Search

Your search keyword '"Wijeyesakere, Sanjeeva J"' showing total 37 results
Start Over Author "Wijeyesakere, Sanjeeva J"
37 results on '"Wijeyesakere, Sanjeeva J"'

3. List of contributors

Author

Anadón, Arturo, primary, Andrys, Rudolf, additional, Avdonin, Pavel, additional, Bajgar, Jiri, additional, Balali-Mood, Mahdi, additional, Balszuweit, Frank, additional, Banerjee, Atrayee, additional, Bast, Cheryl B., additional, Belinskaia, Daria, additional, Bharti, Vijay K., additional, Bollinger, Claire E., additional, Casillas, Robert P., additional, Clark, Ryan, additional, Clarkson, Edward D., additional, Cole, Toby B., additional, Cope, Rhian B., additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Dettbarn, Wolf-D., additional, Dlabkova, Alzbeta, additional, Doss, Robin B., additional, Dziwenka, Margitta M., additional, Estevez, Jorge, additional, Evans, Tim J., additional, Fink, John K., additional, Flora, Swaran J.S., additional, Furlong, Clement E., additional, Fusek, Josef, additional, Garrick, Jacqueline, additional, Gearhart, Jeffery M., additional, Gerecke, Donald R., additional, Glass-Mattie, Dana F., additional, Goel, Saryu, additional, Goncharov, Nikolay, additional, Gordon, Richard K., additional, Gray, Joshua P., additional, Grubic, Zoran, additional, Gulati, Kavita, additional, Gupta, Ramesh C., additional, Gwaltney-Brant, Sharon M., additional, Hamilton, Tracey A., additional, Harris, Kenneth J., additional, Hood, Darryl B., additional, Jakubowski, Edward M., additional, Jenkins, Richard, additional, Jett, David A., additional, Jiao, Yuqin, additional, John, Harald, additional, Johnson, Nathan H., additional, Jokanović, Milan, additional, Jun, Daniel, additional, Karakashev, Georgy, additional, Kassa, Jiri, additional, Katalinic, Maja, additional, Kehe, Kai, additional, Khlebnikova, Natalia, additional, Kodavanti, Urmila P., additional, Korf, Ekaterina, additional, Koryagina, Nadezhda, additional, Kovač, Bojan, additional, Krishna, Gopala, additional, Krishna, Mayur, additional, Kuca, Kamil, additional, Kumar, Dinesh, additional, Kuroiwa, Yukio, additional, Kuznetsov, Sergey, additional, Kuča, Kamil, additional, Larsen, Joseph C., additional, Leninskiy, Mikhail, additional, Liu, Jing, additional, Lochotzki, Heather, additional, Lockridge, Oksana, additional, Lockwich, Jordana, additional, Loganathan, Bommanna G., additional, Lončar-Stojiljković, Dragana, additional, Lushchekina, Sofya V., additional, Lyman, Megan E., additional, Maguire, Mark, additional, Makhaeva, Galina F., additional, Malik, Jitendra K., additional, Malinak, David, additional, Mars, Tomaz, additional, Marsillach, Judit, additional, Martínez-Larrañaga, María-Rosa, additional, Masson, Patrick, additional, Masunaga, Shigeki, additional, McCallister, Monique, additional, McCauley, Linda A., additional, McClellan, Roger O., additional, McNutt, Patrick M., additional, Meek, Edward C., additional, Merrill, Elaine, additional, Milanez, Sylvia, additional, Mindukshev, Igor, additional, Mis, Katarina, additional, Misik, Jan, additional, Murphy, Michael J., additional, Musilek, Kamil, additional, Nakajima, Tamie, additional, Nelson, Marian R., additional, Nepovimova, Eugenie, additional, Okumura, Tetsu, additional, Patocka, Jiri, additional, Pegan, Katarina, additional, Pejchal, Jaroslav, additional, Pirkmajer, Sergej, additional, Pita, René, additional, Pitt, Jason, additional, Pitt, Yiuka, additional, Platoff, Gennady E., additional, Pope, Carey N., additional, Radilov, Andrey, additional, Rahal, Anu, additional, Ramesh, Aramandla, additional, Ray, Arunabha, additional, Rembovskiy, Vladimir, additional, Rhoades, Raina, additional, Richardson, Rudy J., additional, Ristić, Dragana, additional, Robinson, Peter J., additional, Romero, Alejandro, additional, Ruark, Chris, additional, Salem, Harry, additional, Samchenko, Natalia, additional, Satoh, Tetsuo, additional, Savage, Russell E., additional, Savelieva, Elena, additional, Schopfer, Lawrence M., additional, Sciuto, Alfred M., additional, Seto, Yasuo, additional, Shakarjian, Michael P., additional, Shmurak, Vladimir, additional, Skarka, Adam, additional, Škrbić, Ranko, additional, Sogorb, Miguel, additional, Spriggs, Shardell M., additional, Srivastava, Sakshi, additional, Steinritz, Dirk, additional, Stojiljković, Miloš P., additional, Tewari-Singh, Neera, additional, Thiermann, Horst, additional, Thokchom, Suresh Kumar, additional, Thompson, Larry J., additional, Ukolov, Anton, additional, Valerio, Luis G., additional, van der Schans, M.J., additional, Varma, Daya R., additional, Vilanova, Eugenio, additional, Watson, Annetta, additional, Wijeyesakere, Sanjeeva J., additional, Wismer, Tina, additional, Worden, R. Mark, additional, Worek, Franz, additional, Wright, Linzzi K., additional, Yamasue, Hidenori, additional, Yoshida, Takemi, additional, Yoshioka, Toshiharu, additional, Young, Robert A., additional, Zaja-Milatovic, Snjezana, additional, Zinchenko, Valeriy, additional, and Zoltani, Csaba K., additional

