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1. The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Author

Bos, Isabelle, Vos, Stephanie J., Frölich, Lutz, Kornhuber, Johannes, Wiltfang, Jens, Maier, Wolfgang, Peters, Oliver, Rüther, Eckhart, Engelborghs, Sebastiaan, Niemantsverdriet, Ellis, De Roeck, Ellen Elisa, Tsolaki, Magda, Freund-Levi, Yvonne, Johannsen, Peter, Vandenberghe, Rik, Lleó, Alberto, Alcolea, Daniel, Frisoni, Giovanni B., Galluzzi, Samantha, Nobili, Flavio, Morbelli, Silvia, Drzezga, Alexander, Didic, Mira, van Berckel, Bart N., Salmon, Eric, Bastin, Christine, Dauby, Solene, Santana, Isabel, Baldeiras, Inês, de Mendonça, Alexandre, Silva, Dina, Wallin, Anders, Nordlund, Arto, Coloma, Preciosa M., Wientzek, Angelika, Alexander, Myriam, Novak, Gerald P., Gordon, Mark Forrest, Wallin, Åsa K., Hampel, Harald, Soininen, Hilkka, Herukka, Sanna-Kaisa, Scheltens, Philip, Verhey, Frans R., and Visser, Pieter Jelle

Published
2017
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2. Supplementary Figure 1 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, primary, Fanidi, Anouar, primary, Ueland, Per Magne, primary, Relton, Caroline, primary, Midttun, Øivind, primary, Vollset, Stein Emil, primary, Gunter, Marc J., primary, Seckl, Michael J., primary, Travis, Ruth C., primary, Wareham, Nicholas, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Peeters, Petra H.M., primary, Bueno-de-Mesquita, H. Bas, primary, Boeing, Heiner, primary, Wientzek, Angelika, primary, Kuehn, Tilman, primary, Kaaks, Rudolf, primary, Tumino, Rosario, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Naccarati, Alessio, primary, Aicua, Eva Ardanaz, primary, Sánchez, María-José, primary, Quirós, José Ramón, primary, Chirlaque, María-Dolores, primary, Agudo, Antonio, primary, Johansson, Mikael, primary, Grankvist, Kjell, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Fagherazzi, Guy, primary, Weiderpass, Elisabete, primary, Riboli, Elio, primary, Brennan, Paul J., primary, Vineis, Paolo, primary, and Johansson, Mattias, primary

Published
2023
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3. Supplementary Figure 2 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, primary, Fanidi, Anouar, primary, Ueland, Per Magne, primary, Relton, Caroline, primary, Midttun, Øivind, primary, Vollset, Stein Emil, primary, Gunter, Marc J., primary, Seckl, Michael J., primary, Travis, Ruth C., primary, Wareham, Nicholas, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Peeters, Petra H.M., primary, Bueno-de-Mesquita, H. Bas, primary, Boeing, Heiner, primary, Wientzek, Angelika, primary, Kuehn, Tilman, primary, Kaaks, Rudolf, primary, Tumino, Rosario, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Naccarati, Alessio, primary, Aicua, Eva Ardanaz, primary, Sánchez, María-José, primary, Quirós, José Ramón, primary, Chirlaque, María-Dolores, primary, Agudo, Antonio, primary, Johansson, Mikael, primary, Grankvist, Kjell, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Fagherazzi, Guy, primary, Weiderpass, Elisabete, primary, Riboli, Elio, primary, Brennan, Paul J., primary, Vineis, Paolo, primary, and Johansson, Mattias, primary

