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194 results on '"Williams, Donald S."'

4. High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate

Author

Cabal, Antonio, Jayakar, Richa Y., Sardesai, Swanand, Phillips, Eual A., Szumiloski, John, Posavec, Diane J., Mathers, Parker D., Savitz, Alan T., Scott, Boyd B., Winkelmann, Christopher T., Motzel, Sherri, Cook, Lynn, Hargreaves, Richard, Evelhoch, Jeffrey L., Dardzinski, Bernard J., Hangartner, Thomas N., McCracken, Paul J., Duong, Le T., and Williams, Donald S.

Published
2013
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5. Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: A head-to-head comparison with alendronate

Author

Williams, Donald S., McCracken, Paul J., Purcell, Mona, Pickarski, Maureen, Mathers, Parker D., Savitz, Alan T., Szumiloski, John, Jayakar, Richa Y., Somayajula, Sangeetha, Krause, Stephen, Brown, Keenan, Winkelmann, Christopher T., Scott, Boyd B., Cook, Lynn, Motzel, Sherri L., Hargreaves, Richard, Evelhoch, Jeffrey L., Cabal, Antonio, Dardzinski, Bernard J., Hangartner, Thomas N., and Duong, Le T.

Published
2013
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7. Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: A study with odanacatib treatment in the ovariectomized adult rhesus monkey

Author

Jayakar, Richa Y., Cabal, Antonio, Szumiloski, John, Sardesai, Swanand, Phillips, Eual A., Laib, Andres, Scott, Boyd B., Pickarski, Maureen, Duong, Le T., Winkelmann, Christopher T., McCracken, Paul J., Hargreaves, Richard, Hangartner, Thomas N., and Williams, Donald S.

Published
2012
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9. Perfusion MRI Assessment of Cerebral Blood Flow and CO2 Reactivity after Controlled Cortical Impact in Rats

Author

Forbes, Michael L., Hendrich, Kristy S., Schiding, Joanne K., Williams, Donald S., Ho, Chien, DeKosky, Steven T., Marion, Donald W., Kochanek, Patrick M., Nemoto, Edwin M., editor, LaManna, Joseph C., editor, Cooper, Christopher, editor, Delpy, David, editor, Groebe, Karlfried, editor, Hunt, Thomas K., editor, Keipert, Peter, editor, Mayevsky, Avrahim, editor, Pittman, Roland N., editor, Rumsey, William L., editor, Vaupel, Peter, editor, and Wilson, David F., editor

Published
1997
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17. Ischemic Mechanisms in Traumatic Brain Injury

Author

Kochanek, Patrick M., primary, Hendrich, Kristy S., additional, Statler, Kimberly D., additional, Clark, Robert S.B., additional, Jenkins, Larry W., additional, Williams, Donald S., additional, Ho, C., additional, and Marion, Donald W., additional

Published
2003
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21. Magnetic Resonance Imaging of Cerebral Blood Flow**The Pittsburgh NMR Center for Biomedical Research was established by grants from the Richard King Mellon Foundation, the Lucille P. Markey Charitable Trust, the Ben Franklin Partnership Program of the Commonwealth of Pennsylvania, and the Ralph M. Parsons Foundation. The work described was supported by a National Institutes of Health, Division of Research Resources Award RR-03631 to the Pittsburgh NMR Center for Biomedical Research, NIH Research Career Development Award (HL-02847) to APK, NIH Clinical Investigator Development Award (NS-01668) to JAD, and a Brazilian CNPq fellowship to ACS.