Published
2020
Full Text
View/download PDF

15. List of Contributors

Author

Anadón, Arturo, primary, Anderson, Jaime, additional, Anzai, Jun-ichi, additional, Aschner, Michael, additional, Avdonin, Pavel, additional, Bajgar, Jiri, additional, Bakshi, Kulbir, additional, Balali-Mood, Mahdi, additional, Balszuweit, Frank, additional, Banerjee, Atrayee, additional, Bast, Cheryl B., additional, Bhattacharya, Rahul, additional, Bollinger, Claire E., additional, Casillas, Robert P., additional, Chemtob, Sylvain, additional, Clark, Ryan, additional, Clarkson, Edward D., additional, Cole, Toby B., additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Dettbarn, Wolf-D., additional, Dobbins, Dorothy L., additional, Dorsey, Russell, additional, Dziwenka, Margitta, additional, Emmett, George, additional, Estévez, Jorge, additional, Evans, Timothy J., additional, Fink, John K., additional, Flora, Swaran J.S., additional, Fonnum, Frode, additional, Furlong, Clement E., additional, Fusek, Josef, additional, Gearhart, Jeffery M., additional, Gerecke, Donald R., additional, Glass-Mattie, Dana F., additional, Goel, Saryu, additional, Goncharov, Nikolay, additional, Gordon, Richard K., additional, Gray, Joshua P., additional, Grubic, Zoran, additional, Gulati, Kavita, additional, Gupta, Ramesh C., additional, Gwaltney-Brant, Sharon M., additional, Hamilton, Tracey L., additional, Hauschild, Veronique, additional, Hein, Nichole D., additional, Hilmas, Corey J., additional, Hilmas, Elora, additional, Hood, Darryl B., additional, Jakubowski, Edward M., additional, Jenkins, Richard O., additional, Jett, David A., additional, Jiang, George C-T, additional, Jiao, Yuqin, additional, John, Harald, additional, Johnson, Nathan H., additional, Jokanović, Milan, additional, Jun, Daniel, additional, Kadakkuzha, Beena M., additional, Kassa, Jiri, additional, Katalinic, Maja, additional, Kehe, Kai, additional, Khlebnikova, Natalia, additional, King, Joseph, additional, Kodavanti, Urmila P., additional, Korabecny, Jan, additional, Krishna, Gopala, additional, Krivorotova, Nadezhda, additional, Kuca, Kamil, additional, Kuroiwa, Yukio, additional, Kuznetsov, Anatoliy, additional, Kuznetsov, Sergey, additional, Larsen, Joseph C., additional, Leung, Yiuka, additional, Liu, Jing, additional, Liu, Xin-an, additional, Lockridge, Oksana, additional, Loganathan, Bommanna G., additional, Lugo, Andres M., additional, Maguire, Mark, additional, Makhaeva, Galina F., additional, Malik, Jitendra K., additional, Mars, Tomaz, additional, Martínez-Larrañaga, Maria Rosa, additional, Masson, Patrick, additional, Masunaga, Shigeki, additional, McCallister, Monique, additional, McCauley, Linda A., additional, McNutt, Patrick M., additional, Meek, Edward, additional, Merrill, Elaine, additional, Milanez, Sylvia, additional, Mindukshev, Igor, additional, Mis, Katarina, additional, Mulay, Shree, additional, Murphy, Michael J., additional, Musilek, Kamil, additional, Myhrer, Trond, additional, Okumura, Tetsu, additional, Opresko, Dennis, additional, Orlova, Tatiana, additional, Pål, Aas, additional, Pan, Xiaoping, additional, Patocka, Jiri, additional, Pirkmajer, Sergej, additional, Pita, Rene, additional, Pitt, Jason, additional, Pope, Carey, additional, Prokofieva, Daria, additional, Radilov, Andrey, additional, Ramaiah, Shashi K., additional, Ramesh, Aramandla, additional, Ray, Arunabha, additional, Ray, Kausik, additional, Rembovskiy, Vladimir, additional, Rhoades, Raina, additional, Richardson, Rudy J., additional, Rizzo, Valerio, additional, Robinson, Peter J., additional, Ruark, Chris, additional, Salem, Harry, additional, Satoh, Tetsuo, additional, Savage, Russell E., additional, Savelieva, Elena, additional, Schopfer, Lawrence M., additional, Sciuto, Alfred M., additional, Seto, Yasuo, additional, Shakarjian, Michael P., additional, Sogorb, Miguel, additional, Soreq, Hermona, additional, Sterri, Sigrun Hanne, additional, Stick, Melissa, additional, Suzuki, Kouichiro, additional, Taki, Kenji, additional, Thiermann, Horst, additional, Thompson, Larry J., additional, Uchea, Chibuzor, additional, Ukolov, Anton, additional, Valerio, Luis G., additional, Van der Merwe, Deon, additional, van der Schans, Marcel J., additional, Varma, Daya R., additional, Vilanova, Eugenio, additional, Vinokurov, Maxim, additional, Voitenko, Natalia, additional, Waiskopf, Nir, additional, Watson, Annetta, additional, Wijeyesakere, Sanjeeva J., additional, Wismer, Tina, additional, Woltjer, Randall L., additional, Mark Worden, R., additional, Worek, Franz, additional, Wright, Linnzi, additional, Yeung, David T., additional, Yoshida, Takemi, additional, Young, Robert A., additional, Zaja-Milatovic, Snjezana, additional, Zinchenko, Valeriy, additional, and Zoltani, Csaba K., additional

