457 results on '"Wijdenes, J"'
Search Results
2. Clonal deletion and clonal anergy mediated by antibodies to the human CD4 protein
- Author
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Fournel, S., Vincent, C., Morel, P., Fathmi, A., Wijdenes, J., Revillard, J. P., Touraine, J. L., editor, Traeger, J., editor, Bétuel, H., editor, Dubernard, J. M., editor, Revillard, J. P., editor, and Dupuy, C., editor
- Published
- 1994
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3. Increase of Fas-induced apoptosis by inhibition of extracellular phosphorylation of Fas receptor in Jurkat cell line
- Author
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Lautrette*, C., Loum-Ribot, E., Petit, D., Vermot-Desroches, C., Wijdenes, J., and Jauberteau, M. O.
- Published
- 2006
- Full Text
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4. Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors
- Author
-
Gu, Z-J, De Vos, J, Rebouissou, C, Jourdan, M, Zhang, X-G, Rossi, J-F, Wijdenes, J, and Klein, B
- Published
- 2000
- Full Text
- View/download PDF
5. Efficacy and toxicity of plasma-cell-reactive monoclonal antibodies B-B2 and B-B4 and their immunotoxins
- Author
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Vooijs, W. C., Post, J., Wijdenes, J., Schuurman, H.-J., Bolognesi, A., Polito, L., Stirpe, F., Bast, E. J. E. G., de Gast, G. C., and Vooijs, W.
- Published
- 1996
- Full Text
- View/download PDF
6. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
- Author
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. 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7. Effects of an anti-interleuktn-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia
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Bataille, R., Zhang, X. G., Wijdenes, J., Schved, J-F, and Klein, B.
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- 1993
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8. Treatment of rheumatoid arthritis with anti CD4 monoclonal antibody. Open study of 25 patients with the B-F5 clone
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Wendling, D., Racadot, E., Morel-Fourrier, B., and Wijdenes, J.
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9. Sedimentation field flow fractionation purification of immature neural cells from a human tumor neuroblastoma cell line
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Lautrette, C., Cardot, P.J.P., Vermot-Desroches, C., Wijdenes, J., Jauberteau, M.O., and Battu, S.
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10. Involvement of human interleukin-6 in systemic manifestations of human herpesvirus type 8-associated multicentric Castlemanʼs disease
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Foussat, A., Fior, R., Girard, T., Boue, F., Wijdenes, J., Galanaud, P., and Emilie, D.
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11. IL-6 and soluble IL-6 receptors (sIL-6R and sgp130) in human pleural effusions: massive IL-6 production independently of underlying diseases
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Doré, P., Lelièvre, E., Morel, F., Brizard, A., Fourcin, M., Clément, C., Ingrand, P., Daneski, L., Gascan, H., Wijdenes, J., Gombert, J., Preud'homme, J. L., and Lecron, J. C.
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12. Treatment of severe Crohn's disease with anti-CD4 monoclonal antibody
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CANVA-DELCAMBRE, V., JACQUOT, S., ROBINET, E., LÉMANN, M., DROUET, C., LABALETTE, M., DESSAINT, J.-P., BENGOUFA, D., RABIAN, C., MODIGLIANI, R., WIJDENES, J., REVILLARD, J.-P., and COLOMBEL, J.-F.
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13. THE WORKSHOP CD28, CD80 AND CD86 MABS: DEFINITION OF THE SPECIFICITY AND FUNCTIONAL ACTIVITY ON MIXED LEUCOCYTE REACTION: TC-2-02
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Vermot-Desroches, C., Sauvagère, C., and Wijdenes, J.
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14. APO-1 EPITOPIC MAPPING AND FUNCTIONAL ANALYSIS OF THE WORKSHOP CD95 MABS: CR-6-01
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Cattin, M. H., Vermot-Desroches, C., Aarden, L., and Wijdenes, J.
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15. A phase II trial of partially incompatible bone marrow transplantation for high-risk acute lymphoblastic leukaemia in children: prevention of graft rejection with anti-LFA-1 and anti-CD2 antibodies
- Author
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CAVAZZANA-CALVO, M., BORDIGONI, P., MICHEL, G., ESPEROU, H., SOUILLET, G., LEBLANC, T., STEPHAN, J. L., VANNIER, J. P., MECHINAUD, F., REIFFERS, J., VILMER, E., LANDMAN-PARKER, J., BENKERROU, M., BARUCHEL, A., PICO, J., BERNAUDIN, F., BERGERON, C., PLOUVIER, E., THOMAS, C., WIJDENES, J., LACOUR, B., BLANCHE, S., and FISCHER, A.
- Published
- 1996
16. In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients
- Author
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Yi, F.H., Lautrette, C., Vermot-Desroches, C., Bordessoule, D., Couratier, P., Wijdenes, J., Preud’homme, J.L., and Jauberteau, M.O.
