3 results on '"William Uhlrich"'
Search Results
2. Beating versus arrested heart isolated tricuspid valve surgery: An 11-year experience in the current era
- Author
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William Uhlrich, Rémi Buzzi, J.F. Obadia, Martin Connock, Jean Luc Fellahi, Matteo Pozzi, Matthias Jacquet-Lagrèze, Xavier Armoiry, Daniel Grinberg, Michele Flagiello, Hélène Thibault, Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), University of Warwick [Coventry], Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), CarMeN, laboratoire, Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Beating heart ,[SDV]Life Sciences [q-bio] ,Renal function ,tricuspid valve repair ,030204 cardiovascular system & hematology ,tricuspid valve ,03 medical and health sciences ,Impaired renal function ,0302 clinical medicine ,Euroscore ii ,medicine ,Hospital discharge ,Clinical endpoint ,Humans ,tricuspid valve replacement ,Cardiac Surgical Procedures ,Retrospective Studies ,Heart Valve Prosthesis Implantation ,Tricuspid valve ,business.industry ,Middle Aged ,Tricuspid Valve Insufficiency ,Confidence interval ,3. Good health ,Surgery ,[SDV] Life Sciences [q-bio] ,Treatment Outcome ,medicine.anatomical_structure ,arrested heart technique ,030228 respiratory system ,beating heart technique ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; BACKGROUND AND AIM OF THE STUDY: Data about the beating heart (BH) technique for isolated tricuspid valve (TV) surgery compared to the arrested heart (AH) technique are sparse. We compared the outcomes of isolated TV surgery between BH and AH technique. METHODS: We performed an observational analysis of our database of isolated TV surgery. Patients were divided into two groups according to whether surgery was performed without (BH group) or with (AH group) aortic cross-clamping and cardioplegic arrest. The primary endpoint was survival to hospital discharge. Risk factors for in-hospital mortality were searched with multivariate analyses. We undertook further comparisons after propensity-score matching. RESULTS: From January 2007 to December 2017, we performed 82 isolated TV surgery (BH group, n = 47, 57.3%; AH group, n = 35, 42.7%). The mean age was 59.1 years, 56.1% were female. BH group patients were older (61.8 vs. 55.4 years; p = .035), had greater impaired renal function (glomerular filtration rate, 61.1 vs. 74.6 ml/min; p = .012), were more frequently operated for secondary TR (61.7 vs. 31.4%; p = .008), underwent more frequently a reoperation (53.2 vs. 28.6%; p = .042) and exhibited a higher surgical risk (EuroSCORE II, 3.92 vs. 2.50%; p = .013). In-hospital mortality was not different between both groups, either considering unmatched (BH = 10.6 vs. AH = 5.7%; OR = 1.96, 95% confidence interval [CI] = 0.36-10.77) or matched populations (BH = 10.6 vs. AH = 6.4%; OR = 1.89, 95% CI = 0.36-9.97). Age was the only predictor of in-hospital mortality. CONCLUSIONS: The BH technique showed comparable outcomes to the AH technique for isolated TV surgery despite a higher risk profile.
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- 2021
3. The unfinished saga of invasive procedures for secondary mitral regurgitation
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Rémi Buzzi, Matteo Pozzi, Sophie Thivolet, Gilles Rioufol, William Uhlrich, Jean-François Obadia, Daniel Grinberg, Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and CarMeN, laboratoire
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Keynote Lecture Series ,medicine.medical_specialty ,Percutaneous ,[SDV]Life Sciences [q-bio] ,Disease ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Secondary mitral regurgitation (secondary MR) ,Materials Chemistry ,medicine ,percutaneous procedures ,MitraClip ,mitral valve replacement (MVR) ,Mitral regurgitation ,Ischemic cardiomyopathy ,business.industry ,valvular heart disease ,medicine.disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,Heart failure ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,mitral valve repair (MVr) - Abstract
International audience; Secondary mitral regurgitation (MR) is a common valvular heart disease. Its prognostic burden in patients suffering from idiopathic or ischemic cardiomyopathy (ICM) with left ventricular (LV) dysfunction/dilation has been clearly demonstrated. Severe secondary MR is associated with an increased mortality and frequent heart failure hospitalizations. Although guideline-directed medical therapy (GDMT) is the cornerstone of the management of secondary MR, a certain proportion of patients remain symptomatic. For these patients, several surgical techniques have been progressively developed during the last few decades (replacement, repair, sub-valvular apparatus interventions and other ventricular approaches). In the absence of evidence-based medicine, the benefits of these surgical procedures remains controversial, leading to a low level of recommendation in the guidelines. One way to anticipate the future is to look to the past. Recent prospective randomized trials evaluated surgical and percutaneous techniques and led to a better understanding of how best to treat this disease. In this article, we aim to describe the saga of the surgical and percutaneous treatments for secondary MR throughout the previous decades.
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- 2021
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