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1. High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease

Author

Pirazzi C, Håkansson L, Gustafsson C, Omerovic E, Wiklund O, and Mancina RM

Subjects
young, myocardial infarction, CAD, acute coronary event, FH, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Carlo Pirazzi,1 Lina Håkansson,1 Carola Gustafsson,1 Elmir Omerovic,1,2 Olov Wiklund,2 Rosellina Margherita Mancina21Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; 2Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg, Gothenburg, SwedenBackground: Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. Familial Hypercholesterolemia (FH) is a genetic inherited disorder characterized by high LDL-C, and subsequent premature CAD development. Early drug treatment with lipid-lowering medications in FH prevents cardiovascular disease onset. The FH prevalence in the Northern European general population is 0.3%, and it is estimated that it explains 20% of premature CAD cases in individuals with familial clustering. Despite the wide number of papers showing the prevalence of clinical FH in cardiovascular disease, the prevalence of genetic FH in individuals with premature CAD is not yet well known. Here, we examined the prevalence of genetically determined FH in individuals with premature CAD.Patients and methods: 66 patients who underwent coronary angiography with suspected premature acute coronary syndrome (age

Published
2019

2. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., Zamorano J. L., Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Back, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Duran, O, Halvorsen, S, Richard Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrieres, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Ryden, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Monique Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren F., Mach F., Smulders Y. M., Carballo D., Koskinas K. C., Back M., Benetos A., Biffi A., Boavida J. -M., Capodanno D., Cosyns B., Crawford C. A., Davos C. H., Desormais I., Di Angelantonio E., Duran O. H. F., Halvorsen S., Richard Hobbs F. D., Hollander M., Jankowska E. A., Michal M., Sacco S., Sattar N., Tokgozoglu L., Tonstad S., Tsioufis K. P., van Dis I., van Gelder I. C., Wanner C., Williams B., De Backer G., Regitz-Zagrosek V., Aamodt A. H., Abdelhamid M., Aboyans V., Albus C., Asteggiano R., Borger M. A., Brotons C., Celutkiene J., Cifkova R., Cikes M., Cosentino F., Dagres N., De Backer T., De Bacquer D., Delgado V., Ruijter H. D., Dendale P., Drexel H., Falk V., Fauchier L., Ference B. A., Ferrieres J., Ferrini M., Fisher M., Fliser D., Fras Z., Gaita D., Giampaoli S., Gielen S., Graham I., Jennings C., Jorgensen T., Kautzky-Willer A., Kavousi M., Koenig W., Konradi A., Kotecha D., Landmesser U., Lettino M., Lewis B. S., Linhart A., Lochen M. -L., Makrilakis K., Mancia G., Marques-Vidal P., McEvoy J. W., McGreavy P., Merkely B., Neubeck L., Nielsen J. C., Perk J., Petersen S. E., Petronio A. S., Piepoli M., Pogosova N. G., Prescott E. I. B., Ray K. K., Reiner Z., Richter D. J., Ryden L., Shlyakhto E., Sitges M., Sousa-Uva M., Sudano I., Tiberi M., Touyz R. M., Ungar A., Monique Verschuren W. M., Wiklund O., Wood D., and Zamorano J. L.

