Search

Your search keyword '"Wijnen, J."' showing total 846 results
Start Over Author "Wijnen, J."
846 results on '"Wijnen, J."'

1. High-resolution numerical-experimental comparison of heterogeneous slip activity in quasi-2D ferrite sheets

Author

Wijnen, J., Vermeij, T., Hoefnagels, J. P. M., Geers, M. G. D., and Peerlings, R. H. J.

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

The role of heterogeneity in the plastic flow of thin ferrite specimens is investigated in this study. This is done through a recently introduced quasi-2D experimental-numerical framework that allows for a quantitative comparison of the deformation fields of metal microstructures between experiments and simulations at a high level of detail and complexity. The method exploits samples that are locally ultra-thin ("2D") and hence have a practically uniform microstructure through their thickness. This allows testing more complex loading conditions compared to uniaxial micromechanical experiments while avoiding the complexity of an unknown subsurface microstructure, which limits comparisons between experiments and simulations in traditional integrated approaches at the level of the polycrystalline microstructure. The present approach enables to study the effect of microstructural features such as grain boundaries. To study the role of stochastic fluctuations, a constitutive model is employed which introduces random heterogeneity into a crystal plasticity model. A detailed analysis of the simulations is performed at the level of individual slip systems. Since both experimental and numerical results are susceptible to stochastic fluctuations, the outcomes of many simulations are compared to the experimentally obtained result. This comparison allows us to determine how a single experiment relates to an ensemble of simulations. Additionally, results obtained with a conventional crystal plasticity model are considered. The analysis reveals that the heterogeneity in the plasticity model is essential for accurately capturing the deformation mechanisms., Comment: 25 pages, 13 figures, submitted for publication

Published
2024

2. Discrete slip plane analysis of ferrite microtensile tests: On the influence of dislocation source distribution and non-Schmid effects on slip system activity

Author

Wijnen, J., Hoefnagels, J. P. M., Geers, M. G. D., and Peerlings, R. H. J.

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

The slip system activity in microtensile tests of ferrite single crystals is compared with predictions made by the discrete slip plane model proposed by Wijnen et al. (International Journal of Solids and Structures 228, 111094, 2021). This is an extension of conventional crystal plasticity in which the stochastics and physics of dislocation sources are taken into account in a discrete slip band. This results in discrete slip traces and non-deterministic mechanical behavior, similar to what is observed in experiments. A detailed analysis of which slip systems are presumed to be active in experiments is performed. In small-scale mechanical tests on BCC metals and alloys, non-Schmid effects are often needed to explain the observed response. Therefore, these effects are incorporated into the model by extending a non-Schmid framework commonly used to model {110} slip to {112} planes. The slip activity in the simulations is compared to the slip activity in single crystal ferrite microtensile tests. This is done for the discrete slip plane model with and without non-Schmid effects, as well as for a conventional crystal plasticity model. The conventional crystal plasticity model fails to predict the diversity in active slip systems that is observed experimentally. The slip activity obtained with the discrete slip plane model is in convincingly better agreement with the experiments. Including non-Schmid effects only entails minor differences. This suggests that stochastic effects dominate the behavior of ferrite crystals with dimensions in the order of a few micrometers and that non-Schmid effects may not play a large role., Comment: 26 pages, 10 figures, submitted for publication

Published
2024

5. Finding joy, creativity and meaning through unusual interdisciplinary collaborations.

Author

CUCo, Lamain, C., Brugman, S., Boes, M., Schoevaars, C., Tetteroo, D., Veldhuizen, M. D., Wijnen, J. P., Lakens, D., Albronda, F., Hofmann, S., Knittel, S., and Duncan, J.

Subjects
SPACE exploration, STRAINS & stresses (Mechanics), TRUST, ACADEMIA, CULTURE
Abstract

Academics are increasingly calling for and asked to, work in interdisciplinary teams to address pressing social-ecological challenges. However, there are significant barriers to pursuing interdisciplinary collaborations within current university structures. Taking the first two years of our Centre for Unusual Collaborations (CUCo) as a case study of setting up a space for exploration and experimentation, we discuss how unusual interdisciplinary collaborations had unexpected effects, beyond the potential for societal impact. Most surprisingly, we found the CUCo model offered a welcome opportunity to break away from the productivism and competition that is common in academia while stimulating exploration of our own disciplines. This often led to an expansion of ideas and deepened understanding in ways that sparked joy, curiosity, creativity and meaning. We discuss how academic culture currently hampers collaboration: key roadblocks are identified, specifically rewards and recognition, the lack of spaces for trust-building, and competence and skills that are not geared towards collaboration. We present lessons learned in overcoming roadblocks to stimulate research across disciplinary lines and explain how unusual interdisciplinary collaborations provide opportunities for opening and deepening research lines, and how they can be fun and meaningful. We argue that, at a moment when academia faces growing rates of burnout and stress, such collaborations are fundamental. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