Published
2015
Full Text
View/download PDF

16. Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite

Author

Mansouri, Kamel, primary, Karmaus, Agnes L., additional, Fitzpatrick, Jeremy, additional, Patlewicz, Grace, additional, Pradeep, Prachi, additional, Alberga, Domenico, additional, Alepee, Nathalie, additional, Allen, Timothy E.H., additional, Allen, Dave, additional, Alves, Vinicius M., additional, Andrade, Carolina H., additional, Auernhammer, Tyler R., additional, Ballabio, Davide, additional, Bell, Shannon, additional, Benfenati, Emilio, additional, Bhattacharya, Sudin, additional, Bastos, Joyce V., additional, Boyd, Stephen, additional, Brown, J. B., additional, Capuzzi, Stephen J., additional, Chushak, Yaroslav, additional, Ciallella, Heather, additional, Clark, Alex M., additional, Consonni, Viviana, additional, Daga, Pankaj R., additional, Ekins, Sean, additional, Farag, Sherif, additional, Fedorov, Maxim, additional, Fourches, Denis, additional, Gadaleta, Domenico, additional, Gao, Feng, additional, Gearhart, Jeffery M., additional, Goh, Garett, additional, Goodman, Jonathan M., additional, Grisoni, Francesca, additional, Grulke, Christopher M., additional, Hartung, Thomas, additional, Hirn, Matthew, additional, Karpov, Pavel, additional, Korotcov, Alexandru, additional, Lavado, Giovanna J., additional, Lawless, Michael, additional, Li, Xinhao, additional, Luechtefeld, Thomas, additional, Lunghini, Filippo, additional, Mangiatordi, Giuseppe F., additional, Marcou, Gilles, additional, Marsh, Dan, additional, Martin, Todd, additional, Mauri, Andrea, additional, Muratov, Eugene N., additional, Myatt, Glenn J., additional, Nguyen, Dac-Trung, additional, Nicolotti, Orazio, additional, Note, Reine, additional, Pande, Paritosh, additional, Parks, Amanda K., additional, Peryea, Tyler, additional, Polash, Ahsan H., additional, Rallo, Robert, additional, Roncaglioni, Alessandra, additional, Rowlands, Craig, additional, Ruiz, Patricia, additional, Russo, Daniel P., additional, Sayed, Ahmed, additional, Sayre, Risa, additional, Sheils, Timothy, additional, Siegel, Charles, additional, Silva, Arthur C., additional, Simeonov, Anton, additional, Sosnin, Sergey, additional, Southall, Noel, additional, Strickland, Judy, additional, Tang, Yun, additional, Teppen, Brian, additional, Tetko, Igor V., additional, Thomas, Dennis, additional, Tkachenko, Valery, additional, Todeschini, Roberto, additional, Toma, Cosimo, additional, Tripodi, Ignacio, additional, Trisciuzzi, Daniela, additional, Tropsha, Alexander, additional, Varnek, Alexandre, additional, Vukovic, Kristijan, additional, Wang, Zhongyu, additional, Wang, Liguo, additional, Waters, Katrina M., additional, Wedlake, Andrew J., additional, Wijeyesakere, Sanjeeva J., additional, Wilson, Dan, additional, Xiao, Zijun, additional, Yang, Hongbin, additional, Zahoranszky-Kohalmi, Gergely, additional, Zakharov, Alexey V., additional, Zhang, Fagen F., additional, Zhang, Zhen, additional, Zhao, Tongan, additional, Zhu, Hao, additional, Zorn, Kimberley M., additional, Casey, Warren, additional, and Kleinstreuer, Nicole C., additional