Published
2021

3. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, Zamorano, JL, Visseren, F, Mach, F, Smulders, Y, Carballo, D, Koskinas, K, Bäck, M, Benetos, A, Biffi, A, Boavida, J, Capodanno, D, Cosyns, B, Crawford, C, Davos, C, Desormais, I, Di Angelantonio, E, Franco, O, Halvorsen, S, Hobbs, F, Hollander, M, Jankowska, E, Michal, M, Sacco, S, Sattar, N, Tokgozoglu, L, Tonstad, S, Tsioufis, K, van Dis, I, van Gelder, I, Wanner, C, Williams, B, De Backer, G, Regitz-Zagrosek, V, Aamodt, A, Abdelhamid, M, Aboyans, V, Albus, C, Asteggiano, R, Borger, M, Brotons, C, Celutkiene, J, Cifkova, R, Cikes, M, Cosentino, F, Dagres, N, De Backer, T, De Bacquer, D, Delgado, V, Den Ruijter, H, Dendale, P, Drexel, H, Falk, V, Fauchier, L, Ference, B, Ferrières, J, Ferrini, M, Fisher, M, Fliser, D, Fras, Z, Gaita, D, Giampaoli, S, Gielen, S, Graham, I, Jennings, C, Jorgensen, T, Kautzky-Willer, A, Kavousi, M, Koenig, W, Konradi, A, Kotecha, D, Landmesser, U, Lettino, M, Lewis, B, Linhart, A, Lochen, M, Makrilakis, K, Mancia, G, Marques-Vidal, P, Mcevoy, J, Mcgreavy, P, Merkely, B, Neubeck, L, Nielsen, J, Perk, J, Petersen, S, Petronio, A, Piepoli, M, Pogosova, N, Prescott, E, Ray, K, Reiner, Z, Richter, D, Rydén, L, Shlyakhto, E, Sitges, M, Sousa-Uva, M, Sudano, I, Tiberi, M, Touyz, R, Ungar, A, Verschuren, W, Wiklund, O, Wood, D, Zamorano, J, Visseren, FLJ, Smulders, YM, Koskinas, KC, Boavida, JM, Davos, CH, Franco, OH, Hobbs, FDR, Jankowska, EA, Tsioufis, KP, van Gelder, IC, Aamodt, AH, Borger, MA, Ference, BA, Lewis, BS, Lochen, ML, McEvoy, JW, McGreavy, P, Nielsen, JC, Petersen, SE, Petronio, AS, Pogosova, NG, Prescott, EIB, Ray, KK, Richter, DJ, Touyz, RM, Verschuren, WMM, and Zamorano, JL

Published
2022

4. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Author

Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Back, M., Benetos, A., Biffi, A., Boavida, J. -M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., DI Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M., Jankowska, E. A., Michal, M., Sacco, S., Sattar, N., Tokgozoglu, L., Tonstad, S., Tsioufis, K. P., Van DIs, I., Van Gelder, I. C., Wanner, C., Williams, B., De Backer, G., Regitz-Zagrosek, V., Aamodt, A. H., Abdelhamid, M., Aboyans, V., Albus, C., Asteggiano, R., Borger, M. A., Brotons, C., Ielutkiene, J., Cifkova, R., Cikes, M., Cosentino, F., Dagres, N., De Backer, T., De Bacquer, D., Delgado, V., Den Ruijter, H., Dendale, P., Drexel, H., Falk, V., Fauchier, L., Ference, B. A., Ferrieres, J., Ferrini, M., Fisher, M., Fliser, D., Fras, Z., Gaita, D., Giampaoli, S., Gielen, S., Graham, I., Jennings, C., Jorgensen, T., Kautzky-Willer, A., Kavousi, M., Koenig, W., Konradi, A., Kotecha, D., Landmesser, U., Lettino, M., Lewis, B. S., Linhart, A., Lochen, M. -L., Makrilakis, K., Mancia, G., Marques-Vidal, P., Mcevoy, J. W., Mcgreavy, P., Merkely, B., Neubeck, L., Nielsen, J. C., Perk, J., Petersen, S. E., Petronio, A. S., Piepoli, M., Pogosova, N. G., Prescott, E. I. B., Ray, K. K., Reiner, Z., Richter, D. J., Ryden, L., Shlyakhto, E., Sitges, M., Sousa-Uva, M., Sudano, I., Tiberi, M., Touyz, R. M., Ungar, A., Verschuren, W. M. M., Wiklund, O., Wood, D., Zamorano, J. L., Crawford, C. A., Franco Duran, O. H., Richard Hobbs, F. D., Dis, I. V., Group, ESC Scientific Document, Clinical sciences, Cardio-vascular diseases, and Cardiology