Author

Antoniou, AC, Kuchenbaecker, KB, Soucy, P, Beesley, J, Chen, X, McGuffog, L, Lee, A, Barrowdale, D, Healey, S, Sinilnikova, OM, Caligo, MA, Loman, N, Harbst, K, Lindblom, A, Arver, B, Rosenquist, R, Karlsson, P, Nathanson, K, Domchek, S, Rebbeck, T, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Zlowowcka-Perlowska, E, Osorio, A, Duran, M, Andres, R, Benitez, J, Hamann, U, Hogervorst, FB, van Os, TA, Verhoef, S, Meijers-Heijboer, HEJ, Wijnen, J, Garcia, EBG, Ligtenberg, MJ, Kriege, M, Collee, M, Ausems, MGEM, Oosterwijk, JC, Peock, S, Frost, D, Ellis, SD, Platte, R, Fineberg, E, Evans, DG, Lalloo, F, Jacobs, C, Eeles, R, Adlard, J, Davidson, R, Cole, T, Cook, J, Paterson, J, Douglas, F, Brewer, C, Hodgson, S, Morrison, PJ, Walker, L, Rogers, MT, Donaldson, A, Dorkins, H, Godwin, AK, Bove, B, Stoppa-Lyonnet, D, Houdayer, C, Buecher, B, de Pauw, A, Mazoyer, S, Calender, A, Leone, M, Bressac-de Paillerets, B, Caron, O, Sobol, H, Frenay, M, Prieur, F, Ferrer, SF, Mortemousque, I, Buys, S, Daly, M, Miron, A, Terry, MB, Hopper, JL, John, EM, Southey, M, Goldgar, D, Singer, CF, Fink-Retter, A, Tea, M-K, Kaulich, DG, Hansen, TVO, Nielsen, FC, Barkardottir, RB, Gaudet, M, Kirchhoff, T, Joseph, V, Dutra-Clarke, A, Offit, K, and Piedmonte, M

Published
2012

9. Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Author

Mulligan, AM, Couch, FJ, Barrowdale, D, Domchek, SM, Eccles, D, Nevanlinna, H, Ramus, SJ, Robson, M, Sherman, M, Spurdle, AB, Wappenschmidt, B, Lee, A, McGuffog, L, Healey, S, Sinilnikova, OM, Janavicius, R, Hansen, TV, Nielsen, FC, Ejlertsen, B, Osorio, A, Muñoz-Repeto, I, Durán, M, Godino, J, Pertesi, M, Benítez, J, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Cattaneo, E, Bonanni, B, Viel, A, Pasini, B, Papi, L, Ottini, L, Savarese, A, Bernard, L, Radice, P, Hamann, U, Verheus, M, Meijers-Heijboer, HEJ, Wijnen, J, Gómez García, EB, Nelen, MR, Kets, CM, Seynaeve, C, Tilanus-Linthorst, MMA, van der Luijt, RB, Os, TV, Rookus, M, Frost, D, Jones, JL, Evans, DG, Lalloo, F, Eeles, R, Izatt, L, Adlard, J, Davidson, R, Cook, J, Donaldson, A, Dorkins, H, Gregory, H, Eason, J, Houghton, C, Barwell, J, Side, LE, McCann, E, Murray, A, Peock, S, Godwin, AK, Schmutzler, RK, Rhiem, K, Engel, C, Meindl, A, Ruehl, I, Arnold, N, Niederacher, D, Sutter, C, Deissler, H, Gadzicki, D, Kast, K, Preisler-Adams, S, Varon-Mateeva, R, Schoenbuchner, I, Fiebig, B, Heinritz, W, Schäfer, D, Gevensleben, H, and Caux-Moncoutier, V

Abstract

Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour.Methods: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach.Results: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 × 10-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status.Conclusions: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers. © 2011 Mulligan et al.; licensee BioMed Central Ltd.

Published
2011

10. Introduction of ultra-high-field MR brain imaging in infants: vital parameters, temperature and comfort

Author

MS Neonatologie, Arts-assistenten Kinderen, Brain, Child Health, Developmental Disorders, Circulatory Health, Regenerative Medicine and Stem Cells, MS Radiologie, Highfield Research Group, Cancer, Beeldverwerking ISI, Computational Imaging, Infection & Immunity, van Ooijen, I. M., Annink, K. V., Benders, M. J.N.L., Dudink, J., Alderliesten, T., Groenendaal, F., Tataranno, M. L., Lequin, M. H., Hoogduin, J. M., Visser, F., Raaijmakers, A. J.E., Klomp, D. W.J., Wiegers, E. C., Wijnen, J. P., van der Aa, N. E., MS Neonatologie, Arts-assistenten Kinderen, Brain, Child Health, Developmental Disorders, Circulatory Health, Regenerative Medicine and Stem Cells, MS Radiologie, Highfield Research Group, Cancer, Beeldverwerking ISI, Computational Imaging, Infection & Immunity, van Ooijen, I. M., Annink, K. V., Benders, M. J.N.L., Dudink, J., Alderliesten, T., Groenendaal, F., Tataranno, M. L., Lequin, M. H., Hoogduin, J. M., Visser, F., Raaijmakers, A. J.E., Klomp, D. W.J., Wiegers, E. C., Wijnen, J. P., and van der Aa, N. E.

