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1. Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types

Author

Driessens, Stan L. W., Galakhova, Anna A., Heyer, Djai B., Pieterse, Isabel J., Wilbers, René, Mertens, Eline J., Waleboer, Femke, Heistek, Tim S., Coenen, Loet, Meijer, Julia R., Idema, Sander, de Witt Hamer, Philip C., Noske, David P., de Kock, Christiaan P. J., Lee, Brian R., Smith, Kimberly, Ting, Jonathan T., Lein, Ed S., Mansvelder, Huibert D., and Goriounova, Natalia A.

Published
2023
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2. Morpho-electric diversity of human hippocampal CA1 pyramidal neurons

Author

Mertens, Eline J., primary, Leibner, Yoni, additional, Pie, Jean, additional, Galakhova, Anna A., additional, Waleboer, Femke, additional, Meijer, Julia, additional, Heistek, Tim S., additional, Wilbers, René, additional, Heyer, Djai, additional, Goriounova, Natalia A., additional, Idema, Sander, additional, Verhoog, Matthijs B., additional, Kalmbach, Brian E., additional, Lee, Brian R., additional, Gwinn, Ryder P., additional, Lein, Ed S., additional, Aronica, Eleonora, additional, Ting, Jonathan, additional, Mansvelder, Huibert D., additional, Segev, Idan, additional, and de Kock, Christiaan P.J., additional

Published
2024
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3. Human neocortical expansion involves glutamatergic neuron diversification

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Published
2021
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4. Human voltage-gated Na + and K + channel properties underlie sustained fast AP signaling

Author

Wilbers, René, primary, Metodieva, Verjinia D., additional, Duverdin, Sarah, additional, Heyer, Djai B., additional, Galakhova, Anna A., additional, Mertens, Eline J., additional, Versluis, Tamara D., additional, Baayen, Johannes C., additional, Idema, Sander, additional, Noske, David P., additional, Verburg, Niels, additional, Willemse, Ronald B., additional, de Witt Hamer, Philip C., additional, Kole, Maarten H. P., additional, de Kock, Christiaan P. J., additional, Mansvelder, Huibert D., additional, and Goriounova, Natalia A., additional

Published
2023
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5. Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Published
2022
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6. Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling

Author

Sub Cell Biology, Cell Biology, Neurobiology and Biophysics, Wilbers, René, Metodieva, Verjinia D, Duverdin, Sarah, Heyer, Djai B, Galakhova, Anna A, Mertens, Eline J, Versluis, Tamara D, Baayen, Johannes C, Idema, Sander, Noske, David P, Verburg, Niels, Willemse, Ronald B, de Witt Hamer, Philip C, Kole, Maarten H P, de Kock, Christiaan P J, Mansvelder, Huibert D, Goriounova, Natalia A, Sub Cell Biology, Cell Biology, Neurobiology and Biophysics, Wilbers, René, Metodieva, Verjinia D, Duverdin, Sarah, Heyer, Djai B, Galakhova, Anna A, Mertens, Eline J, Versluis, Tamara D, Baayen, Johannes C, Idema, Sander, Noske, David P, Verburg, Niels, Willemse, Ronald B, de Witt Hamer, Philip C, Kole, Maarten H P, de Kock, Christiaan P J, Mansvelder, Huibert D, and Goriounova, Natalia A

Published
2023

7. Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling

Author

Wilbers, René, Metodieva, Verjinia D, Duverdin, Sarah, Heyer, Djai B, Galakhova, Anna A, Mertens, Eline J, Versluis, Tamara D, Baayen, Johannes C, Idema, Sander, Noske, David P, Verburg, Niels, Willemse, Ronald B, de Witt Hamer, Philip C, Kole, Maarten H P, de Kock, Christiaan P J, Mansvelder, Huibert D, Goriounova, Natalia A, Wilbers, René, Metodieva, Verjinia D, Duverdin, Sarah, Heyer, Djai B, Galakhova, Anna A, Mertens, Eline J, Versluis, Tamara D, Baayen, Johannes C, Idema, Sander, Noske, David P, Verburg, Niels, Willemse, Ronald B, de Witt Hamer, Philip C, Kole, Maarten H P, de Kock, Christiaan P J, Mansvelder, Huibert D, and Goriounova, Natalia A