Published
2021
Full Text
View/download PDF

18. CATMoS: Collaborative Acute Toxicity Modeling Suite

Author

Mansouri, K, Karmaus, A, Fitzpatrick, J, Patlewicz, G, Pradeep, P, Alberga, D, Alepee, N, Allen, T, Allen, D, Alves, V, Andrade, C, Auernhammer, T, Ballabio, D, Bell, S, Benfenati, E, Bhattacharya, S, Bastos, J, Boyd, S, Brown, J, Capuzzi, S, Chushak, Y, Ciallella, H, Clark, A, Consonni, V, Daga, P, Ekins, S, Farag, S, Fedorov, M, Fourches, D, Gadaleta, D, Gao, F, Gearhart, J, Goh, G, Goodman, J, Grisoni, F, Grulke, C, Hartung, T, Hirn, M, Karpov, P, Korotcov, A, Lavado, G, Lawless, M, Li, X, Luechtefeld, T, Lunghini, F, Mangiatordi, G, Marcou, G, Marsh, D, Martin, T, Mauri, A, Muratov, E, Myatt, G, Nguyen, D, Nicolotti, O, Note, R, Pande, P, Parks, A, Peryea, T, Polash, A, Rallo, R, Roncaglioni, A, Rowlands, C, Ruiz, P, Russo, D, Sayed, A, Sayre, R, Sheils, T, Siegel, C, Silva, A, Simeonov, A, Sosnin, S, Southall, N, Strickland, J, Tang, Y, Teppen, B, Tetko, I, Thomas, D, Tkachenko, V, Todeschini, R, Toma, C, Tripodi, I, Trisciuzzi, D, Tropsha, A, Varnek, A, Vukovic, K, Wang, Z, Wang, L, Waters, K, Wedlake, A, Wijeyesakere, S, Wilson, D, Xiao, Z, Yang, H, Zahoranszky-Kohalmi, G, Zakharov, A, Zhang, F, Zhang, Z, Zhao, T, Zhu, H, Zorn, K, Casey, W, Kleinstreuer, N, Mansouri, Kamel, Karmaus, Agnes L, Fitzpatrick, Jeremy, Patlewicz, Grace, Pradeep, Prachi, Alberga, Domenico, Alepee, Nathalie, Allen, Timothy E H, Allen, Dave, Alves, Vinicius M, Andrade, Carolina H, Auernhammer, Tyler R, Ballabio, Davide, Bell, Shannon, Benfenati, Emilio, Bhattacharya, Sudin, Bastos, Joyce V, Boyd, Stephen, Brown, J B, Capuzzi, Stephen J, Chushak, Yaroslav, Ciallella, Heather, Clark, Alex M, Consonni, Viviana, Daga, Pankaj R, Ekins, Sean, Farag, Sherif, Fedorov, Maxim, Fourches, Denis, Gadaleta, Domenico, Gao, Feng, Gearhart, Jeffery M, Goh, Garett, Goodman, Jonathan M, Grisoni, Francesca, Grulke, Christopher M, Hartung, Thomas, Hirn, Matthew, Karpov, Pavel, Korotcov, Alexandru, Lavado, Giovanna J, Lawless, Michael, Li, Xinhao, Luechtefeld, Thomas, Lunghini, Filippo, Mangiatordi, Giuseppe F, Marcou, Gilles, Marsh, Dan, Martin, Todd, Mauri, Andrea, Muratov, Eugene N, Myatt, Glenn J, Nguyen, Dac-Trung, Nicolotti, Orazio, Note, Reine, Pande, Paritosh, Parks, Amanda K, Peryea, Tyler, Polash, Ahsan H, Rallo, Robert, Roncaglioni, Alessandra, Rowlands, Craig, Ruiz, Patricia, Russo, Daniel P, Sayed, Ahmed, Sayre, Risa, Sheils, Timothy, Siegel, Charles, Silva, Arthur C, Simeonov, Anton, Sosnin, Sergey, Southall, Noel, Strickland, Judy, Tang, Yun, Teppen, Brian, Tetko, Igor V, Thomas, Dennis, Tkachenko, Valery, Todeschini, Roberto, Toma, Cosimo, Tripodi, Ignacio, Trisciuzzi, Daniela, Tropsha, Alexander, Varnek, Alexandre, Vukovic, Kristijan, Wang, Zhongyu, Wang, Liguo, Waters, Katrina M, Wedlake, Andrew J, Wijeyesakere, Sanjeeva J, Wilson, Dan, Xiao, Zijun, Yang, Hongbin, Zahoranszky-Kohalmi, Gergely, Zakharov, Alexey V, Zhang, Fagen F, Zhang, Zhen, Zhao, Tongan, Zhu, Hao, Zorn, Kimberley M, Casey, Warren, Kleinstreuer, Nicole C, Mansouri, K, Karmaus, A, Fitzpatrick, J, Patlewicz, G, Pradeep, P, Alberga, D, Alepee, N, Allen, T, Allen, D, Alves, V, Andrade, C, Auernhammer, T, Ballabio, D, Bell, S, Benfenati, E, Bhattacharya, S, Bastos, J, Boyd, S, Brown, J, Capuzzi, S, Chushak, Y, Ciallella, H, Clark, A, Consonni, V, Daga, P, Ekins, S, Farag, S, Fedorov, M, Fourches, D, Gadaleta, D, Gao, F, Gearhart, J, Goh, G, Goodman, J, Grisoni, F, Grulke, C, Hartung, T, Hirn, M, Karpov, P, Korotcov, A, Lavado, G, Lawless, M, Li, X, Luechtefeld, T, Lunghini, F, Mangiatordi, G, Marcou, G, Marsh, D, Martin, T, Mauri, A, Muratov, E, Myatt, G, Nguyen, D, Nicolotti, O, Note, R, Pande, P, Parks, A, Peryea, T, Polash, A, Rallo, R, Roncaglioni, A, Rowlands, C, Ruiz, P, Russo, D, Sayed, A, Sayre, R, Sheils, T, Siegel, C, Silva, A, Simeonov, A, Sosnin, S, Southall, N, Strickland, J, Tang, Y, Teppen, B, Tetko, I, Thomas, D, Tkachenko, V, Todeschini, R, Toma, C, Tripodi, I, Trisciuzzi, D, Tropsha, A, Varnek, A, Vukovic, K, Wang, Z, Wang, L, Waters, K, Wedlake, A, Wijeyesakere, S, Wilson, D, Xiao, Z, Yang, H, Zahoranszky-Kohalmi, G, Zakharov, A, Zhang, F, Zhang, Z, Zhao, T, Zhu, H, Zorn, K, Casey, W, Kleinstreuer, N, Mansouri, Kamel, Karmaus, Agnes L, Fitzpatrick, Jeremy, Patlewicz, Grace, Pradeep, Prachi, Alberga, Domenico, Alepee, Nathalie, Allen, Timothy E H, Allen, Dave, Alves, Vinicius M, Andrade, Carolina H, Auernhammer, Tyler R, Ballabio, Davide, Bell, Shannon, Benfenati, Emilio, Bhattacharya, Sudin, Bastos, Joyce V, Boyd, Stephen, Brown, J B, Capuzzi, Stephen J, Chushak, Yaroslav, Ciallella, Heather, Clark, Alex M, Consonni, Viviana, Daga, Pankaj R, Ekins, Sean, Farag, Sherif, Fedorov, Maxim, Fourches, Denis, Gadaleta, Domenico, Gao, Feng, Gearhart, Jeffery M, Goh, Garett, Goodman, Jonathan M, Grisoni, Francesca, Grulke, Christopher M, Hartung, Thomas, Hirn, Matthew, Karpov, Pavel, Korotcov, Alexandru, Lavado, Giovanna J, Lawless, Michael, Li, Xinhao, Luechtefeld, Thomas, Lunghini, Filippo, Mangiatordi, Giuseppe F, Marcou, Gilles, Marsh, Dan, Martin, Todd, Mauri, Andrea, Muratov, Eugene N, Myatt, Glenn J, Nguyen, Dac-Trung, Nicolotti, Orazio, Note, Reine, Pande, Paritosh, Parks, Amanda K, Peryea, Tyler, Polash, Ahsan H, Rallo, Robert, Roncaglioni, Alessandra, Rowlands, Craig, Ruiz, Patricia, Russo, Daniel P, Sayed, Ahmed, Sayre, Risa, Sheils, Timothy, Siegel, Charles, Silva, Arthur C, Simeonov, Anton, Sosnin, Sergey, Southall, Noel, Strickland, Judy, Tang, Yun, Teppen, Brian, Tetko, Igor V, Thomas, Dennis, Tkachenko, Valery, Todeschini, Roberto, Toma, Cosimo, Tripodi, Ignacio, Trisciuzzi, Daniela, Tropsha, Alexander, Varnek, Alexandre, Vukovic, Kristijan, Wang, Zhongyu, Wang, Liguo, Waters, Katrina M, Wedlake, Andrew J, Wijeyesakere, Sanjeeva J, Wilson, Dan, Xiao, Zijun, Yang, Hongbin, Zahoranszky-Kohalmi, Gergely, Zakharov, Alexey V, Zhang, Fagen F, Zhang, Zhen, Zhao, Tongan, Zhu, Hao, Zorn, Kimberley M, Casey, Warren, and Kleinstreuer, Nicole C