- Published
- 2000
- Full Text
- View/download PDF
17. Treatment of sepsis
- Author
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Matamis, D., Koletsos, K., Grammenos, A., Kioumis, I., Sobolos, K., Rigos, D., Lanoret, J. J., Dhainaut, J. F., Fisher, C. J., Opal, S. M., Zimmerman, J., Nightingale, P., Stephens, S., Schein, R. L., Panacek, E. A., Vincent, J. L., Foulke, G. E., Warren, E. L., Garrard, C., Park, G., Bodmer, M. W., Cohen, J., van der Linden, G., Sadoff, J. C., Pochard, F., Boulot, A., Capellier, G., Racadot, E., Tissot, H., Balvay, P., Cordier, A., Wijdenes, J., Herve, P., Barale, F., Lanore, J. J., Briegel, J., Forst, H., Kellermann, W., Haller, M., Bittl, M., Lenhart, F. -P., Peler, K., Fourrier, F., Chopin, C., Huart, J. J., Runge, I., Caron, C., Mehdaoui, H., Goudemand, J., Rime, A., Socolovski, C., CB0006 Study Group, and CB0006 Study Group
- Published
- 1992
- Full Text
- View/download PDF
18. A study of gonadal organogenesis, and the factors influencing regeneration following surgical castration in Deroceras reticulatum (Pulmonata:Limacidae)
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Hogg, N. A. S. and Wijdenes, J.
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- 1979
- Full Text
- View/download PDF
19. An ultrastructural in vitro study on the regulation of neurosecretory activity in the freshwater snail Lymnaea stagnalis (L.) with particular reference to Caudo-dorsal cells
- Author
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Roubos, E. W., Van Minnen, J., Wijdenes, J., and Moorer-Van Delft, Carry M.
- Published
- 1976
- Full Text
- View/download PDF
20. A comparative study on neurosecretion demonstrated by the alcian blue-alcian yellow technique in three terrestrial pulmonates (stylommatophora)
- Author
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Wijdenes, J., van Minnen, J., and Boer, H. H.
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- 1980
- Full Text
- View/download PDF
21. Localization and function of an FMRFamide-like substance in the aorta of Helix aspersa
- Author
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Griffond, Bernadette, Boer, H. H., and Wijdenes, J.
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- 1986
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- View/download PDF
22. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes
- Author
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Burdin, N., Cees van Kooten, Galibert, L., Abrams, Js, Wijdenes, J., Banchereau, J., and Rousset, F.
- Subjects
Immunology ,Immunology and Allergy - Abstract
This study was initiated to explore the contribution of endogenous cytokines to CD40-induced B cell proliferation and differentiation. First, both CD40 and Ag receptor (AgR) cross-linking induced purified tonsillar human B lymphocytes to secrete the same pattern of cytokines, including IL-1 beta, IL-6, IL-10, granulocyte-macrophage-CSF, and TNF-alpha, whereas IL-1 alpha, IL-2, IL-3, IL-4, IL-5, IL-7, granulocyte (G)-CSF, or IFN-gamma were not detected. Second, cotriggering of CD40 and AgR resulted in additive secretion of both IL-6 and IL-10. Addition of IL-4 to CD40-activated B cells increased IL-6 levels but decreased IL-10 levels. In contrast, exogenous IL-10 diminished IL-6 levels. Neutralization of IL-6 and IL-10 using blocking Abs did not alter CD40-induced B cell growth. In contrast, IL-6 neutralization markedly inhibited the IL-4-induced IgE secretion (57 +/- 10%) as well as the IgG and IgM production resulting from AgR and CD40 cotriggering (49 +/- 16.5 and 29.5 +/- 4.5%, respectively). Blocking IL-10 inhibited the IgA secretion (25 +/- 2.7%) obtained after CD40 activation and the production of IgG, IgA, and IgM (24.1 +/- 5.6, 25 +/- 8, and 42 +/- 6.5%, respectively) by B lymphocytes undergoing dual ligation of CD40 Ag and AgR. Simultaneous neutralization of both endogenous IL-6 and IL-10 resulted in an increased inhibition of Ig secretion for B cells cotriggered by CD40 Ag and AgR (65-75%). Thus, endogenously produced IL-6 and IL-10 are involved in the differentiation of CD40-activated B cell.
