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4. Very High-Power Ablation for Contiguous Pulmonary Vein Isolation: Results From the Randomized POWER PLUS Trial

Author

O’Neill, Louisa, El Haddad, Milad, Berte, Benjamin, Kobza, Richard, Hilfiker, Gabriela, Scherr, Daniel, Manninger, Martin, Wijnmaalen, Adrianus P., Trines, Serge A., Wielandts, Jean-Yves, Gillis, Kris, Lycke, Michelle, De Becker, Benjamin, Tavernier, Rene, Le Polain De Waroux, Jean-Benoit, Knecht, Sebastien, and Duytschaever, Mattias

Published
2023
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5. Clinical Outcomes in Patients With Dilated Cardiomyopathy and Ventricular Tachycardia

Author

Zeppenfeld, Katja, Wijnmaalen, Adrianus P., Ebert, Micaela, Baldinger, Samuel H., Berruezo, Antonio, Catto, Valentina, Vaseghi, Marmar, Arya, Arash, Kumar, Saurabh, de Riva, Marta, Deneke, Thomas, Gaspar, Thomas, Soejima, Kyoko, van Rein, Nienke, Tedrow, Usha B., Piorkowski, Chistopher, Shivkumar, Kalyanam, Carbucicchio, Corrado, Hindricks, Gerhard, and Stevenson, William G.

Published
2022
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6. Characterization of atrial arrhythmias following mitral valve repair: Incidence and risk factors.

Author

el Mathari, Sulayman, Tomšič, Anton, Kharbanda, Rohit K., Zappala, Pietro, Wijnmaalen, Adrianus P., Klautz, Robert J. M., Silva, Marta de Riva, and Palmen, Meindert

Subjects
MITRAL valve surgery, RISK assessment, THERAPEUTIC complications, ACADEMIC medical centers, HEART atrium, PROBABILITY theory, RETROSPECTIVE studies, DESCRIPTIVE statistics, MITRAL valve insufficiency, SURGICAL complications, LONGITUDINAL method, ELECTROCARDIOGRAPHY, KAPLAN-Meier estimator, LOG-rank test, ATRIAL arrhythmias, MEDICAL records, ACQUISITION of data, ATRIAL fibrillation, STATISTICS, TACHYCARDIA, CONFIDENCE intervals, SURVIVAL analysis (Biometry), DATA analysis software, PROPORTIONAL hazards models, REGRESSION analysis, DISEASE risk factors
Abstract

Objectives: This study aims to investigate the occurrence, type and correlation of early and late atrial arrhythmias following mitral valve repair in patients with no preoperative history of atrial arrhythmias. Methods: Patients undergoing mitral valve (MV) repair for degenerative disease were included. Early and late postoperative electrocardiograms were evaluated for the incidence and type of atrial arrhythmia (atrial fibrillation [AF] or atrial tachycardia [AT]). Results: The 192 patients were included. Early atrial arrhythmias occurred in 100/192 (52.1%) patients; AF in 61 (31.8%) patients, early AT in 15 (7.8%) and both in 24 (12.5%). In total 89% of patients were discharged in sinus rhythm. During a follow‐up time of 7.3 years, 14 patients (7.3%) died and 49 (25.5%) patients developed late atrial arrhythmias. At 10 years, the cumulative incidence of any late atrial arrhythmia, with death as competing risk, was 64% (95% confidence interval [CI] = 55%–72%). On Fine‐Gray model analysis, only early postoperative AF lasting >24 h was related to the development of late AF (hazard ratio 5.99, 95% CI = 1.78%–20.10%, p =.004). Early postoperative ATs were related to the development of late tachycardias, independent of their duration (<24 h hazard ratio 4.25, 95% CI = 1.89–9.57, p =.001 and >24 h hazard ratio 3.51, 95% CI = 1.65–7.46, p =.001). Conclusions: Early and late atrial arrhythmias were common after MV repair surgery. Only early postoperative AF lasting >24 h was a risk factor for the occurrence of late AF. Conversely, any postoperative AT was correlated to the development of late ATs. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Incidence and Clinical Significance of Cerebral Embolism During Atrial Fibrillation Ablation With Duty-Cycled Phased-Radiofrequency Versus Cooled-Radiofrequency: A Randomized Controlled Trial