Abstract

Background: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management. However, it is cost- and time-prohibitive to evaluate all new and existing chemicals using traditional rodent acute toxicity tests. In silica models built using existing data facilitate rapid acute tox- icity predictions without using animals. Objkctivks: The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Acute Toxicity Workgroup organ- ized an international collaboration to develop in silica models for predicting acute oral toxicity based on five different end points: Lethal Dose 50 (LD50 value, U.S. Environmental Protection Agency hazard (four) categories, Globally Harmonized System for Classification and Labeling hazard (five) categories, very toxic chemicals [LD50 (LD50 ≤ 50 mg/kg)], and nontoxic chemicals (LD50 > 2,000 mg/kg). Mkthods: An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches. Results: The resulting consensus predictions, which leverage the collective strengths of each individual model, form the Collaborative Acute Toxicity Modeling Suite (CATMoS). CATMoS demonstrated high performance in terms of accuracy and robustness when compared with in viva results. Discussion: CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for in viva rat acute oral toxicity studies. CATMoS predictions for more than 800,000 chemica

Published
2021

19. CATMoS: Collaborative Acute Toxicity Modeling Suite

Author

Mansouri, Kamel, primary, Karmaus, Agnes L., additional, Fitzpatrick, Jeremy, additional, Patlewicz, Grace, additional, Pradeep, Prachi, additional, Alberga, Domenico, additional, Alepee, Nathalie, additional, Allen, Timothy E.H., additional, Allen, Dave, additional, Alves, Vinicius M., additional, Andrade, Carolina H., additional, Auernhammer, Tyler R., additional, Ballabio, Davide, additional, Bell, Shannon, additional, Benfenati, Emilio, additional, Bhattacharya, Sudin, additional, Bastos, Joyce V., additional, Boyd, Stephen, additional, Brown, J.B., additional, Capuzzi, Stephen J., additional, Chushak, Yaroslav, additional, Ciallella, Heather, additional, Clark, Alex M., additional, Consonni, Viviana, additional, Daga, Pankaj R., additional, Ekins, Sean, additional, Farag, Sherif, additional, Fedorov, Maxim, additional, Fourches, Denis, additional, Gadaleta, Domenico, additional, Gao, Feng, additional, Gearhart, Jeffery M., additional, Goh, Garett, additional, Goodman, Jonathan M., additional, Grisoni, Francesca, additional, Grulke, Christopher M., additional, Hartung, Thomas, additional, Hirn, Matthew, additional, Karpov, Pavel, additional, Korotcov, Alexandru, additional, Lavado, Giovanna J., additional, Lawless, Michael, additional, Li, Xinhao, additional, Luechtefeld, Thomas, additional, Lunghini, Filippo, additional, Mangiatordi, Giuseppe F., additional, Marcou, Gilles, additional, Marsh, Dan, additional, Martin, Todd, additional, Mauri, Andrea, additional, Muratov, Eugene N., additional, Myatt, Glenn J., additional, Nguyen, Dac-Trung, additional, Nicolotti, Orazio, additional, Note, Reine, additional, Pande, Paritosh, additional, Parks, Amanda K., additional, Peryea, Tyler, additional, Polash, Ahsan H., additional, Rallo, Robert, additional, Roncaglioni, Alessandra, additional, Rowlands, Craig, additional, Ruiz, Patricia, additional, Russo, Daniel P., additional, Sayed, Ahmed, additional, Sayre, Risa, additional, Sheils, Timothy, additional, Siegel, Charles, additional, Silva, Arthur C., additional, Simeonov, Anton, additional, Sosnin, Sergey, additional, Southall, Noel, additional, Strickland, Judy, additional, Tang, Yun, additional, Teppen, Brian, additional, Tetko, Igor V., additional, Thomas, Dennis, additional, Tkachenko, Valery, additional, Todeschini, Roberto, additional, Toma, Cosimo, additional, Tripodi, Ignacio, additional, Trisciuzzi, Daniela, additional, Tropsha, Alexander, additional, Varnek, Alexandre, additional, Vukovic, Kristijan, additional, Wang, Zhongyu, additional, Wang, Liguo, additional, Waters, Katrina M., additional, Wedlake, Andrew J., additional, Wijeyesakere, Sanjeeva J., additional, Wilson, Dan, additional, Xiao, Zijun, additional, Yang, Hongbin, additional, Zahoranszky-Kohalmi, Gergely, additional, Zakharov, Alexey V., additional, Zhang, Fagen F., additional, Zhang, Zhen, additional, Zhao, Tongan, additional, Zhu, Hao, additional, Zorn, Kimberley M., additional, Casey, Warren, additional, and Kleinstreuer, Nicole C., additional

