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Purpose: To introduce and evaluate TrueLung, an automated pipeline for computation and analysis of free-breathing and contrast-agent free pulmonary functional MRI. Material and Methods: time-resolved ultra-fast bSSFP acquisitions are transferred to TrueLung, which includes image quality checks, image registration, and computation of perfusion and ventilation maps with matrix pencil decomposition. Neural network whole-lung and lobar segmentations allow quantification of impaired relative perfusion (RQ) and fractional ventilation (RFV). TrueLung delivers functional maps and quantitative outcomes, reported for clinicians in concise documents. We evaluated the pipeline in 75 cystic fibrosis children. Whole-lung and lobar segmentations were manually refined when necessary, and the impact on RQ and RFV was quantified. Results: Functional imaging was performed at 7.9 $\pm$ 1.8 (mean $\pm$ SD) coronal slice positions per patient, totaling on average 6min 20s scan time per patient. The whole pipeline required 20min calculation time per subject. TrueLung delivered the functional maps of all the subjects for radiological assessment. Quality controlling maps and segmentations lasted 1min 12s per patient. The automated segmentations and quantification of whole-lung defects were satisfying in 88% of patients (97% of slices) and the lobar quantification in 73% (93% of slices). The segmentations refinements required 16s per patient for the whole-lung, and 2min 10s for the lobe masks. The relative differences in RFV and RQ between fully-automated and manually refined data were marginal. Conclusions: TrueLung quickly delivers functional maps and quantitative outcomes in an objective and standardized way, suitable for radiological and pneumological assessment with minimal manual input. TrueLung can be used for clinical research in cystic fibrosis and might be applied across various lung diseases.

Despite the necessity of fault-tolerant quantum sys- tems built on error correcting codes, many popular codes, such as the surface code, have prohibitively large qubit costs. In this work we present a protocol for efficiently implementing a restricted set of space-efficient quantum error correcting (QEC) codes in atom arrays. This protocol enables generalized-bicycle codes that require up to 10x fewer physical qubits than surface codes. Additionally, our protocol enables logical cycles that are 2-3x faster than more general solutions for implementing space- efficient QEC codes in atom arrays. We also evaluate a proof-of-concept quantum memory hier- archy where generalized-bicycle codes are used in conjunction with surface codes for general computation. Through a detailed compilation methodology, we estimate the costs of key fault- tolerant benchmarks in a hierarchical architecture versus a state-of-the-art surface code only architecture. Overall, we find the spatial savings of generalized-bicycle codes outweigh the overhead of loading and storing qubits, motivating the feasibility of a quantum memory hierarchy in practice. Through sensitivity studies, we also identify key program-level and hardware-level features for using a hierarchical architecture.

Recently low-mass dark matter direct searches have been hindered by a low energy background, drastically reducing the physics reach of the experiments. In the CRESST-III experiment, this signal is characterised by a significant increase of events below 200 eV. As the origin of this background is still unknown, it became necessary to develop new detector designs to reach a better understanding of the observations. Within the CRESST collaboration, three new different detector layouts have been developed and they are presented in this contribution., Comment: 8 pages, 4 figures

Diamond operated as a cryogenic calorimeter is an excellent target for direct detection of low-mass dark matter candidates. Following the realization of the first low-threshold cryogenic detector that uses diamond as absorber for astroparticle physics applications, we now present the resulting exclusion limits on the elastic spin-independent interaction cross-section of dark matter with diamond. We measured two 0.175 g CVD (Chemical Vapor Deposition) diamond samples, each instrumented with a W-TES. Thanks to the energy threshold of just 16.8 eV of one of the two detectors, we set exclusion limits on the elastic spin-independent interaction of dark matter particles with carbon nuclei down to dark matter masses as low as 0.122 GeV/c2. This work shows the scientific potential of cryogenic detectors made from diamond and lays the foundation for the use of this material as target for direct detection dark matter experiments., Comment: 6 pages, 6 figures

