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251 results on '"Willén, Helena"'

9. Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry

Author

Willén Helena, Kjærheim Kristina, Røe Oluf D, Sandeck Helmut P, and Larsson Erik

Subjects
Pathology, RB1-214
Abstract

Abstract Background In order to provide reliable tissue material for malignant mesothelioma (MM) studies, we re-evaluated biopsies and autopsy material from 61 patients with a diagnosis of MM from the period of 1980-2002. Methods Basic positive (Calretinin, EMA, Podoplanin, Mesothelin) and negative (CEA, Ber-Ep4) immunohistochemical (IHC) marker reactions were determined. If needed, more markers were used. Histological diagnoses were made by three pathologists. Survival data were calculated. Results 49 cases (80%) were considered being MM by a high degree of likelihood, five more cases possible MM. Of the remaining seven cases, three were diagnosed as adenocarcinoma, three as pleomorphic lung carcinoma, in one peritoneal case a clear entity diagnosis could not be given. One of the possible MM cases and two of the lung carcinoma cases had this already as primary diagnoses, but were registered as MM. With a sensitivity of 100%, Calretinin and CEA were the most reliable single markers. The amount of MM cells with positive immunoreactivity (IR) for Podoplanin and Mesothelin showed most reliable inverse relation to the degree of atypia. In the confirmed MM cases, there had been applied either no IHC or between one and 18 markers. The cases not confirmed by us had either lacked IHC (n = 1), non-specific markers were used (n = 4), IR was different (n = 1), or specific markers had not shown positive IR in the right part of the tumour cells (n = 3). 46 of the 49 confirmed and three of the not confirmed cases had been diagnosed by us as most likely MM before IHC was carried out. Conclusions In order to use archival tissue material with an earlier MM diagnosis for studies, histopathological re-evaluation is important. In possible sarcomatous MM cases without any positive IR for positive MM markers, radiology and clinical picture are essential parts of diagnostics. IHC based on a panel of two positive and two negative MM markers has to be adapted to the differential diagnostic needs in each single case. New diagnostic tools and techniques are desirable for cases where IHC and other established methods cannot provide a clear entity diagnosis, and in order to improve MM treatment.

Published
2010
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17. Unclassified sarcomas: a study to improve classification in a cohort of Golden Retriever dogs

Author

Boerkamp, Kim M, Hellmén, Eva, Willén, Helena, Grinwis, Guy C M, Teske, Erik, Rutteman, Gerard R, dCSCA AVR, dPB CR, Applied Veterinary Research, Sub Oncologie/Cytologie, Veterinair Pathologisch Diagnostisch Cnt, Dep Pathobiologie, dCSCA RMSC-2, dCSCA AVR, dPB CR, Applied Veterinary Research, Sub Oncologie/Cytologie, Veterinair Pathologisch Diagnostisch Cnt, Dep Pathobiologie, and dCSCA RMSC-2

Subjects
Pathology, medicine.medical_specialty, 040301 veterinary sciences, H&E stain, Soft Tissue Neoplasms, 0403 veterinary science, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Dogs, medicine, Animals, Dog Diseases, Medical diagnosis, General Veterinary, business.industry, Soft tissue sarcoma, Not Otherwise Specified, Sarcoma, 04 agricultural and veterinary sciences, soft-tissue sarcoma, medicine.disease, Classification, Immunohistochemistry, 3. Good health, unclassified, Classification, dogs, immunohistochemistry, soft-tissue sarcoma, unclassified, 030220 oncology & carcinogenesis, Cohort, Who classification, business
Abstract

Morphologically, canine soft-tissue sarcomas (STSs) resemble human STSs. In humans, proper classification of STSs is considered essential to improve insight in the biology of these tumors, and to optimize diagnosis and therapy. To date, there is a paucity of data published on the significance of detailed classification of STSs in the dog. We revised a cohort ( n = 110) of proliferative lesions obtained from a study in Golden Retrievers that were considered “soft tissue sarcoma, not otherwise specified or of uncertain subtype” in order to optimize the diagnoses of these lesions. The criteria according to the veterinary WHO classification, recent veterinary literature, and the WHO classification for humans were applied. Revision was initially based on morphologic characteristics of hematoxylin and eosin–stained histologic sections of the neoplasms. If considered necessary ( n = 76), additional immunohistochemistry was applied to aid characterization. The diagnosis of STS was confirmed in 75 neoplasms (68%). Of this group, diagnosis of a specific subtype of the STSs was possible in 58 neoplasms. Seven neoplasms had morphologic characteristics that were suggestive for sarcoma subtypes only described in the WHO classification for humans. Seventeen neoplasms remained “unclassified STSs.” Thirty-one lesions (28%) were diagnosed “neoplasm, not being STS.” Four lesions (4%) were considered nonneoplastic. Because incorrect classification of a tumor could lead to inappropriate therapeutic intervention and prognostication, the results of our study clearly illustrate the importance of revision and further diagnosis of “unclassified STSs” in dogs.

