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405 results on '"Wilke, Lee G."'

6. Engaging Multidisciplinary Teams to Develop Pragmatic Clinical Practice Guidelines to Support Management of Patients With High-Risk Breast Lesions

Author

Neuman, Heather B., Wilke, Lee G., Bozzuto, Laura M., Stelle, Lacey, Melnick, David, Elezaby, Mai, Woods, Ryan W., Chase, Peter, McGregor, Stephanie, Harter, Jo, Weissman, Paul, Greenberg, Caprice C., Burnside, Elizabeth, Fowler, Amy M., DeMartini, Wendy B., Salkowski, Lonie R., and Strigel, Roberta M.

Published
2025
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7. Covid-19 related oncologist’s concerns about breast cancer treatment delays and physician well-being (the CROWN study)

Author

Yao, Katharine A, Attai, Deanna, Bleicher, Richard, Kuchta, Kristine, Moran, Meena, Boughey, Judy, Wilke, Lee G, Dietz, Jill R, Stevens, Randy, Pesce, Catherine, Kopkash, Katherine, Kurtzman, Scott, Sarantou, Terry, and Victorson, David

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Behavioral and Social Science, Prevention, Breast Cancer, Good Health and Well Being, Anxiety, Breast Neoplasms, Burnout, Professional, COVID-19, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Oncologists, Sleep, Surgeons, Surveys and Questionnaires, Time-to-Treatment, United States, Breast cancer delays, Physician well being, COVID-19 treatment delays, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeTo examine how treatment delays brought on by the COVID-19 pandemic impacted the physical and emotional well-being of physicians treating these patients.MethodsA cross-sectional survey of physician breast specialists was posted from April 23rd to June 11th, 2020 on membership list serves and social media platforms of the National Accreditation Program for Breast Centers and the American Society of Breast Surgeons. Physician well-being was measured using 6 COVID-19 burnout emotions and the 4-item PROMIS short form for anxiety and sleep disturbance. We examined associations between treatment delays and physician well-being, adjusting for demographic factors, COVID-19 testing and ten COVID-19 pandemic concerns.Results870 physicians completed the survey, 61% were surgeons. The mean age of physicians was 52 and 548 (63.9%) were female. 669 (79.4%) reported some delay in patient care as a result of the COVID-19 pandemic. 384 (44.1%) and 529 (60.8%) of physicians scored outside normal limits for anxiety and sleep disturbance, respectively. After adjusting for demographic factors and COVID-19 testing, mean anxiety and COVID-19 burnout scores were significantly higher among physicians whose patients experienced either delays in surgery, adjuvant chemotherapy, radiation, breast imaging or specialty consultation. A multivariable model adjusting for ten physician COVID-19 concerns and delays showed that "delays will impact my emotional well-being" was the strongest concern associated with anxiety, sleep disturbance and COVID-19 burnout factors.ConclusionsBreast cancer treatment delays during the initial surge of the COVID-19 pandemic in the United States were associated with a negative impact on physician emotional wellness.

Published
2021

8. Transforming the Future of Surgeon-Scientists

Author

Ladner, Daniela P., Goldstein, Allan M., Billiar, Timothy R., Cameron, Andrew M., Carpizo, Darren R., Chu, Daniel I., Coopersmith, Craig M., DeMatteo, Ronald P., Feng, Sandy, Gallagher, Katherine A., Gillanders, William E., Lal, Brajesh K., Lipshutz, Gerald S., Liu, Annie, Maier, Ronald V., Mittendorf, Elizabeth A., Morris, Arden M., Sicklick, Jason K., Velazquez, Omaida C., Whitson, Bryan A., Wilke, Lee G., Yoon, Sam S., Zeiger, Martha A., Farmer, Diana L., and Hwang, E. Shelley

Published
2024
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16. Cancer registries: A look back and forward.

Author

Wilke, Lee G.

Subjects
*ELECTRONIC health records, *DIGITAL health, *ELECTRONIC records, *MEDICAL care, *PRIVACY
Abstract

As electronic health records and detailed digital health data are standardized and become more accessible with associated privacy support, cancer registries both nationally and worldwide will also continue to improve and provide rich resources for epidemiologic, health services, and outcomes research. [ABSTRACT FROM AUTHOR]

Published
2025
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27. Disorders of the Breast

Author

Zens, Tiffany, Wilke, Lee G., Mattei, Peter, editor, Nichol, Peter F., editor, Rollins, II, Michael D., editor, and Muratore, Christopher S., editor

Published
2017
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28. Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF

