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23 results on '"Wiekmeijer, Anna-Sophia"'

4. List of contributors

Author

Adamik, Juraj, primary, Aurisicchio, Luigi, additional, Bell, John C., additional, Bourgeois-Daigneault, Marie-Claude, additional, Butterfield, Lisa H., additional, Cerullo, Vincenzo, additional, Chiang, Cheryl L.-L., additional, Ciliberto, Gennaro, additional, Conforti, Antonella, additional, Finn, Olivera J., additional, Galli, Maria Cristina, additional, Hadrup, Sine Reker, additional, Hamilton, Duane H., additional, Hawthorne, Jenci, additional, Himuro, Hidetomo, additional, Jacqueline, Camille, additional, Jochems, Caroline, additional, Kadivar, Mohammad, additional, Kandalaft, Lana E., additional, Melief, Cornelis J.M., additional, Munson, Paul V., additional, Nappi, Filomena, additional, Palombo, Fabio, additional, Rammensee, Hans-Georg, additional, Sasada, Tetsuro, additional, Schlom, Jeffrey, additional, Shirwan, Haval, additional, Tagliamonte, Maria, additional, van der Gracht, Esmé T.I., additional, Wiekmeijer, Anna-Sophia, additional, Ylösmäki, Erkko, additional, and Yolcu, Esma, additional

Published
2022
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6. Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo

Author

Jansen, Diahann T. S. L., primary, de Beijer, Monique T. A., additional, Luijten, Robbie J., additional, Kwappenberg, Kitty, additional, Wiekmeijer, Anna-Sophia, additional, Kessler, Amy L., additional, Pieterman, Roel F. A., additional, Bouzid, Rachid, additional, Krebber, Willem-Jan, additional, de Man, Robert A., additional, Melief, Cornelis J. M., additional, and Buschow, Sonja I., additional

Published
2023
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7. Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo

Author

Jansen, Diahann T.S.L., de Beijer, Monique T.A., Luijten, Robbie J., Kwappenberg, Kitty, Wiekmeijer, Anna Sophia, Kessler, Amy L., Pieterman, Roel F.A., Bouzid, Rachid, Krebber, Willem Jan, de Man, Robert A., Melief, Cornelis J.M., Buschow, Sonja I., Jansen, Diahann T.S.L., de Beijer, Monique T.A., Luijten, Robbie J., Kwappenberg, Kitty, Wiekmeijer, Anna Sophia, Kessler, Amy L., Pieterman, Roel F.A., Bouzid, Rachid, Krebber, Willem Jan, de Man, Robert A., Melief, Cornelis J.M., and Buschow, Sonja I.

Abstract

Introduction: Therapeutic vaccination based on synthetic long peptides (SLP®) containing both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B infection (cHBV). Methods: We designed SLPs for three HBV proteins, HBcAg and the non-secreted proteins polymerase and X, and investigated their ability to induce T cell responses ex vivo. A set of 17 SLPs was constructed based on viral protein conservation, functionality, predicted and validated binders for prevalent human leukocyte antigen (HLA) supertypes, validated HLA I epitopes, and chemical producibility. Results: All 17 SLPs were capable of inducing interferon gamma (IFNɣ) production in samples from four or more donors that had resolved an HBV infection in the past (resolver). Further analysis of the best performing SLPs demonstrated activation of both CD8+ and CD4+ multi-functional T cells in one or more resolver and patient sample(s). When investigating which SLP could activate HBV-specific T cells, the responses could be traced back to different peptides for each patient or resolver. Discussion: This indicates that a large population of subjects with different HLA types can be covered by selecting a suitable mix of SLPs for therapeutic vaccine design. In conclusion, we designed a set of SLPs capable of inducing multifunctional CD8+ and CD4+ T cells ex vivo that create important components for a novel therapeutic vaccine to cure cHBV.

