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339 results on '"Willett, Brian J."'

1. Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

Author

Herzog, Catherine M., Aklilu, Fasil, Sibhatu, Demeke, Shegu, Dereje, Belaineh, Redeat, Mohammed, Abde Aliy, Kidane, Menbere, Schulz, Claudia, Willett, Brian J., Cleaveland, Sarah, Bailey, Dalan, Peters, Andrew R., Cattadori, Isabella M., Hudson, Peter J., Asgedom, Hagos, Buza, Joram, Forza, Mesfin Sahle, Chibssa, Tesfaye Rufael, Gebre, Solomon, Juleff, Nick, Bjørnstad, Ottar N., Baron, Michael D., and Kapur, Vivek

Published
2024
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2. Crimean-Congo Hemorrhagic Fever Virus Seroprevalence in Human and Livestock Populations, Northern Tanzania

Author

Hughes, Ellen C., de Glanville, William, Kibona, Tito, Mmbaga, Blandina Theophil, Rostal, Melinda K., Swai, Emanuel S., Cleaveland, Sarah, Lankester, Felix, Willett, Brian J., and Allan, Kathryn J.

Subjects
Hemorrhagic fever, Disease transmission, Epidemiology, Livestock, Health
Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tickborne orthonairovirus with potential to cause severe Crimean-Congo hemorrhagic fever (CCHF) disease in humans, which can lead to human-to-human transmission (1). CCHFV is [...]

Published
2024
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3. SARS-CoV-2 Seroprevalence and Cross-Variant Antibody Neutralization in Cats, United Kingdom

Author

Tyson, Grace B., Jones, Sarah, Logan, Nicola, McDonald, Michael, Marshall, Leigh, Murcia, Pablo R., Willett, Brian J., Weir, William, and Hosie, Margaret J.

Subjects
Antigen-antibody reactions -- Statistics -- Health aspects, Cats -- Health aspects -- Statistics, Disease transmission -- Risk factors -- Statistics, Pets -- Health aspects -- Statistics, Health
Abstract

The World Organisation for Animal Health reported that 26 different animal species had been infected with SARS-CoV-2 by December 31, 2022; [approximately equal to]30% (8/26) of the susceptible species are [...]

Published
2023
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4. Adeno-associated virus 2 infection in children with non-A–E hepatitis

Author

Ho, Antonia, Orton, Richard, Tayler, Rachel, Asamaphan, Patawee, Herder, Vanessa, Davis, Chris, Tong, Lily, Smollett, Katherine, Manali, Maria, Allan, Jay, Rawlik, Konrad, McDonald, Sarah E., Vink, Elen, Pollock, Louisa, Gannon, Louise, Evans, Clair, McMenamin, Jim, Roy, Kirsty, Marsh, Kimberly, Divala, Titus, Holden, Matthew T. G., Lockhart, Michael, Yirrell, David, Currie, Sandra, O’Leary, Maureen, Henderson, David, Shepherd, Samantha J., Jackson, Celia, Gunson, Rory, MacLean, Alasdair, McInnes, Neil, Bradley-Stewart, Amanda, Battle, Richard, Hollenbach, Jill A., Henderson, Paul, Odam, Miranda, Chikowore, Primrose, Oosthuyzen, Wilna, Chand, Meera, Hamilton, Melissa Shea, Estrada-Rivadeneyra, Diego, Levin, Michael, Avramidis, Nikos, Pairo-Castineira, Erola, Vitart, Veronique, Wilkie, Craig, Palmarini, Massimo, Ray, Surajit, Robertson, David L., da Silva Filipe, Ana, Willett, Brian J., Breuer, Judith, Semple, Malcolm G., Turner, David, Baillie, J. Kenneth, and Thomson, Emma C.

Published
2023
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7. Ethnic differences in cellular and humoral immune responses to SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis

Author

Martin, Christopher A., Nazareth, Joshua, Jarkhi, Amar, Pan, Daniel, Das, Mrinal, Logan, Nicola, Scott, Sam, Bryant, Luke, Abeywickrama, Neha, Adeoye, Oluwatobi, Ahmed, Aleem, Asif, Aqua, Bandi, Srini, George, Nisha, Gohar, Marjan, Gray, Laura J., Kaszuba, Ross, Mangwani, Jitendra, Martin, Marianne, Moorthy, Arumugam, Renals, Valerie, Teece, Lucy, Vail, Denny, Khunti, Kamlesh, Moss, Paul, Tattersall, Andrea, Hallis, Bassam, Otter, Ashley D., Rowe, Cathy, Willett, Brian J., Haldar, Pranab, Cooper, Andrea, and Pareek, Manish

Published
2023
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8. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Author

Baillie, J. Kenneth, Openshaw, Peter J.M., Semple, Malcolm G., Alex, Beatrice, Andrikopoulos, Petros, Bach, Benjamin, Barclay, Wendy S., Bogaert, Debby, Chand, Meera, Chechi, Kanta, Cooke, Graham S., da Silva Filipe, Ana, de Silva, Thushan, Docherty, Annemarie B., dos Santos Correia, Gonçalo, Dumas, Marc-Emmanuel, Dunning, Jake, Fletcher, Tom, Green, Christopher A., Greenhalf, William, Griffin, Julian, Gupta, Rishi K., Harrison, Ewen M., Ho, Antonia Y.W., Holden, Karl, Horby, Peter W., Ijaz, Samreen, Khoo, Say, Klenerman, Paul, Law, Andrew, Lewis, Matthew, Liggi, Sonia, Lim, Wei Shen, Maslen, Lynn, Mentzer, Alexander J., Merson, Laura, Meynert, Alison M, Moore, Shona C., Noursadeghi, Mahdad, Olanipekun, Michael, Osagie, Anthonia, Palmarini, Massimo, Palmieri, Carlo, Paxton, William A., Pollakis, Georgios, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Russell, Clark D., Sancho-Shimizu, Vanessa, Sands, Caroline, Scott, Janet T., Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Summers, Charlotte, Swann, Olivia V., Takats, Zoltan, Takis, Panteleimon, Tedder, Richard S., Thompson, A.A. Roger, Thomson, Emma C., Thwaites, Ryan S., Turtle, Lance C.W., Zambon, Maria, Drake, Thomas M., Fairfield, Cameron J., Knight, Stephen R., Mclean, Kenneth A., Murphy, Derek, Norman, Lisa, Pius, Riinu, Shaw, Catherine A., Connor, Marie, Dalton, Jo, Gamble, Carrol, Girvan, Michelle, Halpin, Sophie, Harrison, Janet, Jackson, Clare, Lee, James, Marsh, Laura, Plotkin, Daniel, Roberts, Stephanie, Saviciute, Egle, Clohisey, Sara, Hendry, Ross, Knight, Susan, Lahnsteiner, Eva, Leeming, Gary, Norris, Lucy, Scott-Brown, James, Tait, Sarah, Wham, Murray, Clark, Richard, Coutts, Audrey, Donelly, Lorna, Fawkes, Angie, Gilchrist, Tammy, Hafezi, Katarzyna, MacGillivray, Louise, Maclean, Alan, McCafferty, Sarah, Morrice, Kirstie, Murphy, Lee, Wrobel, Nicola, Carson, Gail, Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Aldera, Erin L., Alegria, Ana, Allen, Sam, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nicholas, Bassford, 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Vidya, Kegg, Stephen, Kelsey, Michael, Kendall, Jason, Kerrison, Caroline, Kerslake, Ian, Koch, Oliver, Koduri, Gouri, Koshy, George, Laha, Shondipon, Laird, Steven, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, Limb, James, Linnett, Vanessa, Little, Jeff, Lyttle, Mark, MacMahon, Michael, MacNaughton, Emily, Mankregod, Ravish, Masson, Huw, Matovu, Elijah, McCullough, Katherine, McEwen, Ruth, Meda, Manjula, Mills, Gary, Minton, Jane, Mohandas, Kavya, Mok, Quen, Moon, James, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Mortimore, Katherine, Moses, Samuel, Mpenge, Mbiye, Mulla, Rohinton, Murphy, Michael, Nagarajan, Thapas, Nagel, Megan, Nelson, Mark, Norris, Lillian, O'Shea, Matthew K., Ostermann, Marlies, Otahal, Igor, Pais, Mark, Panchatsharam, Selva, Papakonstantinou, Danai, Papineni, Padmasayee, Paraiso, Hassan, Patel, Brij, Pattison, Natalie, Pepperell, Justin, Peters, Mark, Phull, Mandeep, Pintus, Stefania, Planche, Tim, Post, Frank, Price, David, Prout, Rachel, Rae, Nikolas, Reschreiter, Henrik, Reynolds, Tim, Richardson, Neil, Roberts, Mark, Roberts, Devender, Rose, Alistair, Rousseau, Guy, Ruge, Bobby, Ryan, Brendan, Saluja, Taranprit, Sarah, Sarah, Schmid, Matthias, Shah, Aarti, Shankar-Hari, Manu, Shanmuga, Prad, Sharma, Anil, Shawcross, Anna, Singh Pooni, Jagtur, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Staines, Nikki, Stambach, Tom, Stewart, Richard, Subudhi, Pradeep, Szakmany, Tamas, Tatham, Kate, Thomas, Jo, Thompson, Chris, Thompson, Robert, Tridente, Ascanio, Tupper-Carey, Darell, Twagira, Mary, Vallotton, Nick, Vancheeswaran, Rama, Vincent, Rachel, Vincent-Smith, Lisa, Visuvanathan, Shico, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Walden, Andrew, Welters, Ingeborg, Whitehouse, Tony, Whittaker, Paul, Whittington, Ashley, Wijesinghe, Meme, Williams, Martin, Wilson, Lawrence, Winchester, Stephen, Wiselka, Martin, Wolverson, Adam, Wootton, Daniel G, Workman, Andrew, Yates, Bryan, Young, Peter, McDonald, Sarah E., Shaw, Victoria, Ahmed, Katie A., Armstrong, Jane A., Ashworth, Milton, Asiimwe, Innocent G., Bakshi, Siddharth, Barlow, Samantha L, Booth, Laura, Brennan, Benjamin, Bullock, Katie, Carlucci, Nicola, Cass, Emily, Catterall, Benjamin W.A., Clark, Jordan J., Clarke, Emily A., Cole, Sarah, Cooper, Louise, Cox, Helen, Davis, Christopher, Dincarslan, Oslem, Doce Carracedo, Alejandra, Dunn, Chris, Dyer, Philip, Elliott, Angela, Evans, Anthony, Finch, Lorna, Fisher, Lewis W.S., Flaherty, Lisa, Foster, Terry, Garcia-Dorival, Isabel, Gunning, Philip, Hartley, Catherine, Holmes, Anthony, Jensen, Rebecca L., Jones, Christopher B., Jones, Trevor R., Khandaker, Shadia, King, Katharine, Kiy, Robyn T., Koukorava, Chrysa, Lake, Annette, Lant, Suzannah, Latawiec, Diane, Lavelle-Langham, Lara, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A, Mancini, Maria, Massey, Hannah, Maziere, Nicole, McDonald, Sarah, McEvoy, Laurence, McLauchlan, John, Metelmann, Soeren, Miah, Nahida S., Middleton, Joanna, Mitchell, Joyce, Murphy, Ellen G, Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P. Matthew, Sales, Debby, Shaw, Victoria E., Shears, Rebecca K., Small, Benjamin, Subramaniam, Krishanthi S., Szemiel, Agnieska, Taggart, Aislynn, Tanianis-Hughes, Jolanta, Thomas, Jordan, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Zhang, J. Eunice, Keating, Seán, Donegan, Cara, Spencer, Rebecca G., Donohue, Chloe, Griffiths, Fiona, Hardwick, Hayley, Oosthuyzen, Wilna, Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A-M., Guillen Guio, B., Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., H Henson, H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., Kaprowska, s., Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., Man, W.D.-C., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., drury, H.J.C., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O'Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Piper Hanley, K., Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., Weir McCall, J., Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Wrey Brown, C., Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., Liew, Felicity, Talwar, Shubha, Cross, Andy, Willett, Brian J., Scott, Sam, Logan, Nicola, Siggins, Matthew K., Swieboda, Dawid, Sidhu, Jasmin K., Efstathiou, Claudia, Davis, Chris, Mohamed, Noura, Nunag, Jose, King, Clara, Rowland-Jones, Sarah L., Chalmers, James D., Ho, Ling-Pei, Horsley, Alexander, Raman, Betty, Poinasamy, Krisnah, Marks, Michael, Kon, Onn Min, Howard, Luke, Wootton, Daniel G., Dunachie, Susanna, Quint, Jennifer K., Evans, Rachael A., Wain, Louise V., Fontanella, Sara, de Silva, Thushan I., Ho, Antonia, Harrison, Ewen, Brightling, Christopher, and Turtle, Lance