- Published
- 1995
23. Structure of Interleukin-6 in complex with a Camelid Fab fragment
- Author
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Klarenbeek, A., primary, Blanchetot, C., additional, Schragel, G., additional, Sadi, A.S., additional, Ongenae, N., additional, Hemrika, W., additional, Wijdenes, J., additional, Spinelli, S., additional, Desmyter, A., additional, Cambillau, C., additional, Hultberg, A., additional, Kretz-rommel, A., additional, Dreier, T., additional, De haard, H.J.W., additional, and Roovers, R.C., additional
- Published
- 2015
- Full Text
- View/download PDF
24. [67] Organomercurial agarose
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Sluyterman, L.A.˦., primary and Wijdenes, J., additional
- Published
- 1974
- Full Text
- View/download PDF
25. THE MULTIPLE ACTIVITIES OF INTERFERON GAMMA
- Author
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Banchereau, J., primary and Wijdenes, J., additional
- Published
- 1986
- Full Text
- View/download PDF
26. Monoclonal Anti-Tumor Necrosis Factor-Alpha Antibody for the Treatment of Severe Acute Graft-versus-Host Disease
- Author
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Herv�, P., primary, Wijdenes, J., additional, Racadot, E., additional, Tiberghien, P., additional, Plouvier, E., additional, Flesch, M., additional, Bordigoni, P., additional, Holler, E., additional, Lioure, B., additional, Bourdeau, H., additional, Kuentz, M., additional, Wilmer, E., additional, Stephan, J. L., additional, Roche, C., additional, and Cahn, J. Y., additional
- Full Text
- View/download PDF
27. Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors
- Author
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Hammacher, A, Wijdenes, J, Hilton, D J, Nicola, N A, Simpson, R J, and Layton, J E
- Subjects
Membrane Glycoproteins ,Base Sequence ,Interleukin-6 ,Recombinant Fusion Proteins ,digestive, oral, and skin physiology ,Cell Membrane ,Antibodies, Monoclonal ,Cell Differentiation ,Ligands ,digestive system ,biological factors ,Cell Line ,Mice ,Antigens, CD ,Receptors, Granulocyte Colony-Stimulating Factor ,Cytokine Receptor gp130 ,Animals ,Humans ,biological phenomena, cell phenomena, and immunity ,Protein Structure, Quaternary ,Dimerization ,hormones, hormone substitutes, and hormone antagonists ,Research Article ,DNA Primers ,Signal Transduction - Abstract
The receptor gp130 is used by the interleukin-6 (IL-6)-type cytokines, which include IL-6 and leukaemia-inhibitory factor (LIF). To investigate the role of the three extracellular membrane-proximal fibronectin-type-III-like (FNIII) modules of gp130 and the related receptor for granulocyte colony-stimulating factor (G-CSFR) in cytokine signal transduction we have transfected into murine myeloid M1-UR21 cells the chimaera (GR-FNIII)gp130, which contains the membrane-proximal FNIII modules of the G-CSFR on a gp130 backbone, and its complement, the chimaera (gp130-FNIII)GR. Whereas the binding affinities of (125)I-labelled IL-6 to (GR-FNIII)gp130, or of (125)I-Tyr1,3-G-CSF to (gp130-FNIII)GR, were similar to wild-type gp130 and wild-type G-CSFR, respectively, (125)I-LIF failed to bind with high affinity to (GR-FNIII)gp130. In assays measuring differentiation the (gp130-FNIII)GR cells were fully responsive to G-CSF, whereas the (GR-FNIII)gp130 cells responded fully to the agonistic anti-gp130 monoclonal antibody (mAb) B-S12, but not to IL-6 or LIF. Neutralizing mAbs that recognize the membrane-proximal FNIII modules of gp130 or the G-CSFR differentially interfered with signalling by B-S12, LIF and G-CSF. The data suggest that B-S12 and G-CSF induce the correct orientation or conformation for signalling by the wild-type and chimaeric homodimeric receptors, that the membrane-proximal region of gp130 is important for the correct formation of the signalling IL-6-IL-6 receptor-gp130 complex and that this region is also involved in LIF-dependent receptor heterodimerization and signalling.
- Published
- 2000
28. Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells
- Author
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Den Berg, J. G., Jan Aten, Chand, M. A., Claessen, N., Dijkink, L., Wijdenes, J., Lakkis, F. G., Weening, J. J., and Other departments
- Subjects
Regulation of Sodium transport in cortical collecting duct ,Regulatie van de Natriumreabsorptie in de corticale verzamelbuis - Abstract
In minimal change nephrosis (MCN), proteinuria is associated with structural changes of the glomerular visceral epithelial cells (GVEC). The occurrence of MCN has been associated with 2 lymphocyte-dependent conditions. To examine a direct role for type 2 cytokines in GVEC injury, the expression of interleukin (IL)-4/IL-13 receptors by GVEC and direct effects of IL-4 and IL-13 on GVEC were studied. Reverse transcription-PCR showed that isolated human and rat glomeruli and cultured human and rat GVEC expressed mRNA for IL-4Ralpha, IL-13Ralpha1, and IL-13Ralpha2. Protein expression of [L-4Ralpha and IL-13Ralpha2 by GVEC in human kidney biopsies and by cultured human GVEC was detected by immunohistochemistry. Western blotting demonstrated phosphorylation of STAT6 in cultured GVEC upon incubation with IL-4 or IL-13. This indicated signal transduction via the heterodimeric receptor complex IL-4R2, which