Author

Koretsky, Alan P., primary, Costa e Silva, Afonso, additional, Williams, Donald S., additional, Zhang, Weiguo, additional, and Detre, John A., additional

Published
1995
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24. MRI of lungs using partial liquid ventilation with water-in-perfluorocarbon emulsions

Author

Huang, Ming Qiang, Ye, Qing, Williams, Donald S., and Ho, Chien

Subjects
FOS: Biological sciences, respiratory system, 69999 Biological Sciences not elsewhere classified, respiratory tract diseases
Abstract

A novel (1)H-MRI contrast modality for rat lungs has been developed using water-in-perfluorocarbon (PFC) emulsions for partial liquid ventilation (PLV). The feasibility of the new ventilation protocol for (1)H-MRI studies of lungs has been demonstrated. (1)H-MR images of lungs have been obtained with sensitivity and spatial resolution higher than those of the (19)F-MRI of lungs previously reported. Diffusion-weighted MRI measurements of lungs showed that the results obtained are related to the pulmonary architecture and functional properties of lungs. Although the methodology needs further improvement and evaluation, it appears to have great potential in a wide range of new applications in the field of lung MRI, such as in vivo detection of lung cancer, emphysema, and allograft rejection following lung transplantation. The ability of this technique to achieve high-quality MR images of lungs, together with its technical simplicity, stability, and low cost, makes this method a promising imaging technique for the lungs.

Published
2018
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29. Investigation of Cross-Species Translatability of Pharmacological MRI in Awake Nonhuman Primate - A Buprenorphine Challenge Study

Author

Seah, Stephanie, primary, Asad, Abu Bakar Ali, additional, Baumgartner, Richard, additional, Feng, Dai, additional, Williams, Donald S., additional, Manigbas, Elaine, additional, Beaver, John D., additional, Reese, Torsten, additional, Henry, Brian, additional, Evelhoch, Jeffrey L., additional, and Chin, Chih-Liang, additional

Published
2014
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34. REPLY TO ADAM BARKMAN.

Author

Williams, Donald S.

Subjects
*CHRISTIAN apologetics, *GOD in Christianity, *CHRISTIAN philosophers
Abstract

The article presents the author's reply to comments in response to his article in favor of British writer C.S. Lewis' apologetic Trilemma argument for the deity of Jesus Christ. The author believes that Lewis' argument as presented in the book "Mere Christianity" assumes without argument that Jesus claims to be God. According to the author, the main point of disagreement seems to be over how strong the case for Jesus' claims to deity actually is.

Published
2015

35. PRO: A DEFENSE OF C. S. LEWIS'S "TRILEMMA".

Author

Williams, Donald S.

Subjects
*CHRISTIAN apologetics, *GOD in Christianity, *PROOF of God
Abstract

The article presents the author's views in favor of British writer C.S. Lewis' apologetic Trilemma argument for the deity of Jesus Christ. The author mentions Lewis' argument mentioned in his book "Mere Christianity," in which he assumes that Jesus claimed to be God. According to the author, Lewis's tripartite form of Jesus gave birth to the Trilemma.

Published
2015

36. Characteristic time courses of cortical and medullary sodium signals measured by noninvasive 23Na-MRI in rat kidney induced by furosemide.

Author

Liu, Haiying, Zhou, Dan, Garcia, Maria L., Kohler, Martin G., Shen, Xiaolan, Williams, Donald S., Klimas, Michael T., Hargreaves, Richard J., and Kaczorowski, Gregory J.

Abstract

Background To characterize regional kidney sodium response by MRI following NKCC2 inhibition. Methods Regional renal sodium signals were monitored noninvasively using 23Na-MRI at 9.4T with a temporal resolution of 1.5 min in anesthetized rats (N = 14). A mild NKCC2 inhibition was induced using a slow intravenous furosemide infusion. Time course of sodium signal was modeled as an exponential transient with a single characteristic time constant. Results Under normal physiological conditions, the renal sodium signals in medullary and cortical regions were stable and found to respond differently to furosemide challenge. Furosemide infusion at 1.2 mg/kg/h (N = 7) increased sodium signal in the cortex by 40 ± 6% ( P < 7 × 10−5) whereas decreased in the medulla by 29 ± 2% ( P < 3 × 10−6) with different temporal kinetics. The characteristic time constants of the change were determined to be: 8 ± 2 and 70 ± 10 min for medulla and cortex. Also, the medullary change occurred 9(±3) times faster than cortical independent of furosemide infusion rate up to 35 mg/kg/h. Conclusion The pharmacological effects in terms of regional kidney sodium signal changes induced by NKCC2 inhibition are region-specific and highly predictable. Using noninvasive sodium MRI, we obtained regional renal sodium kinetics data sets in response to a low dose furosemide infusion in normal rats. J. Magn. Reson. Imaging 2015;41:1622-1628. © 2014 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2015
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37. Effect of Cyclosporine on Hepatic Energy Status and on Fructose Metabolism after Portacaval Shunt in Dog as Monitored by Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy in Vivo