Published
2023
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10. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Author

Willett, Brian J., Grove, Joe, MacLean, Oscar A., Wilkie, Craig, De Lorenzo, Giuditta, Furnon, Wilhelm, Cantoni, Diego, Scott, Sam, Logan, Nicola, Ashraf, Shirin, Manali, Maria, Szemiel, Agnieszka, Cowton, Vanessa, Vink, Elen, Harvey, William T., Davis, Chris, Asamaphan, Patawee, Smollett, Katherine, Tong, Lily, Orton, Richard, Hughes, Joseph, Holland, Poppy, Silva, Vanessa, Pascall, David J., Puxty, Kathryn, da Silva Filipe, Ana, Yebra, Gonzalo, Shaaban, Sharif, Holden, Matthew T. G., Pinto, Rute Maria, Gunson, Rory, Templeton, Kate, Murcia, Pablo R., Patel, Arvind H., Klenerman, Paul, Dunachie, Susanna, Haughney, John, Robertson, David L., Palmarini, Massimo, Ray, Surajit, and Thomson, Emma C.

Published
2022
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11. Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania

Author

Thomas, Kate M., Kibona, Tito, Claxton, John R., de Glanville, William A., Lankester, Felix, Amani, Nelson, Buza, Joram J., Carter, Ryan W., Chapman, Gail E., Crump, John A., Dagleish, Mark P., Halliday, Jo E. B., Hamilton, Clare M., Innes, Elisabeth A., Katzer, Frank, Livingstone, Morag, Longbottom, David, Millins, Caroline, Mmbaga, Blandina T., Mosha, Victor, Nyarobi, James, Nyasebwa, Obed M., Russell, George C., Sanka, Paul N., Semango, George, Wheelhouse, Nick, Willett, Brian J., Cleaveland, Sarah, and Allan, Kathryn J.

Published
2022
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12. Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Author

Dowell, Alexander C., Butler, Megan S., Jinks, Elizabeth, Tut, Gokhan, Lancaster, Tara, Sylla, Panagiota, Begum, Jusnara, Bruton, Rachel, Pearce, Hayden, Verma, Kriti, Logan, Nicola, Tyson, Grace, Spalkova, Eliska, Margielewska-Davies, Sandra, Taylor, Graham S., Syrimi, Eleni, Baawuah, Frances, Beckmann, Joanne, Okike, Ifeanyichukwu O., Ahmad, Shazaad, Garstang, Joanna, Brent, Andrew J., Brent, Bernadette, Ireland, Georgina, Aiano, Felicity, Amin-Chowdhury, Zahin, Jones, Samuel, Borrow, Ray, Linley, Ezra, Wright, John, Azad, Rafaq, Waiblinger, Dagmar, Davis, Chris, Thomson, Emma C., Palmarini, Massimo, Willett, Brian J., Barclay, Wendy S., Poh, John, Amirthalingam, Gayatri, Brown, Kevin E., Ramsay, Mary E., Zuo, Jianmin, Moss, Paul, and Ladhani, Shamez

Published
2022
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13. Distemper, extinction, and vaccination of the Amur tiger

Author

Gilbert, Martin, Sulikhan, Nadezhda, Uphyrkina, Olga, Goncharuk, Mikhail, Kerley, Linda, Castro, Enrique Hernandez, Reeve, Richard, Seimon, Tracie, McAloose, Denise, Seryodkin, Ivan V., Naidenko, Sergey V., Davis, Christopher A., Wilkie, Gavin S., Vattipally, Sreenu B., Adamson, Walt E., Hinds, Chris, Thomson, Emma C., Willett, Brian J., Hosie, Margaret J., Logan, Nicola, McDonald, Michael, Ossiboff, Robert J., Shevtsova, Elena I., Belyakin, Stepan, Yurlova, Anna A., Osofsky, Steven A., Miquelle, Dale G., Matthews, Louise, and Cleaveland, Sarah

Published
2020

14. Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Author

Willett, Brian J., Grove, Joe, MacLean, Oscar A., Wilkie, Craig, De Lorenzo, Giuditta, Furnon, Wilhelm, Cantoni, Diego, Scott, Sam, Logan, Nicola, Ashraf, Shirin, Manali, Maria, Szemiel, Agnieszka, Cowton, Vanessa, Vink, Elen, Harvey, William T., Davis, Chris, Asamaphan, Patawee, Smollett, Katherine, Tong, Lily, Orton, Richard, Hughes, Joseph, Holland, Poppy, Silva, Vanessa, Pascall, David J., Puxty, Kathryn, da Silva Filipe, Ana, Yebra, Gonzalo, Shaaban, Sharif, Holden, Matthew T. G., Pinto, Rute Maria, Gunson, Rory, Templeton, Kate, Murcia, Pablo R., Patel, Arvind H., Klenerman, Paul, Dunachie, Susanna, Haughney, John, Robertson, David L., Palmarini, Massimo, Ray, Surajit, and Thomson, Emma C.

Published
2022
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16. Omicron BA.2.86 cross-neutralising activity in community sera from the UK

Author

Willett, Brian J, primary, Logan, Nicola, additional, Scott, Sam, additional, Davis, Chris, additional, McSorley, Therese, additional, Asamaphan, Patawee, additional, Hosie, Margaret J, additional, Olmo, Paula, additional, Grove, Joe, additional, Orton, Richard, additional, Ho, Antonia, additional, Haughney, John, additional, Robertson, David L, additional, and Thomson, Emma C, additional

Published
2023
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18. SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports

Author

Jones, Sarah, primary, Tyson, Grace B., additional, Orton, Richard J., additional, Smollett, Katherine, additional, Manna, Federica, additional, Kwok, Kirsty, additional, Suárez, Nicolás M., additional, Logan, Nicola, additional, McDonald, Michael, additional, Bowie, Andrea, additional, Filipe, Ana Da Silva, additional, Willett, Brian J., additional, Weir, William, additional, and Hosie, Margaret J., additional

Published
2023
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19. Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants

Author

Tyson, Grace B., primary, Jones, Sarah, additional, Montreuil-Spencer, Chloe, additional, Logan, Nicola, additional, Scott, Sam, additional, Sasvari, Hagar, additional, McDonald, Michael, additional, Marshall, Leigh, additional, Murcia, Pablo R., additional, Willett, Brian J., additional, Weir, William, additional, and Hosie, Margaret J., additional

Published
2023
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20. Emerging viruses are an underestimated cause of undiagnosed febrile illness in Uganda

Author

Ashraf, Shirin, primary, Jerome, Hanna, additional, Bugembe, Daniel Lule, additional, Ssemwanga, Deogratius, additional, Byaruhanga, Timothy, additional, Kayiwa, John Timothy, additional, Downing, Robert, additional, Salazar-Gonzalez, Jesus F., additional, Salazar, Maria G., additional, Shepherd, James G., additional, Davis, Chris, additional, Logan, Nicola, additional, Vattipally, Sreenu B., additional, Wilkie, Gavin S., additional, da Silva Filipe, Ana, additional, Ssekagiri, Alfred, additional, Namuwulya, Prossy, additional, Bukenya, Henry, additional, Kigozi, Brian K., additional, McConnell, Weronika Witkowska, additional, Willett, Brian J., additional, Balinandi, Stephen, additional, Lutwama, Julius, additional, Kaleebu, Pontiano, additional, Bwogi, Josephine, additional, and Thomson, Emma C., additional

Published
2023
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21. The evaluation of five serological assays in determining seroconversion to peste des petits ruminants virus in typical and atypical hosts

Author

Tully, Matthew, Batten, Carrie, Ashby, Martin, Mahapatra, Mana, Parekh, Krupali, Parida, Satya, Njeumi, Felix, Willett, Brian J., Bataille, Arnaud, Libeau, Geneviève, Kwiatek, Olivier, Caron, Alexandre, Berguido, Francisco, Lamien, Charles Euloge, Cattoli, Giovanni, Misinzo, Gerald, Keyyu, Julius, Mdetele, Daniel, Gakuya, Francis, Bodjo, Sanne Charles, Taha, Fatima Abdelazeem, Elbashier, Husna Mohamed, Khalafalla, Abdelmelik Ibrahim, Osman, Abdinasir Y., Kock, Richard, Tully, Matthew, Batten, Carrie, Ashby, Martin, Mahapatra, Mana, Parekh, Krupali, Parida, Satya, Njeumi, Felix, Willett, Brian J., Bataille, Arnaud, Libeau, Geneviève, Kwiatek, Olivier, Caron, Alexandre, Berguido, Francisco, Lamien, Charles Euloge, Cattoli, Giovanni, Misinzo, Gerald, Keyyu, Julius, Mdetele, Daniel, Gakuya, Francis, Bodjo, Sanne Charles, Taha, Fatima Abdelazeem, Elbashier, Husna Mohamed, Khalafalla, Abdelmelik Ibrahim, Osman, Abdinasir Y., and Kock, Richard

