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257 results on '"Wiktor, Stefan Z"'

1. Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission

Author

Abdo, Ayman, Aggarwal, Rakesh, Aghemo, Alessio, Al-Judaibi, Bandar, Al Mahtab, Mamun, Altaf, Arshad, Ameen, Zyaad, Asselah, Tarik, Baatarkkhuu, Oidov, Barber, Ella, Barnes, Eleanor, Boulet, Pascale, Burrows, Louise, Butsashvili, Maia, Chan, Erica, Chow, Chelsea, Cowie, Ben, Cunningham, Chris, de Araujo, Alexandre, Diap, Graciela, Dore, Greg, Doyle, Joseph, Elsayed, Manal, Fajardo, Emmanuel, Gane, Ed, Getahun, Aneley, Goldberg, David, Got, Tiffany, Hickman, Matthew, Hill, Andrew, Hutchinson, Sharon, Jones, Chris, Kamili, Saleem, Khan, Amreen, Lee, Alice, Lee, Tin Yan, Malani, Jioiji, Morris, Tammy Meyers, Nayagam, Shevanthi, Njouom, Richard, Ocama, Ponsiano, Pedrana, Alisa, Peeling, Rosanna, Reddy, Amulya, Sacks, Jilian, Sarin, Shiv, Shimakawa, Yusuke, Silva, Marcela, Skala, Pavlo, Taylor-Robinson, Simon, Thompson, Alex, Thursz, Mark, Tonganibeia, Alfred, Wallace, Jack, Ward, James, Wolff, Fernando, Vickerman, Peter, Yau, Johnny, Cooke, Graham S, Andrieux-Meyer, Isabelle, Applegate, Tanya L, Atun, Rifat, Burry, Jessica R, Cheinquer, Hugo, Dusheiko, Geoff, Feld, Jordan J, Gore, Charles, Griswold, Max G, Hamid, Saeed, Hellard, Margaret E, Hou, JinLin, Howell, Jess, Jia, Jidong, Kravchenko, Natalia, Lazarus, Jeffrey V, Lemoine, Maud, Lesi, Olufunmilayo A, Maistat, Liudmyla, McMahon, Brian J, Razavi, Homie, Roberts, Teri, Simmons, Bryony, Sonderup, Mark W, Spearman, C Wendy, Taylor, Bridie E, Thomas, David L, Waked, Imam, Ward, John W, and Wiktor, Stefan Z

Published
2019
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6. The rollout of Community ART Refill Groups in Zimbabwe: a qualitative evaluation

Author

Bochner, Aaron F., Meacham, Elizabeth, Mhungu, Nathan, Manyanga, Phibion, Petracca, Frances, Muserere, Claudios, Gonese, Gloria, Makunike, Batsirai, Wazara, Blessing, Gwanzura, Clorata, Nyika, Ponesai, Levine, Ruth, Mutasa?Apollo, Tsitsi, Balachandra, Shirish, and Wiktor, Stefan Z.

Subjects
Antiviral agents -- Distribution, Community health services -- Management -- Evaluation, Company business management, Company distribution practices, Health
Abstract

: Introduction: Community ART Refill Groups (CARGs) are an antiretroviral therapy (ART) delivery model where clients voluntarily form into groups, and a group member visits the clinic to collect ART for all group members. In late 2016, Zimbabwe began a nationwide rollout of the CARG model. We conducted a qualitative evaluation to assess the perceived effects of this new national service delivery model. Methods: In March‐June 2018, we visited ten clinics implementing the CARG model across five provinces of Zimbabwe and conducted a focus group discussion with healthcare workers and in‐depth interviews with three ART clients per clinic. Clinics had implemented the CARG model for approximately one year. All discussions were audio recorded, transcribed, and translated into English, and thematic coding was performed by two independent analysts. Results: In focus groups, healthcare workers described that CARGs made ART distribution faster and facilitated client tracking in the community. They explained that their reduced workload allowed them to provide better care to those clients who did visit the clinic, and they felt that the CARG model should be sustained in the future. CARG members reported that by decreasing the frequency of clinic visits, CARGs saved them time and money, reducing previous barriers to collecting ART and improving adherence. CARG members also valued the emotional and informational support that they received from other members of their CARG, further improving adherence. Multiple healthcare workers did express concern that CARG members with diseases that begin with minor symptoms, such as tuberculosis, may not seek treatment at the clinic until the disease has progressed. Conclusions: We found that healthcare workers and clients overwhelmingly perceive CARGs as beneficial. This evaluation demonstrates that the CARG model can be successfully implemented on a national scale. These early results suggest that CARGs may be able to simultaneously improve clinical outcomes and reduce the workload of healthcare workers distributing ART., Introduction As countries work to reach the Joint United Nations Programme on HIV/AIDS Fast‐Track 90‐90‐90 targets by 2020, differentiated service delivery (DSD) is a widely embraced strategy. As outlined in [...]

