2023
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26. Data from ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Author

Centenera, Margaret M., primary, Scott, Julia S., primary, Machiels, Jelle, primary, Nassar, Zeyad D., primary, Miller, Deanna C., primary, Zinonos, Irene, primary, Dehairs, Jonas, primary, Burvenich, Ingrid J.G., primary, Zadra, Giorgia, primary, Chetta, Paolo M., primary, Bango, Clyde, primary, Evergren, Emma, primary, Ryan, Natalie K., primary, Gillis, Joanna L., primary, Mah, Chui Yan, primary, Tieu, Terence, primary, Hanson, Adrienne R., primary, Carelli, Ryan, primary, Bloch, Katarzyna, primary, Panagopoulos, Vasilios, primary, Waelkens, Etienne, primary, Derua, Rita, primary, Williams, Elizabeth D., primary, Evdokiou, Andreas, primary, Cifuentes-Rius, Anna, primary, Voelcker, Nicolas H., primary, Mills, Ian G., primary, Tilley, Wayne D., primary, Scott, Andrew M., primary, Loda, Massimo, primary, Selth, Luke A., primary, Swinnen, Johannes V., primary, and Butler, Lisa M., primary

Published
2023
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31. Supplementary Methods, Tables 1 - 3, Figures 1 - 4 from ATF3 Suppresses Metastasis of Bladder Cancer by Regulating Gelsolin-Mediated Remodeling of the Actin Cytoskeleton

Author

Yuan, Xiangliang, primary, Yu, Liang, primary, Li, Junhua, primary, Xie, Guohua, primary, Rong, Tingting, primary, Zhang, Liang, primary, Chen, Jianhua, primary, Meng, Qiaohong, primary, Irving, Aaron T., primary, Wang, Die, primary, Williams, Elizabeth D., primary, Liu, Jun-Ping, primary, Sadler, Anthony J., primary, Williams, Bryan R.G., primary, Shen, Lisong, primary, and Xu, Dakang, primary

Published
2023
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35. hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer

Author

Adams, Mark N., primary, Croft, Laura V., additional, Urquhart, Aaron, additional, Saleem, Mohamed Ashick Mohamed, additional, Rockstroh, Anja, additional, Duijf, Pascal H. G., additional, Thomas, Patrick B., additional, Ferguson, Genevieve P., additional, Najib, Idris Mohd, additional, Shah, Esha T., additional, Bolderson, Emma, additional, Nagaraj, Shivashankar, additional, Williams, Elizabeth D., additional, Nelson, Colleen C., additional, O'Byrne, Kenneth J., additional, and Richard, Derek J., additional

Published
2023
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41. Chimeric Antigen Receptor T-Cell Therapy in Metastatic Castrate-Resistant Prostate Cancer

Author

Perera, Mahasha P.J., Thomas, Patrick B., Risbridger, Gail P., Taylor, Renea, Azad, Arun, Hofman, Michael S., Williams, Elizabeth D., Vela, Ian, Perera, Mahasha P.J., Thomas, Patrick B., Risbridger, Gail P., Taylor, Renea, Azad, Arun, Hofman, Michael S., Williams, Elizabeth D., and Vela, Ian

Abstract

Prostate cancer is the most commonly diagnosed solid-organ cancer amongst males worldwide. Metastatic castrate-resistant prostate cancer (mCRPC) is a rapidly fatal end-sequelae of prostate cancer. Therapeutic options for men with mCRPC are limited and are not curative in nature. The recent development of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionised the treatment of treatment-resistant haematological malignancies, and several studies are underway investigating the utility of this technology in the treatment of solid tumours. In this review, we evaluate the current treatment options for men with mCRPC as well as the current landscape of preclinical and clinical trials of CAR-T cell therapy against prostate cancer. We also appraise the various prostate cancer-specific tumour-associated antigens that may be targeted by CAR-T cell technology. Finally, we examine the potential translational barriers of CAR-T cell therapy in solid tumours. Despite preclinical success, preliminary clinical trials in men with prostate cancer have had limited efficacy. Therefore, further clinically translatable preclinical models are required to enhance the understanding of the role of this investigational therapeutic in men with mCRPC. In the era of precision medicine, tailored immunotherapy administered to men in a tumour-agnostic approach provides hope to a group of men who otherwise have few treatment options available.

Published
2022

42. Modelling the tumor immune microenvironment for precision immunotherapy

Author

Mackenzie, Nathan J, Nicholls, Clarissa, Templeton, Abby R, Perera, Mahasha Pj, Jeffery, Penny L, Zimmermann, Kate, Kulasinghe, Arutha, Kenna, Tony J, Vela, Ian, Williams, Elizabeth D, Thomas, Patrick B, Mackenzie, Nathan J, Nicholls, Clarissa, Templeton, Abby R, Perera, Mahasha Pj, Jeffery, Penny L, Zimmermann, Kate, Kulasinghe, Arutha, Kenna, Tony J, Vela, Ian, Williams, Elizabeth D, and Thomas, Patrick B