Abstract

Peste des petits ruminants (PPR) is an infectious viral disease, primarily of small ruminants such as sheep and goats, but is also known to infect a wide range of wild and domestic Artiodactyls including African buffalo, gazelle, saiga and camels. The livestock-wildlife interface, where free-ranging animals can interact with captive flocks, is the subject of scrutiny as its role in the maintenance and spread of PPR virus (PPRV) is poorly understood. As seroconversion to PPRV indicates previous infection and/or vaccination, the availability of validated serological tools for use in both typical (sheep and goat) and atypical species is essential to support future disease surveillance and control strategies. The virus neutralisation test (VNT) and enzyme-linked immunosorbent assay (ELISA) have been validated using sera from typical host species. Still, the performance of these assays in detecting antibodies from atypical species remains unclear. We examined a large panel of sera (n = 793) from a range of species from multiple countries (sourced 2015–2022) using three tests: VNT, ID VET N-ELISA and AU-PANVAC H-ELISA. A sub-panel (n = 30) was also distributed to two laboratories and tested using the luciferase immunoprecipitation system (LIPS) and a pseudotyped virus neutralisation assay (PVNA). We demonstrate a 75.0–88.0% agreement of positive results for detecting PPRV antibodies in sera from typical species between the VNT and commercial ELISAs, however this decreased to 44.4–62.3% in sera from atypical species, with an inter-species variation. The LIPS and PVNA strongly correlate with the VNT and ELISAs for typical species but vary when testing sera from atypical species.

Published
2023

24. SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

Author

Cox, MacGregor, Peacock, Thomas P, Harvey, William T, Hughes, Joseph, Wright, Derek W, COVID-19 Genomics UK (COG-UK) Consortium, Willett, Brian J, Thomson, Emma, Gupta, Ravindra K, Peacock, Sharon J, Robertson, David L, Carabelli, Alessandro M, Cox, MacGregor [0000-0002-7408-4636], Harvey, William T [0000-0001-9529-1127], Hughes, Joseph [0000-0003-2556-2563], Wright, Derek W [0000-0003-0411-4497], Willett, Brian J [0000-0001-8912-3266], Thomson, Emma [0000-0003-1482-0889], Peacock, Sharon J [0000-0002-1718-2782], Robertson, David L [0000-0001-6338-0221], Carabelli, Alessandro M [0000-0003-3625-4021], and Apollo - University of Cambridge Repository

Subjects
Epitopes, Infectious Diseases, General Immunology and Microbiology, Amino Acid Substitution, SARS-CoV-2, Humans, Antibodies, Monoclonal, COVID-19, Antibodies, Viral, Microbiology, Antibodies, Neutralizing
Abstract

Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19 and are especially important in high-risk individuals where vaccination is not an option. Given the importance of understanding the evolution of resistance to mAbs by SARS-CoV-2, we reviewed the available in vitro neutralization data for mAbs against live variants and viral constructs containing spike mutations of interest. Unfortunately, evasion of mAb-induced protection is being reported with new SARS-CoV-2 variants. The magnitude of neutralization reduction varied greatly among mAb-variant pairs. For example, sotrovimab retained its neutralization capacity against Omicron BA.1 but showed reduced efficacy against BA.2, BA.4 and BA.5, and BA.2.12.1. At present, only bebtelovimab has been reported to retain its efficacy against all SARS-CoV-2 variants considered here. Resistance to mAb neutralization was dominated by the action of epitope single amino acid substitutions in the spike protein. Although not all observed epitope mutations result in increased mAb evasion, amino acid substitutions at non-epitope positions and combinations of mutations also contribute to evasion of neutralization. This Review highlights the implications for the rational design of viral genomic surveillance and factors to consider for the development of novel mAb therapies.

Published
2022
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25. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Author