Published
2023

26. BISON projectevaluatie:Deliverable 6.2

Author

Janssen, J.P.W., Wopereis, I.G.J.H., Ebus, J.P., Severeyns - Wijenbergh, H.J.M., and van Wijnen, J.

Subjects
BISON project, projectevaluatie
Abstract

Het SURF-project ‘Begeleiden in Synchroon Online oNderwijs’ (BISON) richt zich op de ontwikkeling van een elektronisch handboek met richtlijnen, instructies en voorbeelden voor het ontwerpen, ontwikkelen en verzorgen (begeleiden) van synchroon online onderwijs voor samenwerkend leren. Het project is gerealiseerd met co-funding van de Stimuleringsregeling Open en Online Onderwijs Evaluatie van het project is erop gericht vast te stellen in hoeverre de beoogde resultaten zijn bereikt binnen de gestelde planning en begroting. De evaluatie omvat daarom zowel proces- als resultaatcriteria.

Published
2021

29. Drie scenario's voor online begeleiding van computerondersteund samenwerkend leren in het hoger onderwijs:Deliverable 3.3

Author

Ebus, J.P., Janssen, J.P.W., Severeyns - Wijenbergh, H.J.M., van Wijnen, J., and Wopereis, I.G.J.H.

Subjects
virtuele klas, BISON project, samenwerkend leren, online begeleiden
Abstract

Het SURF-project ‘Begeleiden in Synchroon Online oNderwijs’ (BISON) richt zich op de ontwikkeling van een elektronisch handboek met richtlijnen, instructies en voorbeelden voor het ontwerpen, ontwikkelen en verzorgen (begeleiden) van synchroon online onderwijs voor samenwerkend leren. Deze richtlijnen, instructies en voorbeelden zijn evidence informed: ze worden ontwikkeld aan de hand van drie scenario’s voor samenwerkend leren: case-based (CBL), problem-based (PBL) en project-based learning (PjBL). Dit rapport beschrijft de incremententele ontwikkeling.

Published
2021

30. Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing

Author

De Leeneer, K., Van Bockstal, M., De Brouwer, S., Swietek, N., Schietecatte, P., Sabbaghian, N., Van den Ende, J., Willocx, S., Storm, K., Blaumeiser, B., Van Asperen, C. J., Wijnen, J. T., Leunen, K., Legius, E., Michils, G., Matthijs, G., Blok, M. J., Gomez-Garcia, E., De Paepe, A., Tischkowitz, M., Poppe, B., and Claes, K.

Published
2012
Full Text
View/download PDF

32. Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

Author

Vasen, H. F. A., Möslein, G., Alonso, A., Aretz, S., Bernstein, I., Bertario, L., Blanco, I., Bulow, S., Burn, J., Capella, G., Colas, C., Engel, C., Frayling, I., Rahner, N., Hes, F. J., Hodgson, S., Mecklin, J.-P., Møller, P., Myrhøj, T., Nagengast, F. M., Parc, Y., Ponz de Leon, M., Renkonen-Sinisalo, L., Sampson, J. R., Stormorken, A., Tejpar, S., Thomas, H. J. W., Wijnen, J., Lubinski, J., Järvinen, H., Claes, E., Heinimann, K., Karagiannis, J. A., Lindblom, A., Dove-Edwin, I., and Müller, H.

Published
2010
Full Text
View/download PDF

34. Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Author

Vasen, H.F.A., Moslein, G., Alonso, A., Aretz, S., Bernstein, I., Bertario, L., Blanco, I., Bulow, S., Burn, J., Capella, G., Colas, C., Engel, C., Frayling, I., Friedl, W., Hes, F.J., Hodgson, S., Jarvinen, H., Mecklin, J.-P., Moller, P., Myrhoi, T., Nagengast, F.M., Parc, Y., Phillips, R., Clark, S.K., Ponz de Leon, M., Renkonen-Sinisalo, L., Sampson, J.R., Stormorken, A., Tejpar, S., Thomas, H.J.W., and Wijnen, J.