Author

Keçe, Fehmi, Bruggemans, Eline F., de Riva, Marta, Alizadeh Dehnavi, Reza, Wijnmaalen, Adrianus P., Meulman, Tamara J., Brugman, Julia A., Rooijmans, Anouk M., van Buchem, Mark A., Middelkoop, Huub A., Eikenboom, Jeroen, Schalij, Martin J., Zeppenfeld, Katja, and Trines, Serge A.

Published
2019
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14. CE-452777-3 VENTRICULAR TACHYCARDIA PREDICTS ALL-CAUSE MORTALITY AND NON-SUDDEN CARDIAC DEATH IN NON-ISCHAEMIC CARDIOMYOPATHY

Author

Omara, Sharif, primary, Godsk, Thomas S., additional, Køber, Lars, additional, Thune, Jens J., additional, Pehrson, Steen, additional, Tedrow, Usha B., additional, Hindricks, Gerhard, additional, Ebert, Micaela, additional, Carbucicchio, Corrado, additional, Berruezo, Antonio, additional, Vaseghi, Marmar, additional, Shivkumar, Kalyanam, additional, Deneke, Thomas, additional, Wijnmaalen, Adrianus P., additional, Stevenson, William G., additional, Nielsen, Jens C., additional, and Zeppenfeld, Katja, additional

Published
2023
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17. Head-to-Head Comparison of T1 Mapping and Electroanatomical Voltage Mapping in Patients With Ventricular Arrhythmias

Author

Sramko, Marek (author), Abdel-Kafi, Saif (author), Wijnmaalen, Adrianus P. (author), Tao, Q. (author), van der Geest, R.J. (author), Lamb, Hildo J. (author), Zeppenfeld, Katja (author), Sramko, Marek (author), Abdel-Kafi, Saif (author), Wijnmaalen, Adrianus P. (author), Tao, Q. (author), van der Geest, R.J. (author), Lamb, Hildo J. (author), and Zeppenfeld, Katja (author)

Abstract

Background: Electroanatomical voltage mapping (EAVM) has been compared with late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR), which cannot delineate diffuse fibrosis. T1-mapping CMR overcomes the limitations of LGE-CMR, but it has not been directly compared against EAVM. Objectives: This study aims to assess the relationship between left ventricular (LV) endocardial voltage obtained by EAVM and extracellular volume (ECV) obtained by T1 mapping. Methods: The study investigated patients who underwent endocardial EAVM for ventricular arrhythmias (CARTO 3, Biosense Webster) together with preprocedural contrast-enhanced T1 mapping (Ingenia 3T, Philips Healthcare). After image integration, EAVM datapoints were projected onto LGE-CMR and ECV-encoded images. Average values of unipolar voltage (UV), bipolar voltage (BV), LGE transmurality, and ECV were merged from corresponding cardiac segments (6 per slice) and pooled for analysis. Results: The analysis included data from 628 segments from 18 patients (57 ± 13 years of age, 17% females, LV ejection fraction 48% ± 14%, nonischemic/ischemic cardiomyopathy/controls: 8/6/4 patients). Based on the 95th and 5th percentile values obtained from the controls, ECV >33%, BV <2.9 mV, and UV <6.7 mV were considered abnormal. There was a significant inverse association between voltage and ECV, but only in segments with abnormal ECV. Increased ECV could predict abnormal BV and UV with acceptable accuracy (area under the curve of 0.78 [95% CI: 0.74-0.83] and 0.84 [95% CI: 0.79-0.88]). Conclusions: This study found a significant inverse relationship between LV endocardial voltage and ECV. Real-time integration of T1 mapping may guide catheter mapping and may allow identification of areas of diffuse fibrosis potentially related to ventricular arrhythmias., Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., ImPhys/Tao group