Abstract

Human cortical pyramidal neurons are large, have extensive dendritic trees, and yet have unexpectedly fast input-output properties: Rapid subthreshold synaptic membrane potential changes are reliably encoded in timing of action potentials (APs). Here, we tested whether biophysical properties of voltage-gated sodium (Na+) and potassium (K+) currents in human pyramidal neurons can explain their fast input-output properties. Human Na+ and K+ currents exhibited more depolarized voltage dependence, slower inactivation, and faster recovery from inactivation compared with their mouse counterparts. Computational modeling showed that despite lower Na+ channel densities in human neurons, the biophysical properties of Na+ channels resulted in higher channel availability and contributed to fast AP kinetics stability. Last, human Na+ channel properties also resulted in a larger dynamic range for encoding of subthreshold membrane potential changes. Thus, biophysical adaptations of voltage-gated Na+ and K+ channels enable fast input-output properties of large human pyramidal neurons.

Published
2023

8. Fast and complex neural computation at the basis of cognition

Author

Wilbers, René and Wilbers, René

Abstract

In chapter 2, we recorded AP shapes and underlying Na+ and K+ currents in human cortical pyramidal neurons and compared them to rodents. We found that not only the AP shape, but also the underlying currents have remarkable stability, even when firing hundreds of consecutive APs at frequencies of 60 Hz. We then argued that biophysical adaptations in voltage-gated sodium and potassium channels must be responsible, and tested this by characterizing the voltage-dependent properties of the Na+ and K+ currents. We find that human Na+ and K+ currents had different biophysical features than their mouse counterparts. Then we used in silico models and found that indeed, the observed gating properties result in more stable APs. Furthermore, the models with human-like channel biophysics were able to reliably encode a larger range of inputs than models with rodent-like biophysics. Based on this we concluded that adaptations in the biophysical gating of Na+ and K+ channels contribute to the computational properties of human neurons. Fast Spiking interneurons (FSINs) are specialized in fast input-to-output conversion. The whole neuron is filled with adaptations that support this fast function. Therefore, this is the perfect neuron to study when interested in the speed limits of neural processing. In the human cortex, neurons are spaced further apart to make space for all the elaborate dendritic and axonal trees, which are much more interconnected than in rodents. This could potentially slow down neural signaling, as signals take time to travel and become weaker and slower over distance. Yet neural signaling seems not to be slow in human neurons. In this chapter, we investigated whether and how human FSINs can retain their fast function. We first characterized the dendritic morphology of these neurons and found that indeed, their dendritic paths are much longer. However, when we made paired recordings we did not find a slowdown of input and output, indicating that some compensatory

Published
2023
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9. Structural and functional specializations of human fastspiking neurons support fast cortical signaling.

Author

Wilbers, René, Galakhova, Anna A., Driessens, Stan L. W., Heistek, Tim S., Metodieva, Verjinia D., Hagemann, Jim, Heyer, Djai B., Mertens, Eline J., Suixin Deng, Idema, Sander, de Witt Hamer, Philip C., Noske, David P., van Schie, Paul, Kommers, Ivar, Guoming Luan, Tianfu Li, Yousheng Shu, de Kock, Christiaan P. J., Mansvelder, Huibert D., and Goriounova, Natalia A.

Subjects
*INTERNEURONS, *SODIUM channels, *NEURONS, *EXCITATORY postsynaptic potential
Abstract

The article focuses on understanding the mechanisms underlying fast cortical signaling in human fast-spiking interneurons (FSINs). The study compares human and mouse FSINs, revealing that despite elongated dendrites in human FSINs, they maintain fast inhibition through adaptations such as stronger excitatory inputs, larger dendrite diameter with reduced complexity, faster action potential initiation, and faster and larger inhibitory output.

Published
2023
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10. Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling.