Author

Rossaro, Lorenzo, Mazzaferro, Vincenzo, Scotti-Foglieni, Carlo L., Williams, Donald S., Simplaceanu, Elena, Simplaceanu, Virgil, Francavilla, Antonio, Starzl, Thomas E., Ho, Chien, and Van Thiel, David H.

Subjects
Magnetic Resonance Spectroscopy, Portacaval Shunt, Surgical, Fructosephosphates, Cyclosporins, Phosphorus, Fructose, Article, Adenosine Triphosphate, Dogs, Liver, Reference Values, Animals, Female, Energy Metabolism
Abstract

The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus-31 nuclear magnetic resonance spectroscopy in dogs. Three experimental groups were studied: (a) control dogs (n = 5), (b) dogs 4 days after the creation of an end-to-side portacaval shunt (n = 5), and (c) dogs 4 days after portacaval shunt and continuous infusion of cyclosporin A (4 mg/kg/day) by way of the left portal vein (portacaval shunt plus cyclosporin A, n = 5). The phosphorus-31 nuclear magnetic resonance spectra were obtained at 81 MHz using a Bruker BIOSPEC II 4.7-tesla nuclear magnetic resonance system equipped with a 40-cm horizontal bore superconducting solenoid. The phosphomonoesters (p < 0.01), inorganic phosphate and ATP levels (p < 0.05) were decreased significantly in portacaval shunt–treated and in portacaval shunt-plus-cyclosporin A–treated dogs compared with unshunted control dogs. After a fructose challenge (750 mg/kg body wt, intravenously), fructose-1-phosphate metabolism was reduced in portacaval shunt–treated dogs compared with either the normal or portacaval shunt-plus-cyclosporin A–treated dogs (p < 0.05). Both portacaval shunt– and portacaval shunt-plus-cyclosporin A–treated dogs demonstrated a reduced decline in ATP levels after fructose infusion when compared with the controls (p < 0.05). Immediately after the fructose challenge, the intracellular pH decreased from 7.30 ± 0.03 to 7.00 ± 0.05 in all animals (p < 0.01) and then gradually returned to normal over 60 min. These data, obtained in vivo using phosphorus-31 nuclear magnetic resonance spectroscopy of the liver after a portacaval shunt, suggest that: (a) the energy status of the liver is reduced in dogs with a portacaval shunt compared with that of normal controls and (b) cyclosporin A treatment ameliorates the reduction in hepatic metabolism normally observed after a fructose challenge to the liver with a portacaval shunt.

Published
1991

42. Quantitative Perfusion Imaging Using Arterial Spin Labeling.

Author

Walker, John M., Prasad, Pottumarthi V., and Williams, Donald S.

Abstract

MRI-based perfusion imaging techniques can be classified into those that use exogenously administered contrast agents and those that use an endogenous material that reflects blood flow. This chapter focuses on the technique of arterial spin labeling (ASL), in which endogenous water is made a freely diffusible perfusion tracer by perturbing the magnetization of blood water in arteries prior to their entry into tissue of interest. The technique is totally noninvasive and allows repeated quantitative blood flow measurements in a time scale limited only by the spin lattice relaxation time (T1). Absolute quantitation requires measurement of T1, transit time, and labeling efficiency, as well as careful control for magnetization transfer effects. Two main variants of the ASL technique are in use: continuous ASL (CASL) and pulsed ASL (PASL). This chapter describes basic theory for CASL, and experimental and computational procedures for obtaining quantitative perfusion maps of the brain. Extension of the technique for renal perfusion imaging is outlined. [ABSTRACT FROM AUTHOR]

Published
2006
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