Published
2021
Full Text
View/download PDF

22. Contributors

Author

Ajwa, Husein, primary, Ale, Iris S., additional, Allen, Sandra L., additional, Alsop, Judith, additional, Arce, Gail, additional, Ashworth, D.J., additional, Balakrishnan, Sharada, additional, Barnett, John B., additional, Barr, Dana B., additional, Barry, Terrell, additional, Baynes, Ronald E., additional, Beauvais, Sheryl, additional, Bentley, Karin S., additional, Bernard, Craig E., additional, Besbelli, Nida, additional, Billington, Richard, additional, Blacker, Ann M., additional, Blancazo, Jerry N., additional, Breckenridge, Charles B., additional, Brooks, Gerald T., additional, Bruckner, James, additional, Brundage, Kathleen M., additional, Bui, Quang, additional, Buratti, Franca M., additional, Bus, James S., additional, Calvert, Geoffrey M., additional, Carlock, Linda L., additional, Casida, John E., additional, Chambers, Howard W., additional, Chambers, Janice E., additional, Chan, Heidi P., additional, Chester, Graham, additional, Clark, J. Marshall, additional, Class, Thomas, additional, Clifton, M. Scott, additional, Cochran, Roger, additional, Consiglio, Emma Di, additional, Dary, Curtis C., additional, Dayan, Franck E., additional, De Vries, Allison L., additional, Dix, Kelly J., additional, Dong, Michael H., additional, Dotson, Timothy A., additional, Doull, John, additional, Driver, Jeffrey H., additional, Duke, Stephen O., additional, Dyk, M. Bigelow, additional, Eastmond, David A., additional, Eaton, David L., additional, Ehrich, Marion, additional, Eisenbrandt, David L., additional, Eldridge, J. Charles, additional, Evans, Jeffrey B., additional, Farmer, Donna, additional, Felsot, Allan S., additional, Fenner-Crisp, Penelope A., additional, Fletcher, Joan L., additional, Flores, Sara, additional, Fortmann, Roy, additional, Fujita, Toshio, additional, Gammon, Derek W., additional, Gao, Suduan, additional, Garry, V.F., additional, Gehen, Sean C., additional, Georgopoulos, Panos, additional, Gollapudi, B.B., additional, Gordon, Elliot B., additional, Guerino, F., additional, Hanley, Thomas R., additional, Hanson, Lindsay, additional, Harp, Paul R., additional, Harrass, Michael C., additional, Harris, Jane E., additional, Hayes, Wayland J., additional, Hertner, Thomas, additional, Hess, Frederick G., additional, Heydens, William F., additional, Hodgson, Ernest, additional, Holden, L., additional, Hotchkiss, Jon A., additional, Hurt, Susan, additional, Isukapalli, Sastry, additional, Iyengar, Seshadri, additional, Iyer, Poorni, additional, Jensen, Inge M., additional, Jones, Russell L., additional, Jortner, Bernard S., additional, Kaneko, Hideo, additional, Kavlock, Robert J., additional, Kelly, Iain D., additional, Kenna, Michael P., additional, Kennepohl, Elke, additional, Keum, Young Soo, additional, Kim, Jeong-Han, additional, Kleinschmidt, Loreen, additional, Klonne, Dennis R., additional, Knaak, James B., additional, Krolski, Mike E., additional, Lamb, Ian C., additional, Lampman, Richard L., additional, Langner, Mikael, additional, Lantz, Jennifer L., additional, Lasserre-Bigot, Dominique, additional, Levin, Edward D., additional, Li, Qing X., additional, Liu, Jing, additional, Lock, Edward A, additional, Lotti, Marcello, additional, Lunchick, Curt, additional, Lyubimov, A.V., additional, Maibach, Howard, additional, Maier, Lisa E., additional, Makris, Susan, additional, Manning, Mark J., additional, Marsh, Rex E., additional, Marty, Melanie, additional, May-Hertl, Ursula, additional, McCurdy, Thomas, additional, McKone, Tom, additional, Meek, Edward C., additional, Mehler, Louise N., additional, Mihlan, Gary J., additional, Moore, Thomas B., additional, Morgan, Marsha K., additional, Munro, Ian C., additional, Narahashi, Toshio, additional, Nishimura, Keiichiro, additional, Novak, Robert J., additional, Ntow, William J., additional, O’Malley, Michael A., additional, Oehme, Frederick W., additional, Ollinger, Janet, additional, Osimitz, Thomas G., additional, Pandian, Muhilan D., additional, Parsons, P.P., additional, Paule, Merle G., additional, Payraudeau, Virginie, additional, Peck, Erin C., additional, Pelfrène, Alain F., additional, Pendino, Kimberly, additional, Petersen, Barbara J., additional, Piccirillo, Amanda L., additional, Piccirillo, Vincent J., additional, Pleil, Joachim D., additional, Ponnock, Kathryn, additional, Pope, Carey, additional, Poppenga, Robert H., additional, Qi, Su-wei, additional, Qin, Ruijun, additional, Ramsingh, Deborah, additional, Reiter, Lawrence W., additional, Richardson, Rudy J., additional, Ritter, Leonard, additional, Riviere, Jim E., additional, Ross, John H., additional, Rozman, Karl K., additional, Rubin, Andrew L., additional, Rust, Michael K., additional, Ruzo, Luis O., additional, Salmon, Terrell P., additional, Sangha, G.K. (Ghona), additional, Seiber, James N., additional, Selman, Frank, additional, Sheets, Larry P., additional, Sheldon, Linda S., additional, Silva, Marilyn, additional, Simpkins, James W., additional, Slikker, William, additional, Slovic, Paul, additional, Smith, Andrew G., additional, Snodgrass, Wayne R., additional, Sobus, Jon R., additional, Soderlund, David M., additional, Solomon, Keith R., additional, Spurlock, Frank, additional, Stevens, James T., additional, Stoker, Tammy E., additional, Stott, W.T., additional, Sudakin, Daniel L., additional, Takayama, Chiyozo, additional, Testai, Emanuela, additional, Thongsinthusak, Thomas, additional, Timchalk, Charles, additional, Timofeeva, Olga A., additional, Tobia, Abraham J., additional, Tornero-Velez, Rogelio, additional, Tulve, Nicolle S., additional, Uchida, Matazaemon, additional, Ujváry, István, additional, Vallero, Daniel, additional, van Ravenswaay, Bennard, additional, Waechter, Felix, additional, Weber, Edgar, additional, Wester, Ronald C., additional, Whatling, Paul, additional, Whitmyre, Gary K., additional, Wicke, Heinrich, additional, Wijeyesakere, Sanjeeva J., additional, Wilks, Martin F., additional, Wilson, Alan G.E., additional, Wilson, Barry W., additional, Woodward, Michael D., additional, Wright, Jayne, additional, Yates, S.R., additional, Yoshida, Masanori, additional, Young, Bruce M., additional, Zalom, Frank G., additional, Zartarian, Valerie, additional, Zhai, Hongbo, additional, and Zhang, Xiaofei, additional