is composed of the IL-4Ralpha and the IL-13Ralpha1. Direct effects on GVEC function were examined in monolayer experiments. IL-4 and IL-13 dose-dependently decreased transepithelial electrical resistance of monolayers of rat GVEC to approximately 30 and 40% of baseline values, respectively. The transepithelial electrical resistance decrease was associated with a significant increase in short-circuit current, whereas no changes were observed in the transmonolayer flux of the macromolecules horseradish peroxidase (molecular weight, 44 kD) and 14C-mannitol (molecular weight, 182 Da). No changes in cell structure were observed with electron microscopy. It is concluded that by binding to specific IL-4/ IL-13 receptors, IL-4 and IL-13 can exert specific effects on GVEC function, which could be of pathogenetic relevance for glomerular injury in MCN
- Published
- 2000
29. Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes
- Author
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Foussat A, Wijdenes J, Bouchet L, Gianluca GAIDANO, Neipel F, Balabanian K, Galanaud P, Couderc J, and Emilie D
- Subjects
B-Lymphocytes ,Lymphoma, B-Cell ,Membrane Glycoproteins ,Syndecans ,Interleukin-6 ,Antibodies, Monoclonal ,Mice, SCID ,Receptors, Interleukin-6 ,Interleukin-10 ,Autocrine Communication ,Disease Models, Animal ,Mice ,Antibody Specificity ,Neutralization Tests ,Herpesvirus 8, Human ,Disease Progression ,Tumor Cells, Cultured ,Animals ,Humans ,Proteoglycans ,Syndecan-1 ,Cell Division ,Neoplasm Transplantation - Abstract
Human interleukin-6 (hIL-6) acts as a growth factor in several human B lymphoid cancers. As human herpesvirus-8 (HHV-8) encodes for a viral IL-6 (vIL-6), the viral cytokine may be responsible for several manifestations of HHV-8-related disorders. Using an anti-hIL-6 mAb (B-E8) which does not recognize vIL-6, we investigated the involvement of the human cytokine in the proliferation of HHV-8-positive primary effusion lymphoma (PEL) cells. In vitro, 5/5 PEL cell lines produced hIL-6 (4 to 1,200 pg/ml). The EBV- HHV-8+ cell line (BCBL-1) was adapted to grow in SCID mice. hIL-6 was detected in the serum of mice with grafts, as well as human soluble CD138 (sCD138) and human IL-10 (hIL-10). The serum level of these mediators increased with tumor progression. The effect of treatment with the B-E8 mAb on the tumor progression and survival was evaluated. This treatment significantly slowed down the tumor development: on day 54, there were more mice with low levels of sCD138 and hIL-10 in the treated group than in controls (p = 0.03 and 0.02, respectively); treatment also delayed death (median date of death was day 65 for control mice and day 84 for anti-hIL-6 mAb-treated mice; p0.02). Thus, hIL-6 is expressed in addition to vIL-6 in HHV-8-positive malignant B lymphocytes, and the viral cytokine does not totally substitute for human IL-6 in promoting tumor progression.
- Published
- 1999
30. A randomized, double blind, placebo controlled multicenter trial of murine anti-CD4 monoclonal antibody therapy in rheumatoid arthritis
- Author
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Wendling D, Racadot E, Wijdenes J, Jean Sibilia, Rm, Flipo, Cantagrel A, Miossec P, Jp, Eschard, Macro M, Bertin P, Lioté F, Debiais F, Juvin R, Le Goff P, and Masson C
- Subjects
Adult ,Male ,Antibodies, Monoclonal ,Immunoglobulins, Intravenous ,Middle Aged ,CD4 Lymphocyte Count ,Arthritis, Rheumatoid ,Mice ,C-Reactive Protein ,Treatment Outcome ,Double-Blind Method ,CD4 Antigens ,Animals ,Humans ,Female ,Immunization ,Aged - Abstract
To assess safety and efficacy of a murine anti-CD4 monoclonal antibody (Mab) in a population of patients with rheumatoid arthritis (RA) compared to treatment with placebo.Fifty-eight patients with defined RA were included in this placebo controlled, randomized, double blind, multicenter study. Of the 48 women and 10 men (mean age 54.5 years), 25 were functional class II and 31 were class III, with 9 years' disease duration; the mean of previous disease modifying antirheumatic drugs was 4; 49 were taking steroids (mean dosage 11 mg/day of prednisone). Eighty percent were rheumatoid factor positive. All were in an active state of the disease with: pain4 (mean at inclusion 6.6), tender joints4 (mean 12), swollen joint count3 (mean 9), morning stiffness45 min (mean 185), erythrocyte sedimentation rate30 mm (mean 59) or C-reactive protein (CRP)30 mg/l (mean 63). Treatment was randomized between murine anti-CD4 Mab (B-F5, Diaclone, 20 mg/day) or placebo intravenously for 10 consecutive days. Efficacy was assessed with a composite index (Paulus), with evaluation of number of patients with 20 or 50% improvement in each group. Changes in measures of single clinical or biological variables were also evaluated.The 2 groups were comparable at inclusion. Treatment was well tolerated. Mild side effects (chills, fever, rash) were seen in both groups. Percentage of patients with global 20 or 50% response did not differ between placebo and Mab groups at Day 10 or at Day 30. Evaluation of single variables showed reduced CRP, swollen joint count, and Ritchie index in some B-F5 patients at Day 10, although in the B-F5 group as a whole only CRP was significant.No significant improvement in RA after murine anti-CD4 Mab was observed.