Subjects
medicine.medical_specialty, Epidemiology, Population, air pollution, population, Guidelines, blood pressure, climate change, diabetes, healthy lifestyle, lifetime benefit, lifetime risk, lipids, nutrition, personalized, prevention, psychosocial factors, risk estimation, risk management, shared decision-making, smoking, stepwise approach, Risk Assessment, Humans, Primary Prevention, Risk Factors, Cardiovascular Diseases, Diabetes mellitus, medicine, Intensive care medicine, education, 610 Medicine & health, Risk management, education.field_of_study, business.industry, medicine.disease, Clinical Practice, Blood pressure, guidelines, Heart failure, Lifetime risk, Disease prevention, Cardiology and Cardiovascular Medicine, business, Stepwise approach, 360 Social problems & social services
Abstract

These are the clinical practice guidelines from the European Society of Cardiology on cardiovascular disease prevention in clinical practice, from 2021.

Published
2022
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8. 2019 ESC/EAS Guidelines for the management of dyslipidaemias

Author

Mach, F., Baigent, C., Catapano, A.L., Koskinas, K.C., Casula, M., Badimon, L., Chapman, M.J., Backer, G.G. de, Delgado, V., Ference, B.A., Graham, I.M., Halliday, A., Landmesser, U., Mihaylova, B., Pedersen, T.R., Riccardi, G., Richter, D.J., Sabatine, M.S., Taskinen, M.R., Tokgozoglu, L., Wiklund, O., Nibouche, D., Zelveian, P.H., Siostrzonek, P., Najafov, R., Borne, P. van de, Pojskic, B., Postadzhiyan, A., Kypris, L., Spinar, J., Larsen, M.L., Eldin, H.S., Viigimaa, M., Strandberg, T.E., Ferrieres, J., Agladze, R., Laufs, U., Rallidis, L., Bajnok, L., Gudjonsson, T., Maher, V., Henkin, Y., Gulizia, M.M., Mussagaliyeva, A., Bajraktari, G., Kerimkulova, A., Latkovskis, G., Hamoui, O., Slapikas, R., Visser, L., Dingli, P., Ivanov, V., Boskovic, A., Nazzi, M., Visseren, F., Mitevska, I., Retterstol, K., Jankowski, P., Fontes-Carvalho, R., Gaita, D., Ezhov, M., Foscoli, M., Giga, V., Pella, D., Fras, Z., Isla, L.P. de, Hagstrom, E., Lehmann, R., Abid, L., Ozdogan, O., Mitchenko, O., Patel, R.S., Windecker, S., Aboyans, V., Collet, J.P., Dean, V., Fitzsimons, D., Gale, C.P., Grobbee, D., Halvorsen, S., Hindricks, G., Iung, B., Juni, P., Katus, H.A., Leclercq, C., Lettino, M., Lewis, B.S., Merkely, B., Mueller, C., Petersen, S., Petronio, A.S., Roffi, M., Shlyakhto, E., Simpson, I.A., Sousa-Uva, M., Touyz, R.M., Task Force Members, ESC Natl Cardiac Soc, and ESC Committee Practice Guidelines

Published
2020

9. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)

Author

Mach, F, Baigent, C, Catapano, AL, Koskinas, KC, Casula, M, Badimon, L, Chapman, MJ, De Backer, GG, Delgado, V, Ference, BA, Graham, IM, Halliday, A, Landmesser, U, Mihaylova, B, Pedersen, TR, Riccardi, G, Richter, DJ, Sabatine, MS, Taskinen, MR, Tokgozoglu, L, Wiklund, O, Mueller, C, Drexel, H, Aboyans, V, Corsini, A, Doehner, W, Farnier, M, Gigante, B, Kayikcioglu, M, Krstacic, G, Lambrinou, E, Lewis, BS, Masip, J, Moulin, P, Petersen, S, Petronio, AS, Piepoli, MF, Pinto, X, Raber, L, Ray, KK, Reiner, Z, Riesen, WF, Roffi, M, Schmid, JP, Shlyakhto, E, Simpson, IA, Stroes, E, Sudano, I, Tselepis, AD, Viigimaa, M, Vindis, C, Vonbank, A, Vrablik, M, Vrsalovic, M, Gomez, JLZ, Collet, JP, European Soc Cardiology, and European Atherosclerosis Soc