Published
2019
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9. Cervicovaginal Secretory Antibodies to Human Immunodeficiency Virus Type 1 (HIV-1) That Block Viral Transcytosis through Tight Epithelial Barriers in Highly Exposed HIV-1-Seronegative African Women

Author

Bélec, Laurent, Ghys, Peter D., Hocini, Hakim, Nkengasong, John N., Tranchot-Diallo, Juliette, Diallo, Mamadou O., Ettiègne-Traore, Virginie, Maurice, Chantal, Becquart, Pierre, Matta, Mattieu, Si-Mohamed, Ali, Chomont, Nicolas, Coulibaly, Issa-Malick, Wiktor, Stefan Z., and Kazatchkine, Michel D.

Published
2001

14. Is drinking water in Abidjan, Cote d'Ivoire, safe for infant formula?

Author

Dunne, Eileen F., Angoran-Benie, Hortense, Kamelan-Tano, Akoua, Sibailly, Toussaint S., Monga, Ben B., Kouadio, Luc, Roels, Thierry H., Wiktor, Stefan Z., Lackritz, Eve M., Mintz, Eric D., and Luby, Steve

Subjects
Drinking water -- Contamination, Infant formulas -- Composition, Health
Abstract

Stored drinking water in households in Abidjan, Cote d'Ivoire, West Africa, is often contaminated with the bacterium E. coli and may be unsafe for making infant formulas. E. coli is a normal inhabitant of the lower gastrointestinal tract but can cause illness if swallowed.

Published
2001

15. High prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients receiving antiretroviral therapy in Abidjan, Cote d'Ivoire

Author

Adje, Christiane, Cheingsong, Rachanee, Roels, Thierry H., Maurice, Chantal, Djomand, Gaston, Verbiest, Werner, Hertogs, Kurt, Larder, Brendan, Monga, Ben, Peeters, Martine, Eholie, Serge, Bissagene, Emmanuel, Coulibaly, Makan, Respess, Richard, Wiktor, Stefan Z., Chorba, Terence, and Nkengasong, John N.

Subjects
Drug resistance in microorganisms -- Africa, HIV infection -- Drug therapy, HIV (Viruses), Health
Abstract

Over half of 68 HIV patients in Cote d'Ivoire who were taking AIDS drugs became resistant to one or more of the drugs. Forty percent became resistant to nucleoside reverse transcriptase inhibitors, 8% became resistant to non-nucleoside reverse transcriptase inhibitors, and 6% became resistant to protease inhibitors.

Published
2001

16. Lower HIV-2 plasma viral loads may explain differences between the natural histories of HIV-1 and HIV-2 infections

Author

Shanmugam, Vedapuri, Switzer, William M., Nkengasong, John N., Garcia-Lerma, Gerardo, Green, Timothy A., Ekpini, Ehounou, Sassan-Morokro, Madeleine, Antunes, Francisco, Manshino, Kamal, Soriano, Vincent, Wiktor, Stefan Z., and Heneine, Walid

Subjects
HIV (Viruses) -- Reproduction, HIV infection -- Development and progression, Viremia -- Health aspects, Health
Abstract

HIV-2 does not appear to be as active as HIV-1. In a study of 155 HIV-infected people, viral reverse transcriptase activity was lower in those with HIV-2 infection than in those with HIV-1 infection.

Published
2000

17. Distribution of HIV-1 subtypes among HIV-seropositive patients in the interior of Cote d'Ivoire

Author

Nkengasong, John N., Luo, Chi-Cheng, Abouya, Lucien, Pieniazek, Danuta, Maurice, Chantal, Sassan-Morokro, Madeleine, Ellenberger, Denis, Hu, Dale J., Pau, Chou-Pong, Dobbs, Trudy, Respess, Richard, Coulibaly, Doulourou, Coulbaly, Issa-Malik, Wiktor, Stefan Z., Greenberg, Alan E., and Rayfield, Mark

Subjects
HIV (Viruses) -- Genetic aspects, HIV infection -- Cote d'Ivoire, Health
Abstract

About 95% of HIV patients in Cote d'Ivoire are infected with HIV-1 subtype A, according to a study of 172 patients. Three were infected with subtype D, two with subtype G, one with subtype A/D, and one with subtype A/G (IbNG) circulating recombinant forms.