Liew, Felicity, primary, Talwar, Shubha, additional, Cross, Andy, additional, Willett, Brian J., additional, Scott, Sam, additional, Logan, Nicola, additional, Siggins, Matthew K., additional, Swieboda, Dawid, additional, Sidhu, Jasmin K., additional, Efstathiou, Claudia, additional, Moore, Shona C., additional, Davis, Chris, additional, Mohamed, Noura, additional, Nunag, Jose, additional, King, Clara, additional, Thompson, A.A. Roger, additional, Rowland-Jones, Sarah L., additional, Docherty, Annemarie B., additional, Chalmers, James D., additional, Ho, Ling-Pei, additional, Horsley, Alexander, additional, Raman, Betty, additional, Poinasamy, Krisnah, additional, Marks, Michael, additional, Kon, Onn Min, additional, Howard, Luke, additional, Wootton, Daniel G., additional, Dunachie, Susanna, additional, Quint, Jennifer K., additional, Evans, Rachael A., additional, Wain, Louise V., additional, Fontanella, Sara, additional, de Silva, Thushan I., additional, Ho, Antonia, additional, Harrison, Ewen, additional, Baillie, J. Kenneth, additional, Semple, Malcolm G., additional, Brightling, Christopher, additional, Thwaites, Ryan S., additional, Turtle, Lance, additional, Openshaw, Peter J.M., additional, Alex, Beatrice, additional, Andrikopoulos, Petros, additional, Bach, Benjamin, additional, Barclay, Wendy S., additional, Bogaert, Debby, additional, Chand, Meera, additional, Chechi, Kanta, additional, Cooke, Graham S., additional, da Silva Filipe, Ana, additional, de Silva, Thushan, additional, dos Santos Correia, Gonçalo, additional, Dumas, Marc-Emmanuel, additional, Dunning, Jake, additional, Fletcher, Tom, additional, Green, Christopher A., additional, Greenhalf, William, additional, Griffin, Julian, additional, Gupta, Rishi K., additional, Harrison, Ewen M., additional, Ho, Antonia Y.W., additional, Holden, Karl, additional, Horby, Peter W., additional, Ijaz, Samreen, additional, Khoo, Say, additional, Klenerman, Paul, additional, Law, Andrew, additional, Lewis, Matthew, additional, Liggi, Sonia, additional, Lim, Wei Shen, additional, Maslen, Lynn, additional, Mentzer, Alexander J., additional, Merson, Laura, additional, Meynert, Alison M, additional, Noursadeghi, Mahdad, additional, Olanipekun, Michael, additional, Osagie, Anthonia, additional, Palmarini, Massimo, additional, Palmieri, Carlo, additional, Paxton, William A., additional, Pollakis, Georgios, additional, Price, Nicholas, additional, Rambaut, Andrew, additional, Robertson, David L, additional, Russell, Clark D., additional, Sancho-Shimizu, Vanessa, additional, Sands, Caroline, additional, Scott, Janet T., additional, Sigfrid, Louise, additional, Solomon, Tom, additional, Sriskandan, Shiranee, additional, Stuart, David, additional, Summers, Charlotte, additional, Swann, Olivia V., additional, Takats, Zoltan, additional, Takis, Panteleimon, additional, Tedder, Richard S., additional, Thomson, Emma C., additional, Turtle, Lance C.W., additional, Zambon, Maria, additional, Drake, Thomas M., additional, Fairfield, Cameron J., additional, Knight, Stephen R., additional, Mclean, Kenneth A., additional, Murphy, Derek, additional, Norman, Lisa, additional, Pius, Riinu, additional, Shaw, Catherine A., additional, Connor, Marie, additional, Dalton, Jo, additional, Gamble, Carrol, additional, Girvan, Michelle, additional, Halpin, Sophie, additional, Harrison, Janet, additional, Jackson, Clare, additional, Lee, James, additional, Marsh, Laura, additional, Plotkin, Daniel, additional, Roberts, Stephanie, additional, Saviciute, Egle, additional, Clohisey, Sara, additional, Hendry, Ross, additional, Knight, Susan, additional, Lahnsteiner, Eva, additional, Leeming, Gary, additional, Norris, Lucy, additional, Scott-Brown, James, additional, Tait, Sarah, additional, Wham, Murray, additional, Clark, Richard, additional, Coutts, Audrey, additional, Donelly, Lorna, additional, Fawkes, Angie, additional, Gilchrist, Tammy, additional, Hafezi, Katarzyna, additional, MacGillivray, Louise, additional, Maclean, Alan, additional, McCafferty, Sarah, additional, Morrice, Kirstie, additional, Murphy, Lee, additional, Wrobel, Nicola, additional, Carson, Gail, additional, Adeniji, Kayode, additional, Agranoff, Daniel, additional, Agwuh, Ken, additional, Ail, Dhiraj, additional, Aldera, Erin L., additional, Alegria, Ana, additional, Allen, Sam, additional, Angus, Brian, additional, Ashish, Abdul, additional, Atkinson, Dougal, additional, Bari, Shahedal, additional, Barlow, Gavin, additional, Barnass, Stella, additional, Barrett, Nicholas, additional, Bassford, Christopher, additional, Basude, Sneha, additional, Baxter, David, additional, Beadsworth, Michael, additional, Bernatoniene, Jolanta, additional, Berridge, John, additional, Berry, Colin, additional, Best, Nicola, additional, Bothma, Pieter, additional, Brittain-Long, Robin, additional, Bulteel, Naomi, additional, Burden, Tom, additional, Burtenshaw, Andrew, additional, Caruth, Vikki, additional, Chadwick, David, additional, Chambler, Duncan, additional, Chee, Nigel, additional, Child, Jenny, additional, Chukkambotla, Srikanth, additional, Clark, Tom, additional, Collini, Paul, additional, Cosgrove, Catherine, additional, Cupitt, Jason, additional, Cutino-Moguel, Maria-Teresa, additional, Dark, Paul, additional, Dawson, Chris, additional, Dervisevic, Samir, additional, Donnison, Phil, additional, Douthwaite, Sam, additional, Drummond, Andrew, additional, DuRand, Ingrid, additional, Dushianthan, Ahilanadan, additional, Dyer, Tristan, additional, Evans, Cariad, additional, Eziefula, Chi, additional, Fegan, Chrisopher, additional, Finn, Adam, additional, Fullerton, Duncan, additional, Garg, Sanjeev, additional, Garg, Atul, additional, Gkrania-Klotsas, Effrossyni, additional, Godden, Jo, additional, Goldsmith, Arthur, additional, Graham, Clive, additional, Grammatikopoulos, Tassos, additional, Hardy, Elaine, additional, Hartshorn, Stuart, additional, Harvey, Daniel, additional, Havalda, Peter, additional, Hawcutt, Daniel B., additional, Hobrok, Maria, additional, Hodgson, Luke, additional, Hormis, Anil, additional, Howard, Joanne, additional, Jacobs, Michael, additional, Jain, Susan, additional, Jennings, Paul, additional, Kaliappan, Agilan, additional, Kasipandian, Vidya, additional, Kegg, Stephen, additional, Kelsey, Michael, additional, Kendall, Jason, additional, Kerrison, Caroline, additional, Kerslake, Ian, additional, Koch, Oliver, additional, Koduri, Gouri, additional, Koshy, George, additional, Laha, Shondipon, additional, Laird, Steven, additional, Larkin, Susan, additional, Leiner, Tamas, additional, Lillie, Patrick, additional, Limb, James, additional, Linnett, Vanessa, additional, Little, Jeff, additional, Lyttle, Mark, additional, MacMahon, Michael, additional, MacNaughton, Emily, additional, Mankregod, Ravish, additional, Masson, Huw, additional, Matovu, Elijah, additional, McCullough, Katherine, additional, McEwen, Ruth, additional, Meda, Manjula, additional, Mills, Gary, additional, Minton, Jane, additional, Mohandas, Kavya, additional, Mok, Quen, additional, Moon, James, additional, Moore, Elinoor, additional, Morgan, Patrick, additional, Morris, Craig, additional, Mortimore, Katherine, additional, Moses, Samuel, additional, Mpenge, Mbiye, additional, Mulla, Rohinton, additional, Murphy, Michael, additional, Nagarajan, Thapas, additional, Nagel, Megan, additional, Nelson, Mark, additional, Norris, Lillian, additional, O'Shea, Matthew K., additional, Ostermann, Marlies, additional, Otahal, Igor, additional, Pais, Mark, additional, Panchatsharam, Selva, additional, Papakonstantinou, Danai, additional, Papineni, Padmasayee, additional, Paraiso, Hassan, additional, Patel, Brij, additional, Pattison, Natalie, additional, Pepperell, Justin, additional, Peters, Mark, additional, Phull, Mandeep, additional, Pintus, Stefania, additional, Planche, Tim, additional, Post, Frank, additional, Price, David, additional, Prout, Rachel, additional, Rae, Nikolas, additional, Reschreiter, Henrik, additional, Reynolds, Tim, additional, Richardson, Neil, additional, Roberts, Mark, additional, Roberts, Devender, additional, Rose, Alistair, additional, Rousseau, Guy, additional, Ruge, Bobby, additional, Ryan, Brendan, additional, Saluja, Taranprit, additional, Sarah, Sarah, additional, Schmid, Matthias, additional, Shah, Aarti, additional, Shankar-Hari, Manu, additional, Shanmuga, Prad, additional, Sharma, Anil, additional, Shawcross, Anna, additional, Singh Pooni, Jagtur, additional, Sizer, Jeremy, additional, Smith, Richard, additional, Snelson, Catherine, additional, Spittle, Nick, additional, Staines, Nikki, additional, Stambach, Tom, additional, Stewart, Richard, additional, Subudhi, Pradeep, additional, Szakmany, Tamas, additional, Tatham, Kate, additional, Thomas, Jo, additional, Thompson, Chris, additional, Thompson, Robert, additional, Tridente, Ascanio, additional, Tupper-Carey, Darell, additional, Twagira, Mary, additional, Vallotton, Nick, additional, Vancheeswaran, Rama, additional, Vincent, Rachel, additional, Vincent-Smith, Lisa, additional, Visuvanathan, Shico, additional, Vuylsteke, Alan, additional, Waddy, Sam, additional, Wake, Rachel, additional, Walden, Andrew, additional, Welters, Ingeborg, additional, Whitehouse, Tony, additional, Whittaker, Paul, additional, Whittington, Ashley, additional, Wijesinghe, Meme, additional, Williams, Martin, additional, Wilson, Lawrence, additional, Winchester, Stephen, additional, Wiselka, Martin, additional, Wolverson, Adam, additional, Wootton, Daniel G, additional, Workman, Andrew, additional, Yates, Bryan, additional, Young, Peter, additional, McDonald, Sarah E., additional, Shaw, Victoria, additional, Ahmed, Katie A., additional, Armstrong, Jane A., additional, Ashworth, Milton, additional, Asiimwe, Innocent G., additional, Bakshi, Siddharth, additional, Barlow, Samantha L, additional, Booth, Laura, additional, Brennan, Benjamin, additional, Bullock, Katie, additional, Carlucci, Nicola, additional, Cass, Emily, additional, Catterall, Benjamin W.A., additional, Clark, Jordan J., additional, Clarke, Emily A., additional, Cole, Sarah, additional, Cooper, Louise, additional, Cox, Helen, additional, Davis, Christopher, additional, Dincarslan, Oslem, additional, Doce Carracedo, Alejandra, additional, Dunn, Chris, additional, Dyer, Philip, additional, Elliott, Angela, additional, Evans, Anthony, additional, Finch, Lorna, additional, Fisher, Lewis W.S., additional, Flaherty, Lisa, additional, Foster, Terry, additional, Garcia-Dorival, Isabel, additional, Gunning, Philip, additional, Hartley, Catherine, additional, Holmes, Anthony, additional, Jensen, Rebecca L., additional, Jones, Christopher B., additional, Jones, Trevor R., additional, Khandaker, Shadia, additional, King, Katharine, additional, Kiy, Robyn T., additional, Koukorava, Chrysa, additional, Lake, Annette, additional, Lant, Suzannah, additional, Latawiec, Diane, additional, Lavelle-Langham, Lara, additional, Lefteri, Daniella, additional, Lett, Lauren, additional, Livoti, Lucia A, additional, Mancini, Maria, additional, Massey, Hannah, additional, Maziere, Nicole, additional, McDonald, Sarah, additional, McEvoy, Laurence, additional, McLauchlan, John, additional, Metelmann, Soeren, additional, Miah, Nahida S., additional, Middleton, Joanna, additional, Mitchell, Joyce, additional, Murphy, Ellen G, additional, Penrice-Randal, Rebekah, additional, Pilgrim, Jack, additional, Prince, Tessa, additional, Reynolds, Will, additional, Ridley, P. Matthew, additional, Sales, Debby, additional, Shaw, Victoria E., additional, Shears, Rebecca K., additional, Small, Benjamin, additional, Subramaniam, Krishanthi S., additional, Szemiel, Agnieska, additional, Taggart, Aislynn, additional, Tanianis-Hughes, Jolanta, additional, Thomas, Jordan, additional, Trochu, Erwan, additional, van Tonder, Libby, additional, Wilcock, Eve, additional, Zhang, J. Eunice, additional, Keating, Seán, additional, Donegan, Cara, additional, Spencer, Rebecca