Subjects
high-density lipoproteins, lipoprotein remnants, dyslipidaemias, cholesterol, treatment (drugs), very low-density lipoproteins, Guidelines, treatment (lifestyle), treatment (adherence), lipoprotein(a), total cardiovascular risk, low-density lipoproteins, familial hypercholesterolaemia, apolipoprotein B, triglycerides
Published
2020

10. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Author

Universitat Rovira i Virgili, Borén J; Chapman MJ; Krauss RM; Packard CJ; Bentzon JF; Binder CJ; Daemen MJ; Demer LL; Hegele RA; Nicholls SJ; Nordestgaard BG; Watts GF; Bruckert E; Fazio S; Ference BA; Graham I; Horton JD; Landmesser U; Laufs U; Masana L; Pasterkamp G; Raal FJ; Ray KK; Schunkert H; Taskinen MR; van de Sluis B; Wiklund O; Tokgozoglu L; Catapano AL; Ginsberg HN, Universitat Rovira i Virgili, and Borén J; Chapman MJ; Krauss RM; Packard CJ; Bentzon JF; Binder CJ; Daemen MJ; Demer LL; Hegele RA; Nicholls SJ; Nordestgaard BG; Watts GF; Bruckert E; Fazio S; Ference BA; Graham I; Horton JD; Landmesser U; Laufs U; Masana L; Pasterkamp G; Raal FJ; Ray KK; Schunkert H; Taskinen MR; van de Sluis B; Wiklund O; Tokgozoglu L; Catapano AL; Ginsberg HN

Published
2020

13. Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM

Author

Langlois, M.R., primary, Nordestgaard, B.G., additional, Langsted, A., additional, Chapman, M., additional, Aakre, K.M., additional, Baum, H., additional, Borén, J., additional, Bruckert, E., additional, Catapano, A., additional, Cobbaert, Ch., additional, Collinson, P., additional, Descamps, O.S., additional, Duff, Ch.J., additional, Eckardstein, von A., additional, Hammerer-Lercher, A., additional, Kamstrup, P.R., additional, Kolovou, G., additional, Kronenberg, F., additional, Mora, S., additional, Pulkki, K., additional, Remaley, A.T., additional, Rifai, N., additional, Ros, E., additional, Stankovic, S., additional, Stavljenic-Rukavina, A., additional, Sypniewska, G., additional, Watts, G.F., additional, Wiklund, O., additional, and Laitinen, P., additional

Published
2021
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44. 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