Abstract

The complexity of the cellular and acellular players within thetumor microenvironment (TME) allows for significant variation inTME constitution and role in anticancer treatment response. Spatialalterations in populations of tumor cells and adjacent non-malignant cells, including endothelial cells, fibroblasts and tissue-infiltrating immune cells, often have a major role in determiningdisease progression and treatment response in cancer. Many currentstandard systemic antineoplastic treatments target the cancer cellsand could be further refined to directly target commonlydysregulated cell populations of the TME. Recent developments inimmuno-oncology and bioengineering have created an attractivepotential to model these complexities at the level of the individualpatient. These developments, along with the increasing momentum in precision medicine research and application, have catalysed exciting new discoveries in understanding drug–TME interactions, target identification, and improved efficacy of therapies. While rapid progress has been made, there are still many challenges to overcome in the development of accurate in vitro, in vivo and ex vivo models incorporating the cellular interactions that take place in the TME. In this review, we describe how advances in immuno-oncology and patient-derived models, such as patient-derived organoids and explant cultures, have enhanced the landscape of personalised immunotherapy prediction and treatment of solid organ malignancies. We describe and compare different immunological targets and perspectives on two-dimensional and three-dimensional modelling approaches that may be used to better rationalise immunotherapy use, ultimately providing a knowledge base for the integration of the autologous TME into these predictive models.

Published
2022

43. Circulating Tumour Cells Indicate the Presence of Residual Disease Post-Castration in Prostate Cancer Patient-Derived Xenograft Models

Author

Hassan, Sara, Blick, Tony, Wood, Jack, Thompson, Erik W, Williams, Elizabeth D, Hassan, Sara, Blick, Tony, Wood, Jack, Thompson, Erik W, and Williams, Elizabeth D

Abstract

Castrate-resistant prostate cancer (CRPC) is the lethal form of prostate cancer. Epithelial mesenchymal plasticity (EMP) has been associated with disease progression to CRPC, and prostate cancer therapies targeting the androgen signalling axis, including androgen deprivation therapy (ADT), promote EMP. We explored effects of castration on EMP in the tumours and circulating tumour cells (CTCs) of patient-derived xenograft (PDX)-bearing castrated mice using human-specific RT-qPCR assays and immunocytochemistry. Expression of prostate epithelial cell marker KLK3 was below detection in most tumours from castrated mice (62%, 23/37 mice), consistent with its known up-regulation by androgens. Endpoint tumour size after castration varied significantly in a PDX model-specific pattern; while most tumours were castration-sensitive (BM18, LuCaP70), the majority of LuCaP105 tumours continued to grow following castration. By contrast, LuCaP96 PDX showed a mixed response to castration. CTCs were detected in 33% of LuCaP105, 43% of BM18, 47% of LuCaP70, and 54% of LuCaP96 castrated mice using RPL32 mRNA measurement in plasma. When present, CTC numbers estimated using human RPL32 expression ranged from 1 to 458 CTCs per ml blood, similar to our previous observations in non-castrated mice. In contrast to their non-castrated counterparts, there was no relationship between tumour size and CTC burden in castrated mice. Unsupervised hierarchical clustering of the gene expression profiles of CTCs collected from castrated and non-castrated mice revealed distinct CTC sub-groups within the pooled population that were classified as having mesenchymal, epithelial, or EMP hybrid gene expression profiles. The epithelial signature was only found in CTCs from non-castrated mice. Hybrid and mesenchymal signatures were detected in CTCs from both castrated and non-castrated mice, with an emphasis towards mesenchymal phenotypes in castrated mice. Post-castration serum PSA levels were either below d

Published
2022

44. Correction: A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome

Author

Stylianou, Nataly, Lehman, Melanie L., Wang, Chenwei, Fard, Atefeh Taherian, Rockstroh, Anja, Fazli, Ladan, Jovanovic, Lidija, Ward, Micheal, Sadowski, Martin C., Kashyap, Abhishek S., Buttyan, Ralph, Gleave, Martin E., Westbrook, Thomas F., Williams, Elizabeth D., Gunter, Jennifer H., Nelson, Colleen C., and Hollier, Brett G.

Published
2019
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46. Additional file 1 of Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs

Author

Nowlan, Bianca, Williams, Elizabeth D., and Doran, Michael Robert

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 1: Supplementary Tables.

Published
2022
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47. Supplementary Material for Computationally efficient framework for diagnosing, understanding, and predicting biphasic population growth

Author

Murphy, Ryan J., Maclaren, Oliver J., Calabrese, Alivia R., Thomas, Patrick B., Warne, David J., Williams, Elizabeth D., and Simpson, Matthew J.

Abstract

Synthetic data results. Additional results for coral reef, cell proliferation assay, and spheroid case studies. Results for fourth case study, a proliferation assay with a bladder cancer cell line. Image processing details.

Published
2022
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50. Modelling the tumor immune microenvironment for precision immunotherapy

Author

Mackenzie, Nathan J, primary, Nicholls, Clarissa, additional, Templeton, Abby R, additional, Perera, Mahasha PJ, additional, Jeffery, Penny L, additional, Zimmermann, Kate, additional, Kulasinghe, Arutha, additional, Kenna, Tony J, additional, Vela, Ian, additional, Williams, Elizabeth D, additional, and Thomas, Patrick B, additional

Published
2022
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