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1. Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol

Author

Van Bennekum, Ariette, Werder, Moritz, Thuahnai, Stephen T., Chang-Hoon Han, Phu Duong, Willaims, David L., Wettstein, Philipp, Schulthess, Georg, Phillips, Michael C., and Hauser, Helmut

Subjects
Absorption -- Research, Beta carotene -- Chemical properties, Cholesterol -- Chemical properties, Biological sciences, Chemistry
Abstract

Beta-carotene and cholesterol absorption in wild type and scavenger receptor class B type I (SR-BI) knockout mice and the uptake of these lipids in vitro were measured using brush border membrane (BBM) vesicles. The analysis shows that ezetimibe, a representative of a new class of drugs that inhibit intestinal cholesterol absorption, blocks SR-BI- and CD36-facilitated uptake of cholesterol into COS-7 cells.

Published
2005

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