19 results on '"Willemot L"'
Search Results
2. 108P Real-world (RW) effectiveness and safety of adjuvant nivolumab (NIVO) in patients (pts) with melanoma in Belgium and Luxembourg: PRESERV MEL
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Neyns, B., primary, Willemot, L., additional, McDonald, L., additional, Van Campenhout, H., additional, Berchem, G., additional, Jacobs, C., additional, Rogiers, A., additional, Blockx, N., additional, and Rorive, A., additional
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- 2023
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3. A-283 - Early recurrence in a pooled international cohort of melanoma patients treated with adjuvant nivolumab in a real-world setting
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Mortier, L., Gutzmer, R., Atkinson, V., Dalle, S., Saiag, P., Neyns, B., Rorive, A., Parente, P., Weichenthal, M., Grob, J.-J., Lebbé, C., Mohr, P., Eigentler, T., McDonald, L., Willemot, L., Brellier, F., Bakharevski, O., Houssou, S., Jadhao, M., and Schadendorf, D.
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- 2024
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4. 810P PRESERV MEL: Real-world outcomes and health-related quality of life (HRQoL) in patients receiving adjuvant nivolumab for melanoma in Belgium and Luxembourg
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Rogiers, A., primary, Willemot, L., additional, McDonald, L., additional, Van Campenhout, H., additional, Vouk, K., additional, Berchem, G., additional, Jacobs, C., additional, Rorive, A., additional, and Neyns, B., additional
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- 2022
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5. Neonatal cephalohematoma
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Willemot, L, primary, Lagae, P, additional, Jeannin, P, additional, Baelde, N, additional, and Verstraete, K, additional
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- 2013
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6. Noisy Robots? Comparison of Occupational Noise Levels Between Robotic-Assisted and Conventional Total Knee Arthroplasty.
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Willemot L, Gilmour A, Mulford J, and Penn D
- Abstract
Background: Noise exposure during surgery is a known occupational hazard, impacting staff hearing and surgical outcomes. Despite guidelines such as the Australian Work Health and Safety Act, noise safety remains largely neglected in orthopaedic surgery. Anecdotally, the introduction of robotic-assisted arthroplasty has contributed to increased noise production. This research article aims to investigate the role of robots in noise levels during arthroplasty., Methods: In this prospective observational study, we collected noise exposure data during total knee arthroplasty with and without robotic assistance. Noise levels were measured using a smartphone placed in the surgeon's breast pocket. Patient demographics and surgical details were collected for subgroup analysis. Mean (LAeq), time-weighted average, and peak noise levels, as well as dose equivalent were calculated to quantify the exposure., Results: A total of 65 knee arthroplasty sound recordings were included with a mean noise level of 82.0 dB (standard deviation [SD]: 3.9). Robotic-assisted surgeries exhibited significantly higher levels than using the conventional technique: 82.4 (SD: 3.2) vs 78.4 dB (SD: 3.8) (<0.0001). These values exceed some of the recommended guidelines. Peak exposure levels were similar in both categories at 109.6 (SD: 2.7) and 110.7 dB (SD: 4.3), remaining below the safety threshold., Conclusions: This study highlights the potential for harmful noise exposure in orthopaedic surgery, emphasizing the contribution of robotic-assisted procedures. Our findings indicate noise levels approximate or exceed international safety guidelines. The results support the wearing of personal protective hearing equipment, and other preventative strategies. Our study provides insights into an underappreciated aspect of orthopaedic surgery., (© 2024 The Authors.)
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- 2024
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7. Snapping Triceps Syndrome: Surgical Technique.
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Chan FY, Lam C, Butorac R, and Willemot L
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- Humans, Ultrasonography, Elbow Joint surgery, Muscle, Skeletal pathology, Muscle, Skeletal surgery, Pain pathology, Pain surgery
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Snapping triceps syndrome is a rare cause of medial elbow pain and ulnar neuritis caused by subluxation and triggering of the medial tricipital muscle belly over the medial distal humeral ridge and condyle. The diagnosis and surgical management of snapping triceps syndrome can be challenging due to the subtlety of the symptoms and the infrequent presentation. Despite the diagnosis relying largely on clinical examination, noninvasive dynamic ultrasonography may facilitate detection. Correct recognition of this condition is crucial in the avoidance of surgical misadventure and revision surgery. This paper illustrates our surgical technique for the management of snapping triceps and reviews the available literature on this relatively obscure condition., Competing Interests: Conflicts of Interest and Source of Funding: The authors report no conflicts of interest and no source of funding., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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8. Real-World Effectiveness, Safety, and Health-Related Quality of Life in Patients Receiving Adjuvant Nivolumab for Melanoma in Belgium and Luxembourg: Results of PRESERV MEL.