Author

Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corrà U, Cosyns B, Deaton C, Graham I, Hall MS, Hobbs FDR, Løchen ML, Löllgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter DJ, Sattar N, Smulders Y, Tiberi M, van der Worp HB, van Dis I, Verschuren WMM1, Binno S, De Backer G, Roffi M, Aboyans V, Bachl N, Bueno H, Carerj S, Cho L, Cox J, De Sutter J, Egidi G, Fisher M, Fitzsimons D, Franco OH, Guenoun M, Jennings C, Jug B, Kirchhof P, Kotseva K, Lip GY, Mach F, Mancia G, Bermudo FM, Mezzani A, Niessner A, Ponikowski P, Rauch B, Rydén L, Stauder A, Turc G, Wiklund O, Windecker S, Zamorano JL, Achenbach S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Dean V, Erol Ç, Gaemperli O, Kolh P, Lancellotti P, Nihoyannopoulos P, Torbicki A, Vaz Carneiro A, Metzler B, Najafov R, Stelmashok V, De Maeyer C, Dilic M, Gruev I, Milicic D, Vaverkova H, Gustafsson I, Attia I, Duishvili D, Kostova N, Ferrières J, Klimiashvili Z, Hambrecht R, Tsioufis K, Szabados E, Andersen K, Vaughan C, Zafrir B, Novo S, Davletov K, Jashari F, Kerimkulova A, Mintale I, Saade G, Petrulioniene Z, Delagardelle C, Magri CJ, Rudi V, Oukerraj L, Çölkesen BE, Schirmer H, Jankowski P, Dos Reis RP, Gherasim D, Nedogoda S, Zavatta M, Giga V, Filipova S, Padial LR, Kiessling A, Mahdhaoui A, Ural D, Nesukay E, Gale C., Internal medicine, ICaR - Circulation and metabolism, Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corrà U, Cosyns B, Deaton C, Graham I, Hall MS, Hobbs FDR, Løchen ML, Löllgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter DJ, Sattar N, Smulders Y, Tiberi M, van der Worp HB, van Dis I, Verschuren WMM1, Binno S, De Backer G, Roffi M, Aboyans V, Bachl N, Bueno H, Carerj S, Cho L, Cox J, De Sutter J, Egidi G, Fisher M, Fitzsimons D, Franco OH, Guenoun M, Jennings C, Jug B, Kirchhof P, Kotseva K, Lip GY, Mach F, Mancia G, Bermudo FM, Mezzani A, Niessner A, Ponikowski P, Rauch B, Rydén L, Stauder A, Turc G, Wiklund O, Windecker S, Zamorano JL, Zamorano JL, Aboyans V, Achenbach S, Agewall S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Bueno H, Carerj S, Dean V, Erol Ç, Fitzsimons D, Gaemperli O, Kirchhof P, Kolh P, Lancellotti P, Lip GY, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Roffi M, Torbicki A, Vaz Carneiro A, Windecker S, Metzler B, Najafov R, Stelmashok V, De Maeyer C, Dilic M, Gruev I, Milicic D, Vaverkova H, Gustafsson I, Attia I, Duishvili D, Kostova N, Ferrières J, Klimiashvili Z, Hambrecht R, Tsioufis K, Szabados E, Andersen K, Vaughan C, Zafrir B, Novo S, Davletov K, Jashari F, Kerimkulova A, Mintale I, Saade G, Petrulioniene Z, Delagardelle C, Magri CJ, Rudi V, Oukerraj L, Çölkesen BE, Schirmer H, Jankowski P, Dos Reis RP, Gherasim D, Nedogoda S, Zavatta M, Giga V, Filipova S, Padial LR, Kiessling A, Mach F, Mahdhaoui A, Ural D, Nesukay E, Gale C., Cardio-vascular diseases, and Clinical sciences

Subjects
Cost-Benefit Analysis, General Practice, 030204 cardiovascular system & hematology, Guideline, Diabete, 0302 clinical medicine, Hyperlipidemia, Stakeholder, Medicine, 030212 general & internal medicine, Multiple Chronic Conditions, Practice Patterns, Physicians', Societies, Medical, Risk assessment, education.field_of_study, Cardiac Rehabilitation, Diabetes, Rehabilitation, Smoking, Psychosocial factor, Age Factors, Lipid, Middle Aged, Primary care, Pedigree, Europe, Cardiovascular Diseases, Psychosocial factors, Hypertension, Blood pressure, Diet, Healthy, Cardiology and Cardiovascular Medicine, Adult, Diagnostic Imaging, medicine.medical_specialty, Ambulatory blood pressure, Population, Cardiology, Healthy lifestyle, Hyperlipidemias, Health Promotion, Diabetic angiopathy, Guidelines, Risk Assessment, 03 medical and health sciences, Sex Factors, Diabetes mellitus, Journal Article, Humans, Clinical settings, Healthy Lifestyle, Intensive care medicine, education, Exercise, Antihypertensive Agents, Nutrition, Aged, business.industry, Vascular disease, Physical activity, Prevention, medicine.disease, body regions, Clinical setting, Risk management, Socioeconomic Factors, Smoking Cessation, Joint Esc Guidelines, business, Biomarkers, Diabetic Angiopathies
Abstract

ABI : ankle–brachial (blood pressure) index ABPM : ambulatory blood pressure monitoring ACCORD : Action to Control Cardiovascular Risk in Diabetes ACE-I : angiotensin-converting enzyme inhibitor ACS : acute coronary syndromes ADVANCE : Action in Diabetes and Vascular disease: PreterAx