Published
2023
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19. Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence After Ablation Independent From Cardiac Function: Comparison With Patients With Ischemic Heart Disease

Author

Kimura, Yoshitaka, primary, de Riva, Marta, additional, Ebert, Micaela, additional, Glashan, Claire, additional, Wijnmaalen, Adrianus P., additional, Piers, Sebastiaan R., additional, Dekkers, Olaf M., additional, Trines, Serge A., additional, and Zeppenfeld, Katja, additional

Published
2023
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21. CE-522-02 THE OUTCOME SPECTRUM FOR DILATED CARDIOMYOPATHY AND VENTRICULAR TACHYCARDIA: RESULTS FROM THE PROSPECTIVE, MULTICENTER, DCM VT ABLATION STUDY

Author

Zeppenfeld, Katja, primary, Wijnmaalen, Adrianus P., additional, Ebert, Micaela, additional, Baldinger, Samuel H., additional, Catto, Valentina, additional, Vaseghi, Marmar, additional, Arya, Arash, additional, Kumar, Saurabh, additional, De Riva Silva, Marta, additional, Gaspar, Thomas, additional, Tedrow, Usha B., additional, Deneke, Thomas, additional, Soejima, Kyoko, additional, Piorkowski, Christopher, additional, Shivkumar, Kalyanam, additional, Carbucicchio, Corrado, additional, Berruezo, Antonio, additional, Hindricks, Gerhard, additional, and Stevenson, William G., additional

Published
2022
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31. Head-to-head comparison of contrast-enhanced magnetic resonance imaging and electroanatomical voltage mapping to assess post-infarct scar characteristics in patients with ventricular tachycardias: real-time image integration and reversed registration

Author

Wijnmaalen, Adrianus P., van der Geest, Rob J., van Huls van Taxis, Carine F.B., Siebelink, Hans-Marc J., Kroft, Lucia J.M., Bax, Jeroen J., Reiber, Johan H.C., Schalij, Martin J., and Zeppenfeld, Katja

Published
2011
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34. Mechanisms of sex differences in atrial fibrillation: role of hormones and differences in electrophysiology, structure, function, and remodelling

Author

Odening, Katja E, Deiß, Sebastian, Dilling-Boer, Dagmara, Didenko, Maxim, Eriksson, Urs, Nedios, Sotirios, Ng, Fu Siong, Roca Luque, Ivo, Sanchez Borque, Pepa, Vernooy, Kevin, Wijnmaalen, Adrianus P, Yorgun, Hikmet, Odening, Katja E, Deiß, Sebastian, Dilling-Boer, Dagmara, Didenko, Maxim, Eriksson, Urs, Nedios, Sotirios, Ng, Fu Siong, Roca Luque, Ivo, Sanchez Borque, Pepa, Vernooy, Kevin, Wijnmaalen, Adrianus P, and Yorgun, Hikmet

Abstract

Atrial fibrillation (AF) is the clinically most prevalent rhythm disorder with large impact on quality of life and increased risk for hospitalizations and mortality in both men and women. In recent years, knowledge regarding epidemiology, risk factors, and patho-physiological mechanisms of AF has greatly increased. Sex differences have been identified in the prevalence, clinical presentation, associated comorbidities, and therapy outcomes of AF. Although it is known that age-related prevalence of AF is lower in women than in men, women have worse and often atypical symptoms and worse quality of life as well as a higher risk for adverse events such as stroke and death associated with AF. In this review, we evaluate what is known about sex differences in AF mechanisms-covering structural, electrophysiological, and hormonal factors-and underscore areas of knowledge gaps for future studies. Increasing our understanding of mechanisms accounting for these sex differences in AF is important both for prognostic purposes and the optimization of (targeted, mechanism-based, and sex-specific) therapeutic approaches.

