Search

Your search keyword '"Willaime, Hervé"' showing total 19 results
Start Over Author "Willaime, Hervé"
19 results on '"Willaime, Hervé"'

1. Vortex density spectrum of quantum turbulence

Author

Roche, Philippe-Emmanuel P. -E., Diribarne, Pantxo, Didelot, Thomas, Français, Olivier, Rousseau, Lionel, and Willaime, Hervé

Subjects
Condensed Matter - Other Condensed Matter, Physics - Classical Physics
Abstract

The fluctuations of the vortex density in a turbulent quantum fluid are deduced from local second-sound attenuation measurements. These measurements are performed with a micromachined open-cavity resonator inserted across a flow of turbulent He-II near 1.6 K. The power spectrum of the measured vortex line density is compatible with a (-5/3) power law. The physical interpretation, still open, is discussed., Comment: Submitted to Europhys. Lett

Published
2007
Full Text
View/download PDF

14. Bubble phononic crystals

Author

Bretagne, Alice, primary, Tourin, Arnaud, additional, Tabeling, Patrick, additional, Leroy, Valentin, additional, Pannacci, Nicolas, additional, Willaime, Hervé, additional, and Fink, Mathias, additional

Published
2008
Full Text
View/download PDF

17. ‘Green’ fluorine-free mesoporous iron(III) trimesate nanoparticles for drug delivery

Author

Willaime, Hervé, Gref, Ruxandra, Horcajada, Patricia, Couvreur, Patrick, Rodriguez-Ruiz, Violeta, Agostoni, Valentina, and Serre, Christian

Abstract

A comparison of the properties of the highly porous iron(III) trimesate MIL-100 nanoparticles (nano-MOFs) obtained through a hydrofluoric acid-free ‘green’ synthesis route with those obtained from the ‘conventional’ HF procedure is reported, in terms of particle crystallinity, porosity and space time yield (STY). It appears that the use of more concentrated reaction conditions have led to the highest STY values while maintaining a good degree of purity. As the fluorinated nano-MOFs, the F-free solids are able to encapsulate high payloads of a challenging antiviral drug, azidothymidine triphosphate, and to release it on a progressive manner. Furthermore, the F-free nano-MOFs were shown to be highly taken up by macrophages, targets for antiviral therapy, without inducing any detectable toxic side effects. This study opens up novel perspectives for the large-scale synthesis of ‘green’ MIL-100 nano-MOFs for biomedical applications. Supplementary information will be available at http://www.icevirtuallibrary.com/upload/10.1680gmat.13.00001_SupplementaryInformation.pdf

Published
2016
Full Text
View/download PDF

18. Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles

Author

Agostoni, Valentina, Chalati, Tamim, Horcajada, Patricia, Willaime, Hervé, Anand, Resmi, Semiramoth, Nicolas, Baati, Tarek, Hall, Shaun, Maurin, Guillaume, Chacun, Hélène, Bouchemal, Kawthar, Martineau, Charlotte, Taulelle, Francis, Couvreur, Patrick, Rogez-Kreuz, Christine, Clayette, Pascal, Monti, Sandra, Serre, Christian, Gref, Ruxandra, Agostoni, Valentina, Chalati, Tamim, Horcajada, Patricia, Willaime, Hervé, Anand, Resmi, Semiramoth, Nicolas, Baati, Tarek, Hall, Shaun, Maurin, Guillaume, Chacun, Hélène, Bouchemal, Kawthar, Martineau, Charlotte, Taulelle, Francis, Couvreur, Patrick, Rogez-Kreuz, Christine, Clayette, Pascal, Monti, Sandra, Serre, Christian, and Gref, Ruxandra

Abstract

Nanoscale mesoporous iron carboxylates metal-organic frameworks (nanoMOFs) have recently emerged as promising platforms for drug delivery, showing biodegradability, biocompatibility and important loading capability of challenging highly water-soluble drugs such as azidothymidine tryphosphate (AZT-TP). In this study, nanoMOFs made of iron trimesate (MIL-100) were able to act as efficient molecular sponges, quickly adsorbing up to 24 wt% AZT-TP with entrapment efficiencies close to 100%, without perturbation of the supramolecular crystalline organization. These data are in agreement with molecular modelling predictions, indicating maximal loadings of 33 wt% and preferential location of the drug in the large cages. Spectrophotometry, isothermal titration calorimetry, and solid state NMR investigations enable to gain insight on the mechanism of interaction of AZT and AZT-TP with the nanoMOFs, pointing out the crucial role of phosphates strongly coordinating with the unsaturated iron(III) sites. Finally, contrarily to the free AZT-TP, the loaded nanoparticles efficiently penetrate and release their cargo of active triphosphorylated AZT inside major HIV target cells, efficiently protecting against HIV infection.

Full Text
View/download PDF

19. Monodisperse colloids synthesized with nanofluidic technology.

Author

Malloggi F, Pannacci N, Attia R, Monti F, Mary P, Willaime H, Tabeling P, Cabane B, and Poncet P

Subjects
Animals, Colloids chemical synthesis, Colloids chemistry, Drug Delivery Systems, Macrophages chemistry, Mice, Nanotechnology, Particle Size, Surface Properties, Microfluidic Analytical Techniques methods
Abstract

Limitations in the methods employed to generate micrometric colloidal droplets hinder the emergence of key applications in the fields of material science and drug delivery. Through the use of dedicated nanofluidic devices and by taking advantage of an original physical effect called capillary focusing, we could circumvent some of these limitations. The nanofluidic (i.e., submicrometric) devices introduced herein are made of soft materials, and their fabrication relies upon rapid technologies. The objects that we have generated are simple droplets, multiple droplets, particles, and Janus particles whose sizes lie between 900 nm and 3 microm (i.e., within the colloidal range). Colloidal droplets have been assembled on-chip into clusters and crystals, yielding discrete diffraction patterns. We illustrate potential applications in the field of drug delivery by demonstrating the ability of multiple droplets to be phagocytosed by murine macrophage-type cells.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results