Published
2016
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45. 2016 European Guidelines on cardiovascular disease prevention in clinical practice

Author

Piepoli, MF, Hoes, AW, Agewall, S, Albus, C, Brotons, C, Catapano, AL, Cooney, MT, Corrà, U, Cosyns, B, Deaton, C, Graham, I, Hall, MS, Hobbs, FDR, Løchen, ML, Löllgen, H, Marques-Vidal, P, Perk, J, Prescott, E, Redon, J, Richter, DJ, Sattar, N, Smulders, Y, Tiberi, M, Van Der Worp, HB, Van Dis, I, Verschuren, WM M, Binno, S, De Backer, G, Roffi, M, Aboyans, V, Bachl, N, Carerj, S, Cho, Le, Cox, J, De Sutter, J, Egidi, G, Fisher, M, Fitzsimons, D, Franco, OH, Guenoun, M, Jennings, C, Jug, B, Kirchhof, P, Kotseva, K, Lip, GYH, Mach, F, Mancia, G, Bermudo, FM, Mezzani, A, Niessner, A, Ponikowski, P, Rauch, B, Stauder, A, Turc, G, Wiklund, O, Windecker, S, Zamorano, JL, Achenbach, S, Badimon, L, Barón-Esquivias, G, Baumgartner, H, Bax, JJ, Dean, V, Erol, Ç, Gaemperli, O, Kolh, P, Lancellotti, P, Nihoyannopoulos, P, Torbicki, A, Carneiro, AV, Metzler, B, Najafov, R, Stelmashok, V, De Maeyer, C, Dilić, M, Gruev, I, Miličić, D, Vaverkova, H, Gustafsson, I, Attia, I, Duishvili, D, Ferrières, J, Kostova, N, Klimiashvili, Z, Hambrecht, R, Tsioufis, K, Szabados, E, Andersen, K, Vaughan, C, Zafrir, B, Novo, S, Davletov, K, Jashari, F, Kerimkulova, A, Mintale, I, Saade, G, Petrulioniene, Z, Delagardelle, C, Magri, CJ, Rudi, V, Oukerraj, L, Çölkesen, BE, Schirmer, H, Dos Reis, RP, Gherasim, D, Nedogoda, S, Zavatta, M, Giga, V, Filipova, S, Padial, LR, Kiessling, A, Mahdhaoui, A, Ural, D, Nesukay, E, Gale, C, Piepoli, M, Hoes, A, Agewall, S, Albus, C, Brotons, C, Catapano, A, Cooney, M, Corrà, U, Cosyns, B, Deaton, C, Graham, I, Hall, M, Hobbs, F, Løchen, M, Löllgen, H, Marques-Vidal, P, Perk, J, Prescott, E, Redon, J, Richter, D, Sattar, N, Smulders, Y, Tiberi, M, Van Der Worp, H, Van Dis, I, Verschuren, W, Binno, S, De Backer, G, Roffi, M, Aboyans, V, Bachl, N, Carerj, S, Cho, L, Cox, J, De Sutter, J, Egidi, G, Fisher, M, Fitzsimons, D, Franco, O, Guenoun, M, Jennings, C, Jug, B, Kirchhof, P, Kotseva, K, Lip, G, Mach, F, Mancia, G, Bermudo, F, Mezzani, A, Niessner, A, Ponikowski, P, Rauch, B, Stauder, A, Turc, G, Wiklund, O, Windecker, S, Zamorano, J, Achenbach, S, Badimon, L, Barón-Esquivias, G, Baumgartner, H, Bax, J, Dean, V, Erol, Ç, Gaemperli, O, Kolh, P, Lancellotti, P, Nihoyannopoulos, P, Torbicki, A, Carneiro, A, Metzler, B, Najafov, R, Stelmashok, V, De Maeyer, C, Dilić, M, Gruev, I, Miličić, D, Vaverkova, H, Gustafsson, I, Attia, I, Duishvili, D, Ferrières, J, Kostova, N, Klimiashvili, Z, Hambrecht, R, Tsioufis, K, Szabados, E, Andersen, K, Vaughan, C, Zafrir, B, Novo, S, Davletov, K, Jashari, F, Kerimkulova, A, Mintale, I, Saade, G, Petrulioniene, Z, Delagardelle, C, Magri, C, Rudi, V, Oukerraj, L, Çölkesen, B, Schirmer, H, Dos Reis, R, Gherasim, D, Nedogoda, S, Zavatta, M, Giga, V, Filipova, S, Padial, L, Kiessling, A, Mahdhaoui, A, Ural, D, Nesukay, E, and Gale, C