Using CaWO$_4$ crystals as cryogenic calorimeters, the CRESST experiment searches for nuclear recoils caused by the scattering of potential Dark Matter particles. A reliable identification of a potential signal crucially depends on an accurate background model. In this work we introduce an improved normalisation method for CRESST's model of the electromagnetic backgrounds. Spectral templates, based on Geant4 simulations, are normalised via a Bayesian likelihood fit to experimental background data. Contrary to our previous work, no assumption of partial secular equilibrium is required, which results in a more robust and versatile applicability. Furthermore, considering the correlation between all background components allows us to explain 82.7% of the experimental background within [1 keV, 40 keV], an improvement of 18.6% compared to our previous method., Comment: 24 pages, 14 figures, submitted to EPJC

New-generation direct searches for low mass dark matter feature detection thresholds at energies well below 100 eV, much lower than the energies of commonly used X-ray calibration sources. This requires new calibration sources with sub-keV energies. When searching for nuclear recoil signals, the calibration source should ideally cause mono-energetic nuclear recoils in the relevant energy range. Recently, a new calibration method based on the radiative neutron capture on $^{182}$W with subsequent de-excitation via single $\gamma$-emission leading to a nuclear recoil peak at 112 eV was proposed. The CRESST-III dark matter search operated several CaWO$_{4}$-based detector modules with detection thresholds below 100 eV in the past years. We report the observation of a peak around the expected energy of 112 eV in the data of three different detector modules recorded while irradiated with neutrons from different AmBe calibration sources. We compare the properties of the observed peaks with Geant-4 simulations and assess the prospects of using this for the energy calibration of CRESST-III detectors., Comment: 8 pages, 4 figures; submitted to Phys. Rev. D

In superconducting architectures, limited connectivity remains a significant challenge for the synthesis and compilation of quantum circuits. We consider models of entanglement-assisted computation where long-range operations are achieved through injections of large GHZ states. These are prepared using ancillary qubits acting as an ``entanglement bus,'' unlocking global operation primitives such as multi-qubit Pauli rotations and fan out gates. We derive bounds on the circuit size for several well studied problems, such as CZ circuit, CX circuit, and Clifford circuit synthesis. In particular, in an architecture using one such entanglement bus, we give an $O(n^3)$-complexity synthesis scheme for arbitrary Clifford operations requiring at most $2n + 1$ layers of entangled-state-injections. In a square-lattice architecture with two entanglement buses, we show that a graph state can be synthesized using at most $\lceil \frac{1}{2}n \rceil + 1$ layers of GHZ state injections, and Clifford operations require only $\lceil\frac{3}{2} n \rceil + O(\sqrt n)$ layers of GHZ state injections., Comment: Update to include additional references on Clifford decomposition as transvections and Lempel's factorization for CZ synthesis, and corrected several typos

We present limits on the spin-independent interaction cross section of dark matter particles with silicon nuclei, derived from data taken with a cryogenic calorimeter with 0.35 g target mass operated in the CRESST-III experiment. A baseline nuclear recoil energy resolution of $(1.36\pm 0.05)$ eV$_{\text{nr}}$, currently the lowest reported for macroscopic particle detectors, and a corresponding energy threshold of $(10.0\pm 0.2)$ eV$_{\text{nr}}$ have been achieved, improving the sensitivity to light dark matter particles with masses below 160 MeV/c$^2$ by a factor of up to 20 compared to previous results. We characterize the observed low energy excess, and we exclude noise triggers and radioactive contaminations on the crystal surfaces as dominant contributions., Comment: 8 pages, 5 figures; precised the position of the calibration source in Fig. 1; extended the discussion about the observed energy spectrum; added the DM limit curve to ancillary files. Published in Phys. Rev. D

