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27 results on '"Wieland Sommer"'

1. Pathological Reporting of Radical Prostatectomy Specimens Following ICCR Recommendation: Impact of Electronic Reporting Tool Implementation on Quality and Interdisciplinary Communication in a Large University Hospital

Author

Caroline Richter, Eva Mezger, Peter J. Schüffler, Wieland Sommer, Federico Fusco, Katharina Hauner, Sebastian C. Schmid, Jürgen E. Gschwend, Wilko Weichert, Kristina Schwamborn, Dominik Pförringer, and Anna Melissa Schlitter

Subjects
prostate cancer, pathological reporting, structured reporting templates, quality improvement, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Prostate cancer represents one of the most common malignant tumors in male patients in Germany. The pathological reporting of radical prostatectomy specimens following a structured process constitutes an excellent prototype for the introduction of software-based standardized structured reporting in pathology. This can lead to reports of higher quality and could create a fundamental improvement for future AI applications. A software-based reporting template was used to generate standardized structured pathological reports of radical prostatectomy specimens of patients treated at the University Hospital Klinikum rechts der Isar of Technische Universität München, Germany. Narrative reports (NR) and standardized structured reports (SSR) were analyzed with regard to completeness, and clinicians’ satisfaction with each report type was evaluated. SSR show considerably higher completeness than NR. A total of 10 categories out of 32 were significantly more complete in SSR than in NR (p < 0.05). Clinicians awarded overall high scores in NR and SSR reports. One rater acknowledged a significantly higher level of clarity and time saving when comparing SSR to NR. Our findings highlight that the standardized structured reporting of radical prostatectomy specimens, qualifying as level 5 reports, significantly increases objectively measured content quality and the level of completeness. The implementation of nationwide SSR in Germany, particularly in oncologic pathology, can serve pathologists, clinicians, and patients.

Published
2022
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2. Subclinical Changes in Cardiac Functional Parameters as Determined by Cardiovascular Magnetic Resonance (CMR) Imaging in Sleep Apnea and Snoring: Findings from UK Biobank

Author

Adrian Curta, Holger Hetterich, Regina Schinner, Aaron M. Lee, Wieland Sommer, Nay Aung, Mihir M. Sanghvi, Kenneth Fung, Elena Lukaschuk, Jackie A. Cooper, José Miguel Paiva, Valentina Carapella, Stefan Neubauer, Stefan K. Piechnik, and Steffen E. Petersen

Subjects
cardiac MRI, sleep apnea, heart, epidemiology, Medicine (General), R5-920
Abstract

Background and Objectives: Obstructive sleep apnea (OSA) is a common disorder with an increased risk for left ventricular and right ventricular dysfunction. Most studies to date have examined populations with manifest cardiovascular disease using echocardiography to analyze ventricular dysfunction with little or no reference to ventricular volumes or myocardial mass. Our aim was to explore these parameters with cardiac MRI. We hypothesized that there would be stepwise increase in left ventricular mass and right ventricular volumes from the unaffected, to the snoring and the OSA group. Materials and Methods: We analyzed cardiac MRI data from 4978 UK Biobank participants free from cardiovascular disease. Participants were allocated into three cohorts: with OSA, with self-reported snoring and without OSA or snoring (n = 118, 1886 and 2477). We analyzed cardiac parameters from balanced cine-SSFP sequences and indexed them to body surface area. Results: Patients with OSA were mostly males (47.3% vs. 79.7%; p < 0.001) with higher body mass index (25.7 ± 4.0 vs. 31.3 ± 5.3 kg/m²; p < 0.001) and higher blood pressure (135 ± 18 vs. 140 ± 17 mmHg; p = 0.012) compared to individuals without OSA or snoring. Regression analysis showed a significant effect for OSA in left ventricular end-diastolic index (LVEDVI) (β = −4.9 ± 2.4 mL/m²; p = 0.040) and right ventricular end-diastolic index (RVEDVI) (β = −6.2 ± 2.6 mL/m²; p = 0.016) in females and for right ventricular ejection fraction (RVEF) (β = 1.7 ± 0.8%; p = 0.031) in males. A significant effect was discovered in snoring females for left ventricular mass index (LVMI) (β = 3.5 ± 0.9 g/m²; p < 0.001) and in males for left ventricular ejection fraction (LVEF) (β = 1.0 ± 0.3%; p = 0.001) and RVEF (β = 1.2 ± 0.3%; p < 0.001). Conclusion: Our study suggests that OSA is highly underdiagnosed and that it is an evolving process with gender specific progression. Females with OSA show significantly lower ventricular volumes while males with snoring show increased ejection fractions which may be an early sign of hypertrophy. Separate prospective studies are needed to further explore the direction of causality.