G., additional, Donohue, Chloe, additional, Griffiths, Fiona, additional, Hardwick, Hayley, additional, Oosthuyzen, Wilna, additional, Abel, K., additional, Adamali, H., additional, Adeloye, D., additional, Adeyemi, O., additional, Adrego, R., additional, Aguilar Jimenez, L.A., additional, Ahmad, S., additional, Ahmad Haider, N., additional, Ahmed, R., additional, Ahwireng, N., additional, Ainsworth, M., additional, Al-Sheklly, B., additional, Alamoudi, A., additional, Ali, M., additional, Aljaroof, M., additional, All, A.M., additional, Allan, L., additional, Allen, R.J., additional, Allerton, L., additional, Allsop, L., additional, Almeida, P., additional, Altmann, D., additional, Alvarez Corral, M., additional, Amoils, S., additional, Anderson, D., additional, Antoniades, C., additional, Arbane, G., additional, Arias, A., additional, Armour, C., additional, Armstrong, L., additional, Armstrong, N., additional, Arnold, D., additional, Arnold, H., additional, Ashish, A., additional, Ashworth, A., additional, Ashworth, M., additional, Aslani, S., additional, Assefa-Kebede, H., additional, Atkin, C., additional, Atkin, P., additional, Aul, R., additional, Aung, H., additional, Austin, L., additional, Avram, C., additional, Ayoub, A., additional, Babores, M., additional, Baggott, R., additional, Bagshaw, J., additional, Baguley, D., additional, Bailey, L., additional, Baillie, J.K., additional, Bain, S., additional, Bakali, M., additional, Bakau, M., additional, Baldry, E., additional, Baldwin, D., additional, Baldwin, M., additional, Ballard, C., additional, Banerjee, A., additional, Bang, B., additional, Barker, R.E., additional, Barman, L., additional, Barratt, S., additional, Barrett, F., additional, Basire, D., additional, Basu, N., additional, Bates, M., additional, Bates, A., additional, Batterham, R., additional, Baxendale, H., additional, Bayes, H., additional, 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additional, Brown, J., additional, Brown, J.S., additional, Brown, M., additional, Brown, V., additional, Brugha, T., additional, Brunskill, N., additional, Buch, M., additional, Buckley, P., additional, Bularga, A., additional, Bullmore, E., additional, Burden, L., additional, Burdett, T., additional, Burn, D., additional, Burns, G., additional, Burns, A., additional, Busby, J., additional, Butcher, R., additional, Butt, A., additional, Byrne, S., additional, Cairns, P., additional, Calder, P.C., additional, Calvelo, E., additional, Carborn, H., additional, Card, B., additional, Carr, C., additional, Carr, L., additional, Carson, G., additional, Carter, P., additional, Casey, A., additional, Cassar, M., additional, Cavanagh, J., additional, Chablani, M., additional, Chalder, T., additional, Chalmers, J.D., additional, Chambers, R.C., additional, Chan, F., additional, Channon, K.M., additional, Chapman, K., additional, Charalambou, A., additional, Chaudhuri, N., additional, Checkley, A., additional, Chen, J., additional, Cheng, Y., additional, Chetham, L., additional, Childs, C., additional, Chilvers, E.R., additional, Chinoy, H., additional, Chiribiri, A., additional, Chong-James, K., additional, Choudhury, G., additional, Choudhury, N., additional, Chowienczyk, P., additional, Christie, C., additional, Chrystal, M., additional, Clark, D., additional, Clark, C., additional, Clarke, J., additional, Clohisey, S., additional, Coakley, G., additional, Coburn, Z., additional, Coetzee, S., additional, Cole, J., additional, Coleman, C., additional, Conneh, F., additional, Connell, D., additional, Connolly, B., additional, Connor, L., additional, Cook, A., additional, Cooper, B., additional, Cooper, J., additional, Cooper, S., additional, Copeland, D., additional, Cosier, T., additional, Coulding, M., additional, Coupland, C., additional, Cox, E., additional, Craig, T., additional, Crisp, P., additional, Cristiano, D., additional, Crooks, M.G., additional, Cross, A., additional, Cruz, I., additional, Cullinan, P., additional, Cuthbertson, D., additional, Daines, L., additional, Dalton, M., additional, Daly, P., additional, Daniels, A., additional, Dark, P., additional, Dasgin, J., additional, David, A., additional, David, C., additional, Davies, E., additional, Davies, F., additional, Davies, G., additional, Davies, G.A., additional, Davies, K., additional, Davies, M.J., additional, Dawson, J., additional, Daynes, E., additional, De Soyza, A., additional, Deakin, B., additional, Deans, A., additional, Deas, C., additional, Deery, J., additional, Defres, S., additional, Dell, A., additional, Dempsey, K., additional, Denneny, E., additional, Dennis, J., additional, Dewar, A., additional, Dharmagunawardena, R., additional, Diar-Bakerly, N., additional, Dickens, C., additional, Dipper, A., additional, Diver, S., additional, Diwanji, S.N., additional, Dixon, M., additional, Djukanovic, R., additional, Dobson, H., additional, Dobson, S.L., additional, Docherty, A.B., additional, Donaldson, A., additional, Dong, T., additional, Dormand, N., additional, Dougherty, A., additional, Dowling, R., additional, Drain, S., additional, Draxlbauer, K., additional, Drury, K., additional, Dulawan, P., additional, Dunleavy, A., additional, Dunn, S., additional, Dupont, C., additional, Earley, J., additional, Easom, N., additional, Echevarria, C., additional, Edwards, S., additional, Edwardson, C., additional, El-Taweel, H., additional, Elliott, A., additional, Elliott, K., additional, Ellis, Y., additional, Elmer, A., additional, Elneima, O., additional, Evans, D., additional, Evans, H., additional, Evans, J., additional, Evans, R., additional, Evans, R.A., additional, Evans, R.I., additional, Evans, T., additional, Evenden, C., additional, Evison, L., additional, Fabbri, L., additional, Fairbairn, S., additional, Fairman, A., additional, Fallon, K., additional, Faluyi, D., additional, Favager, C., additional, Fayzan, T., additional, Featherstone, J., additional, Felton, T., additional, Finch, J., additional, Finney, S., additional, Finnigan, J., additional, Finnigan, L., additional, Fisher, H., additional, Fletcher, S., additional, Flockton, R., additional, Flynn, M., additional, Foot, H., additional, Foote, D., additional, Ford, A., additional, Forton, D., additional, Fraile, E., additional, Francis, C., additional, Francis, R., additional, Francis, S., additional, Frankel, A., additional, Fraser, E., additional, Free, R., additional, French, N., additional, Fu, X., additional, Fuld, J., additional, Furniss, J., additional, Garner, L., additional, Gautam, N., additional, Geddes, J.R., additional, George, J., additional, George, P., additional, Gibbons, M., additional, Gill, M., additional, Gilmour, L., additional, Gleeson, F., additional, Glossop, J., additional, Glover, S., additional, Goodman, N., additional, Goodwin, C., additional, Gooptu, B., additional, Gordon, H., additional, Gorsuch, T., additional, Greatorex, M., additional, Greenhaff, P.L., additional, Greenhalf, W., additional, Greenhalgh, A., additional, Greening, N.J., additional, Greenwood, J., additional, Gregory, H., additional, Gregory, R., additional, Grieve, D., additional, Griffin, D., additional, Griffiths, L., additional, Guerdette, A-M., additional, Guillen Guio, B., additional, Gummadi, M., additional, Gupta, A., additional, Gurram, S., additional, Guthrie, E., additional, Guy, Z., additional, H Henson, H., additional, Hadley, K., additional, Haggar, A., additional, Hainey, K., additional, Hairsine, B., additional, Haldar, P., additional, Hall, I., additional, Hall, L., additional, Halling-Brown, M., additional, Hamil, R., additional, Hancock, A., additional, Hancock, K., additional, Hanley, N.A., additional, Haq, S., additional, Hardwick, H.E., additional, Hardy, E., additional, Hardy, T., additional, Hargadon, B., additional, Harrington, K., additional, Harris, E., additional, Harris, V.C., additional, Harrison, E.M., additional, Harrison, P., additional, Hart, N., additional, Harvey, A., additional, Harvey, M., additional, Harvie, M., additional, Haslam, L., additional, Havinden-Williams, M., additional, Hawkes, J., additional, Hawkings, N., additional, Haworth, J., additional, Hayday, A., additional, Haynes, M., additional, Hazeldine, J., additional, Hazelton, T., additional, Heaney, L.G., additional, Heeley, C., additional, Heeney, J.L., additional, Heightman, M., additional, Heller, S., additional, Henderson, M., additional, Hesselden, L., additional, Hewitt, M., additional, Highett, V., additional, Hillman, T., additional, Hiwot, T., additional, Ho, L.P., additional, Hoare, A., additional, Hoare, M., additional, Hockridge, J., additional, Hogarth, P., additional, Holbourn, A., additional, Holden, S., additional, Holdsworth, L., additional, Holgate, D., additional, Holland, M., additional, Holloway, L., additional, Holmes, K., additional, Holmes, M., additional, Holroyd-Hind, B., additional, Holt, L., additional, Hormis, A., additional, Horsley, A., additional, Hosseini, A., additional, Hotopf, M., additional, Houchen-Wolloff, L., additional, Howard, K., additional, Howard, L.S., additional, Howell, A., additional, Hufton, E., additional, Hughes, A.D., additional, Hughes, J., additional, Hughes, R., additional, Humphries, A., additional, Huneke, N., additional, Hurditch, E., additional, Hurst, J., additional, Husain, M., additional, Hussell, T., additional, Hutchinson, J., additional, Ibrahim, W., additional, Ilyas, F., additional, Ingham, J., additional, Ingram, L., additional, Ionita, D., additional, Isaacs, K., additional, Ismail, K., additional, Jackson, T., additional, Jacob, J., additional, James, W.Y., additional, Jang, W., additional, Jarman, C., additional, Jarrold, I., additional, Jarvis, H., additional, Jastrub, R., additional, Jayaraman, B., additional, Jenkins, R.G., additional, Jezzard, P., additional, Jiwa, K., additional, Johnson, C., additional, Johnson, S., additional, Johnston, D., additional, Jolley, C.J., additional, Jones, D., additional, Jones, G., additional, Jones, H., additional, Jones, I., additional, Jones, L., additional, Jones, M.G., additional, Jones, S., additional, Jose, S., additional, Kabir, T., additional, Kaltsakas, G., additional, Kamwa, V., additional, Kanellakis, N., additional, Kaprowska, s., additional, Kausar, Z., additional, Keenan, N., additional, Kelly, S., additional, Kemp, G., additional, Kerr, S., additional, Kerslake, H., additional, Key, A.L., additional, Khan, F., additional, Khunti, K., additional, Kilroy, S., additional, King, B., additional, King, C., additional, Kingham, L., additional, Kirk, J., additional, Kitterick, P., additional, Klenerman, P., additional, Knibbs, L., additional, Knight, S., additional, Knighton, A., additional, Kon, O., additional, Kon, S., additional, Kon, S.S., additional, Koprowska, S., additional, Korszun, A., additional, Koychev, I., additional, Kurasz, C., additional, Kurupati, P., additional, Laing, C., additional, Lamlum, H., additional, Landers, G., additional, Langenberg, C., additional, Lasserson, D., additional, Lavelle-Langham, L., additional, Lawrie, A., additional, Lawson, C., additional, Layton, A., additional, Lea, A., additional, Leavy, O.C., additional, Lee, D., additional, Lee, J-H., additional, Lee, E., additional, Leitch, K., additional, Lenagh, R., additional, Lewis, D., additional, Lewis, J., additional, Lewis, K.E., additional, Lewis, V., additional, Lewis-Burke, N., additional, Li, X., additional, Light, T., additional, Lightstone, L., additional, Lilaonitkul, W., additional, Lim, L., additional, Linford, S., additional, Lingford-Hughes, A., additional, Lipman, M., additional, Liyanage, K., additional, Lloyd, A., additional, Logan, S., additional, Lomas, D., additional, Lone, N.I., additional, Loosley, R., additional, Lord, J.M., additional, Lota, H., additional, Lovegrove, W., additional, Lucey, A., additional, Lukaschuk, E., additional, Lye, A., additional, Lynch, C., additional, MacDonald, S., additional, MacGowan, G., additional, Macharia, I., additional, Mackie, J., additional, Macliver, L., additional, Madathil, S., additional, Madzamba, G., additional, Magee, N., additional, Magtoto, M.M., additional, Mairs, N., additional, Majeed, N., additional, Major, E., additional, Malein, F., additional, Malim, M., additional, Mallison, G., additional, Man, W.D.