Published
2023
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4. Supplementary Figure 5 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, primary, Fanidi, Anouar, primary, Ueland, Per Magne, primary, Relton, Caroline, primary, Midttun, Øivind, primary, Vollset, Stein Emil, primary, Gunter, Marc J., primary, Seckl, Michael J., primary, Travis, Ruth C., primary, Wareham, Nicholas, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Peeters, Petra H.M., primary, Bueno-de-Mesquita, H. Bas, primary, Boeing, Heiner, primary, Wientzek, Angelika, primary, Kuehn, Tilman, primary, Kaaks, Rudolf, primary, Tumino, Rosario, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Naccarati, Alessio, primary, Aicua, Eva Ardanaz, primary, Sánchez, María-José, primary, Quirós, José Ramón, primary, Chirlaque, María-Dolores, primary, Agudo, Antonio, primary, Johansson, Mikael, primary, Grankvist, Kjell, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Fagherazzi, Guy, primary, Weiderpass, Elisabete, primary, Riboli, Elio, primary, Brennan, Paul J., primary, Vineis, Paolo, primary, and Johansson, Mattias, primary

Published
2023
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5. Supplementary Figure 4 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, primary, Fanidi, Anouar, primary, Ueland, Per Magne, primary, Relton, Caroline, primary, Midttun, Øivind, primary, Vollset, Stein Emil, primary, Gunter, Marc J., primary, Seckl, Michael J., primary, Travis, Ruth C., primary, Wareham, Nicholas, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Peeters, Petra H.M., primary, Bueno-de-Mesquita, H. Bas, primary, Boeing, Heiner, primary, Wientzek, Angelika, primary, Kuehn, Tilman, primary, Kaaks, Rudolf, primary, Tumino, Rosario, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Naccarati, Alessio, primary, Aicua, Eva Ardanaz, primary, Sánchez, María-José, primary, Quirós, José Ramón, primary, Chirlaque, María-Dolores, primary, Agudo, Antonio, primary, Johansson, Mikael, primary, Grankvist, Kjell, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Fagherazzi, Guy, primary, Weiderpass, Elisabete, primary, Riboli, Elio, primary, Brennan, Paul J., primary, Vineis, Paolo, primary, and Johansson, Mattias, primary

Published
2023
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6. Supplementary Figure 3 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, primary, Fanidi, Anouar, primary, Ueland, Per Magne, primary, Relton, Caroline, primary, Midttun, Øivind, primary, Vollset, Stein Emil, primary, Gunter, Marc J., primary, Seckl, Michael J., primary, Travis, Ruth C., primary, Wareham, Nicholas, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Peeters, Petra H.M., primary, Bueno-de-Mesquita, H. Bas, primary, Boeing, Heiner, primary, Wientzek, Angelika, primary, Kuehn, Tilman, primary, Kaaks, Rudolf, primary, Tumino, Rosario, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Naccarati, Alessio, primary, Aicua, Eva Ardanaz, primary, Sánchez, María-José, primary, Quirós, José Ramón, primary, Chirlaque, María-Dolores, primary, Agudo, Antonio, primary, Johansson, Mikael, primary, Grankvist, Kjell, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Fagherazzi, Guy, primary, Weiderpass, Elisabete, primary, Riboli, Elio, primary, Brennan, Paul J., primary, Vineis, Paolo, primary, and Johansson, Mattias, primary

Published
2023
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9. Physical activity and risk of breast cancer overall and by hormone receptor status: The European prospective investigation into cancer and nutrition

Author

Steindorf, Karen, Ritte, Rebecca, Eomois, Piia-Piret, Lukanova, Annekatrin, Tjonneland, Anne, Johnsen, Nina Fns, Overvad, Kim, stergaard, Jane Nautrup, Clavel-Chapelon, Françoise, Fournier, Agnès, Dossus, Laure, Teucher, Birgit, Rohrmann, Sabine, Boeing, Heiner, Wientzek, Angelika, Trichopoulou, Antonia, Karapetyan, Tina, Trichopoulos, Dimitrios, Masala, Giovanna, Berrino, Franco, Mattiello, Amalia, Tumino, Rosario, Ricceri, Fulvio, Quirós, Ramón J., Travier, Noémie, Sánchez, María-José, Navarro, Carmen, Ardanaz, Eva, Amiano, Pilar, Bueno-de-Mesquita, B(as). H., van Duijnhoven, Franzel, Monninkhof, Evelyn, May, Anne M., Khaw, Kay-Tee, Wareham, Nick, Key, Tim J., Travis, Ruth C., Borch, Kristin Benjaminsen, Sund, Malin, Andersson, Anne, Fedirko, Veronika, Rinaldi, Sabina, Romieu, Isabelle, Wahrendorf, Jürgen, Riboli, Elio, and Kaaks, Rudolf

Published
2013
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10. Serum Metabolites Related to Cardiorespiratory Fitness, Physical Activity Energy Expenditure, Sedentary Time and Vigorous Activity.

