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Bromelain (Br) is a proteolytic enzyme with various pharmacological properties, such as antibacterial, antioxidant, anti-inflammatory, anticancer, and anti-angiogenic properties. However, due to its low solubility and bioavailability, its absorption is low, so a delivery mechanism is needed to achieve the desired therapeutic effects. Bromelain was chemically synthesized and loaded onto gold nanoparticles (AuNPs). Different methods and techniques were used for detection and characterization, including color-change detection, UV spectroscopy, XRD, SEM, TEM, and FTIR. The in vitro antioxidant activity was detected using DPPH assays, and the wound-healing activity was investigated in mice. The current study revealed that the formulated AuNPs-Br showed effective antioxidant activity and the strongest wound-healing properties, as demonstrated by histopathological and in vivo studies, and showed anti-angiogenic effects.

The main problem encountered in thyroid nodule is difficult to differentiate between a benign and malignant lesion. Differential between follicular thyroid cancer (FTC) and benign follicular thyroid adenoma (FTA) is a great challenge for even an experienced pathologist and requires special effort. A total of 120 paraffin block were included in the study, 30 blocks were (FC), 30 blocks were (FVPC). 30 blocks were (FA), 30 blocks were blocks thyroid follicular hyperplasia.20 blocks endocervical epithelium.20 paraffin blocks of colonic epithelium as control. From each paraffin block, 4 slides, each of thicken were taken, stained with Hematoxylin and Eosin (H&E) for revision of histopathological diagnosis. The histological arrangement in follicular carcinoma and follicular adenoma was significant (P= 0.001) in trabecular pattern and the difference was significant (P= 0.016) in mixed pattern while no significance with microfollicular, macrofollicular and normofollicular pattern in both follicular carcinoma and adenoma. There was no significant difference in size follicular lesion among FA, FVPC and follicular hyperplasia (P> 0.05) while, the size follicular lesion in of (FC) was significantly higher from all other groups (P< 0.05).

The study includes histological structure of pyloric caeca , intestine and rectum of Liza abu , the results show that the pyloric caeca are non-branched fingerlings structures numbering (4) and length rate was (0.5) cm , while the intestine of Liza abu was long narrow tube composed of a number of laps , the anterior part of intestine was wider in diameter than the posterior part , the length of intestine was (32) cm , the rectum was straight tube extends from the end of posterior part of intestine to the anus. The wall of pyloric caeca , intestine and rectum consists of main layers : mucosa , submucosa , muscularis and serosa , lining epithelium of pyloric caeca , intestine and rectum were simple columnar consisting of enterocytes having goblet cells in between , goblet cells react positively with PAS and AB in intestine and rectum , and with PAS only in pyloric caeca , tunica submucosa was a thin layer of dense connective tissue , tunica muscularis consists of smooth muscle fibersarranged in two layers : internal circular and external longitudinal , tunica serosa was thin layer of loose connective tissue surrounded by mesothelium .

The study current included histological structure of stomach of Liza abu , anatomical results found that stomach represent the expander non-convoluted part of gastrointestinal tract it is located between the end of the esophagus and the beginning of the intestine , the average length of stomach was (1.5) cm , composed of two parts : cardiac stomach which is represent the anterior part and be thin- walled , the other part was pyloric stomach or gizzard and the walls were thick . The internal surface of cardiac and pyloric stomach contain longitudinal folds numbering (7), folds branching to finger shape structures extend inside the lumen . Histological study showed that stomach wall composed of three main histological layers : mucosa , sub mucosa , muscularis and externa serosa , the epithelial tissue that lining stomach was simple columnar with thickness of (15)μ and (13)μ. In cardiac and pyloric stomach respectively. Lamina propria of cardiac stomach contain tubular gastric glands , pyloric part do not contain gastric glands at all sub mucosa was dense connective tissue extend from mucosa to muscularis externa with thickness of (49)μ and (84)μ in cardiac and pyloric stomach respectively. Layer with muscularis externa composed of smooth muscle fibers arranged in two layers : internal circular thickness of (288.7)μ and (1666)μ in cardiac and pyloric stomach respectively and external longitudinal layer with thickness of (157.5)μ and (31)μ. In cardiac and pyloric stomach, serosa was a thin layer of loose connective tissue surrounding by squamous epithelial cells with a thicknessof (10.5)μ .