-C., additional, Mandal, S., additional, Mangion, K., additional, Manisty, C., additional, Manley, R., additional, March, K., additional, Marciniak, S., additional, Marino, P., additional, Mariveles, M., additional, Marks, M., additional, Marouzet, E., additional, Marsh, S., additional, Marshall, B., additional, Marshall, M., additional, Martin, J., additional, Martineau, A., additional, Martinez, L.M., additional, Maskell, N., additional, Matila, D., additional, Matimba-Mupaya, W., additional, Matthews, L., additional, Mbuyisa, A., additional, McAdoo, S., additional, McAllister-Williams, H., additional, McArdle, A., additional, McArdle, P., additional, McAulay, D., additional, McCann, G.P., additional, drury, H.J.C., additional, McCormick, J., additional, McCormick, W., additional, McCourt, P., additional, McGarvey, L., additional, McGee, C., additional, Mcgee, K., additional, McGinness, J., additional, McGlynn, K., additional, McGovern, A., additional, McGuinness, H., additional, McInnes, I.B., additional, McIntosh, J., additional, McIvor, E., additional, McIvor, K., additional, McLeavey, L., additional, McMahon, A., additional, McMahon, M.J., additional, McMorrow, L., additional, Mcnally, T., additional, McNarry, M., additional, McNeill, J., additional, McQueen, A., additional, McShane, H., additional, Mears, C., additional, Megson, C., additional, Megson, S., additional, Mehta, P., additional, Meiring, J., additional, Melling, L., additional, Mencias, M., additional, Menzies, D., additional, Merida Morillas, M., additional, Michael, A., additional, Miller, C., additional, Milligan, L., additional, Mills, C., additional, Mills, N.L., additional, Milner, L., additional, Misra, S., additional, Mitchell, J., additional, Mohamed, A., additional, Mohamed, N., additional, Mohammed, S., additional, Molyneaux, P.L., additional, Monteiro, W., additional, Moriera, S., additional, Morley, A., additional, Morrison, L., additional, Morriss, R., additional, Morrow, A., additional, Moss, A.J., additional, Moss, P., additional, Motohashi, K., additional, Msimanga, N., additional, Mukaetova-Ladinska, E., additional, Munawar, U., additional, Murira, J., additional, Nanda, U., additional, Nassa, H., additional, Nasseri, M., additional, Neal, A., additional, Needham, R., additional, Neill, P., additional, Neubauer, S., additional, Newby, D.E., additional, Newell, H., additional, Newman, T., additional, Newton-Cox, A., additional, Nicholson, T., additional, Nicoll, D., additional, Nikolaidis, A., additional, Nolan, C.M., additional, Noonan, M.J., additional, Norman, C., additional, Novotny, P., additional, Nunag, J., additional, Nwafor, L., additional, Nwanguma, U., additional, Nyaboko, J., additional, O'Brien, C., additional, O'Donnell, K., additional, O'Regan, D., additional, O'Brien, L., additional, Odell, N., additional, Ogg, G., additional, Olaosebikan, O., additional, Oliver, C., additional, Omar, Z., additional, Openshaw, P.J.M., additional, Orriss-Dib, L., additional, Osborne, L., additional, Osbourne, R., additional, Ostermann, M., additional, Overton, C., additional, Owen, J., additional, Oxton, J., additional, Pack, J., additional, Pacpaco, E., additional, Paddick, S., additional, Painter, S., additional, Pakzad, A., additional, Palmer, S., additional, Papineni, P., additional, Paques, K., additional, Paradowski, K., additional, Pareek, M., additional, Parekh, D., additional, Parfrey, H., additional, Pariante, C., additional, Parker, S., additional, Parkes, M., additional, Parmar, J., additional, Patale, S., additional, Patel, B., additional, Patel, M., additional, Patel, S., additional, Pattenadk, D., additional, Pavlides, M., additional, Payne, S., additional, Pearce, L., additional, Pearl, J.E., additional, Peckham, D., additional, Pendlebury, J., additional, Peng, Y., additional, Pennington, C., additional, Peralta, I., additional, Perkins, E., additional, Peterkin, Z., additional, Peto, T., additional, Petousi, N., additional, Petrie, J., additional, Pfeffer, P., additional, Phipps, J., additional, Pimm, J., additional, Piper Hanley, K., additional, Pius, R., additional, Plant, H., additional, Plein, S., additional, Plekhanova, T., additional, Plowright, M., additional, Poinasamy, K., additional, Polgar, O., additional, Poll, L., additional, Porter, J.C., additional, Porter, J., additional, Portukhay, S., additional, Powell, N., additional, Prabhu, A., additional, Pratt, J., additional, Price, A., additional, Price, C., additional, Price, D., additional, Price, L., additional, Prickett, A., additional, Propescu, J., additional, Prosper, S., additional, Pugmire, S., additional, Quaid, S., additional, Quigley, J., additional, Quint, J., additional, Qureshi, H., additional, Qureshi, I.N., additional, Radhakrishnan, K., additional, Rahman, N.M., additional, Ralser, M., additional, Raman, B., additional, Ramos, A., additional, Ramos, H., additional, Rangeley, J., additional, Rangelov, B., additional, Ratcliffe, L., additional, Ravencroft, P., additional, Reddington, A., additional, Reddy, R., additional, Redfearn, H., additional, Redwood, D., additional, Reed, A., additional, Rees, M., additional, Rees, T., additional, Regan, K., additional, Reynolds, W., additional, Ribeiro, C., additional, Richards, A., additional, Richardson, E., additional, Richardson, M., additional, Rivera-Ortega, P., additional, Roberts, K., additional, Robertson, E., additional, Robinson, E., additional, Robinson, L., additional, Roche, L., additional, Roddis, C., additional, Rodger, J., additional, Ross, A., additional, Ross, G., additional, Rossdale, J., additional, Rostron, A., additional, Rowe, A., additional, Rowland, A., additional, Rowland, J., additional, Rowland, M.J., additional, Rowland-Jones, S.L., additional, Roy, K., additional, Roy, M., additional, Rudan, I., additional, Russell, R., additional, Russell, E., additional, Saalmink, G., additional, Sabit, R., additional, Sage, E.K., additional, Samakomva, T., additional, Samani, N., additional, Sampson, C., additional, Samuel, K., additional, Samuel, R., additional, Sanderson, A., additional, Sapey, E., additional, Saralaya, D., additional, Sargant, J., additional, Sarginson, C., additional, Sass, T., additional, Sattar, N., additional, Saunders, K., additional, Saunders, R.M., additional, Saunders, P., additional, Saunders, L.C., additional, Savill, H., additional, Saxon, W., additional, Sayer, A., additional, Schronce, J., additional, Schwaeble, W., additional, Scott, J.T., additional, Scott, K., additional, Selby, N., additional, Semple, M.G., additional, Sereno, M., additional, Sewell, T.A., additional, Shah, A., additional, Shah, K., additional, Shah, P., additional, Shankar-Hari, M., additional, Sharma, M., additional, Sharpe, C., additional, Sharpe, M., additional, Shashaa, S., additional, Shaw, A., additional, Shaw, K., additional, Shaw, V., additional, Sheikh, A., additional, Shelton, S., additional, Shenton, L., additional, Shevket, K., additional, Shikotra, A., additional, Short, J., additional, Siddique, S., additional, Siddiqui, S., additional, Sidebottom, J., additional, Sigfrid, L., additional, Simons, G., additional, Simpson, J., additional, Simpson, N., additional, Singapuri, A., additional, Singh, C., additional, Singh, S., additional, Singh, S.J., additional, Sissons, D., additional, Skeemer, J., additional, Slack, K., additional, Smith, A., additional, Smith, D., additional, Smith, S., additional, Smith, J., additional, Smith, L., additional, Soares, M., additional, Solano, T.S., additional, Solly, R., additional, Solstice, A.R., additional, Soulsby, T., additional, Southern, D., additional, Sowter, D., additional, Spears, M., additional, Spencer, L.G., additional, Speranza, F., additional, Stadon, L., additional, Stanel, S., additional, Steele, N., additional, Steiner, M., additional, Stensel, D., additional, Stephens, G., additional, Stephenson, L., additional, Stern, M., additional, Stewart, I., additional, Stimpson, R., additional, Stockdale, S., additional, Stockley, J., additional, Stoker, W., additional, Stone, R., additional, Storrar, W., additional, Storrie, A., additional, Storton, K., additional, Stringer, E., additional, Strong-Sheldrake, S., additional, Stroud, N., additional, Subbe, C., additional, Sudlow, C.L., additional, Suleiman, Z., additional, Summers, C., additional, Summersgill, C., additional, Sutherland, D., additional, Sykes, D.L., additional, Sykes, R., additional, Talbot, N., additional, Tan, A.L., additional, Tarusan, L., additional, Tavoukjian, V., additional, Taylor, A., additional, Taylor, C., additional, Taylor, J., additional, Te, A., additional, Tedd, H., additional, Tee, C.J., additional, Teixeira, J., additional, Tench, H., additional, Terry, S., additional, Thackray-Nocera, S., additional, Thaivalappil, F., additional, Thamu, B., additional, Thickett, D., additional, Thomas, C., additional, Thomas, D.C., additional, Thomas, S., additional, Thomas, A.K., additional, Thomas-Woods, T., additional, Thompson, T., additional, Thompson, A.A.R., additional, Thornton, T., additional, Thorpe, M., additional, Thwaites, R.S., additional, Tilley, J., additional, Tinker, N., additional, Tiongson, G.F., additional, Tobin, M., additional, Tomlinson, J., additional, Tong, C., additional, Toshner, M., additional, Touyz, R., additional, Tripp, K.A., additional, Tunnicliffe, E., additional, Turnbull, A., additional, Turner, E., additional, Turner, S., additional, Turner, V., additional, Turner, K., additional, Turney, S., additional, Turtle, L., additional, Turton, H., additional, Ugoji, J., additional, Ugwuoke, R., additional, Upthegrove, R., additional, Valabhji, J., additional, Ventura, M., additional, Vere, J., additional, Vickers, C., additional, Vinson, B., additional, Wade, E., additional, Wade, P., additional, Wain, L.V., additional, Wainwright, T., additional, Wajero, L.O., additional, Walder, S., additional, Walker, S., additional, Wall, E., additional, Wallis, T., additional, Walmsley, S., additional, Walsh, J.A., additional, Walsh, S., additional, Warburton, L., additional, Ward, T.J.C., additional, Warwick, K., additional, Wassall, H., additional, Waterson, S., additional, Watson, E., additional, Watson, L., additional, Watson, J., additional, Weir McCall, J., additional, Welch, C., additional, Welch, H., additional, Welsh, B., additional, Wessely, S., additional, West, S., additional, Weston, H., additional, Wheeler, H., additional, White, S., additional, Whitehead, V., additional, Whitney, J., additional, Whittaker, S., additional, Whittam, B., additional, Whitworth, V., additional, Wight, A., additional, Wild, J., additional, Wilkins, M., additional, Wilkinson, D., additional, Williams, B., additional, Williams, N., additional, Williams, J., additional, Williams-Howard, S.A., additional, Willicombe, M., additional, Willis, G., additional, Willoughby, J., additional, Wilson, A., additional, Wilson, D., additional, Wilson, I., additional, Window, N., additional, Witham, M., additional, Wolf-Roberts, R., additional, Wood, C., additional, Woodhead, F., additional, Woods, J., additional, Wootton, D.G., additional, Wormleighton, J., additional, Worsley, J., additional, Wraith, D., additional, Wrey Brown, C., additional, Wright, C., additional, Wright, L., additional, Wright, S., additional, Wyles, J., additional, Wynter, I., additional, Xu, M., additional, Yasmin, N., additional, Yasmin, S., additional, Yates, T., additional, Yip, K.P., additional, Young, B., additional, Young, S., additional, Young, A., additional, Yousuf, A.J., additional, Zawia, A., additional, Zeidan, L., additional, Zhao, B., additional, Zheng, B., additional, and Zongo, O., additional