Author

Wientzek, Angelika, Floegel, Anna, Knüppel, Sven, Vigl, Matthaeus, Drogan, Dagmar, Adamski, Jerzy, Pischon, Tobias, and Boeing, Heiner

Subjects
*CONFIDENCE intervals, *STATISTICAL correlation, *ENERGY metabolism, *EXERCISE tests, *FACTOR analysis, *GOODNESS-of-fit tests, *METABOLISM, *PHYSICAL fitness, *REGRESSION analysis, *RESEARCH funding, *STATISTICAL sampling, *STATISTICS, *DATA analysis, *BODY mass index, *SEDENTARY lifestyles, *DATA analysis software, *DESCRIPTIVE statistics
Abstract

The aim of our study was to investigate the relationship between objectively measured physical activity (PA) and cardiorespiratory fitness (CRF) and serum metabolites measured by targeted metabolomics in a population- based study. A total of 100 subjects provided 2 fasting blood samples and engaged in a CRF and PA measurement at 2 visits 4 months apart. CRF was estimated from a step test, whereas physical activity energy expenditure (PAEE), time spent sedentary and time spend in vigorous activity were measured by a combined heart rate and movement sensor for a total of 8 days. Serum metabolite concentrations were determined by flow injection analysis tandem mass spectrometry (FIA-MS/MS). Linear mixed models were applied with multivariable adjustment and p-values were corrected for multiple testing. Furthermore, we explored the associations between CRF, PA and two metabolite factors that have previously been linked to risk of Type 2 diabetes. CRF was associated with two phosphatidylcholine clusters independently of all other exposures. Lysophosphatidylcholine C14:0 and methionine were significantly negatively associated with PAEE and sedentary time. CRF was positively associated with the Type 2 diabetes protective factor. Vigorous activity was positively associated with the Type 2 diabetes risk factor in the mutually adjusted model. Our results suggest that CRF and PA are associated with serum metabolites, especially CRF with phosphatidylcholines and with the Type 2 diabetes protective factor. PAEE and sedentary time were associated with methionine. The identified metabolites could be potential mediators of the protective effects of CRF and PA on chronic disease risk. [ABSTRACT FROM AUTHOR]

Published
2014
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11. Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun Fanidi, Anouar Ueland, Per Magne Relton, Caroline Midttun, Oivind Vollset, Stein Emil Gunter, Marc J. and Seckl, Michael J. Travis, Ruth C. Wareham, Nicholas and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Peeters, Petra H. M. Bueno-de-Mesquita, H. Bas Boeing, Heiner and Wientzek, Angelika Kuehn, Tilman Kaaks, Rudolf Tumino, Rosario Agnoli, Claudia Palli, Domenico Naccarati, Alessio and Ardanaz Aicua, Eva Sanchez, Maria-Jose Ramon Quiros, Jose and Chirlaque, Maria-Dolores Agudo, Antonio Johansson, Mikael and Grankvist, Kjell Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise Fagherazzi, Guy Weiderpass, Elisabete and Riboli, Elio Brennan, Paul J. Vineis, Paolo Johansson, Mattias