- Published
- 1998
31. The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes
- Author
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Minty A, Asselin S, Armand Bensussan, Shire D, Vita N, Vyakarnam A, Wijdenes J, Ferrara P, and Caput D
- Subjects
Interleukin-13 ,Base Sequence ,T-Lymphocytes ,In Vitro Techniques ,Th1 Cells ,Lymphocyte Activation ,Polymerase Chain Reaction ,Kinetics ,Th2 Cells ,Gene Expression Regulation ,Humans ,Interleukin-4 ,RNA, Messenger ,DNA Primers - Abstract
We have compared the production of the related cytokines IL-13 and IL-4 by T lymphocytes, and the effects of the two cytokines on these cells. IL-13 and IL-4 production differ in a number of respects. IL-13 is produced at higher levels than IL-4 by activated T lymphocytes, and its accumulation in the culture medium can be more prolonged, corresponding partly to differential mRNA accumulation and partly to a preferential depletion of IL-4 from the culture medium. Certain inducing combinations such as PMA and anti-CD28, stimulate high levels of IL-13 and IL-13 mRNA, but little or no IL-4 or IL-4 mRNA. The ratio of IL-13 to IL-4, both at protein and mRNA levels, is higher in CD8+ lymphocyte than in CD4+ lymphocyte populations. Although after in vitro polarization of peripheral blood lymphocytes leading to type 1 and type 2 populations, IL-13 is made principally by cells of a type 2 phenotype, as is IL-4; it can also be produced by type 1 CD4+ and CD8+ T lymphocyte clones making large amounts of IFN-gamma and very little IL-4. IL-13 and IL-4 exert different effects on T lymphocyte functions. IL-13 does not significantly inhibit the IL-2-induced T lymphocyte production of IFN-gamma, RANTES, MIP-1 alpha or MIP-1 beta, nor that of perforin mRNA, as does IL-4. We have also been unable to demonstrate STAT6 activation by IL-13 on T lymphocytes purified in a number of ways, despite strong activation of STAT6 by IL-4 in these cells. This is contrary to some previous reports, but is consistent with the notion that the majority of T lymphocytes lack functional IL-13 receptors. A higher and more prolonged T lymphocyte production of IL-13 than that of IL-4 may thus be permissible because IL-13 does not inhibit T-cell functions. Conversely, sustained IL-13 production may be partly due to the absence of receptor-mediated depletion of this cytokine.
- Published
- 1997
32. Étude clinique de phase I avec bénéfice individuel direct de radioimmunothérapie du myélome multiple utilisant l’anticorps anti-CD138 marqué à l’iode 131 (131I-B-B4)
- Author
-
Lacombe, M., primary, Ferrer, L., additional, Supiot, S., additional, Bardiès, M., additional, Davodeau, F., additional, Faivre-Chauvet, A., additional, Baumgartner, P., additional, Wijdenes, J., additional, Barbet, J., additional, Guillaume, T., additional, Moreau, P., additional, Harousseau, J.-L., additional, Kraeber-Bodéré, F., additional, Cherel, M., additional, and Rousseau, C., additional
- Published
- 2012
- Full Text
- View/download PDF
33. Enhanced antitumor effects of CD20 over CD19 monoclonal antibodies in a nude mouse xenograft model
- Author
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Erik Hooijberg, Pc, Den Berk, Jj, Sein, Wijdenes J, Aa, Hart, Rw, Boer, Cj, Melief, and Hekman A
- Subjects
Cytotoxicity, Immunologic ,Male ,Mice, Inbred BALB C ,Antigens, CD19 ,Transplantation, Heterologous ,Antibody-Dependent Cell Cytotoxicity ,Antibodies, Monoclonal ,Mice, Nude ,Macrophage Activation ,Antigens, CD20 ,Burkitt Lymphoma ,Models, Biological ,Antigens, Differentiation, B-Lymphocyte ,Mice ,Antigens, CD ,Antigens, Neoplasm ,Antigens, Surface ,Tumor Cells, Cultured ,Animals ,Humans ,Interleukin-2 ,Cell Division ,Neoplasm Transplantation ,Spleen - Abstract
We used a nude mouse xenograft tumor model to compare the efficacy of unconjugated CD19 and CD20 mAbs (IgG2a subclass) in mediating antilymphoma effects. Treatment with the CD20 mAbs NKI-B20 and BCA-B20 resulted in a drastic decrease in tumor take rate (P0.0001) in comparison to controls, whereas the CD19 mAb CLB-CD19 was ineffective. Tumor growth rates were reduced by both CD19 and CD20 (P0.0001). The decrease in growth rate induced by NKI-B20 or BCA-B20 was larger than that induced by CLB-CD19 (P = 0.0022). In vitro experiments showed that NKI-B20 or BCA-B20 are more powerful than CLB-CD19 in mediating lysis by interleukin 2-activated natural killer cells. No difference was observed between different isotypes (IgG1, IgG2a, IgG2b) of the switch variants of NKI-B20 or CLB-CD19. A positive correlation between antigen density and the sensitivity to antibody-dependent cellular cytotoxicity was demonstrated with human lymphoblastoid B cells, JY, transfected with cDNA encoding the human CD19 antigen that expressed high levels of this antigen. These cells are more efficiently killed by natural killer cells when coated with CLB-CD19 mAbs than JY wildtype cells that express 1 log lower levels of the CD19 antigen. Antibody-dependent cellular cytotoxicity experiments with thioglycolate-activated macrophages show a more complex relationship between antigen density, isotype of the mAb, and cytotoxicity. BCA-B20 (IgG2a) and CLB-CD19 (IgG2a) and all isotypes of NKI-B20 mediated strong cytotoxicity, whereas CLB-CD19 isotypes IgG1 and IgG2b were associated with limited cytotoxicity. Proliferation of Daudi cells was inhibited with high concentrations of all isotypes of CLB-CD19, but not with any of the CD20 mAbs. To our knowledge this is the first report showing that the antitumor effects in vivo of unconjugated CD20 mAbs are far superior to those of CD19 mAbs.