Published
2000

18. Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, CA[acute accent]te d'Ivoire: a randomised controlled trial

Author

Wiktor, Stefan Z, Sassan-Morokro, Madeleine, Grant, Alison D, Abouya, Lucien, Karon, John M, Maurice, Chantal, Djomand, Gaston, Ackah, Alain, Domoua, Kouao, Kadio, Auguste, Yapi, Achy, Combe, Patrice, Tossou, Odette, Roels, Thierry H, Lackritz, Eve M, Coulibaly, Doulourou, Cock, Kevin M De, Coulibaly, Issa-Malick, and Greenberg, Alan E

Subjects
Chemoprevention -- Methods, Chemoprevention -- Health aspects, HIV infection -- Prevention, Trimethoprim -- Dosage and administration, Trimethoprim -- Health aspects
Published
1999

19. Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission

Author

Cooke, Graham S, Andrieux-Meyer, Isabelle, Applegate, Tanya L, Atun, Rifat, Burry, Jessica R, Cheinquer, Hugo, Dusheiko, Geoff, Feld, Jordan J, Gore, Charles, Griswold, Max G, Hamid, Saeed, Hellard, Margaret E, Hou, JinLin, Howell, Jess, Jia, Jidong, Kravchenko, Natalia, Lazarus, Jeffrey V, Lemoine, Maud, Lesi, Olufunmilayo A, Maistat, Liudmyla, McMahon, Brian J, Razavi, Homie, Roberts, Teri, Simmons, Bryony, Sonderup, Mark W, Spearman, C Wendy, Taylor, Bridie E, Thomas, David L, Waked, Imam, Ward, John W, Wiktor, Stefan Z, and Lancet Gastroenterology & Hepatology Commissioners

Abstract

Viral hepatitis is a major public health threat and a leading cause of death worldwide. Annual mortality from viral hepatitis is similar to that of other major infectious diseases such as HIV and tuberculosis. Highly effective prevention measures and treatments have made the global elimination of viral hepatitis a realistic goal, endorsed by all WHO member states. Ambitious targets call for a global reduction in hepatitis-related mortality of 65% and a 90% reduction in new infections by 2030. This Commission draws together a wide range of expertise to appraise the current global situation and to identify priorities globally, regionally, and nationally needed to accelerate progress. We identify 20 heavily burdened countries that account for over 75% of the global burden of viral hepatitis. Key recommendations include a greater focus on national progress towards elimination with support given, if necessary, through innovative financing measures to ensure elimination programmes are fully funded by 2020. In addition to further measures to improve access to vaccination and treatment, greater attention needs to be paid to access to affordable, high-quality diagnostics if testing is to reach the levels needed to achieve elimination goals. Simplified, decentralised models of care removing requirements for specialised prescribing will be required to reach those in need, together with sustained efforts to tackle stigma and discrimination. We identify key examples of the progress that has already been made in many countries throughout the world, demonstrating that sustained and coordinated efforts can be successful in achieving the WHO elimination goals.

Published
2019

20. Late postnatal mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire

Author

Ekpini, Ehounou R., Wiktor, Stefan Z., Satten, Glen A., Adjorlolo-Johnson, Georgette T., Sibailly, Toussaint S., Ou, Chin-Yih, Karon, John M., Brattegaard, Kari, Whitaker, J. Patrick, Gnaore, Emmanuel, De Cock, Kevin M., and Greenberg, Alan E.

Subjects
HIV infection, Breast feeding -- Health aspects, Mother and infant -- Physiological aspects, Breast milk -- Contamination
Published
1997

26. Assessment of the validity of and adherence to sexually transmitted infection algorithms at a female sex worker clinic in Abidjan, Cote D'Ivoire

Author

Vuylsteke, Bea L., Ettiegne-Traore, Virginie, Anoma, Camille K., Bandama, Claude, Ghys, Peter D., Maurice, Chantal E., Van Dyck, Eddy, Wiktor, Stefan Z., and Laga, Marie

Subjects
Patient compliance -- Analysis, Sexually transmitted diseases -- Care and treatment, Medical case management -- Models, Health
Abstract

Background: Algorithms for sexually transmitted infection (STI) case management were designed in a female sex worker (FSW) clinic in Abidjan, Cote d'Ivoire, in 1993. Goal: The goal was to evaluate the long-term validity of the algorithms for returning clients of the clinic and to assess the adherence of the health workers to their application. Study Design: A cross-sectional study was conducted from 1999 to 2000 among FSWs attending as returning clients. Results: The prevalences of genital infections were as follows: Neisseria gonorrhoeae and/or Chlamydia trachomatis, 8.2%; Trichomonas vaginalis, 16.7%; bacterial vaginosis, 62.3%; and Candida albicans, 6.2%. The sensitivity of the algorithms was 20% and the positive predictive value was 14% for cervical infection. The proportion of cases for which all steps of the algorithm were correctly applied was 30%. Conclusion: Algorithms for the treatment of STIs in FSWs should be periodically reevaluated and adapted to the changing population. To maintain healthcare workers' adherence to the algorithms, supervision should be ongoing and reinforced.