Abstract

Background: Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated in several cancers, including lung cancer. Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer andNutrition (EPIC) that included 893 incident lung cancer cases and 1,748matched controls. Circulating levels of tryptophan and six of its metabolites were measured and evaluated in relation to lung cancer risk. Results: Tryptophan (P-trend = 2 Chi 10(-5)) and the kynurenine/ tryptophan ratio (KTR; P-trend 4 Chi 10(-5)) were associated with lung cancer risk overall after adjusting for established risk factors. The ORs comparing the fifth and first quintiles (OR5th (vs. 1st)) were 0.52 [ 95% confidence interval (CI), 0.37-0.74] for tryptophan and 1.74 (95% CI, 1.24-2.45) for KTR. After adjusting for plasma methionine (available fromprevious work, which was strongly correlated with tryptophan), the associations of tryptophan (adjusted P-trend 0.13) and KTR (P-trend = 0.009) were substantially attenuated. KTR was positively associated with squamous cell carcinoma, the OR5th vs. 1st being 2.83 (95% CI, 1.62-4.94, P-trend -3 Chi 10(-5)) that was only marginally affected by adjusting for methionine. Conclusions: This study indicates that biomarkers of tryptophan metabolism are associated with subsequent lung cancer risk. Although this result would seem consistent with the immune system having a role in lung cancer development, the overall associations were dependent on methionine, and further studies are warranted to further elucidate the importance of these metabolites in lung cancer etiology. Impact: This is the first prospective study investigating the tryptophan pathway in relation to lung cancer risk.

Published
2014

12. Cross-Sectional Associations of Objectively Measured Physical Activity, Cardiorespiratory Fitness and Anthropometry in European Adults

Author

Wientzek, Angelika Tormo Diaz, Maria-Jose Huerta Castano, Jose Maria Amiano, Pilar Arriola, Larraitz Overvad, Kim and Ostergaard, Jane Nautrup Charles, Marie-Aline Fagherazzi, Guy and Palli, Domenico Bendinelli, Benedetta Skeie, Guri Borch, Kristin Benjaminsen Wendel-Vos, Wanda de Hollander, Ellen and May, Anne M. den Ouden, Marjolein E. M. Trichopoulou, Antonia and Valanou, Elissavet Soederberg, Stefan Franks, Paul W. and Brage, Soren Vigl, Matthaus Boeing, Heiner Ekelund, Ulf

Subjects
human activities, hormones, hormone substitutes, and hormone antagonists
Abstract

Objective: To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men and women. Methods: 2,056 volunteers from 12 centers across Europe were fitted with a heart rate and movement sensor at 2 visits 4 months apart for a total of 8 days. CRF (ml/kg/min) was estimated from an 8 minute ramped step test. A cross-sectional analysis of the independent associations between objectively measured PA (m/s(2)/d), moderate and vigorous physical activity (MVPA) (% time/d), sedentary time (% time/d), CRF, and anthropometry using sex stratified multiple linear regression was performed. Results: In mutually adjusted models, CRF, PA, and MVPA were inversely associated with all anthropometric markers in women. In men, CRF, PA, and MVPA were inversely associated with BMI, whereas only CRF was significantly associated with the other anthropometric markers. Sedentary time was positively associated with all anthropometric markers, however, after adjustment for CRF significant in women only. Conclusion: CRF, PA, MVPA, and sedentary time are differently associated with anthropometric markers in men and women. CRF appears to attenuate associations between PA, MVPA, and sedentary time. These observations may have implications for prevention of obesity.

Published
2014

13. Cross-Sectional Associations of Objectively Measured Physical Activity, Cardiorespiratory Fitness and Anthropometry in European Adults