- Published
- 1995
34. Soluble Interleukin-6 receptor in patients with severe sepsis
- Author
-
Frieling, J.T.M., Deuren, M. van, Wijdenes, J., Meer, J.W.M. van der, Clement, C., Linden, C.J. van der, and Sauerwein, R.W.
- Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Contains fulltext : 21153___.PDF (Publisher’s version ) (Open Access)
- Published
- 1995
35. Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2
- Author
-
Kuiper, H. M., Jong, R., Brouwer, M., Lammers, K., Wijdenes, J., Rene van Lier, and Other departments
- Subjects
Interferon-gamma ,Kinetics ,CD28 Antigens ,T-Lymphocytes ,Cytokines ,Humans ,Interleukin-2 ,Interleukin-4 ,RNA, Messenger ,Blotting, Northern ,Cells, Cultured ,Research Article - Abstract
Interaction of CD28 with its ligand B7 plays an important role in the initiation of immune responses. The co-stimulatory signal generated by cross-linking of CD28 molecules results in enhanced T-cell proliferation and augmentation of cytokine production. In particular, mRNA levels of T-helper 1 (Th1)-type cytokines, such as interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) are reported to be strongly increased. We investigated the effect of CD28 co-stimulation on the production of Th2-type cytokines. CD28 mAb induced a strong augmentation of IL-2 secretion in activated T-cell clones. Production of IFN-gamma was also enhanced, but the increase in IL-4 secretion was generally moderate. Augmentation of IL-4 production by CD28 was most pronounced in clones that produced low amounts of IL-2, compared to clones producing high levels of IL-2. It was found that the up-regulation of IL-4 by CD28 co-stimulation was mainly controlled indirectly via an increase of IL-2. Some clones could produce IL-4 in an IL-2-independent manner; in these situations CD28 co-stimulation had no augmenting effect on the production of IL-4. The secretion of IL-4 by peripheral blood CD4+ T cells, that were activated with B7-expressing transfectants, was also found to be dependent on IL-2. Finally, Northern blot analysis confirmed that co-stimulation of CD28 primarily affected IL-2 production, and that inhibition of IL-2/IL-2 receptor interaction abolished the augmenting action of CD28 monoclonal antibody on the production of the Th2-type cytokines IL-4, IL-5 and IL-10 and of the Th1 cytokine IFN-gamma.
- Published
- 1994
36. Role of IL-6 in promoting growth of human EBV-induced B-cell tumors in severe combined immunodeficient mice
- Author
-
Anne Durandy, Emilie D, Peuchmaur M, Forveille M, Clement C, Wijdenes J, and Fischer A
- Subjects
B-Lymphocytes ,Herpesvirus 4, Human ,Lymphoma, B-Cell ,Base Sequence ,Interleukin-6 ,Immunology ,Molecular Sequence Data ,Antibodies, Monoclonal ,Mice, SCID ,Receptors, Interleukin ,Receptors, Interleukin-6 ,Cell Line ,Mice ,Cell Transformation, Neoplastic ,Immunology and Allergy ,Animals ,Humans ,Receptors, Complement 3d - Abstract
To investigate the role of IL-6 as a growth factor in EBV-induced B lymphoproliferative disorders in immune-suppressed patients, we analyzed two B cell lines derived from two different patients for IL-6 production, expression of the p80 chain of the IL-6 receptor, and the effects on cell growth in vitro and in vivo of neutralizing mAbs specific for IL-6. One of the cell lines (LCL41) was shown to produce large amounts of IL-6 and to express IL-6 receptors. Its in vitro growth was weakly inhibited by the anti-IL-6 MAb. After inoculation into SCID mice, this cell line provoked human B cell tumors, the growth of which was controlled by the anti-IL-6 mAb. Indeed, four i.v. infusions of 0.1 mg at days 30 to 42 after i.p. inoculation of cells led to complete remission in most mice and long term survival in 40% of cases. In contrast, the other B cell line (LCL48) produced smaller amounts of IL-6; its growth was not inhibited in vitro by the anti-IL-6 Ab and was poorly blocked in vivo in SCID mice (40% of remissions and 20% of long-term survival). In addition, a clone derived in vivo in SCID mice from LCL48 was completely IL-6-independent. These results demonstrate that B cell tumors transformed in vivo by EBV in immune-suppressed patients are heterogeneous with respect to IL-6 requirements for proliferation. An antitumoral effect in some of them can be achieved by neutralizing the IL-6-dependent proliferative loop.