Published
2019

35. Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia.

Author

Riva, Marta de, Naruse, Yoshihisa, Ebert, Micaela, Watanabe, Masaya, Scholte, Arthur J, Wijnmaalen, Adrianus P, Trines, Serge A, Schalij, Martin J, Montero-Cabezas, Jose M, Zeppenfeld, Katja, and de Riva, Marta

Subjects
MYOCARDIAL infarction complications, CATHETER ablation, MYOCARDIAL infarction, RETROSPECTIVE studies, VENTRICULAR tachycardia, DISEASE relapse, TREATMENT effectiveness, ENDOCARDIUM
Abstract

Aims: In patients with post-myocardial infarction (post-MI) ventricular tachycardia (VT), the presence of myocardial calcification (MC) may prevent heating of a subepicardial VT substrate contributing to endocardial ablation failure. The aims of this study were to assess the prevalence of MC in patients with post-MI VT and evaluate the impact of MC on outcome after endocardial ablation.Methods and Results: In 158 patients, the presence of MC was retrospectively assessed on fluoroscopy recordings in seven standard projections obtained during pre-procedural coronary angiograms. Myocardial calcification, defined as a distinct radiopaque area that moved synchronously with the cardiac contraction, was detected in 30 patients (19%). After endocardial ablation, only 6 patients (20%) with MC were rendered non-inducible compared with 56 (44%) without MC (P = 0.033) and of importance, 8 (27%) remained inducible for the clinical VT [compared with 9 (6%) patients without MC; P = 0.003] requiring therapy escalation. After a median follow-up of 31 months, 61 patients (39%) had VT recurrence and 47 (30%) died. Patients with MC had a lower survival free from the composite endpoint of VT recurrence or therapy escalation at 24-month follow-up (26% vs. 59%; P = 0.003). Presence of MC (HR 1.69; P = 0.046), a lower LV ejection fraction (HR 1.03 per 1% decrease; P = 0.017), and non-complete procedural success (HR 2.42; P = 0.002) were independently associated with a higher incidence of VT recurrence or therapy escalation.Conclusion: Myocardial calcification was present in 19% of post-MI patients referred for VT ablation and was associated with a high incidence of endocardial ablation failure. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Mechanisms of sex differences in atrial fibrillation: role of hormones and differences in electrophysiology, structure, function, and remodelling

Author

Odening, Katja E, primary, Deiß, Sebastian, additional, Dilling-Boer, Dagmara, additional, Didenko, Maxim, additional, Eriksson, Urs, additional, Nedios, Sotirios, additional, Ng, Fu Siong, additional, Roca Luque, Ivo, additional, Sanchez Borque, Pepa, additional, Vernooy, Kevin, additional, Wijnmaalen, Adrianus P, additional, and Yorgun, Hikmet, additional

Published
2018
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38. Programmed electrical stimulation-guided encircling cryoablation concomitant to surgical ventricular reconstruction for primary prevention of ventricular arrhythmias

Author

van Huls van Taxis, Carine F, primary, Wijnmaalen, Adrianus P, additional, Klein, Patrick, additional, Dekkers, Olaf M, additional, Braun, Jerry, additional, Verwey, Harriette F, additional, Schalij, Martin J, additional, Klautz, Robert J, additional, and Zeppenfeld, Katja, additional

Published
2018
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39. Arrhythmogenic anatomical isthmuses identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired tetralogy of Fallot

Author

Kapel, Gijsbert F.L., primary, Sacher, Frédéric, additional, Dekkers, Olaf M., additional, Watanabe, Masaya, additional, Blom, Nico A., additional, Thambo, Jean-Benoît, additional, Derval, Nicolas, additional, Schalij, Martin J., additional, Jalal, Zakaria, additional, Wijnmaalen, Adrianus P., additional, and Zeppenfeld, Katja, additional