Published
2023

11. 1181 Therapeutic vaccines consisting of cancer germline antigen-based synthetic long peptides are immunogenic in human hepatocellular carcinoma patients

Author

Rakké, Yannick, primary, Schoenmaekers-Welters, Marij, additional, Noordam, Lisanne, additional, Boekestijn, Sanne, additional, Magre, Luc, additional, Luijten, Robbie, additional, Gemerden, Rachelle van, additional, Beijer, Monique de, additional, Doukas, Michael, additional, Demmers, Jeroen, additional, Wiekmeijer, Anna-Sophia, additional, Krebber, Willem-Jan, additional, Melief, Cornelis, additional, IJzermans, Jan, additional, Kwekkeboom, Jaap, additional, Burg, Sjoerd van der, additional, Buschow, Sonja, additional, and Sprengers, Dave, additional

Published
2022
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12. Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides.

Author

Stegmann, Toon, Wiekmeijer, Anna-Sophia, Kwappenberg, Kitty, van Duikeren, Suzanne, Bhoelan, Farien, Bemelman, Denzel, Beenakker, Thomas J. M., Krebber, Willem-Jan, Arens, Ramon, and Melief, Cornelis J. M.

Subjects
*T cells, *PEPTIDOMIMETICS, *T cell receptors, *CANCER vaccines, *HUMAN papillomavirus, *PEPTIDES
Abstract

Therapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and synthetic long peptide (SLP) vaccines, all aiming at robust T cell responses. SLPs linked to the Amplivant® adjuvant (Amplivant-SLP) have shown effective delivery to dendritic cells, resulting in improved immunogenicity in mice. We have now tested virosomes as a delivery vehicle for SLPs. Virosomes are nanoparticles made from influenza virus membranes and have been used as vaccines for a variety of antigens. Amplivant-SLP virosomes induced the expansion of more antigen-specific CD8 + T memory cells in ex vivo experiments with human PBMCs than Amplivant-SLP conjugates alone. The immune response could be further improved by including the adjuvants QS-21 and 3D-PHAD in the virosomal membrane. In these experiments, the SLPs were anchored in the membrane through the hydrophobic Amplivant adjuvant. In a therapeutic mouse model of HPV16 E6/E7+ cancer, mice were vaccinated with virosomes loaded with either Amplivant-conjugated SLPs or lipid-coupled SLPs. Vaccination with both types of virosomes significantly improved the control of tumor outgrowth, leading to elimination of the tumors in about half the animals for the best combinations of adjuvants and to their survival beyond 100 days. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

Author

Homminga, Irene, Pieters, Rob, Langerak, Anton W., de Rooi, Johan J., Stubbs, Andrew, Verstegen, Monique, Vuerhard, Maartje, Buijs-Gladdines, Jessica, Kooi, Clarissa, Klous, Petra, van Vlierberghe, Pieter, Ferrando, Adolfo A., Cayuela, Jean Michel, Verhaaf, Brenda, Beverloo, H. Berna, Horstmann, Martin, de Haas, Valerie, Wiekmeijer, Anna-Sophia, Pike-Overzet, Karin, Staal, Frank J.T., de Laat, Wouter, Soulier, Jean, Sigaux, Francois, and Meijerink, Jules P.P.

Published
2011
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17. The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease

Author

Schmitz, Frederike, primary, Kooy-Winkelaar, Yvonne, additional, Wiekmeijer, Anna-Sophia, additional, Brugman, Martijn H, additional, Mearin, M Luisa, additional, Mulder, Chris, additional, Chuva de Sousa Lopes, Susana, additional, Mummery, Christine L, additional, Staal, Frank JT, additional, van Bergen, Jeroen, additional, and Koning, Frits, additional

Published
2015
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19. The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.

Author

Schmitz, Frederike, Kooy-Winkelaar, Yvonne, Wiekmeijer, Anna-Sophia, Brugman, Martijn H., Mearin, M. Luisa, Mulder, Chris, de Sousa Lopes, Susana Chuva, Mummery, Christine L., Staal, Frank J. T., van Bergen, Jeroen, and Koning, Frits

Subjects
DUODENAL diseases, LYMPHOCYTES, CELIAC disease, T cells, PHENOTYPES, HIERARCHICAL clustering (Cluster analysis), KILLER cells, CD antigens
Published
2016
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20. MEF2C as Novel Oncogene for Early T-Cell Precursor (ETP) Leukemia