Author

Wilbers, René, Metodieva, Verjinia D., Duverdin, Sarah, Heyer, Djai B., Galakhova, Anna A., Mertens, Eline J., Versluis, Tamara D., Baayen, Johannes C., Idema, Sander, Noske, David P., Verburg, Niels, Willemse, Ronald B., de Witt Hamer, Philip C., Kole, Maarten H. P., de Kock, Christiaan P. J., Mansvelder, Huibert D., and Goriounova, Natalia A.

Subjects
*SODIUM channels, *PYRAMIDAL neurons, *MEMBRANE potential, *ACTION potentials
Abstract

The article focuses on the biophysical properties of voltage-gated sodium (Na+) and potassium (K+) channels in human and mouse pyramidal neurons and their impact on the stability of action potentials (APs) during sustained firing. Human pyramidal neurons exhibit stable and fast AP kinetics, attributed to more depolarized voltage dependence, slower inactivation, and faster recovery from inactivation of Na+ channels, as well as right-shifted activation and inactivation curves of K+ channels.

Published
2023
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11. Human voltage-gated Na+and K+channel properties underlie sustained fast AP signaling

Author

Wilbers, René, primary, Metodieva, Verjinia D., additional, Duverdin, Sarah, additional, Heyer, Djai B., additional, Galakhova, Anna A., additional, Mertens, Eline J., additional, Versluis, Tamara D., additional, Baayen, Johannes C., additional, Idema, Sander, additional, Noske, David P., additional, Verburg, Niels, additional, Willemse, Ronald B., additional, de Witt Hamer, Philip C., additional, Kole, Maarten H. P., additional, de Kock, Christiaan P.J., additional, Mansvelder, Huibert D., additional, and Goriounova, Natalia A., additional

Published
2022
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12. Structural and functional specializations of human fast spiking neurons support fast cortical signaling

Author

Wilbers, René, primary, Galakhova, Anna A., additional, Heistek, Tim S., additional, Metodieva, Verjinia D., additional, Hagemann, Jim, additional, Heyer, Djai B., additional, Mertens, Eline J., additional, Deng, Suixin, additional, Idema, Sander, additional, de Witt Hamer, Philip C., additional, Noske, David P., additional, van Schie, Paul, additional, Kommers, Ivar, additional, Luan, Guoming, additional, Li, Tianfu, additional, Shu, Yousheng, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huibert D., additional, and Goriounova, Natalia A., additional

Published
2022
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13. Large and fast excitatory transcriptomic neuron types in human cortex preferentially express genes of intelligence and HARs.

Author

Driessens, Stan, primary, Driessens, Stan, additional, Heyer, Djai, additional, Pieterse, Isabel, additional, Wilbers, René, additional, Mertens, Eline, additional, Waleboer, Femke, additional, Heistek, Tim, additional, Coenen, Loet, additional, Idema, Sander, additional, Hamer, Philip de Witt, additional, Noske, David, additional, de Kock, Christiaan, additional, Lee, Brian, additional, Smith, Kimberly, additional, Ting, Jonathan, additional, Lein, Ed S., additional, Mansvelder, Huibert, additional, and Goriounova, Natalia, additional

Published
2022
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14. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

Author

Hunt, Sarah, primary, Leibner, Yoni, additional, Mertens, Eline J, additional, Barros-Zulaica, Natalí, additional, Kanari, Lida, additional, Heistek, Tim S, additional, Karnani, Mahesh M, additional, Aardse, Romy, additional, Wilbers, René, additional, Heyer, Djai B, additional, Goriounova, Natalia A, additional, Verhoog, Matthijs B, additional, Testa-Silva, Guilherme, additional, Obermayer, Joshua, additional, Versluis, Tamara, additional, Benavides-Piccione, Ruth, additional, de Witt-Hamer, Philip, additional, Idema, Sander, additional, Noske, David P, additional, Baayen, Johannes C, additional, Lein, Ed S, additional, DeFelipe, Javier, additional, Markram, Henry, additional, Mansvelder, Huibert D, additional, Schürmann, Felix, additional, Segev, Idan, additional, and de Kock, Christiaan P J, additional

Published
2022
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15. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