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Rogiers A, Willemot L, McDonald L, Van Campenhout H, Berchem G, Jacobs C, Blockx N, Rorive A, and Neyns B
- Abstract
Background: Nivolumab, an anti-programmed cell death 1 immuno-oncology therapy, is approved as an adjuvant treatment for patients with completely resected stage III or stage IV melanoma. PRESERV MEL (Prospective and REtrospective Study of nivolumab thERapy in adjuVant MELanoma) is a real-world observational study evaluating the effectiveness and safety of adjuvant nivolumab in patients with completely resected stage III or stage IV melanoma in clinical practice in Belgium and Luxembourg., Methods: Patients were enrolled prospectively and retrospectively during a 2-year period (January 2019-January 2021), and will be followed for 5 years. The results reported here are for the second interim analysis (cutoff date 31 December 2021). The index date was the date of first administration of adjuvant nivolumab. Patients received nivolumab for up to 12 months per label. Outcomes included relapse-free survival (RFS), adverse events (AEs)/treatment-related AEs (TRAEs), and health-related quality of life (HRQoL; assessed in prospectively enrolled patients using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30), Functional Assessment of Cancer Therapy-Melanoma (FACT-M), and EQ-5D-3L instruments). HRQoL was evaluated at group level (mean change in scores from baseline based on minimally important differences) and individual patient level (percentage of patients with clinically important scores based on threshold of clinical importance). Outcomes were analyzed descriptively., Results: The study enrolled 152 patients (125 prospective, 27 retrospective) at 15 hospitals in Belgium and Luxembourg. Minimum potential follow-up at time of analysis was 11.4 months. Median age was 60 years (range 29-85), and 53% of patients were male. At 12 and 18 months, the RFS rates were 74.7% (95% confidence interval (CI): 66.9-80.9) and 68.4% (95% CI: 60.0-75.5), respectively. Median RFS was not reached. Grade 3 or 4 TRAEs were reported in 14% of patients. AEs led to treatment discontinuation in 23% of patients. Deaths occurred in 3% of patients and were not related to treatment. Questionnaire completion rates for HRQoL were high at baseline (90-94%) and at 24 months (78-81%). In the group-level analysis for HRQoL, mean changes in scores from baseline remained stable and did not exceed prespecified thresholds for minimally important differences during and after treatment, except for a clinically meaningful improvement in FACT-M surgery subscale scores. In the individual patient-level analysis for EORTC QLQ-C30 subscales, the percentages of patients who reported clinically relevant scores for fatigue and cognitive impairment increased during treatment (at 9 months) compared with baseline. After treatment cessation (at 18 months), the percentage of patients who reported clinically relevant scores for fatigue decreased. However, the percentages of patients who reported clinically relevant scores for emotional, cognitive, and social impairment increased at 18 months compared with during treatment. Most patients with emotional impairment at 9 and 18 months did not experience disease recurrence (91% and 89%, respectively)., Conclusions: These results confirm the real-world effectiveness and safety of nivolumab as an adjuvant treatment for patients with completely resected stage III or stage IV melanoma. Cancer-specific, disease-specific, and generic HRQoL were maintained during and after treatment. The percentage of patients reporting emotional and cognitive impairment increased after treatment cessation, emphasizing the need for further investigation and tailored supportive care in these patients.
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- 2023
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9. Novel reverse Ishiguro Kirschner wire technique for the repair of osseous flexor digitorum profundus avulsion injuries.
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Briffa J, Willemot L, Dong X, and Larsen M
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- Humans, Hand, Bone and Bones, Bone Wires, Finger Injuries surgery
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- 2023
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10. Fellowship Review: Launceston Regional Plastic Surgery Fellowship.
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Willemot L
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- Humans, United States, Fellowships and Scholarships, Education, Medical, Graduate, Surgery, Plastic education, Plastic Surgery Procedures, Internship and Residency
- Abstract
Competing Interests: Conflicts of interest and sources of funding: none declared.
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- 2023
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11. Introduction to surgical coaching.