Published
2016

18. Unclassified sarcomas

Author

Boerkamp, Kim M., primary, Hellmén, Eva, additional, Willén, Helena, additional, Grinwis, Guy C. M., additional, Teske, Erik, additional, and Rutteman, Gerard R., additional

Published
2016
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32. The Myxoid/Round Cell Liposarcoma Fusion Oncogene FUS-DDIT3 and the Normal DDIT3 Induce a Liposarcoma Phenotype in Transfected Human Fibrosarcoma Cells

Author

Engström, Katarina, primary, Willén, Helena, additional, Kåbjörn-Gustafsson, Christina, additional, Andersson, Carola, additional, Olsson, Marita, additional, Göransson, Melker, additional, Järnum, Sofia, additional, Olofsson, Anita, additional, Warnhammar, Elisabeth, additional, and Åman, Pierre, additional

Published
2006
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35. Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group

Author

Tallini, Giovanni, primary, Dorfman, Howard, additional, Brys, Peter, additional, Dal Cin, Paola, additional, De Wever, Ivo, additional, Fletcher, Christopher D. M., additional, Jonson, Kjell, additional, Mandahl, Nils, additional, Mertens, Fredrik, additional, Mitelman, Felix, additional, Rosai, Juan, additional, Rydholm, Anders, additional, Samson, Ignace, additional, Sciot, Raf, additional, Van den Berghe, Herman, additional, Vanni, Roberta, additional, and Willén, Helena, additional

Published
2001
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38. Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP study group

Author

Mertens, Fredrik, primary, Dal Cin, Paola, additional, De Wever, Ivo, additional, Fletcher, Christopher D. M., additional, Mandahl, Nils, additional, Mitelman, Felix, additional, Rosai, Juan, additional, Rydholm, Anders, additional, Sciot, Raf, additional, Tallini, Giovanni, additional, van den Berghe, Herman, additional, Vanni, Roberta, additional, and Willén, Helena, additional

Published
2000
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41. Chemotherapy in osteosarcoma

Author

Sæter, Gunnar, primary, Wiebe, Thomas, additional, Wiklund, Tom, additional, Monge, Odd, additional, Wahlqvist, Yngve, additional, Engström, Katarina, additional, Forestier, Erik, additional, Holmström, Teddy, additional, Stenwig, Anna E, additional, Willén, Helena, additional, Brosjö, Otte, additional, Follerås, Gunnar, additional, Alvegård, Thor A, additional, and Strander, Hans, additional

Published
1999
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42. Morphologic review of 1000 soft tissue sarcomas from the Scandinavian Sarcoma Group (SSG) Register

Author

Meis-Kindblom, Jeanne M, primary, Bjerkehage, Bodil, additional, Böhling, Tom, additional, Domanski, Henryk, additional, Halvorsen, Tore B, additional, Larsson, Olle, additional, Lilleng, Peer, additional, Myhre-Jensen, Olaf, additional, Stenwig, Elisabeth, additional, Virolainen, Martti, additional, Willén, Helena, additional, Åkerman, Måns, additional, and Kindblom, Lars-Gunnar, additional

Published
1999
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45. Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: A report of the CHAMP study group

Author

Mertens, Fredrik, primary, Fletcher, Christopher D. M., additional, Dal Cin, Paola, additional, De Wever, Ivo, additional, Mandahl, Nils, additional, Mitelman, Felix, additional, Rosai, Juan, additional, Rydholm, Anders, additional, Sciot, Raf, additional, Tallini, Giovanni, additional, Van den Berghe, Herman, additional, Vanni, Roberta, additional, and Willén, Helena, additional

Published
1998
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46. Comparison of Chromosomal Patterns with Clinical Features in 165 Lipomas: A Report of the CHAMP Study Group

Author

Willén, Helena, primary, Åkerman, Måns, additional, Dal Cin, Paola, additional, De Wever, Ivo, additional, Fletcher, Christopher D.M, additional, Mandahl, Nils, additional, Mertens, Fredrik, additional, Mitelman, Felix, additional, Rosai, Juan, additional, Rydholm, Anders, additional, Sciot, Raf, additional, Tallini, Giovanni, additional, Van Den Berghe, Herman, additional, and Vanni, Roberta, additional

Published
1998
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49. Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors. A report of the CHAMP collaborative study group

Author

Mandahl, Nils, primary, Åkerman, Måns, additional, Åman, Pierre, additional, Dal Cin, Paola, additional, De Wever, Ivo, additional, Fletcher, Christopher D. M., additional, Mertens, Fredrik, additional, Mitelman, Felix, additional, Rosai, Juan, additional, Rydholm, Anders, additional, Sciot, Raf, additional, Tallini, Giovanni, additional, Van den Berghe, Herman, additional, Van de Ven, Wim, additional, Vanni, Roberta, additional, and Willén, Helena, additional

Published
1996
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