Author

Cajal Blue Brain, École Polytechnique Fédérale de Lausanne, Ministerio de Ciencia e Innovación (España), Center for Neurogenomics and Cognitive Research (The Netherlands), European Commission, National Institutes of Health (US), Gatsby Charitable Foundation, Hunt, Sarah, Leibner, Yoni, Mertens, Eline J., Barros-Zulaica, Natali, Kanari, Lida, Heistek, Tim S., Karnani, Masheh M., Aardse, Romy, Wilbers, René, Heyer, Djai B, Goriounova, N.A., Verhoog, M. B., Testa-Silva, Guilherme, Obermayer, Joshua, Versluis, Tamara, Benavides-Piccione, Ruth, Witt-Hamer, Philip de, Idema, Sander, Noske, David P., Baayen, Johannes C., Lein, Ed S., DeFelipe, Javier, Markram, Henry, Mansvelder, H.D., Schürmann, Felix, Segev, Idan, de Kock, C.P.J., Cajal Blue Brain, École Polytechnique Fédérale de Lausanne, Ministerio de Ciencia e Innovación (España), Center for Neurogenomics and Cognitive Research (The Netherlands), European Commission, National Institutes of Health (US), Gatsby Charitable Foundation, Hunt, Sarah, Leibner, Yoni, Mertens, Eline J., Barros-Zulaica, Natali, Kanari, Lida, Heistek, Tim S., Karnani, Masheh M., Aardse, Romy, Wilbers, René, Heyer, Djai B, Goriounova, N.A., Verhoog, M. B., Testa-Silva, Guilherme, Obermayer, Joshua, Versluis, Tamara, Benavides-Piccione, Ruth, Witt-Hamer, Philip de, Idema, Sander, Noske, David P., Baayen, Johannes C., Lein, Ed S., DeFelipe, Javier, Markram, Henry, Mansvelder, H.D., Schürmann, Felix, Segev, Idan, and de Kock, C.P.J.

Published
2022

16. Author Correction:Human neocortical expansion involves glutamatergic neuron diversification (Nature, (2021), 598, 7879, (151-158), 10.1038/s41586-021-03813-8)

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Abstract

In the version of this Article initially published, the Acknowledgements statement contained an error. Originally appearing with thanks for support given in part as follows, “R01EY023173 from The National Eye Institute, U01MH105982 from the National Institute of Mental Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development, and R011EY023173 from The National Institute of Allergy and Infectious Disease,” the last number (R011EY023173) was mistakenly added and is not in fact a grant or one provided by the NIAID. The mention has been removed. The changes have been made to the online version of the Article.

Published
2022

17. Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe Epilepsy

Author

Douw, Linda, primary, Nissen, Ida A, additional, Fitzsimmons, Sophie M D D, additional, Santos, Fernando A N, additional, Hillebrand, Arjan, additional, van Straaten, Elisabeth C W, additional, Stam, Cornelis J, additional, De Witt Hamer, Philip C, additional, Baayen, Johannes C, additional, Klein, Martin, additional, Reijneveld, Jaap C, additional, Heyer, Djai B, additional, Verhoog, Matthijs B, additional, Wilbers, René, additional, Hunt, Sarah, additional, Mansvelder, Huibert D, additional, Geurts, Jeroen J G, additional, de Kock, Christiaan P J, additional, and Goriounova, Natalia A, additional

Published
2021
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18. Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe Epilepsy.

Author

Douw, Linda, Nissen, Ida A, Fitzsimmons, Sophie M D D, Santos, Fernando A N, Hillebrand, Arjan, Straaten, Elisabeth C W van, Stam, Cornelis J, Hamer, Philip C De Witt, Baayen, Johannes C, Klein, Martin, Reijneveld, Jaap C, Heyer, Djai B, Verhoog, Matthijs B, Wilbers, René, Hunt, Sarah, Mansvelder, Huibert D, Geurts, Jeroen J G, Kock, Christiaan P J de, and Goriounova, Natalia A

Published
2022
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19. Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