Subjects
Polyposis, Familial -- Care and treatment, Practice guidelines (Medicine) -- Evaluation, Colorectal cancer -- Risk factors, Colorectal cancer -- Prevention, Health
Published
2008

37. Online active learning: a comparison of three virtual classroom collaborative learning scenarios

Author

Janssen, J., Wopereis, I., Swennenhuis, P., Ebus, P., Severeyns - Wijenbergh, H., van Wijnen, J., Gómez Chova, L., López Martínez, A., Candel Torres, I., Department of Online Learning and Instruction, RS-Theme Technology Enhanced Assessment, RS-Theme Multimodal Learning Experiences, Expertise Centre for Education (Consultancy, Training and Production), RS-Research Program Welten Onderzoeksprogramma (WO), Department of Technology Enhanced Learning and Innovation, Department of Private Law, RS-Research Program Law in a network society (LNS), Department of Environmental Sciences, and RS-Research Line Resilience (part of LIRS program)

Subjects
Online active learning, ComputingMilieux_COMPUTERSANDEDUCATION, Virtual classroom, Collaborative learning
Abstract

Although virtual classroom (videoconferencing) technology has developed into full maturity, from a pedagogical perspective its deployment in higher online education is still rather limited in terms of interactivity and student-centred learning designs. Whereas current virtual classroom functionalities support the use of a plethora of collaborative learning techniques, teachers appear reluctant in exploring them. We describe the development, implementation and evaluation of three didactical scenarios for collaborative learning in the virtual classroom: case-based learning, project-based learning and problem-based learning. The scenarios were developed building on existing initiatives in three different fields (Law, Science, and Educational Sciences). The three scenarios involve a variety of online collaborative learning activities in parallel groups of various sizes. The scenarios have been evaluated with students through online questionnaires and in focus groups, drawing on the Group Learning Activities Instructional Design framework. Results indicate high satisfaction levels across the scenarios regarding the technology used (virtual classroom as well as its communication tools). Satisfaction regarding collaborative activities varied, depending on duration (i.e., size) of the group learning task and related feedback needs.

Published
2020

38. Introduction of Ultra-High-Field MR Imaging in Infants : Preparations and Feasibility

Author

Annink, K. V, Aa, N. E. van der, Dudink, J., Alderliesten, T., Groenendaal, F., Lequin, M., Jansen, F.E., Rhebergen, K. S., Luijten, P., Hendrikse, J., Hoogduin, H. J. M., Huijing, E. R., Versteeg, E., Visser, F., Raaijmakers, A. J. E., Wiegers, E.C., Klomp, D. W. J., Wijnen, J. P., Benders, M. J. N. L., Annink, K. V, Aa, N. E. van der, Dudink, J., Alderliesten, T., Groenendaal, F., Lequin, M., Jansen, F.E., Rhebergen, K. S., Luijten, P., Hendrikse, J., Hoogduin, H. J. M., Huijing, E. R., Versteeg, E., Visser, F., Raaijmakers, A. J. E., Wiegers, E.C., Klomp, D. W. J., Wijnen, J. P., and Benders, M. J. N. L.

Published
2020

45. Skeletal Gene Expression in Nuclear Microenvironments

Author

Stein, Gary S., primary, Lian, Jane B., additional, Montecino, Martin, additional, van Wijnen, J., additional, Stein, Janet L., additional, Javed, Amjad, additional, Young, Daniel W., additional, Hassan, Mohammad Q., additional, and Zaidi, Sayyed K., additional

Published
2008
Full Text
View/download PDF

48. OC-0586: Can MRI predict pathologic response after single dose neoadjuvant partial breast irradiation?

Author

Vasmel, J., primary, Groot Koerkamp, M., additional, Charaghvandi, R., additional, Vreuls, C., additional, Van Diest, P., additional, Witkamp, A., additional, Koelemij, R., additional, Doeksen, A., additional, Van Dalen, T., additional, Van der Wall, E., additional, Wijnen, J., additional, Van der Velden, B., additional, Moman, M., additional, Veldhuis, W., additional, Philippens, M., additional, Mandija, S., additional, Lagendijk, J., additional, Verkooijen, H., additional, Houweling, A., additional, and Van den Bongard, D., additional

Published
2020
Full Text
View/download PDF

49. Peutz–Jeghers syndrome: a systematic review and recommendations for management

Author

Beggs, A D, Latchford, A R, Vasen, H F, Moslein, G, Alonso, A, Aretz, S, Bertario, L, Blanco, I, Bülow, S, Burn, J, Capella, G, Colas, C, Friedl, W, Møller, P, Hes, F J, Järvinen, H, Mecklin, J-P, Nagengast, F M, Parc, Y, Phillips, R K, Hyer, W, Ponz de Leon, M, Renkonen-Sinisalo, L, Sampson, J R, Stormorken, A, Tejpar, S, Thomas, H J, Wijnen, J T, Clark, S K, and Hodgson, S V

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results