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Willemot L, Lee MJ, and Mulford J
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- Humans, Clinical Competence, Mentoring methods, Surgeons, Burnout, Professional prevention & control
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Surgical coaching is a new approach to continuous professional development (CPD). Advocates claim that coaching improves surgical and non-technical skills, leading to enhanced performance and reduced stress and burnout. Widespread acceptance of coaching in the surgical community is limited due to a paucity of evidence, surgery-specific obstacles and lack of resources. This narrative review introduces what 'surgical coaching' is and describes its origins. Coaching techniques are based on live or video observation of procedures, followed by collaborative analysis, reflection and goal planning in a non-competitive setting aided by an expert, peer or lay coach. Technical skills improvements have been reported using coaching techniques, yet long-term influence on non-technical competencies, overall performance and surgeon wellbeing are largely hypothetical. There are clear potential benefits in the application of surgical coaching to daily surgical practice. However, significant knowledge gaps remain. Dedicated research into the short-term applicability and the long-term effects of surgical coaching are required., (© 2023 Royal Australasian College of Surgeons.)
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- 2023
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12. Reconstruction of an infected midshaft radius and ulna nonunion using a free vascularized fibula and medial femoral condyle flap.
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Willemot L, Stewart D, and Lawson R
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- Adult, Bone Transplantation, Fibula surgery, Humans, Radius surgery, Ulna, Young Adult, Free Tissue Flaps, Plastic Surgery Procedures
- Abstract
Conventional grafts do not perform well in the treatment of large diaphyseal bone defects. Forearm nonunions are especially challenging due to complex biomechanical and kinematic demands. Free bone flaps may yield more predictable bony restoration in these cases, while keeping morbidity acceptable to the patient. We aim to illustrate one combination of flaps which can be used in these conditions. This article reports on a 23 year old patient with an 8 cm diaphyseal nonunion of the radius and a similar 7 cm defect of the ulna after infection of fracture fixation hardware. The radius was treated with a free fibular flap (FFF) and the ulna with a medial femoral condyle (MFC) flap in a staged procedure after initial debridement. The patient was followed up for 6 months without significant complications. Both flaps healed within 3 months, yet the MFC demonstrated faster bony incorporation. We attributed this to the spongious nature of the MFC flap compared to the thick cortical FFF. This case report hopes to illustrate one type of flap combination for extensive forearm bone defects. The selection and approach minimizes donor site morbidity to a single limb and possibly hastens bony union of the forearm., (© 2021 Wiley Periodicals LLC.)
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- 2021
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13. Analysis of failures after the Bristow-Latarjet procedure for recurrent shoulder instability.
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Willemot L, De Boey S, Van Tongel A, Declercq G, De Wilde L, and Verborgt O
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- Adult, Arthroplasty methods, Bone Transplantation methods, Coracoid Process diagnostic imaging, Female, Humans, Joint Instability diagnostic imaging, Joint Instability etiology, Male, Recurrence, Reoperation, Retrospective Studies, Shoulder diagnostic imaging, Shoulder surgery, Shoulder Injuries, Shoulder Joint diagnostic imaging, Shoulder Joint pathology, Treatment Failure, Young Adult, Arthroplasty adverse effects, Bone Transplantation adverse effects, Coracoid Process transplantation, Joint Instability surgery, Shoulder Joint surgery
- Abstract
Purpose: Despite good clinical results and low recurrence rates, post-operative complications of coracoid process transfer procedures are not well understood. This study aims to evaluate the underlying failure mechanism in cases requiring major open revision surgery after prior Bristow or Latarjet stabilization., Methods: Between January 2006 and January 2017, 26 patients underwent major open revision after primary Bristow or Latarjet procedure. Clinical notes and radiographic images were retrospectively reviewed for all cases to determine underlying pathology. Choice of treatment and clinical and radiographic outcome were similarly reported for all cases., Results: The underlying failure mechanism was associated with non-union in 42.3%, resorption in 23.1%, graft malpositioning in 15.4%, and trauma or graft fracture in 19.2% of cases. Although none of the patients reported any dislocations, mean subjective shoulder score was 60.2% and WOSI scores averaged 709.3 points at final follow-up. Radiographic signs of deteriorating degenerative arthritis were seen in 34.6%., Conclusion: Graft non-union resulting in recurrent instability was the main indication for open revision surgery after Bristow or Latarjet procedure, followed by resorption, malpositioning, and graft fracture in this retrospective case series. Revision surgery consisted of a structural iliac crest bone graft in the majority of cases. Clinical and radiographic outcomes are predictably variable in this population of multioperated patients.
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- 2019
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14. Valgus instability of the elbow: acute and chronic form.