Author

Homminga, Irene, primary, Pieters, Rob, additional, Langerak, Anton, additional, de Rooi, Johan, additional, Stubbs, Andrew, additional, Verstegen, Monique, additional, Vuerhard, Maartje, additional, Buijs-Gladdines, Jessica, additional, Kooi, Clarissa, additional, Klous, Petra, additional, Van lierberghe, Pieter, additional, Ferrando, Adolfo, additional, Cayuela, Jean-Michel, additional, Verhaaf, Brenda, additional, Beverloo, Berna, additional, Horstmann, Martin A., additional, de Haas, Valerie, additional, Wiekmeijer, Anna-Sophia, additional, Pike-Overzet, Karin, additional, Staal, Frank, additional, de Laat, Wouter, additional, Soulier, Jean, additional, Sigaux, Francois, additional, and Meijerink, Jules, additional

Published
2010
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21. Identification of a Novel T-ALL Entity with NKX2-1/NKX2-2 Rearrangements

Author

Homminga, Irene, primary, Pieters, Rob, additional, Langerak, Anton, additional, de Rooi, Johan, additional, Stubbs, Andrew, additional, Verstegen, Monique, additional, Vuerhard, Maartje, additional, Buijs-Gladdines, Jessica, additional, Kooi, Clarissa, additional, Klous, Petra, additional, Van lierberghe, Pieter, additional, Ferrando, Adolfo, additional, Cayuela, Jean-Michel, additional, Verhaaf, Brenda, additional, Beverloo, Berna, additional, Horstmann, Martin A., additional, de Haas, Valerie, additional, Wiekmeijer, Anna-Sophia, additional, Pike-Overzet, Karin, additional, Staal, Frank, additional, de Laat, Wouter, additional, Soulier, Jean, additional, Sigaux, Francois, additional, and Meijerink, Jules P.P., additional

Published
2010
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22. MEF2Cas Novel Oncogene for Early T-Cell Precursor (ETP) Leukemia

Author

Homminga, Irene, Pieters, Rob, Langerak, Anton, de Rooi, Johan, Stubbs, Andrew, Verstegen, Monique, Vuerhard, Maartje, Buijs-Gladdines, Jessica, Kooi, Clarissa, Klous, Petra, Van lierberghe, Pieter, Ferrando, Adolfo, Cayuela, Jean-Michel, Verhaaf, Brenda, Beverloo, Berna, Horstmann, Martin A., de Haas, Valerie, Wiekmeijer, Anna-Sophia, Pike-Overzet, Karin, Staal, Frank, de Laat, Wouter, Soulier, Jean, Sigaux, Francois, and Meijerink, Jules

Abstract

Abstract 9

Published
2010
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23. Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.

Author

Wiekmeijer AS, Pike-Overzet K, Brugman MH, Salvatori DC, Egeler RM, Bredius RG, Fibbe WE, and Staal FJ

Abstract

Hematopoietic stem cells (HSCs) are defined by their ability to repopulate the bone marrow of myeloablative conditioned and/or (lethally) irradiated recipients. To study the repopulating potential of human HSCs, murine models have been developed that rely on the use of immunodeficient mice that allow engraftment of human cells. The NSG xenograft model has emerged as the current standard for this purpose allowing for engraftment and study of human T cells. Here, we describe adaptations to the original NSG xenograft model that can be readily implemented. These adaptations encompass use of adult mice instead of newborns and a short ex vivo culture. This protocol results in robust and reproducible high levels of lympho-myeloid engraftment. Immunization of recipient mice with relevant antigen resulted in specific antibody formation, showing that both T cells and B cells were functional. In addition, bone marrow cells from primary recipients exhibited repopulating ability following transplantation into secondary recipients. Similar results were obtained with cryopreserved human bone marrow samples, thus circumventing the need for fresh cells and allowing the use of patient derived bio-bank samples. Our findings have implications for use of this model in fundamental stem cell research, immunological studies in vivo and preclinical evaluations for HSC transplantation, expansion, and genetic modification.

Published
2014
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