Author

Wientzek, Angelika, Tormo Diaz, Maria-Jose, Huerta Castano, Jose Maria, Amiano, Pilar, Arriola, Larraitz, Overvad, Kim, Ostergaard, Jane Nautrup, Charles, Marie-Aline, Fagherazzi, Guy, Palli, Domenico, Bendinelli, Benedetta, Skeie, Guri, Borch, Kristin Benjaminsen, Wendel-Vos, Wanda, de Hollander, Ellen, May, Anne M., den Ouden, Marjolein E. M., Trichopoulou, Antonia, Valanou, Elissavet, Söderberg, Stefan, Franks, Paul W., Brage, Soren, Vigl, Matthaus, Boeing, Heiner, Ekelund, Ulf, Wientzek, Angelika, Tormo Diaz, Maria-Jose, Huerta Castano, Jose Maria, Amiano, Pilar, Arriola, Larraitz, Overvad, Kim, Ostergaard, Jane Nautrup, Charles, Marie-Aline, Fagherazzi, Guy, Palli, Domenico, Bendinelli, Benedetta, Skeie, Guri, Borch, Kristin Benjaminsen, Wendel-Vos, Wanda, de Hollander, Ellen, May, Anne M., den Ouden, Marjolein E. M., Trichopoulou, Antonia, Valanou, Elissavet, Söderberg, Stefan, Franks, Paul W., Brage, Soren, Vigl, Matthaus, Boeing, Heiner, and Ekelund, Ulf

Abstract

Objective: To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men and women. Methods: 2,056 volunteers from 12 centers across Europe were fitted with a heart rate and movement sensor at 2 visits 4 months apart for a total of 8 days. CRF (ml/kg/min) was estimated from an 8 minute ramped step test. A cross-sectional analysis of the independent associations between objectively measured PA (m/s(2)/d), moderate and vigorous physical activity (MVPA) (% time/d), sedentary time (% time/d), CRF, and anthropometry using sex stratified multiple linear regression was performed. Results: In mutually adjusted models, CRF, PA, and MVPA were inversely associated with all anthropometric markers in women. In men, CRF, PA, and MVPA were inversely associated with BMI, whereas only CRF was significantly associated with the other anthropometric markers. Sedentary time was positively associated with all anthropometric markers, however, after adjustment for CRF significant in women only. Conclusion: CRF, PA, MVPA, and sedentary time are differently associated with anthropometric markers in men and women. CRF appears to attenuate associations between PA, MVPA, and sedentary time. These observations may have implications for prevention of obesity.

Published
2014
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14. Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, Fanidi, Anouar, Ueland, Per Magne, Relton, Caroline, Midttun, Oivind, Vollset, Stein Emil, Gunter, Marc J., Seckl, Michael J., Travis, Ruth C., Wareham, Nicholas, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Boeing, Heiner, Wientzek, Angelika, Kuehn, Tilman, Kaaks, Rudolf, Tumino, Rosario, Agnoli, Claudia, Palli, Domenico, Naccarati, Alessio, Ardanaz Aicua, Eva, Sanchez, Maria-Jose, Ramon Quiros, Jose, Chirlaque, Maria-Dolores, Agudo, Antonio, Johansson, Mikael, Grankvist, Kjell, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, Guy, Weiderpass, Elisabete, Riboli, Elio, Brennan, Paul J., Vineis, Paolo, Johansson, Mattias, Chuang, Shu-Chun, Fanidi, Anouar, Ueland, Per Magne, Relton, Caroline, Midttun, Oivind, Vollset, Stein Emil, Gunter, Marc J., Seckl, Michael J., Travis, Ruth C., Wareham, Nicholas, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Boeing, Heiner, Wientzek, Angelika, Kuehn, Tilman, Kaaks, Rudolf, Tumino, Rosario, Agnoli, Claudia, Palli, Domenico, Naccarati, Alessio, Ardanaz Aicua, Eva, Sanchez, Maria-Jose, Ramon Quiros, Jose, Chirlaque, Maria-Dolores, Agudo, Antonio, Johansson, Mikael, Grankvist, Kjell, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, Guy, Weiderpass, Elisabete, Riboli, Elio, Brennan, Paul J., Vineis, Paolo, and Johansson, Mattias