Author

Berg, Jim, primary, Sorensen, Staci A., additional, Ting, Jonathan T., additional, Miller, Jeremy A., additional, Chartrand, Thomas, additional, Buchin, Anatoly, additional, Bakken, Trygve E., additional, Budzillo, Agata, additional, Dee, Nick, additional, Ding, Song-Lin, additional, Gouwens, Nathan W., additional, Hodge, Rebecca D., additional, Kalmbach, Brian, additional, Lee, Changkyu, additional, Lee, Brian R., additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Barkan, Eliza, additional, Beller, Allison, additional, Berry, Kyla, additional, Bertagnolli, Darren, additional, Bickley, Kris, additional, Bomben, Jasmine, additional, Braun, Thomas, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Chong, Peter, additional, Crichton, Kirsten, additional, Dalley, Rachel, additional, de Frates, Rebecca, additional, Desta, Tsega, additional, Dingman Lee, Samuel, additional, D’Orazi, Florence, additional, Dotson, Nadezhda, additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Farrell, Colin, additional, Feng, David, additional, Fong, Olivia, additional, Furdan, Szabina, additional, Galakhova, Anna A., additional, Gamlin, Clare, additional, Gary, Amanda, additional, Glandon, Alexandra, additional, Goldy, Jeff, additional, Gorham, Melissa, additional, Goriounova, Natalia A., additional, Gratiy, Sergey, additional, Graybuck, Lucas, additional, Gu, Hong, additional, Hadley, Kristen, additional, Hansen, Nathan, additional, Heistek, Tim S., additional, Henry, Alex M., additional, Heyer, Djai B., additional, Hill, DiJon, additional, Hill, Chris, additional, Hupp, Madie, additional, Jarsky, Tim, additional, Kebede, Sara, additional, Keene, Lisa, additional, Kim, Lisa, additional, Kim, Mean-Hwan, additional, Kroll, Matthew, additional, Latimer, Caitlin, additional, Levi, Boaz P., additional, Link, Katherine E., additional, Mallory, Matthew, additional, Mann, Rusty, additional, Marshall, Desiree, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica, additional, Mertens, Eline J., additional, Mezei, Leona, additional, Mihut, Norbert, additional, Mok, Stephanie, additional, Molnar, Gabor, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Ngo, Kiet, additional, Nicovich, Philip R., additional, Nyhus, Julie, additional, Olah, Gaspar, additional, Oldre, Aaron, additional, Omstead, Victoria, additional, Ozsvar, Attila, additional, Park, Daniel, additional, Peng, Hanchuan, additional, Pham, Trangthanh, additional, Pom, Christina A., additional, Potekhina, Lydia, additional, Rajanbabu, Ramkumar, additional, Ransford, Shea, additional, Reid, David, additional, Rimorin, Christine, additional, Ruiz, Augustin, additional, Sandman, David, additional, Sulc, Josef, additional, Sunkin, Susan M., additional, Szafer, Aaron, additional, Szemenyei, Viktor, additional, Thomsen, Elliot R., additional, Tieu, Michael, additional, Torkelson, Amy, additional, Trinh, Jessica, additional, Tung, Herman, additional, Wakeman, Wayne, additional, Ward, Katelyn, additional, Wilbers, René, additional, Williams, Grace, additional, Yao, Zizhen, additional, Yoon, Jae-Geun, additional, Anastassiou, Costas, additional, Arkhipov, Anton, additional, Barzo, Pal, additional, Bernard, Amy, additional, Cobbs, Charles, additional, de Witt Hamer, Philip C., additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gwinn, Ryder P., additional, Hawrylycz, Michael J., additional, Hof, Patrick R., additional, Idema, Sander, additional, Jones, Allan R., additional, Keene, C.Dirk, additional, Ko, Andrew L., additional, Murphy, Gabe J., additional, Ng, Lydia, additional, Ojemann, Jeffrey G., additional, Patel, Anoop P., additional, Phillips, John W., additional, Silbergeld, Daniel L., additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Yuste, Rafael, additional, Segev, Idan, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huibert D., additional, Tamas, Gabor, additional, Zeng, Hongkui, additional, Koch, Christof, additional, and Lein, Ed S., additional

Published
2020
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20. Morpho-electric diversity of human hippocampal CA1pyramidal neurons

Author

Mertens, Eline J., Leibner, Yoni, Pie, Jean, Galakhova, Anna A., Waleboer, Femke, Meijer, Julia, Heistek, Tim S., Wilbers, René, Heyer, Djai, Goriounova, Natalia A., Idema, Sander, Verhoog, Matthijs B., Kalmbach, Brian E., Lee, Brian R., Gwinn, Ryder P., Lein, Ed S., Aronica, Eleonora, Ting, Jonathan, Mansvelder, Huibert D., Segev, Idan, and de Kock, Christiaan P.J.