Published
2021
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3. Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study.

Author

Roberto Lorbeer, Holger Hetterich, Ralf Strobl, Anina Schafnitzel, Hannah Patscheider, Andreas Schindler, Katharina Müller-Peltzer, Wieland Sommer, Annette Peters, Christa Meisinger, Margit Heier, Wolfgang Rathmann, Fabian Bamberg, and Eva Grill

Subjects
Medicine, Science
Abstract

We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample.Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided.Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5).In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.

Published
2017
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4. The Liver Tumor Segmentation Benchmark (LiTS)

Author

Patrick Bilic, Patrick Christ, Hongwei Bran Li, Eugene Vorontsov, Avi Ben-Cohen, Georgios Kaissis, Adi Szeskin, Colin Jacobs, Gabriel Efrain Humpire Mamani, Gabriel Chartrand, Fabian Lohöfer, Julian Walter Holch, Wieland Sommer, Felix Hofmann, Alexandre Hostettler, Naama Lev-Cohain, Michal Drozdzal, Michal Marianne Amitai, Refael Vivanti, Jacob Sosna, Ivan Ezhov, Anjany Sekuboyina, Fernando Navarro, Florian Kofler, Johannes C. Paetzold, Suprosanna Shit, Xiaobin Hu, Jana Lipková, Markus Rempfler, Marie Piraud, Jan Kirschke, Benedikt Wiestler, Zhiheng Zhang, Christian Hülsemeyer, Marcel Beetz, Florian Ettlinger, Michela Antonelli, Woong Bae, Míriam Bellver, Lei Bi, Hao Chen, Grzegorz Chlebus, Erik B. Dam, Qi Dou, Chi-Wing Fu, Bogdan Georgescu, Xavier Giró-i-Nieto, Felix Gruen, Xu Han, Pheng-Ann Heng, Jürgen Hesser, Jan Hendrik Moltz, Christian Igel, Fabian Isensee, Paul Jäger, Fucang Jia, Krishna Chaitanya Kaluva, Mahendra Khened, Ildoo Kim, Jae-Hun Kim, Sungwoong Kim, Simon Kohl, Tomasz Konopczynski, Avinash Kori, Ganapathy Krishnamurthi, Fan Li, Hongchao Li, Junbo Li, Xiaomeng Li, John Lowengrub, Jun Ma, Klaus Maier-Hein, Kevis-Kokitsi Maninis, Hans Meine, Dorit Merhof, Akshay Pai, Mathias Perslev, Jens Petersen, Jordi Pont-Tuset, Jin Qi, Xiaojuan Qi, Oliver Rippel, Karsten Roth, Ignacio Sarasua, Andrea Schenk, Zengming Shen, Jordi Torres, Christian Wachinger, Chunliang Wang, Leon Weninger, Jianrong Wu, Daguang Xu, Xiaoping Yang, Simon Chun-Ho Yu, Yading Yuan, Miao Yue, Liping Zhang, Jorge Cardoso, Spyridon Bakas, Rickmer Braren, Volker Heinemann, Christopher Pal, An Tang, Samuel Kadoury, Luc Soler, Bram van Ginneken, Hayit Greenspan, Leo Joskowicz, Bjoern Menze, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. CROMAI - Computing Resources Orchestration and Management for AI