Abstract

Background: Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated in several cancers, including lung cancer. Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer andNutrition (EPIC) that included 893 incident lung cancer cases and 1,748matched controls. Circulating levels of tryptophan and six of its metabolites were measured and evaluated in relation to lung cancer risk. Results: Tryptophan (P-trend = 2 Chi 10(-5)) and the kynurenine/ tryptophan ratio (KTR; P-trend 4 Chi 10(-5)) were associated with lung cancer risk overall after adjusting for established risk factors. The ORs comparing the fifth and first quintiles (OR5th (vs. 1st)) were 0.52 [ 95% confidence interval (CI), 0.37-0.74] for tryptophan and 1.74 (95% CI, 1.24-2.45) for KTR. After adjusting for plasma methionine (available fromprevious work, which was strongly correlated with tryptophan), the associations of tryptophan (adjusted P-trend 0.13) and KTR (P-trend = 0.009) were substantially attenuated. KTR was positively associated with squamous cell carcinoma, the OR5th vs. 1st being 2.83 (95% CI, 1.62-4.94, P-trend -3 Chi 10(-5)) that was only marginally affected by adjusting for methionine. Conclusions: This study indicates that biomarkers of tryptophan metabolism are associated with subsequent lung cancer risk. Although this result would seem consistent with the immune system having a role in lung cancer development, the overall associations were dependent on methionine, and further studies are warranted to further elucidate the importance of these metabolites in lung cancer etiology. Impact: This is the first prospective study investigating the tryptophan pathway in relation to lung cancer risk.

Published
2014
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16. Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Author

Chuang, Shu-Chun, primary, Fanidi, Anouar, additional, Ueland, Per Magne, additional, Relton, Caroline, additional, Midttun, Øivind, additional, Vollset, Stein Emil, additional, Gunter, Marc J., additional, Seckl, Michael J., additional, Travis, Ruth C., additional, Wareham, Nicholas, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Trichopoulos, Dimitrios, additional, Peeters, Petra H.M., additional, Bueno-de-Mesquita, H. Bas, additional, Boeing, Heiner, additional, Wientzek, Angelika, additional, Kuehn, Tilman, additional, Kaaks, Rudolf, additional, Tumino, Rosario, additional, Agnoli, Claudia, additional, Palli, Domenico, additional, Naccarati, Alessio, additional, Aicua, Eva Ardanaz, additional, Sánchez, María-José, additional, Quirós, José Ramón, additional, Chirlaque, María-Dolores, additional, Agudo, Antonio, additional, Johansson, Mikael, additional, Grankvist, Kjell, additional, Boutron-Ruault, Marie-Christine, additional, Clavel-Chapelon, Françoise, additional, Fagherazzi, Guy, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Brennan, Paul J., additional, Vineis, Paolo, additional, and Johansson, Mattias, additional

Published
2014
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18. Cross‐sectional associations of objectively measured physical activity, cardiorespiratory fitness and anthropometry in European adults

Author

Wientzek, Angelika, primary, Tormo Díaz, María‐José, additional, Castaño, Jose Maria Huerta, additional, Amiano, Pilar, additional, Arriola, Larraitz, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Charles, Marie‐Aline, additional, Fagherazzi, Guy, additional, Palli, Domenico, additional, Bendinelli, Benedetta, additional, Skeie, Guri, additional, Borch, Kristin Benjaminsen, additional, Wendel‐Vos, Wanda, additional, Hollander, Ellen, additional, May, Anne M., additional, Ouden, Marjolein EM, additional, Trichopoulou, Antonia, additional, Valanou, Elissavet, additional, Söderberg, Stefan, additional, Franks, Paul W., additional, Brage, Soren, additional, Vigl, Matthäus, additional, Boeing, Heiner, additional, and Ekelund, Ulf, additional

Published
2013
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19. Prospective Study on Physical Activity and Risk of In Situ Breast Cancer

