Abstract This quality improvement project involved developing, implementing and evaluating an educational intervention using computer‐based training (CBT) and high‐fidelity simulation (HFS) to increase knowledge, confidence and compliance of nurses identifying sepsis. A one‐group pretest‐posttest design was used. Participants were nurses on a general ward of an academic medical centre. Study variables were measured over three timepoints: 2 weeks before, immediately after and 90 days after implementation. Data were collected from January 30, 2018, to June 22, 2018. SQUIRE 2.0 checklist for quality improvement reporting used. Improvements in knowledge of sepsis (F(2,83) = 18.14, p