Author

Bean, Gregory R, Bryson, Andrew D, Pilie, Patrick G, Goldenberg, Vanessa, Baker, Joseph C, Ibarra, Catherine, Brander, Danielle MU, Paisie, Carolyn, Case, Natalie R, Gauthier, Mona, Reynolds, Paul A, Dietze, Eric, Ostrander, Julie, Scott, Victoria, Wilke, Lee G, Yee, Lisa, Kimler, Bruce F, Fabian, Carol J, Zalles, Carola M, Broadwater, Gloria, Tlsty, Thea D, and Seewaldt, Victoria L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Genetics, Breast Cancer, Prevention, Women's Health, Aging, 2.1 Biological and endogenous factors, Adult, Aged, Breast Neoplasms, Cyclin-Dependent Kinase Inhibitor p16, DNA Methylation, Epithelial Cells, Female, Gene Silencing, Humans, Mammary Glands, Human, Middle Aged, Promoter Regions, Genetic, Risk, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Purposep16(INK4a) has been appreciated as a key regulator of cell cycle progression and senescence. Cultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction, centrosomal dysfunction, a sustained stress response, and, most recently, a dysregulation of chromatin remodeling and DNA methylation. These data suggest that cells that lack p16(INK4a) activity would be at high risk for breast cancer development and may exhibit an increased frequency of DNA methylation events in early cancer.Experimental designTo test this hypothesis, the frequencies of INK4a/ARF promoter hypermethylation, as well as four additional selected loci, were tested in the initial random periareolar fine needle aspiration samples from 86 asymptomatic women at high risk for development of breast cancer, stratified using the Masood cytology index.ResultsINK4a/ARF promoter hypermethylation was observed throughout all early stages of intraepithelial neoplasia and, importantly, in morphologically normal-appearing mammary epithelial cells; 29 of 86 subjects showed INK4a/ARF promoter hypermethylation in at least one breast. Importantly, INK4a/ARF promoter hypermethylation was not associated with atypia, and the frequency of hypermethylation did not increase with increasing Masood cytology score. The frequency of INK4a/ARF promoter hypermethylation was associated with the combined frequency of promoter hypermethylation of retinoic acid receptor-beta2, estrogen receptor-alpha, and breast cancer-associated 1 genes (P = 0.001).ConclusionsBecause INK4a/ARF promoter hypermethylation does not increase with age but increases with the frequency of other methylation events, we predict that INK4a/ARF promoter hypermethylation may serve as a marker of global methylation dysregulation.

Published
2007

36. Data from Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS–STING Signaling in Triple-Negative Breast Cancer

Author

Hu, Yang, primary, Manasrah, Baraa K., primary, McGregor, Stephanie M., primary, Lera, Robert F., primary, Norman, Roshan X., primary, Tucker, John B., primary, Scribano, Christina M., primary, Yan, Rachel E., primary, Humayun, Mouhita, primary, Wisinski, Kari B., primary, Tevaarwerk, Amye J., primary, O'Regan, Ruth M., primary, Wilke, Lee G., primary, Weaver, Beth A., primary, Beebe, David J., primary, Jin, Ning, primary, and Burkard, Mark E., primary

Published
2023
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38. Video 1 from Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS–STING Signaling in Triple-Negative Breast Cancer

Author

Hu, Yang, primary, Manasrah, Baraa K., primary, McGregor, Stephanie M., primary, Lera, Robert F., primary, Norman, Roshan X., primary, Tucker, John B., primary, Scribano, Christina M., primary, Yan, Rachel E., primary, Humayun, Mouhita, primary, Wisinski, Kari B., primary, Tevaarwerk, Amye J., primary, O'Regan, Ruth M., primary, Wilke, Lee G., primary, Weaver, Beth A., primary, Beebe, David J., primary, Jin, Ning, primary, and Burkard, Mark E., primary

Published
2023
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39. Supplementary Data from Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS–STING Signaling in Triple-Negative Breast Cancer

Author

Hu, Yang, primary, Manasrah, Baraa K., primary, McGregor, Stephanie M., primary, Lera, Robert F., primary, Norman, Roshan X., primary, Tucker, John B., primary, Scribano, Christina M., primary, Yan, Rachel E., primary, Humayun, Mouhita, primary, Wisinski, Kari B., primary, Tevaarwerk, Amye J., primary, O'Regan, Ruth M., primary, Wilke, Lee G., primary, Weaver, Beth A., primary, Beebe, David J., primary, Jin, Ning, primary, and Burkard, Mark E., primary

Published
2023
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40. Video 2 from Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS–STING Signaling in Triple-Negative Breast Cancer

Author

Hu, Yang, primary, Manasrah, Baraa K., primary, McGregor, Stephanie M., primary, Lera, Robert F., primary, Norman, Roshan X., primary, Tucker, John B., primary, Scribano, Christina M., primary, Yan, Rachel E., primary, Humayun, Mouhita, primary, Wisinski, Kari B., primary, Tevaarwerk, Amye J., primary, O'Regan, Ruth M., primary, Wilke, Lee G., primary, Weaver, Beth A., primary, Beebe, David J., primary, Jin, Ning, primary, and Burkard, Mark E., primary

Published
2023
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48. Contralateral Prophylactic Mastectomy Consensus Statement from the American Society of Breast Surgeons: Additional Considerations and a Framework for Shared Decision Making

Author

Boughey, Judy C., Attai, Deanna J., Chen, Steven L., Cody, Hiram S., Dietz, Jill R., Feldman, Sheldon M., Greenberg, Caprice C., Kass, Rena B., Landercasper, Jeffrey, Lemaine, Valerie, MacNeill, Fiona, Margenthaler, Julie A., Song, David H., Staley, Alicia C., Wilke, Lee G., Willey, Shawna C., and Yao, Katharine A.

Published
2016
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50. Contralateral Prophylactic Mastectomy (CPM) Consensus Statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks

Author

Boughey, Judy C., Attai, Deanna J., Chen, Steven L., Cody, Hiram S., Dietz, Jill R., Feldman, Sheldon M., Greenberg, Caprice C., Kass, Rena B., Landercasper, Jeffrey, Lemaine, Valerie, MacNeill, Fiona, Song, David H., Staley, Alicia C., Wilke, Lee G., Willey, Shawna C., Yao, Katharine A., and Margenthaler, Julie A.

Published
2016
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