Published
2010
Full Text
View/download PDF

26. Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Lethality.

Author

Sullivan, Kristie M., Allen, David G., Clippinger, Amy J., Wilson, Daniel M., Edwards, Stephen W., Glover, Kyle, Mansouri, Kamel, Settivari, Raja, Wijeyesakere, Sanjeeva J., and Casey, Warren

Abstract

Efforts are underway to develop and implement nonanimal approaches which can characterize acute systemic lethality. A workshop was held in October 2019 to discuss developments in the prediction of acute oral lethality for chemicals and mixtures, as well as progress and needs in the understanding and modeling of mechanisms of acute lethality. During the workshop, each speaker led the group through a series of charge questions to determine clear next steps to progress the aims of the workshop. Participants concluded that a variety of approaches will be needed and should be applied in a tiered fashion. Non-testing approaches, including waiving tests, computational models for single chemicals, and calculating the acute lethality of mixtures based on the LD50 values of mixture components, could be used for some assessments now, especially in the very toxic or non-toxic classification ranges. Agencies can develop policies indicating contexts under which mathematical approaches for mixtures assessment are acceptable; to expand applicability, poorly predicted mixtures should be examined to understand discrepancies and adapt the approach. Transparency and an understanding of the variability of in vivo approaches are crucial to facilitate regulatory application of new approaches. In a replacement strategy, mechanistically based in vitro or in silico models will be needed to support non-testing approaches especially for highly acutely toxic chemicals. The workshop discussed approaches that can be used in the immediate or near term for some applications and identified remaining actions needed to implement approaches to fully replace the use of animals for acute systemic toxicity testing. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

32. Mechanisms of Aging of Phosphylated Serine Hydrolases

Author

MICHIGAN UNIV ANN ARBOR, Richardson, Rudy J., Wijeyesakere, Sanjeeva J., MICHIGAN UNIV ANN ARBOR, Richardson, Rudy J., and Wijeyesakere, Sanjeeva J.

Abstract

The overall goal was to study mechanisms of aging of serine esterases inhibited by organophosphorus compounds capable of producing acute and delayed neurotoxicity. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and neuropathy target esterase catalytic domain (NEST) were reacted with diisopropylphosphorofluoridate (DFP) and N,N'-diisopropylphosphorodiamidofluoridate (mipafox, MlP). Bimolecular rate constants of inhibition and first-order rate constants of aging were determined colorimetrically. Phosphyl adducts of inhibited and aged., The original document contains color images.

Published
2009

33. Mixed Inhibition of Adenosine Deaminase Activity by 1,3-Dinitrobenzene: A Model for Understanding Cell-Selective Neurotoxicity in Chemically-Induced Energy Deprivation Syndromes in Brain

Author

Wang, Yipei, primary, Liu, Xin, additional, Schneider, Brandon, additional, Zverina, Elaina A., additional, Russ, Kristen, additional, Wijeyesakere, Sanjeeva J., additional, Fierke, Carol A., additional, Richardson, Rudy J., additional, and Philbert, Martin A., additional