Published
2023
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28. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Author

Liew, Felicity, Talwar, Shubha, Cross, Andy, Willett, Brian J, Scott, Sam, Logan, Nicola, Siggins, Matthew K, Swieboda, Dawid, Sidhu, Jasmin K, Efstathiou, Claudia, Moore, Shona C, Davis, Chris, Mohamed, Noura, Nunag, Jose, King, Clara, Thompson, AA Roger, Rowland-Jones, Sarah L, Docherty, Annemarie B, Chalmers, James D, Ho, Ling-Pei, Horsley, Alexander, Raman, Betty, Poinasamy, Krisnah, Marks, Michael, Kon, Onn Min, Howard, Luke, Wootton, Daniel G, Dunachie, Susanna, Quint, Jennifer K, Evans, Rachael A, Wain, Louise V, Fontanella, Sara, de Silva, Thushan I, Ho, Antonia, Harrison, Ewen, Baillie, J Kenneth, Semple, Malcolm G, Brightling, Christopher, Thwaites, Ryan S, Turtle, Lance, Openshaw, Peter JM, ISARIC4C Investigators, PHOSP-COVID collaborative group, and Apollo - University of Cambridge Repository

Subjects
Adult, Chemical Biology & High Throughput, SARS-CoV-2 variants, COVID-19 Vaccines, SARS-CoV-2, SARS-CoV-2 immunity, Vaccination, COVID-19, Antibodies, Viral, Antibodies, Neutralizing, Immunoglobulin A, Hospitalization, Metabolism, Mucosal immunity, Nasal antibody, Ecology,Evolution & Ethology, Immunoglobulin G, Humans, Convalescent, Follow-Up Studies, Computational & Systems Biology, Structural Biology & Biophysics
Abstract

BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript.

Published
2023
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30. Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Author

Liew, Felicity, primary, Talwar, Shubha, additional, Cross, Andy, additional, Willett, Brian J., additional, Scott, Sam, additional, Logan, Nicola, additional, Siggins, Matthew K., additional, Swieboda, Dawid, additional, Sidhu, Jasmin K., additional, Efstathiou, Claudia, additional, Moore, Shona C., additional, Davis, Chris, additional, Mohamed, Noura, additional, Nunag, Jose, additional, King, Clara, additional, Roger Thompson, A. A., additional, Rowland-Jones, Sarah L., additional, Docherty, Annemarie B., additional, Chalmers, James D., additional, Ho, Ling-Pei, additional, Horsley, Alexander, additional, Raman, Betty, additional, Poinasamy, Krisnah, additional, Marks, Michael, additional, Kon, Onn Min, additional, Howard, Luke, additional, Wootton, Daniel G., additional, Dunachie, Susanna, additional, Quint, Jennifer K., additional, Evans, Rachael A., additional, Wain, Louise V., additional, Fontanella, Sara, additional, de Silva, Thushan I., additional, Ho, Antonia, additional, Harrison, Ewen, additional, Baillie, J. Kenneth, additional, Semple, Malcolm G., additional, Brightling, Christopher, additional, Thwaites, Ryan S., additional, Turtle, Lance, additional, and Openshaw, Peter J.M., additional

Published
2022
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31. An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania

Author

de Glanville, William A, primary, Allan, Kathryn J, additional, Nyarobi, James M, additional, Thomas, Kate M, additional, Lankester, Felix, additional, Kibona, Tito J, additional, Claxton, John R, additional, Brennan, Benjamin, additional, Carter, Ryan W, additional, Crump, John A, additional, Halliday, Jo E B, additional, Ladbury, Georgia, additional, Mmbaga, Blandina T, additional, Mramba, Furaha, additional, Nyasebwa, Obed M, additional, Rubach, Matthew P, additional, Rostal, Melinda K, additional, Sanka, Paul, additional, Swai, Emmanuel S, additional, Szemiel, Agnieszka M, additional, Willett, Brian J, additional, and Cleaveland, Sarah, additional

Published
2022
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33. mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273

Author

Dowell, Alexander C., primary, Powell, Annabel A., additional, Davis, Chris, additional, Scott, Sam, additional, Logan, Nicola, additional, Willett, Brian J., additional, Bruton, Rachel, additional, Ayodele, Morenike, additional, Jinks, Elizabeth, additional, Gunn, Juliet, additional, Spalkova, Eliska, additional, Sylla, Panagiota, additional, Nicol, Samantha M., additional, Zuo, Jianmin, additional, Ireland, Georgina, additional, Okike, Ifeanyichukwu, additional, Baawuah, Frances, additional, Beckmann, Joanne, additional, Ahmad, Shazaad, additional, Garstang, Joanna, additional, Brent, Andrew J., additional, Brent, Bernadette, additional, White, Marie, additional, Collins, Aedin, additional, Davis, Francesca, additional, Lim, Ming, additional, Cohen, Jonathan, additional, Kenny, Julia, additional, Linley, Ezra, additional, Poh, John, additional, Amirthalingam, Gayatri, additional, Brown, Kevin, additional, Ramsay, Mary E., additional, Azad, Rafaq, additional, Wright, John, additional, Waiblinger, Dagmar, additional, Moss, Paul, additional, and Ladhani, Shamez N., additional

Published
2022
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36. Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

Author

Willett, Brian J., primary, Kurshan, Ashwini, additional, Thakur, Nazia, additional, Newman, Joseph, additional, Manali, Maria, additional, Tyson, Grace, additional, Logan, Nicola, additional, Murcia, Pablo R., additional, Snell, Luke B., additional, Edgeworth, Jonathan D., additional, Zhou, Jie, additional, Sukhova, Ksenia, additional, Amirthalingam, Gayatri, additional, Brown, Kevin, additional, Charleston, Bryan, additional, Malim, Michael H., additional, Thomson, Emma C., additional, Barclay, Wendy S., additional, Bailey, Dalan, additional, Doores, Katie J., additional, and Peacock, Thomas P., additional

Published
2022
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37. Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model

Author

Bryden, Steven R, primary, Dunlop, James I, additional, Clarke, Andrew T, additional, Fares, Mazigh, additional, Pingen, Marieke, additional, Wu, Yan, additional, Willett, Brian J, additional, Patel, Arvind H, additional, Gao, George F, additional, Kohl, Alain, additional, and Brennan, Benjamin, additional

Published
2022
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39. Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

Author

Lee, Benhur, Davis, Chris, Logan, Nicola, Tyson, Grace, Orton, Richard, Harvey, William T., Perkins, Jonathan S., Mollett, Guy, Blacow, Rachel M., Peacock, Thomas P., Barclay, Wendy S., Cherepanov, Peter, Palmarini, Massimo, Murcia, Pablo R., Patel, Arvind H., Robertson, David L., Haughney, John, Thomson, Emma C., Willett, Brian J., Bashton, Matthew, Smith, Darren, Nelson, Andrew, Young, Greg, McCann, Clare, Yew, Wen Chyin, The COVID-19 Genomics UK (COG-UK) Consortium, on behalf of the COVID-19 DeplOyed VaccinE (DOVE) Cohort Study, Tyson, Grace [0000-0001-9496-5660], Orton, Richard [0000-0002-3389-4325], Harvey, William T [0000-0001-9529-1127], Perkins, Jonathan S [0000-0002-7448-471X], Mollett, Guy [0000-0003-1613-4540], Blacow, Rachel M [0000-0002-0946-5539], Peacock, Thomas P [0000-0001-7077-2928], Cherepanov, Peter [0000-0002-0634-538X], Palmarini, Massimo [0000-0001-7007-4070], Murcia, Pablo R [0000-0002-4352-394X], Patel, Arvind H [0000-0003-4600-2047], Robertson, David L [0000-0001-6338-0221], Haughney, John [0000-0002-6809-6964], Thomson, Emma C [0000-0003-1482-0889], Willett, Brian J [0000-0001-8912-3266], and Apollo - University of Cambridge Repository

Subjects
RNA viruses, Physiology, Coronaviruses, Antibody Response, B200, Antibodies, Viral, Biochemistry, Neutralization, Medical Conditions, Immune Physiology, Medicine and Health Sciences, Medicine, Public and Occupational Health, Biology (General), Enzyme-Linked Immunoassays, Antigenic Drift and Shift, Immune Response, Pathology and laboratory medicine, Vaccines, Immune System Proteins, biology, Viral Vaccine, Genome Integrity & Repair, Medical microbiology, C700, Vaccination and Immunization, Vaccination, Infectious Diseases, Viruses, Antibody, SARS CoV 2, Pathogens, Research Article, Infectious Disease Control, SARS coronavirus, QH301-705.5, Immunology, Immunization, Secondary, B100, Vaccine Efficacy, Research and Analysis Methods, Biochemistry & Proteomics, Microbiology, Antigenic drift, Antibodies, Antigen, Immunity, Virology, Vaccine Development, Genetics, Humans, Immunoassays, Molecular Biology, BNT162 Vaccine, business.industry, SARS-CoV-2, Organisms, Viral pathogens, Biology and Life Sciences, Proteins, COVID-19, Viral Vaccines, RC581-607, Vaccine efficacy, Antibodies, Neutralizing, Microbial pathogens, HEK293 Cells, biology.protein, Immunologic Techniques, Cell Cycle & Chromosomes, Parasitology, Preventive Medicine, Immunologic diseases. Allergy, business, Structural Biology & Biophysics
Abstract