Published
2016
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40. Re-Entry Using Anatomically Determined Isthmuses

Author

Kapel, Gijsbert F.L., primary, Reichlin, Tobias, additional, Wijnmaalen, Adrianus P., additional, Piers, Sebastiaan R.D., additional, Holman, Eduard R., additional, Tedrow, Usha B., additional, Schalij, Martin J., additional, Stevenson, William G., additional, and Zeppenfeld, Katja, additional

Published
2015
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41. Arrhythmogenic anatomical isthmuses identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired Tetralogy of Fallot.

Author

Kapel, Gijsbert F. L., Dekkers, Olaf M., Masaya Watanabe, Blom, Nico A., Thambo, Jean-Benoît, Derval, Nicolas, Schalij, Martin J., Jalal, Zakaria, Wijnmaalen, Adrianus P., Zeppenfeld, Katja, and Sacher, Frédéric

Abstract

Aims The majority of ventricular tachycardias (VTs) in repaired tetralogy of Fallot (rTOF) are related to anatomically defined isthmuses. We aimed to identify specific electroanatomical characteristics of anatomical isthmuses (AI) related to VT which may allow for individualized risk stratification and tailored ablation. Methods and results Seventy-four consecutive rTOF patients (40 ± 16 years, 63% male) underwent VT induction and right ventricular electroanatomical voltage and activation mapping during sinus rhythm (SR) to identify the presence and characteristics of AI (isthmus width, length and conduction velocity index [CVi]). Twenty-eight patients were inducible for 41 VTs. All 74 patients had at least one AI. However, AI in patients with VT were longer (22 ± 7 vs. 16 ± 7 mm, P = 0.001), narrower (20 ± 8 vs. 28 ± 11 mm, P < 0.001) and had lower CVi (0.36 ± 0.34 vs. 0.78 ± 0.24 m/s, P < 0.001). Thirty-seven VTs in 24 patients were mapped (pace-, entrainment mapping, and/or VT termination by ablation) to 28 AI. All 28 AI related to VT had a CVi < 0.5 m/s (slow conducting AI (SCAI)). In contrast, 87 of 89 AI of the 46 patients without VT had CVi ≥ 0.5 m/s. Sixty-two patients were discharged without the presence of an SCAI (44 had no SCAI at baseline, 18 underwent ablation of the SCAI) and 10 still had an SCAI (no/failed ablation). During follow-up (50 ± 22 months), no patient without SCAI had any VT, which occurred in 5/10 patients with SCAI (P < 0.001). Conclusion In rTOF, slow conducting anatomical isthmuses identified by electroanatomical mapping during SR are the dominant substrate for VT allowing individualized risk stratification and preventive ablation. [ABSTRACT FROM AUTHOR]

Published
2017
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45. Epicardial Ablation for Ventricular Tachycardia

Author

Della Bella, Paolo, primary, Brugada, Josep, additional, Zeppenfeld, Katja, additional, Merino, Jose, additional, Neuzil, Petr, additional, Maury, Philippe, additional, Maccabelli, Giuseppe, additional, Vergara, Pasquale, additional, Baratto, Francesca, additional, Berruezo, Antonio, additional, and Wijnmaalen, Adrianus P., additional

Published
2011
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48. Early Reperfusion Therapy Affects Inducibility, Cycle Length, and Occurrence of Ventricular Tachycardia Late After Myocardial Infarction

Author

Piers, Sebastiaan R.D., primary, Wijnmaalen, Adrianus P., additional, Borleffs, C. Jan Willem, additional, van Huls van Taxis, Carine F.B., additional, Thijssen, Joep, additional, van Rees, Johannes B., additional, Cannegieter, Suzanne C., additional, Bax, Jeroen J., additional, Schalij, Martin J., additional, and Zeppenfeld, Katja, additional

Published
2011
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