Published
2011
Full Text
View/download PDF

35. CATMoS: Collaborative Acute Toxicity Modeling Suite

Author

Mansouri, Kamel, Karmaus, Agnes L, Fitzpatrick, Jeremy, Patlewicz, Grace, Pradeep, Prachi, Alberga, Domenico, Alepee, Nathalie, Allen, Timothy EH, Allen, Dave, Alves, Vinicius M, Andrade, Carolina H, Auernhammer, Tyler R, Ballabio, Davide, Bell, Shannon, Benfenati, Emilio, Bhattacharya, Sudin, Bastos, Joyce V, Boyd, Stephen, Brown, JB, Capuzzi, Stephen J, Chushak, Yaroslav, Ciallella, Heather, Clark, Alex M, Consonni, Viviana, Daga, Pankaj R, Ekins, Sean, Farag, Sherif, Fedorov, Maxim, Fourches, Denis, Gadaleta, Domenico, Gao, Feng, Gearhart, Jeffery M, Goh, Garett, Goodman, Jonathan M, Grisoni, Francesca, Grulke, Christopher M, Hartung, Thomas, Hirn, Matthew, Karpov, Pavel, Korotcov, Alexandru, Lavado, Giovanna J, Lawless, Michael, Li, Xinhao, Luechtefeld, Thomas, Lunghini, Filippo, Mangiatordi, Giuseppe F, Marcou, Gilles, Marsh, Dan, Martin, Todd, Mauri, Andrea, Muratov, Eugene N, Myatt, Glenn J, Nguyen, Dac-Trung, Nicolotti, Orazio, Note, Reine, Pande, Paritosh, Parks, Amanda K, Peryea, Tyler, Polash, Ahsan H, Rallo, Robert, Roncaglioni, Alessandra, Rowlands, Craig, Ruiz, Patricia, Russo, Daniel P, Sayed, Ahmed, Sayre, Risa, Sheils, Timothy, Siegel, Charles, Silva, Arthur C, Simeonov, Anton, Sosnin, Sergey, Southall, Noel, Strickland, Judy, Tang, Yun, Teppen, Brian, Tetko, Igor V, Thomas, Dennis, Tkachenko, Valery, Todeschini, Roberto, Toma, Cosimo, Tripodi, Ignacio, Trisciuzzi, Daniela, Tropsha, Alexander, Varnek, Alexandre, Vukovic, Kristijan, Wang, Zhongyu, Wang, Liguo, Waters, Katrina M, Wedlake, Andrew J, Wijeyesakere, Sanjeeva J, Wilson, Dan, Xiao, Zijun, Yang, Hongbin, Zahoranszky-Kohalmi, Gergely, Zakharov, Alexey V, Zhang, Fagen F, Zhang, Zhen, Zhao, Tongan, Zhu, Hao, Zorn, Kimberley M, Casey, Warren, and Kleinstreuer, Nicole C

Subjects
Government Agencies, 13. Climate action, Toxicity Tests, Acute, Animals, Computer Simulation, United States Environmental Protection Agency, United States, 3. Good health, Rats
Abstract

BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management. However, it is cost- and time-prohibitive to evaluate all new and existing chemicals using traditional rodent acute toxicity tests. In silico models built using existing data facilitate rapid acute toxicity predictions without using animals. OBJECTIVES: The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Acute Toxicity Workgroup organized an international collaboration to develop in silico models for predicting acute oral toxicity based on five different end points: Lethal Dose 50 (LD50 value, U.S. Environmental Protection Agency hazard (four) categories, Globally Harmonized System for Classification and Labeling hazard (five) categories, very toxic chemicals [LD50 (LD50≤50mg/kg)], and nontoxic chemicals (LD50>2,000mg/kg). METHODS: An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches. RESULTS: The resulting consensus predictions, which leverage the collective strengths of each individual model, form the Collaborative Acute Toxicity Modeling Suite (CATMoS). CATMoS demonstrated high performance in terms of accuracy and robustness when compared with in vivo results. DISCUSSION: CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for in vivo rat acute oral toxicity studies. CATMoS predictions for more than 800,000 chemicals have been made available via the National Toxicology Program's Integrated Chemical Environment tools and data sets (ice.ntp.niehs.nih.gov). The models are also implemented in a free, standalone, open-source tool, OPERA, which allows predictions of new and untested chemicals to be made. https://doi.org/10.1289/EHP8495.

36. Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate.

Author

Wijeyesakere SJ, Nasser FA, Kampf JW, Aksinenko AY, Sokolov VB, Malygin VV, Makhaeva GF, and Richardson RJ

Abstract

The title compound, C(13)H(16)F(6)NO(5)PS, is of inter-est with respect to inhibition of serine hydro-lases. Its structure contains a 1.8797 (13) Å P-C bond and two inter-molecular N-H⋯O=P hydrogen bonds, resulting in centrosymmetric dimers. An intra-molecular N-H⋯O=P hydrogen bond is also present.

Published
2008
Full Text
View/download PDF

37. The incidence of tinnitus in people with disorders of the temporomandibular joint.

Author

Upton LG and Wijeyesakere SJ

Subjects
Data Interpretation, Statistical, Female, Humans, Incidence, Male, Michigan epidemiology, Retrospective Studies, Tinnitus etiology, Temporomandibular Joint Disorders complications, Tinnitus epidemiology
Abstract

This study was conducted to compare the prevalence of tinnitus in the general population with its incidence in people with dysfunction of the temporomandibular joint (TMJD) within the temporomandibular disorder (TMD) population. Earlier studies had indicated the prevalence of tinnitus in the general population to be in the range of 10-14%. Between 1981 and 1990, analysis of 989 consecutive TMJD patients from a TMD database found the incidence of tinnitus to be 7.28% (72 patients). In addition, no statistical difference was found between the occurrence of tinnitus in men and women. Thirty-nine patients of the tinnitus group (54.17%) claimed to have pain in the ear as compared to 318 patients (32.15%) in the total population. No patient with tinnitus claimed to have decreased hearing, whereas three patients (0.30% of the total population) complained of a decrease in hearing.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results