Subjects
Adult, Diagnostic Imaging, Diabetic Angiopathie, Healthy Diet, General Practice, Population, Healthy lifestyle, Health Promotion, Sex Factor, Guideline, Guidelines, Diabete, Socioeconomic Factor, Blood pressure, Clinical settings, Diabetes, Lipid, Nutrition, Physical activity, Prevention, Primary care, Psychosocial factors, Rehabilitation, Risk assessment, Risk management, Smoking, Stakeholder, Cardiology and Cardiovascular Medicine, Cardiovascular Disease, Age Factor, Cost-Benefit Analysi, Practice Patterns, Physicians', Exercise, Aged, Cardiac Rehabilitation, Psychosocial factor, Biomarker, Middle Aged, Multiple Chronic Condition, Pedigree, Clinical setting, Antihypertensive Agent, Hyperlipidemia, Hypertension, Smoking Cessation, Human
Published
2016

46. 2016 European Guidelines on the Prevention of Cardiovascular Diseases in Clinical Practice Sixth Joint Task Force of the European Society of Cardiology and other Societies on the Prevention of Cardiovascular Diseases in Clinical Practice (consisting of representatives of 10 companies and invited experts) drafted with the extraordinary contribution of the European Association for Cardiovascular Prevention and Rehabilitation (EACPR)

Author

Piepoli M, Hoes A, Agewall S, Albus C, Brotons C, Catapano A, Cooney M, Corra U, Cosyns B, Deaton C, Graham I, Hall M, Hobbs F, Lochen M, Lollgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter D, Sattar N, Smulders Y, Tiberi M, van der Worp H, van Dis I, Verschuren W, Binno S, De Backer G, Roffi M, Aboyans V, Bachl N, Bueno H, Carerj S, Cho L, Cox J, De Sutter J, Egidi G, Fisher M, Fitzsimons D, Franco O, Guenoun M, Jennings C, Jug B, Kirchhof P, Kotseva K, Lip G, Mach F, Mancia G, Bermudo F, Mezzani A, Niessner A, Ponikowski P, Rauch B, Ryden L, Stauder A, Turc G, Wiklund O, Windecker S, Zamorano J, Soc Europea Cardiologia, and Soc Prevenzione Malattie Cardiovas

Published
2017

48. Familial hypercholesterolæmia in children and adolescents: Gaining decades of life by optimizing detection and treatment

Author

Wiegman, A., Gidding, S., Watts, G., Chapman, M., Ginsberg, H., Cuchel, M., Ose, L., Averna, M., Boileau, C., Borén, J., Bruckert, E., Catapano, A., Defesche, J., Descamps, O., Hegele, R., Hovingh, G., Humphries, S., Kovanen, P., Kuivenhoven, J., Masana, L., Nordestgaard, B., Pajukanta, P., Parhofer, K., Raal, F., Ray, K., Santos, R., Stalenhoef, A., Steinhagen Thiessen, E., Stroes, E., Taskinen, M., Tybjealigrg Hansen, A., Wiklund, O., Wiegman, A., Gidding, S., Watts, G., Chapman, M., Ginsberg, H., Cuchel, M., Ose, L., Averna, M., Boileau, C., Borén, J., Bruckert, E., Catapano, A., Defesche, J., Descamps, O., Hegele, R., Hovingh, G., Humphries, S., Kovanen, P., Kuivenhoven, J., Masana, L., Nordestgaard, B., Pajukanta, P., Parhofer, K., Raal, F., Ray, K., Santos, R., Stalenhoef, A., Steinhagen- Thiessen, E., Stroes, E., Taskinen, M., Tybjealigrg-Hansen, A., Wiklund, O., and Steinhagen-Thiessen, E.