We investigated the electronic structure of the enigmatic CeRh$_3$B$_2$ using resonant inelastic scattering and x-ray absorption spectroscopy in combination with $ab$ $initio$ density functional calculations. We find that the Rh 4$d$ states are irrelevant for the high-temperature ferromagnetism and the Kondo effect. We also find that the Ce 4$f$ crystal-field strength is too small to explain the strong reduction of the Ce magnetic moment. The data reveal instead the presence of two different active Ce 4$f$ orbitals, with each coupling selectively to different bands in CeRh$_3$B$_2$. The inter-site hybridization of the |J=5/2,Jz=+/-1/2> crystal-field state and Ce 5$d$ band combined with the intra-site Ce 4$f$-5$d$ exchange creates the strong ferromagnetism, while hybridization between the |J=5/2,Jz=+/-5/2> and the B $sp$ in the $ab$-plane contributes to the Kondo interaction which causes the moment reduction. This orbital selective coupling explains the unique and seemingly contradictory properties of CeRh$_3$B$_2$., Comment: 15 pages, 14 figures

The CRESST experiment employs cryogenic calorimeters for the sensitive measurement of nuclear recoils induced by dark matter particles. The recorded signals need to undergo a careful cleaning process to avoid wrongly reconstructed recoil energies caused by pile-up and read-out artefacts. We frame this process as a time series classification task and propose to automate it with neural networks. With a data set of over one million labeled records from 68 detectors, recorded between 2013 and 2019 by CRESST, we test the capability of four commonly used neural network architectures to learn the data cleaning task. Our best performing model achieves a balanced accuracy of 0.932 on our test set. We show on an exemplary detector that about half of the wrongly predicted events are in fact wrongly labeled events, and a large share of the remaining ones have a context-dependent ground truth. We furthermore evaluate the recall and selectivity of our classifiers with simulated data. The results confirm that the trained classifiers are well suited for the data cleaning task., Comment: 12 pages, 8 figures, 6 tables

A Hadamard-free Clifford transformation is a circuit composed of quantum Phase (P), CZ, and CNOT gates. It is known that such a circuit can be written as a three-stage computation, -P-CZ-CNOT-, where each stage consists only of gates of the specified type. In this paper, we focus on the minimization of circuit depth by entangling gates, corresponding to the important time-to-solution metric and the reduction of noise due to decoherence. We consider two popular connectivity maps: Linear Nearest Neighbor (LNN) and all-to-all. First, we show that a Hadamard-free Clifford operation can be implemented over LNN in depth $5n$, i.e., in the same depth as the -CNOT- stage alone. This allows us to implement arbitrary Clifford transformation over LNN in depth no more than $7n{-}4$, improving the best previous upper bound of $9n$. Second, we report heuristic evidence that on average a random uniformly distributed Hadamard-free Clifford transformation over $n{>}6$ qubits can be implemented with only a tiny additive overhead over all-to-all connected architecture compared to the best-known depth-optimized implementation of the -CNOT- stage alone. This suggests the reduction of the depth of Clifford circuits from $2n\,{+}\,O(\log^2(n))$ to $1.5n\,{+}\,O(\log^2(n))$ over unrestricted architectures.

CRESST is a leading direct detection sub-$\mathrm{GeVc}^{-2}$ dark matter experiment. During its second phase, cryogenic bolometers were used to detect nuclear recoils off the $\mathrm{CaWO}_4$ target crystal nuclei. The previously established electromagnetic background model relies on secular equilibrium (SE) assumptions. In this work, a validation of SE is attempted by comparing two likelihood-based normalisation results using a recently developed spectral template normalisation method based on Bayesian likelihood. We find deviations from SE; further investigations are necessary to determine their origin., Comment: Part of special issue: ICRM-LLRMT22 8th International Conference on Radionuclide Metrology - Low Level Radioactivity Measurement and Techniques, 6 pages, 3 figures