Subjects
FOS: Computer and information sciences, Radiological and Ultrasound Technology, Computer Vision and Pattern Recognition (cs.CV), Computer Science - Computer Vision and Pattern Recognition, Health Informatics, Deep learning, Enginyeria de la telecomunicació::Processament del senyal::Processament de la imatge i del senyal vídeo [Àrees temàtiques de la UPC], Benchmark, Computer Graphics and Computer-Aided Design, Informàtica::Aplicacions de la informàtica [Àrees temàtiques de la UPC], Liver -- Cancer, Segmentation, All institutes and research themes of the Radboud University Medical Center, Liver, Ct, Deep Learning, Liver Tumor, Diagnostic imaging, Fetge -- Càncer, Radiology, Nuclear Medicine and imaging, Computer Vision and Pattern Recognition, Liver tumor, Imatgeria per al diagnòstic, CT, Aprenentatge profund, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liver tumor segmentation algorithms were trained on a set of 131 computed tomography (CT) volumes and were tested on 70 unseen test images acquired from different patients. We found that not a single algorithm performed best for both liver and liver tumors in the three events. The best liver segmentation algorithm achieved a Dice score of 0.963, whereas, for tumor segmentation, the best algorithms achieved Dices scores of 0.674 (ISBI 2017), 0.702 (MICCAI 2017), and 0.739 (MICCAI 2018). Retrospectively, we performed additional analysis on liver tumor detection and revealed that not all top-performing segmentation algorithms worked well for tumor detection. The best liver tumor detection method achieved a lesion-wise recall of 0.458 (ISBI 2017), 0.515 (MICCAI 2017), and 0.554 (MICCAI 2018), indicating the need for further research. LiTS remains an active benchmark and resource for research, e.g., contributing the liver-related segmentation tasks in \url{http://medicaldecathlon.com/}. In addition, both data and online evaluation are accessible via \url{www.lits-challenge.com}., Patrick Bilic, Patrick Christ, Hongwei Bran Li, and Eugene Vorontsov made equal contributions to this work. Published in Medical Image Analysis

Published
2022

5. Künstliche intelligenz: Von der Notwendigkeit einer KI-Infrastruktur

Author

Wieland Sommer

Abstract

Das Gesundheitssystem steht finanziell und personell unter enormem Druck. Künstliche Intelligenz hat das Potenzial, Ärzten Werkzeuge an die Hand zu geben, um den stetig steigenden Herausforderungen gerecht zu werden und gleichzeitig Fehler in der Diagnostik zu vermeiden.

Published
2019

6. Structured Radiology Reporting: Addressing the Communication Quality Gap

Author

Julian Dobranowski and Wieland Sommer

Subjects
medicine.medical_specialty, Health professionals, business.industry, Patient care, law.invention, Radiology report, law, Medicine public health, Radiological weapon, Health care, CLARITY, Medicine, Radiology, business, Communication quality
Abstract

Ineffective communication in healthcare contributes to patient morbidity and mortality. Understanding why failures in communication occur requires an understanding of how healthcare professionals communicate and models explaining the communication process. Radiologists communicate most commonly using the radiology report. Worldwide it is estimated that billions of radiological examinations are performed annually. The quality of each radiology report can contribute to patient care either in a positive manner leading to better outcomes or can be a source of medical error. Recent articles highlight quality gaps in radiology reports related not only to accuracy but also to clarity and completeness. We review and highlight the gaps related to the quality of radiology reports and discuss strategies to improve effective communication.

Published
2019

7. 9 ZNS (I) ZNS (Zentralnervensystem) Zentralnervensystem (ZNS)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

8. 6 Nuklearmedizin

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

9. Vorwort

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

10. 2 Strahlenbiologie

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

11. 4 Skelett (I)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

12. 10 Wirbelsäule und Spinalkanal (I)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

13. 2 Herz (I) Herz

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

14. 1 Physikalische Grundlagen

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

15. 3 Grundlagen des Strahlenschutzes* Die Darstellung in diesem Kapitel bezieht sich auf das zum Zeitpunkt der Drucklegung geltende Strahlenschutzrecht. Basierend auf der Richtlinie 2013/59/Euratom vom 05.12.2013 wird dieses zurzeit überarbeitet. Soweit neuere Zahlenwerte bereits absehbar waren, wurden diese in den Tablellen in Klammern hinzugefügt. Da die Überarbeitung auch die Einführung eines Strahlenschutzgesetztes mit neuen nachramgigen Verordnungen vorsieht, wird sich auch die Zuordnung der rechtlichen Regelungen zu den einzelnen Rechtsvorschriften grundlegend ändern, wobei aber der Inhalt der Vorschriften im Wesentlichen erhalten bleibt