Author

Steindorf, Karen, primary, Ritte, Rebecca, additional, Tjonneland, Anne, additional, Johnsen, Nina Føns, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Clavel-Chapelon, Françoise, additional, Fournier, Agnès, additional, Dossus, Laure, additional, Lukanova, Annekatrin, additional, Chang-Claude, Jenny, additional, Boeing, Heiner, additional, Wientzek, Angelika, additional, Trichopoulou, Antonia, additional, Karapetyan, Tina, additional, Trichopoulos, Dimitrios, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Polidoro, Silvia, additional, Quirós, José Ramón, additional, Travier, Noémie, additional, Sánchez, María-José, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Bueno-de-Mesquita, H. Bas, additional, van Duijnhoven, Fränzel J.B., additional, Monninkhof, Evelyn, additional, May, Anne M., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Key, Tim J., additional, Travis, Ruth C., additional, Borch, Kristin Benjaminsen, additional, Fedirko, Veronika, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Wark, Petra A., additional, Norat, Teresa, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2012
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20. Physical activity and risk of breast cancer overall and by hormone receptor status: The European prospective investigation into cancer and nutrition

Author

Steindorf, Karen, primary, Ritte, Rebecca, additional, Eomois, Piia‐Piret, additional, Lukanova, Annekatrin, additional, Tjonneland, Anne, additional, Johnsen, Nina Føns, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Clavel‐Chapelon, Françoise, additional, Fournier, Agnès, additional, Dossus, Laure, additional, Teucher, Birgit, additional, Rohrmann, Sabine, additional, Boeing, Heiner, additional, Wientzek, Angelika, additional, Trichopoulou, Antonia, additional, Karapetyan, Tina, additional, Trichopoulos, Dimitrios, additional, Masala, Giovanna, additional, Berrino, Franco, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Quirós, J.Ramón, additional, Travier, Noémie, additional, Sánchez, María‐José, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Bueno‐de‐Mesquita, H.B(as)., additional, van Duijnhoven, Franzel, additional, Monninkhof, Evelyn, additional, May, Anne M., additional, Khaw, Kay‐Tee, additional, Wareham, Nick, additional, Key, Tim J., additional, Travis, Ruth C., additional, Borch, Kristin Benjaminsen, additional, Sund, Malin, additional, Andersson, Anne, additional, Fedirko, Veronika, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Wahrendorf, Jürgen, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2012
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21. Cross-sectional associations of objectively measured physical activity, cardiorespiratory fitness and anthropometry in European adults.

Author

Wientzek A, Tormo Díaz MJ, Castaño JM, Amiano P, Arriola L, Overvad K, Østergaard JN, Charles MA, Fagherazzi G, Palli D, Bendinelli B, Skeie G, Borch KB, Wendel-Vos W, de Hollander E, May AM, den Ouden ME, Trichopoulou A, Valanou E, Söderberg S, Franks PW, Brage S, Vigl M, Boeing H, and Ekelund U

Subjects
Adult, Body Mass Index, Body Weight, Cross-Sectional Studies, Europe, Exercise Test methods, Female, Healthy Volunteers, Humans, Male, Middle Aged, Obesity prevention & control, Prospective Studies, Sedentary Behavior, Waist Circumference, Cardiovascular System metabolism, Motor Activity, Physical Fitness, White People
Abstract

Objective: To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men and women., Methods: 2,056 volunteers from 12 centers across Europe were fitted with a heart rate and movement sensor at 2 visits 4 months apart for a total of 8 days. CRF (ml/kg/min) was estimated from an 8 minute ramped step test. A cross-sectional analysis of the independent associations between objectively measured PA (m/s(2)/d), moderate and vigorous physical activity (MVPA) (%time/d), sedentary time (%time/d), CRF, and anthropometry using sex stratified multiple linear regression was performed., Results: In mutually adjusted models, CRF, PA, and MVPA were inversely associated with all anthropometric markers in women. In men, CRF, PA, and MVPA were inversely associated with BMI, whereas only CRF was significantly associated with the other anthropometric markers. Sedentary time was positively associated with all anthropometric markers, however, after adjustment for CRF significant in women only., Conclusion: CRF, PA, MVPA, and sedentary time are differently associated with anthropometric markers in men and women. CRF appears to attenuate associations between PA, MVPA, and sedentary time. These observations may have implications for prevention of obesity., (Copyright © 2013 The Obesity Society.)

Published
2014
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