- Published
- 1994
37. 377 Oncogenic role of neuropilin-2
- Author
-
Grandclement, C., primary, Bedel, R., additional, Kantelip, B., additional, Wijdenes, J., additional, Remy Martin, J.P., additional, Klagsbrun, M., additional, Ferrand, C., additional, Pivot, X., additional, and Borg, C., additional
- Published
- 2010
- Full Text
- View/download PDF
38. Detection of single cells secreting IFN-gamma, IL-6, and IL-10 in irreversibly rejected human kidney allografts, and their modulation by IL-2 and IL-4
- Author
-
Claire Pouteil-Noble, P. Merville, Jean Louis Touraine, Luc Potaux, Jacques Banchereau, and Wijdenes J
- Subjects
Graft Rejection ,medicine.medical_treatment ,Antigen-Presenting Cells ,Enzyme-Linked Immunosorbent Assay ,Monocytes ,Interferon-gamma ,Immune system ,Adjuvants, Immunologic ,medicine ,Humans ,Transplantation, Homologous ,Interleukin 4 ,Transplantation ,business.industry ,Interleukin-6 ,ELISPOT ,Interleukin ,Molecular biology ,Kidney Transplantation ,Interleukin-10 ,Killer Cells, Natural ,Interleukin 10 ,Cytokine ,Phenotype ,Immunology ,Cytokines ,Interleukin-2 ,Interleukin-4 ,business ,CD8 - Abstract
The frequency of isolated low-density graft-infiltrating cells (GIC) secreting IFN-gamma, IL-6, and IL-10 was studied in 8 cases of irreversible rejection of human renal allografts, using ELISA and SPOT-forming cells (ELISPOT) assays. The GIC were mostly CD8+ T cells, although CD4+ T cells, B cells, and macrophages could also be detected. On the average, in 10(6) cells, 189 secreted IFN-gamma, 747 IL-10, and 17114 IL-6. Culture of GIC in the presence of IL-2 resulted in an increase in the frequency of IFN-gamma-producing cells (IFN-gamma-PC), in a dose-dependent manner, with an optimal 6.5-fold increase at 50 U/ml. In contrast, 25 U/ml IL-4 decreased the frequency of spontaneous and IL-2-induced IFN-gamma-PC by 71.3% and 52.8%, respectively. Furthermore, IL-4 reduced the frequency of IL-6-PC (56.8%). By this new approach to graft rejection, it becomes easier to determine cytokine profiles within an allograft and to study their modulation by different agents. It could be a useful model of study for the development of new treatment.
- Published
- 1993
39. CD4 antibody therapy in chronic inflammatory dermatological diseases
- Author
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Morel P, Jp, Revillard, JEAN FRANCOIS NICOLAS, and Wijdenes J
- Subjects
CD4 Antigens ,Chronic Disease ,Antibodies, Monoclonal ,Humans ,Psoriasis ,Dermatitis ,Immunotherapy - Published
- 1993
40. Effects of an anti-interleukin-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia
- Author
-
B. Klein, R. Bataille, Schved Jf, Wijdenes J, and Zhang Xg
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,medicine.drug_class ,Cell Survival ,medicine.medical_treatment ,Monoclonal antibody ,Mice ,In vivo ,Internal medicine ,medicine ,Tumor Cells, Cultured ,Animals ,Humans ,Viability assay ,Interleukin 6 ,Aged ,Aged, 80 and over ,Acute leukemia ,Hematology ,biology ,business.industry ,Interleukin-6 ,Antibodies, Monoclonal ,Immunotherapy ,Acute Monoblastic Leukemia ,Oncology ,Immunology ,Leukemia, Monocytic, Acute ,biology.protein ,business ,Cell Division - Abstract
Because IL-6 has been involved in the pathogenesis of acute monoblastic leukemia, we investigated the in vitro anti-proliferative effect and the in vivo anti-tumoral effect of an anti-IL-6 murine monoclonal antibody (mAb) in a patient with M5B type acute leukemia. In the current study, we clearly show the IL-6 dependence of monoblastic cell viability and proliferation in vitro in short-term cultures of malignant cells and the clinical activity of the anti-IL-6 murine mAb. The complete neutralization of IL-6 in vivo was associated with a transient but complete disappearance of malignant monoblastic cells in the peripheral blood, with improvement or even normalization of several other biological parameters of disease activity. No immunization against the anti-IL-6 murine mAb was observed.
- Published
- 1993
41. B-B10 (anti-CD25)-saporin immunotoxin--a possible tool in graft-versus-host disease treatment
- Author
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Tazzari, Pl, Bolognesi, A, De Totero, D, Pileri, S, Conte, R, Wijdenes, J, Hervé, P, Soria, M, Stirpe, F, and Gobbi, Marco
- Published
- 1992
42. Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells
- Author
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Berg, J.G. van den, Aten, J., Anwar Chand, M., Claessen, N., Dijkink, L., Wijdenes, J., Lakkis, F.G., Weening, J.J., Berg, J.G. van den, Aten, J., Anwar Chand, M., Claessen, N., Dijkink, L., Wijdenes, J., Lakkis, F.G., and Weening, J.J.