Published
2003

31. HIV-2 and Natural Protection Against HIV-1 Infection

Author

Greenberg, Alan E., Wiktor, Stefan Z., DeCook, Kevin M., Smith, Peter, Jaffe, Harold W., Dondero,, Timothy J., Kanki, Phyllis J., Eisen, Geoffrey, Travers, Karin U., Marlink, Richard G., Essex, Myron E., Hsieh, Chung-cheng, and MBoup, Souleymane

Published
1996

36. Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, Cote d'Ivoire: a randomised controlled trial

Author

Wiktor, Stefan Z, Sassan-Morokro, Madeleine, Grant, Alison D, Abouya, Lucien, Karon, John M, Maurice, Chantal, Djomand, Gaston, Ackah, Alain, Domoua, Kouao, Kadio, Auguste, Yapi, Achy, Combe, Patrice, Tossou, Odette, Roels, Thierry H, Lackritz, Eve M, Coulibaly, Doulourou, De Cock, Kevin M, Coulibaly, Issa-Malick, and Greenberg, Alan E

Published
1999

40. Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission

Author

Cooke, Graham S, primary, Andrieux-Meyer, Isabelle, additional, Applegate, Tanya L, additional, Atun, Rifat, additional, Burry, Jessica R, additional, Cheinquer, Hugo, additional, Dusheiko, Geoff, additional, Feld, Jordan J, additional, Gore, Charles, additional, Griswold, Max G, additional, Hamid, Saeed, additional, Hellard, Margaret E, additional, Hou, JinLin, additional, Howell, Jess, additional, Jia, Jidong, additional, Kravchenko, Natalia, additional, Lazarus, Jeffrey V, additional, Lemoine, Maud, additional, Lesi, Olufunmilayo A, additional, Maistat, Liudmyla, additional, McMahon, Brian J, additional, Razavi, Homie, additional, Roberts, Teri, additional, Simmons, Bryony, additional, Sonderup, Mark W, additional, Spearman, C Wendy, additional, Taylor, Bridie E, additional, Thomas, David L, additional, Waked, Imam, additional, Ward, John W, additional, Wiktor, Stefan Z, additional, Abdo, Ayman, additional, Aggarwal, Rakesh, additional, Aghemo, Alessio, additional, Al-Judaibi, Bandar, additional, Al Mahtab, Mamun, additional, Altaf, Arshad, additional, Ameen, Zyaad, additional, Asselah, Tarik, additional, Baatarkkhuu, Oidov, additional, Barber, Ella, additional, Barnes, Eleanor, additional, Boulet, Pascale, additional, Burrows, Louise, additional, Butsashvili, Maia, additional, Chan, Erica, additional, Chow, Chelsea, additional, Cowie, Ben, additional, Cunningham, Chris, additional, de Araujo, Alexandre, additional, Diap, Graciela, additional, Dore, Greg, additional, Doyle, Joseph, additional, Elsayed, Manal, additional, Fajardo, Emmanuel, additional, Gane, Ed, additional, Getahun, Aneley, additional, Goldberg, David, additional, Got, Tiffany, additional, Hickman, Matthew, additional, Hill, Andrew, additional, Hutchinson, Sharon, additional, Jones, Chris, additional, Kamili, Saleem, additional, Khan, Amreen, additional, Lee, Alice, additional, Lee, Tin Yan, additional, Malani, Jioiji, additional, Morris, Tammy Meyers, additional, Nayagam, Shevanthi, additional, Njouom, Richard, additional, Ocama, Ponsiano, additional, Pedrana, Alisa, additional, Peeling, Rosanna, additional, Reddy, Amulya, additional, Sacks, Jilian, additional, Sarin, Shiv, additional, Shimakawa, Yusuke, additional, Silva, Marcela, additional, Skala, Pavlo, additional, Taylor-Robinson, Simon, additional, Thompson, Alex, additional, Thursz, Mark, additional, Tonganibeia, Alfred, additional, Wallace, Jack, additional, Ward, James, additional, Wolff, Fernando, additional, Vickerman, Peter, additional, and Yau, Johnny, additional