Abstract

Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent strong evolutionary reorganization and shows lower theta rhythm frequencies. To test whether biophysical properties of human Cornu Amonis subfield 1(CA1) pyramidal neurons can explain observed rhythms, we map the morpho-electric properties of individual CA1pyramidal neurons in human, non-pathological hippocampal slices from neurosurgery. Human CA1pyramidal neurons have much larger dendritic trees than mouse CA1pyramidal neurons, have a large number of oblique dendrites, and resonate at 2.9 Hz, optimally tuned to human theta frequencies. Morphological and biophysical properties suggest cellular diversity along a multidimensional gradient rather than discrete clustering. Across the population, dendritic architecture and a large number of oblique dendrites consistently boost memory capacity in human CA1pyramidal neurons by an order of magnitude compared to mouse CA1 pyramidal neurons.

Published
2024
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21. A cellular basis of human intelligence

Author

Goriounova, Natalia A., Heyer, Djai B., Wilbers, René, Verhoog, Matthijs B., Giugliano, Michele, Verbist, Christophe, Obermayer, Joshua, Kerkhofs, Amber, Smeding, Harriët, Verberne, Maaike, Idema, Sander, Baayen, Johannes C., Pieneman, Anton W., de Kock, Christiaan P. J., Klein, Martin, Mansvelder, Huibert D., Amsterdam Neuroscience - Systems & Network Neuroscience, Neurosurgery, Medical psychology, NCA - Neurobiology of mental health, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
nervous system
Abstract

It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although gray matter thickness and activity of temporal and frontal cortical areas correlate with IQ scores, no direct evidence exists that links structural and physiological properties of neurons to human intelligence. Here, we find that high IQ scores and large temporal cortical thickness associate with larger, more complex dendrites of human pyramidal neurons. We show in silico that larger dendritic trees enable pyramidal neurons to track activity of synaptic inputs with higher temporal precision, due to fast action potential kinetics. Indeed, we find that human pyramidal neurons of individuals with higher IQ scores sustain fast action potential kinetics during repeated firing. These findings provide the first evidence that human intelligence is associated with neuronal complexity, action potential kinetics and efficient information transfer from inputs to output within cortical neurons.

Published
2018

22. Group I mGluR-Mediated Activation of Martinotti Cells Inhibits Local Cortical Circuitry in Human Cortex

Author

Kroon, Tim, primary, Dawitz, Julia, additional, Kramvis, Ioannis, additional, Anink, Jasper, additional, Obermayer, Joshua, additional, Verhoog, Matthijs B., additional, Wilbers, René, additional, Goriounova, Natalia A., additional, Idema, Sander, additional, Baayen, Johannes C., additional, Aronica, Eleonora, additional, Mansvelder, Huibert D., additional, and Meredith, Rhiannon M., additional

Published
2019
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23. Large and fast human pyramidal neurons associate with intelligence

Author

Goriounova, Natalia A, primary, Heyer, Djai B, additional, Wilbers, René, additional, Verhoog, Matthijs B, additional, Giugliano, Michele, additional, Verbist, Christophe, additional, Obermayer, Joshua, additional, Kerkhofs, Amber, additional, Smeding, Harriët, additional, Verberne, Maaike, additional, Idema, Sander, additional, Baayen, Johannes C, additional, Pieneman, Anton W, additional, de Kock, Christiaan PJ, additional, Klein, Martin, additional, and Mansvelder, Huibert D, additional

Published
2018
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24. Author response: Large and fast human pyramidal neurons associate with intelligence