Subjects
Counseling, European Atherosclerosis Society Consensus Panel, Pediatrics, Cardiac & Cardiovascular Systems, STATIN THERAPY, Settore MED/09 - Medicina Interna, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Familial hypercholesterolemia, Adolescents, Carotid Intima-Media Thickness, INTIMA-MEDIA THICKNESS, Cost of Illness, Pregnancy, Risk Factors, Diagnosis, YOUNG-ADULTS, HIPERCOLESTEROLEMIA (DIAGNÓSTICO, TERAPIA, TENDÊNCIAS), Family history, Young adult, Child, Children, Evidence-Based Medicine, medicine.diagnostic_test, Homozygote, Middle Aged, Familial hypercholesterolæmia, 3. Good health, Economics, Medical, Consensus statement, Ezetimibe, LDL cholesterol, PCSK9 inhibitor, Statin, Treatment, Cardiology and Cardiovascular Medicine, CARDIOVASCULAR-DISEASE, Female, lipids (amino acids, peptides, and proteins), Familial hypercholesterolaemia, Life Sciences & Biomedicine, Diagnosi, medicine.drug, Adult, Heterozygote, medicine.medical_specialty, Adolescent, medicine.drug_class, ENDOTHELIAL FUNCTION, LOW-DENSITY-LIPOPROTEIN, Reviews, COST-EFFECTIVENESS ANALYSIS, 1102 Cardiovascular Medicine And Haematology, Medication Adherence, Hyperlipoproteinemia Type II, Young Adult, Life Expectancy, medicine, Humans, CORONARY-HEART-DISEASE, Genetic Testing, Genetic testing, Science & Technology, Clinical Laboratory Techniques, business.industry, Prevention, Atherosclerosis, medicine.disease, Diet, ASSOCIATION EXPERT PANEL, BLOOD-PRESSURE RESEARCH, Pregnancy Complications, Early Diagnosis, Intima-media thickness, Cardiovascular System & Hematology, Dietary Supplements, Physical therapy, Cardiovascular System & Cardiology, business
Abstract

Contains fulltext : 155263.pdf (Publisher’s version ) (Open Access) Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated early in childhood, individuals with FH can have normal life expectancy. This consensus paper aims to improve awareness of the need for early detection and management of FH children. Familial hypercholesterolaemia is diagnosed either on phenotypic criteria, i.e. an elevated low-density lipoprotein cholesterol (LDL-C) level plus a family history of elevated LDL-C, premature coronary artery disease and/or genetic diagnosis, or positive genetic testing. Childhood is the optimal period for discrimination between FH and non-FH using LDL-C screening. An LDL-C >/=5 mmol/L (190 mg/dL), or an LDL-C >/=4 mmol/L (160 mg/dL) with family history of premature CHD and/or high baseline cholesterol in one parent, make the phenotypic diagnosis. If a parent has a genetic defect, the LDL-C cut-off for the child is >/=3.5 mmol/L (130 mg/dL). We recommend cascade screening of families using a combined phenotypic and genotypic strategy. In children, testing is recommended from age 5 years, or earlier if homozygous FH is suspected. A healthy lifestyle and statin treatment (from age 8 to 10 years) are the cornerstones of management of heterozygous FH. Target LDL-C is 10 years, or ideally 50% reduction from baseline if 8-10 years, especially with very high LDL-C, elevated lipoprotein(a), a family history of premature CHD or other cardiovascular risk factors, balanced against the long-term risk of treatment side effects. Identifying FH early and optimally lowering LDL-C over the lifespan reduces cumulative LDL-C burden and offers health and socioeconomic benefits. To drive policy change for timely detection and management, we call for further studies in the young. Increased awareness, early identification, and optimal treatment from childhood are critical to adding decades of healthy life for children and adolescents with FH.

Published
2015

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