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670 results on '"Wieloch, Tadeusz"'

4. Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity

Author

Hakon, Jakob, primary, Quattromani, Miriana J, additional, Sjölund, Carin, additional, Talhada, Daniela, additional, Kim, Bungchan, additional, Moyanova, Slavianka, additional, Mastroiacovo, Federica, additional, Di Menna, Luisa, additional, Olsson, Roger, additional, Englund, Elisabet, additional, Nicoletti, Ferdinando, additional, Ruscher, Karsten, additional, Bauer, Adam Q, additional, and Wieloch, Tadeusz, additional

Published
2023
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7. Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.

Author

Hakon, Jakob, Quattromani, Miriana J, Sjölund, Carin, Talhada, Daniela, Kim, Byungchan, Moyanova, Slavianka, Mastroiacovo, Federica, Menna, Luisa Di, Olsson, Roger, Englund, Elisabet, Nicoletti, Ferdinando, Ruscher, Karsten, Bauer, Adam Q, and Wieloch, Tadeusz

Subjects
STROKE, GLUTAMATE receptors, INTRINSIC optical imaging, ISCHEMIC stroke, KNOCKOUT mice, ALTEPLASE
Abstract

Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischaemic stroke, there is no clinically-approved pharmacological treatment that alleviates sensorimotor impairments. Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connections. The type-5 metabotropic glutamate receptor (mGluR5) has been shown to modulate brain plasticity and function and is a therapeutic target in neurological diseases outside of stroke. We investigated whether mGluR5 influences functional recovery and network reorganization rodent models of focal ischaemia. Using multiple behavioural tests, we observed that treatment with negative allosteric modulators (NAMs) of mGluR5 (MTEP, fenobam and AFQ056) for 12 days, starting 2 or 10 days after stroke, restored lost sensorimotor functions, without diminishing infarct size. Recovery was evident within hours after initiation of treatment and progressed over the subsequent 12 days. Recovery was prevented by activation of mGluR5 with the positive allosteric modulator VU0360172 and accelerated in mGluR5 knock-out mice compared with wild-type mice. After stroke, multisensory stimulation by enriched environments enhanced recovery, a result prevented by VU0360172, implying a role of mGluR5 in enriched environment-mediated recovery. Additionally, MTEP treatment in conjunction with enriched environment housing provided an additive recovery enhancement compared to either MTEP or enriched environment alone. Using optical intrinsic signal imaging, we observed brain-wide disruptions in resting-state functional connectivity after stroke that were prevented by mGluR5 inhibition in distinct areas of contralesional sensorimotor and bilateral visual cortices. The levels of mGluR5 protein in mice and in tissue samples of stroke patients were unchanged after stroke. We conclude that neuronal circuitry subserving sensorimotor function after stroke is depressed by a mGluR5-dependent maladaptive plasticity mechanism that can be restored by mGluR5 inhibition. Post-acute stroke treatment with mGluR5 NAMs combined with rehabilitative training may represent a novel post-acute stroke therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Author response: Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke

Author

Bice, Annie R, primary, Xiao, Qingli, additional, Kong, Justin, additional, Yan, Ping, additional, Rosenthal, Zachary Pollack, additional, Kraft, Andrew W, additional, Smith, Karen P, additional, Wieloch, Tadeusz, additional, Lee, Jin-Moo, additional, Culver, Joseph P, additional, and Bauer, Adam Q, additional

Published
2022
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25. Plasticity-Enhancing Effects of Levodopa Treatment after Stroke

Author

Talhada, Daniela, Marklund, Niklas, Wieloch, Tadeusz, Kuric, Enida, and Ruscher, Karsten

Subjects
Male, Nogo Receptors, QH301-705.5, Nogo Proteins, Dopamine Agents, Down-Regulation, stroke recovery, Article, Nogo A, Brain Ischemia, Levodopa, Mice, GAP-43 Protein, Animals, Rats, Wistar, Biology (General), QD1-999, Nogo receptor, Neuronal Plasticity, Dopaminergic Neurons, Infarction, Middle Cerebral Artery, Thrombosis, Oligodendrocyte Transcription Factor 2, neuronal plasticiticy, Stroke, Disease Models, Animal, Oligodendroglia, Chemistry, dopamine, oligodendrocyte
Abstract

Dopaminergic treatment in combination with rehabilitative training enhances long-term recovery after stroke. However, the underlying mechanisms on structural plasticity are unknown. Here, we show an increased dopaminergic innervation of the ischemic territory during the first week after stroke induced in Wistar rats subjected to transient occlusion of the middle cerebral artery (tMCAO) for 120 min. This response was also found in rats subjected to permanent focal ischemia induced by photothrombosis (PT) and mice subjected to PT or tMCAO. Dopaminergic branches were detected in the infarct core of mice and rats in both stroke models. In addition, the Nogo A pathway was significantly downregulated in rats treated with levodopa (LD) compared to vehicle-treated animals subjected to tMCAO. Specifically, the number of Nogo A positive oligodendrocytes as well as the levels of Nogo A and the Nogo A receptor were significantly downregulated in the peri-infarct area of LD-treated animals, while the number of Oligodendrocyte transcription factor 2 positive cells increased in this region after treatment. In addition, we observed lower protein levels of Growth Associated Protein 43 in the peri-infarct area compared to sham-operated animals without treatment effect. The results provide the first evidence of the plasticity-promoting actions of dopaminergic treatment following stroke.

Published
2021

34. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

Author

Mattiasson, Gustav, Shamloo, Mehrdad, Gido, Gunilla, Mathi, Kavitha, Tomasevic, Gregor, Yi, Saili, Warden, Craig H., Castilho, Roger F., Melcher, Thorsten, Gonzalez-Zulueta, Mirella, Nikolich, Karoly, and Wieloch, Tadeusz

Abstract

Author(s): Gustav Mattiasson [1, 5]; Mehrdad Shamloo [2, 5]; Gunilla Gido [1]; Kavitha Mathi [2]; Gregor Tomasevic [1]; Saili Yi [2]; Craig H. Warden [3]; Roger F. Castilho [4]; Thorsten [...]

Published
2003
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