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

16. 4 Radiologische Verfahren

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

17. 5 Strahlentherapie (I)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

18. 8 Mamma

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

19. 13 Bildgebende Diagnostik im Kindesalter

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

20. Radiologie

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

21. 7 Leber, biliäres System, Pankreas, Milz (I)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

22. 1 Thorax (I)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Subjects
business.industry, Medicine, Thorax (insect anatomy), Anatomy, business
Published
2017

23. 6 Ösophagus, Magen, Dünn- und Dickdarm (I)

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

24. 12 Hals

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

25. Sachverzeichnis

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

26. 11 Schädelbasis, Gesichtsschädel und Orbita

Author

Kirsten Beitzel, Roland Brüning, Jürgen Debus, Volkher Engelbrecht, Sylvaine Fritzsche, Gotthard Grützner, Alexander Haug, Andreas Helck, Karin Hellerhoff, Thomas Helmberger, Hannah Hentschel, Karin A. Herrmann, Holger Hetterich, Ralph Hünerbein, Oliver Jäkel, Christian P. Karger, Inga Katharina Koerte, Ingrid Krüger-Stollfuß, Fritz-Peter Kuhn, Jörg Detlev Moritz, Marc Münter, Jörg Reinartz, Maximilian Reiser, Peter Reuter, Dorothea Rjosk-Dendorfer, Stefan Rohde, Jürgen Scheidler, Christine Schmid-Tannwald, Karl Otto Schneider, Daniela Schulz-Ertner, Florian Schwarz, Wieland Sommer, Florian Sterzing, Marcus Treitl, Detlev Uhlenbrock, Thomas J. Vogl, Klaus-Josef Weber, and Christoph J. Zech

Published
2017

27. Application of single- and dual-energy CT brain tissue segmentation to PET monitoring of proton therapy.

Author

Bianca Berndt, Guillaume Landry, Florian Schwarz, Thomas Tessonnier, Florian Kamp, George Dedes, Christian Thieke, Matthias Würl, Christopher Kurz, Ute Ganswindt, Frank Verhaegen, Jürgen Debus, Claus Belka, Wieland Sommer, Maximilian Reiser, Julia Bauer, and Katia Parodi

Subjects
DUAL energy CT (Tomography), BRAIN banks, POSITRON emission tomography
Abstract

The purpose of this work was to evaluate the ability of single and dual energy computed tomography (SECT, DECT) to estimate tissue composition and density for usage in Monte Carlo (MC) simulations of irradiation induced β+ activity distributions. This was done to assess the impact on positron emission tomography (PET) range verification in proton therapy. A DECT-based brain tissue segmentation method was developed for white matter (WM), grey matter (GM) and cerebrospinal fluid (CSF). The elemental composition of reference tissues was assigned to closest CT numbers in DECT space (DECTdist). The method was also applied to SECT data (SECTdist). In a validation experiment, the proton irradiation induced PET activity of three brain equivalent solutions (BES) was compared to simulations based on different tissue segmentations. Five patients scanned with a dual source DECT scanner were analyzed to compare the different segmentation methods. A single magnetic resonance (MR) scan was used for comparison with an established segmentation toolkit. Additionally, one patient with SECT and post-treatment PET scans was investigated. For BES, DECTdist and SECTdist reduced differences to the reference simulation by up to 62% when compared to the conventional stoichiometric segmentation (SECTSchneider). In comparison to MR brain segmentation, Dice similarity coefficients for WM, GM and CSF were 0.61, 0.67 and 0.66 for DECTdist and 0.54, 0.41 and 0.66 for SECTdist. MC simulations of PET treatment verification in patients showed important differences between DECTdist/SECTdist and SECTSchneider for patients with large CSF areas within the treatment field but not in WM and GM. Differences could be misinterpreted as PET derived range shifts of up to 4 mm. DECTdist and SECTdist yielded comparable activity distributions, and comparison of SECTdist to a measured patient PET scan showed improved agreement when compared to SECTSchneider. The agreement between predicted and measured PET activity distributions was improved by employing a brain specific segmentation applicable to both DECT and SECT data. [ABSTRACT FROM AUTHOR]

Published
2017
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