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Willemot L, Hendrikx FR, Byrne AM, and van Riet RP
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There has been an increase in thrower-specific elbow injuries in recent years. High valgus stresses during the late cocking and acceleration phases of throwing need to be compensated by the flexor pronator muscles as these can exceed the tensile strength of the medial collateral ligament complex. Prevention of injuries is the priority, with a focus on strengthening, reducing throwing frequency, decreasing force, and promoting a technique. The spectrum of thrower injuries ranges from a simple sprain to complete failure of the valgus stabilizing factors. The medial collateral ligament can stretch, leading to posteromedial impingement and radiocapitellar compression forces. This in turn can result in arthrosis and the formation of osteophytes. Ligament failure may eventually occur, making it impossible for the athlete to continue their throwing activities. The outcome of conservative treatment with strengthening, improvement of technique, and relative rest is often disappointing. Direct repair may no longer be possible in these acute-on-chronic injuries and a reconstruction with a tendon graft may be necessary., Competing Interests: Compliance with ethical guidelinesR.P. van Riet is a consultant with Acumed and Wright Medical. L. Willemot, F.R. Hendrikx, and A.-M. Byrne declare that they have no competing interests.
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- 2018
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15. Radiological and clinical outcome of arthroscopic labral repair with all-suture anchors.
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Willemot L, Elfadalli R, Jaspars KC, Ahw MH, Peeters J, Jansen N, Declerq G, and Verborgt O
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- Adolescent, Adult, Arthroscopy adverse effects, Female, Humans, Joint Instability diagnostic imaging, Male, Middle Aged, Postoperative Complications, Prospective Studies, Radiography, Shoulder Joint diagnostic imaging, Treatment Outcome, Young Adult, Arthroscopy methods, Joint Instability surgery, Shoulder Joint surgery, Suture Anchors
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Purpose: The aim of this study was to assess radiological and clinical outcome after arthroscopic all--suture anchor labral repair., Method: 20 patients treated for anterior and superior labral instability (mean age 29, range 14-51 years) were assessed at a minimum follow-up time of 1 year (mean 19 months ; range, 12-28 months). Postoperative MRI scans were assessed by 3 independent radiologists. The radiological appearance of bone at the anchor-site was judged by the presence of cyst formation, tunnel widening (> 2 mm) or bone edema. Clinical outcome analysis included standard follow-up and the Disabilities of the Arm, Shoulder and Hand score (DASH), Constant Shoulder score and the Western Ontario Shoulder Instability Index (WOSI)., Result: All patients were available for follow-up. In total, 58 all-suture anchors were implanted. None of the patients displayed large cyst formation. Small cysts were found in two patients (2 anchors). Tunnel widening was apparent in 3 patients (3 anchors) with an average widening of 3.3 mm (range 3-4 mm). Bone edema at the anchor-site was seen in 6 patients (8 anchors). The remaining 9 patients (45 anchors) did not display reactive bone changes. Clinical outcomes showed a WOSI of 70.6, a DASH of 18.9 and a Constant score of 89.3, and no recurrence of instability., Conclusions: Satisfying radiological and clinical outcome was observed after arthroscopic instability surgery using all-suture anchors. Imaging revealed good labral healing without important bony reactions or the formation of large cysts at early follow-up. Level of evidence : IV Case series.
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- 2016
16. 3D printed guides for controlled alignment in biomechanics tests.
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Verstraete MA, Willemot L, Van Onsem S, Stevens C, Arnout N, and Victor J
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- Aged, Biomechanical Phenomena, Cadaver, Computer Simulation, Equipment Design, Female, Femur physiology, Humans, Knee physiology, Knee Joint physiology, Male, Reproducibility of Results, Software, Tibia physiology, Printing, Three-Dimensional
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The bone-machine interface is a vital first step for biomechanical testing. It remains challenging to restore the original alignment of the specimen with respect to the test setup. To overcome this issue, we developed a methodology based on virtual planning and 3D printing. In this paper, the methodology is outlined and a proof of concept is presented based on a series of cadaveric tests performed on our knee simulator. The tests described in this paper reached an accuracy within 3-4° and 3-4mm with respect to the virtual planning. It is however the authors' belief that the method has the potential to achieve an accuracy within one degree and one millimeter. Therefore, this approach can aid in reducing the imprecisions in biomechanical tests (e.g. knee simulator tests for evaluating knee kinematics) and improve the consistency of the bone-machine interface., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
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- 2016
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17. Mid-range shoulder instability modeled as a cam-follower mechanism.