Published
2019
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41. Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study

Author

Adjorlolo-Johnson Georgette, Unger Elizabeth R, Boni-Ouattara Edith, Touré-Coulibaly Kadidiata, Maurice Chantal, Vernon Suzanne D, Sissoko Marcel, Greenberg Alan E, Wiktor Stefan Z, and Chorba Terence L

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, taking into account HPV infection and other potential risk factors for cervical cancer. Methods Women with invasive cervical cancer (cases) or normal cervical cytology (controls) were recruited in a hospital-based case-control study in Abidjan, Côte d'Ivoire. Odds ratios and 95% confidence intervals (CI) were estimated in logistic regression analyses controlling for important cofactors. Results HIV infection was noted in 22/132 (16.7%) cases and 10/120 (8.3%) controls (p = 0.048). High-risk HPV infection was detected in cervical tumor samples from 89.4% of case-participants and in cervical cytology samples in 31.1% of control-participants. In logistic regression analysis, HIV infection was associated with cervical cancer in women with HPV (OR 3.4; 95% CI 1.1-10.8). Among women aged ≤ 40 years, risk factors for cervical cancer were high-risk HPV infection (OR 49.3; 95% CI 8.2-295.7); parity > 2 (OR 7.0; 95% CI 1.9-25.7) and HIV infection (OR 4.5; 95% CI 1.5-13.6). Among women aged > 40 years, high-risk HPV infection (OR 23.5; 95% CI 9.1-60.6) and parity > 2 (OR 5.5; 95% CI 2.3-13.4), but association with HIV infection was not statistically significant. Conclusions These data support the hypothesis that HIV infection is a cofactor for cervical cancer in women with HPV infection, and, as in all populations, the need for promoting cervical screening in populations with high prevalence of HIV infection.

Published
2010
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49. High rates of sexual contact with female sex workers, sexually transmitted diseases, and condom neglect among HIV-infected and uninfected men with tuberculosis in Abidjan, Cote d'Ivoire

Author

Sassan-Morokro, Madeleine, Greenberg, Alan E., Coulibaly, Issa-Malick, Coulibaly, Doulhourou, Sidibe, Kassim, Ackah, Alain, Tossou, Odette, Bnaore, Emmanuel, Wiktor, Stefan Z., and De Cock, Kevin M.

Subjects
Abidjan, Cote D'Ivoire -- Health aspects, Tuberculosis -- Patients, HIV infection -- Prevention, Sex, Health
Abstract

Men in Abidjan, Ivory Coast with tuberculosis appear to have a high risk of HIV due to frequent sexual relations with female sex workers, failure to use condoms, and a high incidence of sexually transmitted diseases. Researchers administered questionnaires and physical exams to 490 HIV-positive and 239 HIV-negative men with tuberculosis in Abidjan. Compared with uninfected men, infected men were two to three times more likely to have had sexual relations with a female sex worker or to have had urethritis or genital ulcer disease in the previous 5 years. Condoms were never used by 70% of the uninfected men and 76% of the infected men. HIV infection was also significantly associated with lack of circumcision. HIV education programs should be developed in Abidjan which emphasize condom use and the risks of having sex with female sex workers.

Published
1996

50. Distribution of HIV-1 plasma RNA viral load and CD4 (super)+ T-cell counts among HIV-infected Africans evaluated for antiretroviral therapy

Author

Nkengasong, John N., Borget, Marie-Yolande, Maurice, Chantal, Boateng, Emmanuel, Kalou, Mireille, Djomand, Gaston, Ekpini, Rene, Eholie, Serge, Bissagene, Emmanuel, Coulibaly, Makan, Wiktor, Stefan Z., Roels, Thierry H., and Chorba, Terence

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Genetic aspects, HIV patients -- Demographic aspects, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Genetic aspects, HIV infection -- Prevention, HIV infection -- Demographic aspects, HIV infection -- Health aspects, RNA -- Genetic aspects, T cells -- Genetic aspects, Highly active antiretroviral therapy -- Analysis, Highly active antiretroviral therapy -- Methods, AIDS (Disease) -- Research, Health
Abstract

The authors discuss the availability of antiretroviral drug therapy for treating HIV-infected persons in Africa. They report that the access to early testing the treatment with antiretroviral drug therapy regimens will help to avoid virologic failure and to milimize drug resistance development.

Published
2001

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