Author

Goriounova, Natalia A, primary, Heyer, Djai B, additional, Wilbers, René, additional, Verhoog, Matthijs B, additional, Giugliano, Michele, additional, Verbist, Christophe, additional, Obermayer, Joshua, additional, Kerkhofs, Amber, additional, Smeding, Harriët, additional, Verberne, Maaike, additional, Idema, Sander, additional, Baayen, Johannes C, additional, Pieneman, Anton W, additional, de Kock, Christiaan PJ, additional, Klein, Martin, additional, and Mansvelder, Huibert D, additional

Published
2018
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28. Large and fast human pyramidal neurons associate with intelligence

Author

Goriounova, Natalia A., primary, Heyer, Djai B., additional, Wilbers, René, additional, Verhoog, Matthijs B., additional, Giugliano, Michele, additional, Verbist, Christophe, additional, Obermayer, Joshua, additional, Kerkhofs, Amber, additional, Smeding, Harriët, additional, Verberne, Maaike, additional, Idema, Sander, additional, Baayen, Johannes C., additional, Pieneman, Anton W., additional, de Kock, Christiaan P.J., additional, Klein, Martin, additional, and Mansvelder, Huibert D., additional

Published
2018
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30. Multiparametric Assessment of the Effects of Tyrosine Kinase Inhibitors (TKIs) on the (Electro)physiology of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocytes

Author

de Korte, Tessa, primary, Nacken, Peter, additional, Pijnenburg, Dirk, additional, Ruijtenbeek, Rob, additional, Stevenhagen, Fleur, additional, Wilbers, René, additional, den Hartogh, Sabine, additional, Groten, John, additional, Braam, Stefan, additional, and Vlaming, Maria, additional

Published
2017
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31. Assessment of Compound Effects on Electrophysiology of hiPSC-Derived Ventricular Cardiomyocytes Using Patch Clamp and Multielectrode Array (MEA) Analysis

Author

de Korte, Tessa, primary, Guilbot, Stéphanie, additional, Printemps, Richard, additional, Hautefeuille, Ludovic, additional, Le Grand, Marie, additional, Wilbers, René, additional, Stevenhagen, Fleur, additional, den Hartogh, Sabine, additional, Nacken, Peter, additional, Langenberg, Karin, additional, Dunska, Marta, additional, Braam, Stefan, additional, and Vlaming, Maria, additional

Published
2017
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37. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.

Author

Hunt S, Leibner Y, Mertens EJ, Barros-Zulaica N, Kanari L, Heistek TS, Karnani MM, Aardse R, Wilbers R, Heyer DB, Goriounova NA, Verhoog MB, Testa-Silva G, Obermayer J, Versluis T, Benavides-Piccione R, de Witt-Hamer P, Idema S, Noske DP, Baayen JC, Lein ES, DeFelipe J, Markram H, Mansvelder HD, Schürmann F, Segev I, and de Kock CPJ

Subjects
Rats, Adult, Animals, Humans, Mice, Rats, Wistar, Pyramidal Cells physiology, Synaptic Transmission physiology, Synapses physiology, Receptors, N-Methyl-D-Aspartate physiology, Neocortex
Abstract

Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent but not human neocortex. We characterized synaptic transmission between pyramidal neurons in layers 2 and 3 using neurosurgically resected human middle temporal gyrus (MTG, Brodmann area 21), which is part of the distributed language circuitry. We find that local connectivity is comparable with mouse layer 2/3 connections in the anatomical homologue (temporal association area), but synaptic connections in human are 3-fold stronger and more reliable (0% vs 25% failure rates, respectively). We developed a theoretical approach to quantify properties of spinous synapses showing that synaptic conductance and voltage change in human dendritic spines are 3-4-folds larger compared with mouse, leading to significant NMDA receptor activation in human unitary connections. This model prediction was validated experimentally by showing that NMDA receptor activation increases the amplitude and prolongs decay of unitary excitatory postsynaptic potentials in human but not in mouse connections. Since NMDA-dependent recurrent excitation facilitates persistent activity (supporting working memory), our data uncovers cortical microcircuit properties in human that may contribute to language processing in MTG., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)

Published
2023
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