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Willemot L, Thoreson A, Ryan Breighner, Hooke A, Verborgt O, and An KN
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- Biomechanical Phenomena, Humans, Humeral Head physiopathology, Models, Biological, Range of Motion, Articular, Shoulder physiopathology, Joint Instability physiopathology, Shoulder Joint physiopathology
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In this paper, we model a simplified glenohumeral joint as a cam-follower mechanism during experimental simulated dislocation. Thus, humeral head trajectory and translational forces are predicted using only contact surface geometry and compressive forces as function inputs. We demonstrate this new interpretation of glenohumeral stability and verify the accuracy of the method by physically testing a custom-molded, idealized shoulder model and comparing data to the output of the 2D mathematical model. Comparison of translational forces between experimental and mathematical approaches resulted in r(2) of 0.88 and 0.90 for the small and large humeral head sizes, respectively. Comparison of the lateral displacement resulted in r(2) of 0.99 and 0.98 for the small and larger humeral head sizes, respectively. Comparing translational forces between experiments and the mathematical model when varying the compressive force to 30 N, 60 N, and 90 N resulted in r(2) of 0.90, 0.82, and 0.89, respectively. The preliminary success of this study is motivation to introduce the effects of soft tissue such as cartilage and validation with a cadaver model. The use of simple mathematical models such as this aid in the set-up and understanding of experiments in stability research and avoid unnecessary depletion of cadaveric resources., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
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- 2015
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18. Neonatal cephalohematoma.
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Willemot L, Lagae P, Jeannin P, Baelde N, and Verstraete K
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- Brain Diseases complications, Cerebral Hemorrhage etiology, Hematoma etiology, Humans, Infant, Newborn, Brain Diseases diagnosis, Cerebral Hemorrhage diagnosis, Hematoma diagnosis
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- 2013
- Full Text
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19. Two-year follow-up study on clinical and radiological outcomes of polyurethane meniscal scaffolds.
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De Coninck T, Huysse W, Willemot L, Verdonk R, Verstraete K, and Verdonk P
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- Adolescent, Adult, Arthroscopy, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Polyurethanes therapeutic use, Prosthesis Design, Tibial Meniscus Injuries, Young Adult, Menisci, Tibial surgery, Prosthesis Implantation, Tissue Scaffolds
- Abstract
Background: Little is known about radial displacement (RD) of polyurethane (PU) scaffolds, intended for partial meniscus defect substitution; no data are available on whether rim thickness influences RD and whether RD correlates with clinical outcome scores., Hypotheses: The meniscus is not extruded preoperatively, but RD occurs after scaffold implantation. A thicker rim will limit RD, and there is no correlation between RD and clinical outcome., Study Design: Case series; Level of evidence, 4., Methods: Twenty-six patients were implanted with a PU scaffold (8 lateral, 18 medial). Radial displacement (mm) was evaluated on magnetic resonance images preoperatively and at 3 months, 1 year, and 2 years postoperatively. At each time point, it was determined whether a correlation existed between the rim and RD. Clinical outcome was determined using a visual analog scale (VAS) for pain as well as the Lysholm knee scoring scale, Knee Injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) score., Results: Radial displacement of lateral scaffolds was not significantly different (P = .178) either preoperatively (mean ± SD, 3.42 ± 0.99 mm) or at 3 months (4.82 ± 0.59 mm), 1 year (4.55 ± 0.87 mm), or 2 years postoperatively (4.10 ± 0.93 mm). No correlation was observed between the rim and lateral RD at all time points. Medial scaffold RD increased significantly (P < .001) from preoperative values (2.17 ± 0.84 mm) to those at 3 months (4.25 ± 0.89 mm), 1 year (4.43 ± 1.01 mm), and 2 years postoperatively (4.41 ± 0.96 mm). A strong negative correlation between medial RD and the rim was observed at all time points. There was no significant correlation between clinical outcome scores and RD, either preoperatively or postoperatively., Conclusion: This study demonstrated that limited medial meniscal RD was present preoperatively but increased by 2 mm after scaffold implantation. Lateral RD was also present preoperatively but did not increase after scaffold implantation. Importantly, a strong negative correlation was found between the rim and postoperative medial RD; a thicker rim limited RD. However, in the lateral compartment, rim thickness did not correlate with RD because RD was already strongly present preoperatively. Finally, no correlations were observed between scaffold RD and clinical outcome scores, either preoperatively or postoperatively.
- Published
- 2013
- Full Text
- View/download PDF
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