Vaccines are proving to be highly effective in controlling hospitalisation and deaths associated with SARS-CoV-2 infection but the emergence of viral variants with novel antigenic profiles threatens to diminish their efficacy. Assessment of the ability of sera from vaccine recipients to neutralise SARS-CoV-2 variants will inform the success of strategies for minimising COVID19 cases and the design of effective antigenic formulations. Here, we examine the sensitivity of variants of concern (VOCs) representative of the B.1.617.1 and B.1.617.2 (first associated with infections in India) and B.1.351 (first associated with infection in South Africa) lineages of SARS-CoV-2 to neutralisation by sera from individuals vaccinated with the BNT162b2 (Pfizer/BioNTech) and ChAdOx1 (Oxford/AstraZeneca) vaccines. Across all vaccinated individuals, the spike glycoproteins from B.1.617.1 and B.1.617.2 conferred reductions in neutralisation of 4.31 and 5.11-fold respectively. The reduction seen with the B.1.617.2 lineage approached that conferred by the glycoprotein from B.1.351 (South African) variant (6.29-fold reduction) that is known to be associated with reduced vaccine efficacy. Neutralising antibody titres elicited by vaccination with two doses of BNT162b2 were significantly higher than those elicited by vaccination with two doses of ChAdOx1. Fold decreases in the magnitude of neutralisation titre following two doses of BNT162b2, conferred reductions in titre of 7.77, 11.30 and 9.56-fold respectively to B.1.617.1, B.1.617.2 and B.1.351 pseudoviruses, the reduction in neutralisation of the delta variant B.1.617.2 surpassing that of B.1.351. Fold changes in those vaccinated with two doses of ChAdOx1 were 0.69, 4.01 and 1.48 respectively. The accumulation of mutations in these VOCs, and others, demonstrate the quantifiable risk of antigenic drift and subsequent reduction in vaccine efficacy. Accordingly, booster vaccines based on updated variants are likely to be required over time to prevent productive infection. This study also suggests that two dose regimes of vaccine are required for maximal BNT162b2 and ChAdOx1-induced immunity., Author summary The SARS-CoV-2 virus is likely to have emerged following a cross-species jump from bats to humans in Wuhan, China at the end of 2019. As the virus has evolved to adapt to humans, new viral variants have emerged that incorporate mutations in the “spike” gene. The spike protein is expressed on the surface of the virus, it facilitates entry into human cells and is the main target of neutralising antibodies. Mutations change the shape of the spike protein, preventing antibody recognition and enabling the virus to escape from the immunity induced by vaccination. Using samples collected from vaccinated people as part of the COVID-19 Deployed Vaccine Cohort Study (DOVE), we assessed the capacity of different variants (beta, kappa and delta) to evade the protective immune response in recipients of the Astra Zeneca ChAdOx1 and Pfizer BNT162b2 vaccines, both of which are based on the early Wuhan virus spike gene. We noted a reduction in neutralisation of both the beta and delta variants by vaccine sera from recipients of both vaccines. While vaccines remain highly effective at preventing severe infection and death, ongoing monitoring of vaccine effectiveness is indicated as the virus continues to evolve over time, especially in vulnerable groups.

Published
2021
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42. Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Author

Dowell, Alexander C., primary, Butler, Megan S., additional, Jinks, Elizabeth, additional, Tut, Gokhan, additional, Lancaster, Tara, additional, Sylla, Panagiota, additional, Begum, Jusnara, additional, Bruton, Rachel, additional, Pearce, Hayden, additional, Verma, Kriti, additional, Logan, Nicola, additional, Tyson, Grace, additional, Spalkova, Eliska, additional, Margielewska-Davies, Sandra, additional, Taylor, Graham S., additional, Syrimi, Eleni, additional, Baawuah, Frances, additional, Beckmann, Joanne, additional, Okike, Ifeanyichukwu O., additional, Ahmad, Shazaad, additional, Garstang, Joanna, additional, Brent, Andrew J., additional, Brent, Bernadette, additional, Ireland, Georgina, additional, Aiano, Felicity, additional, Amin-Chowdhury, Zahin, additional, Jones, Samuel, additional, Borrow, Ray, additional, Linley, Ezra, additional, Wright, John, additional, Azad, Rafaq, additional, Waiblinger, Dagmar, additional, Davis, Chris, additional, Thomson, Emma C., additional, Palmarini, Massimo, additional, Willett, Brian J., additional, Barclay, Wendy S., additional, Poh, John, additional, Amirthalingam, Gayatri, additional, Brown, Kevin E., additional, Ramsay, Mary E., additional, Zuo, Jianmin, additional, Moss, Paul, additional, and Ladhani, Shamez, additional

Published
2021
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44. Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation

Author

Morgan, Danielle C., Morris, Caroline, Mahindra, Amit, Blair, Connor M., Tejeda, Gonzalo, Herbert, Imogen, Turnbull, Matthew L., Lieber, Gauthier, Willett, Brian J., Logan, Nicola, Smith, Brian, Tobin, Andrew B., Bhella, David, Baillie, George S., and Jamieson, Andrew G.

Subjects
viruses, hormones, hormone substitutes, and hormone antagonists
Abstract

COVID‐19 is caused by a novel coronavirus called severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). Virus cell entry is mediated through a protein‐protein interaction (PPI) between the SARS‐CoV‐2 spike protein and angiotensin‐converting enzyme 2 (ACE2). A series of stapled peptide ACE2 peptidomimetics based on the ACE2 interaction motif were designed to bind the coronavirus S‐protein RBD and inhibit binding to the human ACE2 receptor. The peptidomimetics were assessed for antiviral activity in an array of assays including a neutralization pseudovirus assay, immunofluorescence (IF) assay and in‐vitro fluorescence polarization (FP) assay. However, none of the peptidomimetics showed activity in these assays, suggesting that an enhanced binding interface is required to outcompete ACE2 for S‐protein RBD binding and prevent virus internalization.

Published
2021

45. In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2

Author

Szemiel, Agnieszka M., primary, Merits, Andres, additional, Orton, Richard J., additional, MacLean, Oscar A., additional, Pinto, Rute Maria, additional, Wickenhagen, Arthur, additional, Lieber, Gauthier, additional, Turnbull, Matthew L., additional, Wang, Sainan, additional, Furnon, Wilhelm, additional, Suarez, Nicolas M., additional, Mair, Daniel, additional, da Silva Filipe, Ana, additional, Willett, Brian J., additional, Wilson, Sam J., additional, Patel, Arvind H., additional, Thomson, Emma C., additional, Palmarini, Massimo, additional, Kohl, Alain, additional, and Stewart, Meredith E., additional

Published
2021
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46. An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania, 2018

Author

de Glanville, William A., primary, Allan, Kathryn J., additional, Nyarobi, James M., additional, Thomas, Kate. M., additional, Lankester, Felix, additional, Kibona, Tito, additional, Claxton, John R., additional, Brennan, Benjamin, additional, Carter, Ryan W., additional, Crump, John A., additional, Halliday, Jo E.B., additional, Ladbury, Georgia, additional, Mmbaga, Blandina T., additional, Mramba, Furaha, additional, Nyasebwa, Obed M., additional, Rubach, Matthew P., additional, Rostal, Melinda K., additional, Sanka, Paul, additional, Swai, Emmanuel S., additional, Szemiel, Agnieszka M., additional, Willett, Brian J., additional, and Cleaveland, Sarah, additional

Published
2021
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48. Detection of SARS-CoV-2 in respiratory samples from cats in the UK associated with human-to-cat transmission

Author

Hosie, Margaret J., Epifano, Ilaria, Herder, Vanessa, Orton, Richard J., Stevenson, Andrew, Johnson, Natasha, MacDonald, Emma, Dunbar, Dawn, McDonald, Michael, Howie, Fiona, Tennant, Bryn, Herrity, Darcy, Da Silva Filipe, Ana, Streicker, Daniel G., COVID-19 Genomics UK (COG-UK) consortium, ., Willett, Brian J., Murcia, Pablo R., Jarrett, Ruth F., Robertson, David L., Weir, William, Hosie, Margaret J [0000-0002-4313-5023], and Apollo - University of Cambridge Repository

Subjects
SARS-CoV-2, Zoonoses, viruses, cats, COVID-19, Animals, Humans, RNA, Viral, Female, Cat Diseases, Lung, reverse zoonosis, United Kingdom
Abstract

Objectives: \ud The aim of the study was to find evidence of SARS‐CoV‐2 infection in UK cats.\ud \ud Design: \ud Tissue samples were tested for SARS‐CoV‐2 antigen using immunofluorescence and for viral RNA by in situ hybridisation. A set of 387 oropharyngeal swabs that had been submitted for routine respiratory pathogen testing was tested for SARS‐CoV‐2 RNA using reverse transcriptase quantitative PCR.\ud \ud Results: \ud Lung tissue collected post‐mortem from cat 1 tested positive for both SARS‐CoV‐2 nucleocapsid antigen and RNA. SARS‐CoV‐2 RNA was detected in an oropharyngeal swab collected from cat 2 that presented with rhinitis and conjunctivitis. High throughput sequencing of the viral genome revealed five single nucleotide polymorphisms (SNPs) compared to the nearest UK human SARS‐CoV‐2 sequence, and this human virus contained eight SNPs compared to the original Wuhan‐Hu‐1 reference sequence. An analysis of the viral genome of cat 2 together with nine other feline‐derived SARS‐CoV‐2 sequences from around the world revealed no shared cat‐specific mutations.\ud \ud Conclusions: \ud These findings indicate that human‐to‐cat transmission of SARS‐CoV‐2 occurred during the COVID‐19 pandemic in the UK, with the infected cats developing mild or severe respiratory disease. Given the ability of the new coronavirus to infect different species, it will be important to monitor for human‐to‐cat, cat‐to‐cat and cat‐to‐human transmission.

Published
2021

49. Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania

Author

Thomas, Kate M., primary, Kibona, Tito, additional, Claxton, John R., additional, de Glanville, William A., additional, Lankester, Felix, additional, Amani, Nelson, additional, Buza, Joram J., additional, Carter, Ryan W., additional, Chapman, Gail E., additional, Crump, John A., additional, Dagleish, Mark P., additional, Halliday, Jo E. B., additional, Hamilton, Clare M., additional, Innes, Elisabeth A., additional, Katzer, Frank, additional, Livingstone, Morag, additional, Longbottom, David, additional, Millins, Caroline, additional, Mmbaga, Blandina T., additional, Mosha, Victor, additional, Nyarobi, James, additional, Nyasebwa, Obed M., additional, Russell, George C., additional, Sanka, Paul N., additional, Semango, George, additional, Wheelhouse, Nick, additional, Willett, Brian J., additional, Cleaveland, Sarah, additional, and Allan, Kathryn J., additional

Published
2021
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50. Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins

Author

Kosugi, Yusuke, primary, Uriu, Keiya, additional, Suzuki, Narumi, additional, Yamamoto, Keisuke, additional, Nagaoka, Shumpei, additional, Kimura, Izumi, additional, Konno, Yoriyuki, additional, Aso, Hirofumi, additional, Willett, Brian J., additional, Kobayashi, Tomoko, additional, Koyanagi, Yoshio, additional, Ueda, Mahoko Takahashi, additional, Ito, Jumpei, additional, and Sato, Kei, additional

Published
2021
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