- Abstract
Item does not contain fulltext
- Published
- 2000
43. Monoclonal anti TNF alpha antibody in the treatment of acute GvHD refractory both to corticosteroids and anti IL-2 R antibody
- Author
-
Hervé P, Racadot E, Wijdenes J, Flesch M, Pierre Tiberghien, Bordigoni P, Holler E, Powles M, Bourdeau M, and Wilmer E
- Subjects
Adrenal Cortex Hormones ,Recurrence ,Tumor Necrosis Factor-alpha ,Immunoglobulin G ,Drug Resistance ,Antibodies, Monoclonal ,Drug Evaluation ,Graft vs Host Disease ,Humans ,Pilot Projects ,Receptors, Interleukin-2 ,Bone Marrow Transplantation - Published
- 1991
44. Circulating Concentrations of Soluble Interleukin 6 Receptors gp80 an gp130 in Chronic Renal Failure and Effects of Renal Replacement Therapy
- Author
-
Frieling, J.T.M., Hamersvelt, H.W. van, Wijdenes, J., Hendriks, T., Sauerwein, R.W., Linden, C.J. van der, Frieling, J.T.M., Hamersvelt, H.W. van, Wijdenes, J., Hendriks, T., Sauerwein, R.W., and Linden, C.J. van der
- Abstract
Item does not contain fulltext
- Published
- 1999
45. Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway
- Author
-
Thiel, S., Behrmann, Iris, Dittrich, E., Muys, L., Tavernier, J., Wijdenes, J., Heinrich, P. C., Graeve, L., Thiel, S., Behrmann, Iris, Dittrich, E., Muys, L., Tavernier, J., Wijdenes, J., Heinrich, P. C., and Graeve, L.
- Abstract
Signalling receptors often undergo receptor-mediated endocytosis. In many cases this internalization is stimulated by ligand binding and activation of intrinsic receptor tyrosine kinases, resulting in a receptor down-regulation. We have analysed whether internalization of the interleukin 6 signal transducer gp130 is dependent on the activation of receptor-associated Jak kinases. By using a chimaeric receptor system we found that receptor mutants that lack box1 and therefore are not capable of activating Jak and signal transducer and activator of transcription (STAT) proteins are still endocytosed efficiently. A chimaeric receptor with the recently identified dileucine internalization motif being replaced by two alanine residues was not efficiently internalized but still capable of recruiting STATs. Furthermore an antagonistic antibody that inhibits the signalling of all interleukin-6-type cytokines via gp130 was internalized as efficiently as an agonistic one that activates the Jak/STAT pathway. Our findings suggest that the endocytosis of gp130 is signal-independent.
- Published
- 1998
- Full Text
- View/download PDF
46. Interleukin-6 and its soluble receptor during acute meningococcal infections: Effect of plasma or whole blood exchange
- Author
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Frieling, J.T.M., Deuren, M. van, Wijdenes, J., Dalen, R. van, Bartelink, A.K.M., Linden, C.J. van der, Sauerwein, R.W., Frieling, J.T.M., Deuren, M. van, Wijdenes, J., Dalen, R. van, Bartelink, A.K.M., Linden, C.J. van der, and Sauerwein, R.W.
- Abstract
Contains fulltext : 24150___.PDF (publisher's version ) (Open Access)
- Published
- 1996
47. Circulating interleukin-6 receptor in patients with sepsis syndrome
- Author
-
Frieling, J.T.M., Deuren, M. van, Wijdenes, J., Meer, J.W.M. van der, Clement, C., Linden, C.J. van der, Sauerwein, R.W., Frieling, J.T.M., Deuren, M. van, Wijdenes, J., Meer, J.W.M. van der, Clement, C., Linden, C.J. van der, and Sauerwein, R.W.
- Abstract
Contains fulltext : 4795.pdf (publisher's version ) (Open Access)
- Published
- 1995
48. Reactivity of anti-human adhesion molecules and von Willebrand factor monoclonal antibodies with pig antigens
- Author
-
Azimzadeh, A, primary, Romain, N, additional, Vermot-Desroches, C, additional, Chenard, M.P, additional, Meyer, C, additional, Wijdenes, J, additional, Hervé, P, additional, Cinqualbre, J, additional, and Wolf, P, additional
- Published
- 1998
- Full Text
- View/download PDF
49. An antagonistic monoclonal antibody (B-N6) specific for the human neurotensin receptor-1
- Author
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Ovigne, J.-M, primary, Vermot-Desroches, C, additional, Lecron, J.-C, additional, Portier, M, additional, Lupker, J, additional, Pecceu, F, additional, and Wijdenes, J, additional
- Published
- 1998
- Full Text
- View/download PDF
50. Circulating ICAM-3 (CD 50) levels after kidney transplantation
- Author
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Büchler, M., primary, Khalfoun, B., additional, Al Najjar, A., additional, Vermot Desroches, C., additional, Wijdenes, J., additional, and Lebranchu, Y., additional
- Published
- 1997
- Full Text
- View/download PDF
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