Data-driven modeling of non-Markovian dynamics is a recent topic of research with applications in many fields such as climate research, molecular dynamics, biophysics, or wind power modeling. In the frequently used standard Langevin equation, memory effects can be implemented through an additional hidden component which functions as correlated noise, thus resulting in a non-Markovian model. It can be seen as part of the model class of partially observed diffusions which are usually adapted to observed data via Bayesian estimation, whereby the difficulty of the unknown noise values is solved through a Gibbs sampler. However, when regarding large data sets with a length of $10^6$ or $10^7$ data points, sampling the distribution of the same amount of latent variables is unfeasible. For the model discussed in this work, we solve this issue through a direct derivation of the posterior distribution of the Euler-Maruyama approximation of the model via analytical marginalization of the latent variables. Yet, in the case of a nonlinear noise process, the inverse problem of model estimation proves to be ill-posed and still numerically expensive. We handle these complications by restricting the noise to an Ornstein-Uhlenbeck process, which considerably reduces the ambiguity of the estimation. Further, in this case, the estimation can be performed very efficiently if the drift and diffusion functions of the observed component are approximated in a piecewise constant manner. We illustrate the resulting procedure of efficient Bayesian estimation of the considered non-Markovian Langevin model by an example from turbulence.

The CRESST experiment observes an unexplained excess of events at low energies. In the current CRESST-III data-taking campaign we are operating detector modules with different designs to narrow down the possible explanations. In this work, we show first observations of the ongoing measurement, focusing on the comparison of time, energy and temperature dependence of the excess in several detectors. These exclude dark matter, radioactive backgrounds and intrinsic sources related to the crystal bulk as a major contribution., Comment: 10 pages, 5 figures; to be published in IDM2022 proceedings; corrected several minor typos

In the past decades, numerous experiments have emerged to unveil the nature of dark matter, one of the most discussed open questions in modern particle physics. Among them, the CRESST experiment, located at the Laboratori Nazionali del Gran Sasso, operates scintillating crystals as cryogenic phonon detectors. In this work, we present first results from the operation of two detector modules which both have 10.46 g LiAlO$_2$ targets in CRESST-III. The lithium contents in the crystal are $^6$Li, with an odd number of protons and neutrons, and $^7$Li, with an odd number of protons. By considering both isotopes of lithium and $^{27}$Al, we set the currently strongest cross section upper limits on spin-dependent interaction of dark matter with protons and neutrons for the mass region between 0.25 and 1.5 GeV/c$^2$., Comment: 9 pages, 8 figures

Many low-threshold experiments observe sharply rising event rates of yet unknown origins below a few hundred eV, and larger than expected from known backgrounds. Due to the significant impact of this excess on the dark matter or neutrino sensitivity of these experiments, a collective effort has been started to share the knowledge about the individual observations. For this, the EXCESS Workshop was initiated. In its first iteration in June 2021, ten rare event search collaborations contributed to this initiative via talks and discussions. The contributing collaborations were CONNIE, CRESST, DAMIC, EDELWEISS, MINER, NEWS-G, NUCLEUS, RICOCHET, SENSEI and SuperCDMS. They presented data about their observed energy spectra and known backgrounds together with details about the respective measurements. In this paper, we summarize the presented information and give a comprehensive overview of the similarities and differences between the distinct measurements. The provided data is furthermore publicly available on the workshop's data repository together with a plotting tool for visualization., Comment: 44 pages, 20 figures; Editors: A. Fuss, M. Kaznacheeva, F. Reindl, F. Wagner; updated copyright statements and funding information

CRESST is one of the most prominent direct detection experiments for dark matter particles with sub-GeV/c$^2$ mass. One of the advantages of the CRESST experiment is the possibility to include a large variety of nuclides in the target material used to probe dark matter interactions. In this work, we discuss in particular the interactions of dark matter particles with protons and neutrons of $^{6}$Li. This is now possible thanks to new calculations on nuclear matrix elements of this specific isotope of Li. To show the potential of using this particular nuclide for probing dark matter interactions, we used the data collected previously by a CRESST prototype based on LiAlO$_2$ and operated in an above ground test-facility at Max-Planck-Institut f\"ur Physik in Munich, Germany. In particular, the inclusion of $^{6}$Li in the limit calculation drastically improves the result obtained for spin-dependent interactions with neutrons in the whole mass range. The improvement is significant, greater than two order of magnitude for dark matter masses below 1 GeV/c$^2$, compared to the limit previously published with the same data.